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Proteomic approach for personalized Medicine in cancer chemotherapy

Research Project

Project/Area Number 18390053
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Medical pharmacy
Research InstitutionKeio University

Principal Investigator

TANIGAWARA Yusuke  Keio University, School of Medicine, Professor (30179832)

Co-Investigator(Kenkyū-buntansha) SUZUKI Sayo  Keio University, School of Medicine, Instructor (90424134)
Project Period (FY) 2006 – 2007
Project Status Completed (Fiscal Year 2007)
Budget Amount *help
¥17,130,000 (Direct Cost: ¥15,300,000、Indirect Cost: ¥1,830,000)
Fiscal Year 2007: ¥7,930,000 (Direct Cost: ¥6,100,000、Indirect Cost: ¥1,830,000)
Fiscal Year 2006: ¥9,200,000 (Direct Cost: ¥9,200,000)
Keywordspersonalized medecine / proteome / metabolome / biomarker / chemosensitivity / protein chip / oxaliplatin / irinotecan / 抗がん剤 / 個人差 / SELDI-TOF MS / MALDI-MS
Research Abstract

To improve cancer chemotherapy, personalized medicine based on the individual tumor characteristics is urgently needed. Useful biomarkers that can predict the chemosensitivity is expected to be one of the strong tools to select the optimal treatment for each patient. Colorectal cancer is a common and lethal disease, and oxaliplatin (L-OHP), irinotecan (CPT-11) and fluorouracil (5-FU)are key drugs in the treatments for colorectal cancer. We aimed to discover useful biomarkers for predicting the sensitivity to chemotherapy by proteomic and metabolomic approach.
1. Discovery of biomarkers for L-OHP sensitivity: Using various types of 11 human colorectal cancer cell lines, we evaluated the oxaliplatin sensitivity as IC50 values, and analyzed their intracellular protein expression profiles by surface-enhanced laser desorption/ionization time-of-flight mass spectrometry (SELDI-TOF MS). By Expression Difference Mapping analysis and linear regression analysis between oxaliplatin sensitivity and … More the peak intensity of each mass detected, we found a potential protein biomarker for predicting L-OHP sensitivity which expression is well associated with L-OHP sensitivity.
2. Discovery of biomarkers for CPT-11 sensitivity: To elucidate the responsiveness of cancer cells to CPT-11, human colorectal carcinoma with low sensitivity(HT-29)or high sensitivity (HCT-116) was implanted subcutaneously into nude mice, and their serum was analyzed by capillary electrophoresis time-of-flight mass spectrometry (CE-TOFMS). A characteristic peak was detected between low sensitivity and high sensitivity cancer cells in the serum metabolites. It might be a useful biomarker that can reveal sensitivity of cancer to CPT-11 therapy.
3. The metabolic responsiveness of cancer cells to 5-FU exposure: Human colorectal carcinoma LS174T cells were exposed to high (100 μM) or low (2 μM) 5-FU concentration. After 0, 4, 8, and 12 h exposure, all intracellular metabolites were extracted and analyzed by CE-TOFMS. We firstly showed the dynamics of intracellular metabolites flux after 5-FU exposure. Less

Report

(3 results)
  • 2007 Annual Research Report   Final Research Report Summary
  • 2006 Annual Research Report
  • Research Products

    (71 results)

All 2008 2007 2006

All Journal Article (38 results) (of which Peer Reviewed: 17 results) Presentation (19 results) Book (10 results) Patent(Industrial Property Rights) (4 results)

  • [Journal Article] 小児深在性真菌症患者におけるmicafunginの有効性、安全性および薬物動態2008

    • Author(s)
      砂川 慶介
    • Journal Title

      日本化学療法学会雑誌 56

      Pages: 190-201

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Annual Research Report 2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] 呼吸器感染症に対するsitafloxacinの一般臨床試験2008

    • Author(s)
      斎藤 厚
    • Journal Title

      日本化学療法学会雑誌 56(増刊)

      Pages: 63-80

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Efficacy, safety and pharmacokinetics of micafungin in preatric patiens wirh deep mycoses. (Japanese)2008

    • Author(s)
      K., Sunagawa
    • Journal Title

      Jpn. J. Chemother 56

      Pages: 190-201

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Open study of sitafloxacin in patients with respiratory tract infections PK/PD study. (Japanese)2008

    • Author(s)
      A., Saito
    • Journal Title

      Jpn. J. Chemother 56

      Pages: 63-80

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Phase II Study of Oxaliplatin in Japanese Patients with Metastatic Colorectal Cancer Refractory to Fluoropyrimidines2007

    • Author(s)
      N.Boku
    • Journal Title

      Jpn.J.Clin.Oncol 10

      Pages: 440-445

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] がん化学療法レジメンのエビデンスとなる臨床論文の副作用特性に基づいた「副作用グレード評価シート」の作成2007

    • Author(s)
      今村 知世
    • Journal Title

      日本病院薬剤師会雑誌 43

      Pages: 796-799

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Phase II study of oxaliplatin in Japanese patients with metastatic colorectal cancer refractory to fluoropyrimidines2007

    • Author(s)
      N., Boku
    • Journal Title

      Jpn. J. Clin. Oncol 37

      Pages: 440-445

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Preparation of the form for adverse reaction monitoring and grading for chemotherapy regimens based on their adverse reaction profiles reported from clinical trials. (Japanese)2007

    • Author(s)
      C., Imamura
    • Journal Title

      J. Jpn. Soc. Hospital Pharmaceutics 43

      Pages: 796-799

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Phase II Study of Oxaliplatin in Japanese Patients with Metastatic Colorectal Cancer Refractory to Fluoropyrimidines2007

    • Author(s)
      N. Boku
    • Journal Title

      Jpn. J. Clin. Oncol. 10

      Pages: 440-445

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] がん化学療法レジメンのエビデンスとなる臨床論文の副作用特性に基づいた 「副作用グレード評価シート」の作成2007

    • Author(s)
      今村 知世
    • Journal Title

      日本病院薬剤師会雑誌 43

      Pages: 796-799

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Thalidomide for the treatment of leptoningeal multiple myeloma2006

    • Author(s)
      Y.Hattori
    • Journal Title

      Eur.J.Haematol 76

      Pages: 358-359

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Effects of methylene- tetrahydorofolate reductase and reduced folate carrier 1 polymorphisms on high-dose methotrexate-induced toxicities in children with acute lymphoblastic leukemia or lymphoma2006

    • Author(s)
      N.Shimasaki
    • Journal Title

      J.Pediatric Hematol.Oncol 28

      Pages: 64-68

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Novel application of protein chip technology exploring acuterejection markers of rat small bowel transplantation2006

    • Author(s)
      Y.Yamayoshi
    • Journal Title

      Transpalntation 82

      Pages: 320-326

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Population pharmacokinetics of arbekacin in patients infected with Methicillin-resistant Staphylococcus aureus2006

    • Author(s)
      Y.Tanigawara
    • Journal Title

      Antimicrobial Agents Chemother 50

      Pages: 3754-3765

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Pharmacokinetic- pharmacodynamic relationship of arbekacin for treatment of patients infected with Methicillin-resistant Staohvlococcus aureus2006

    • Author(s)
      R.Sato
    • Journal Title

      Antimicrobial Agents Chemother 50

      Pages: 3763-3769

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Phase I/II study of oxaliplatin with weekly bolus fluorouracil and high-dose leucovorin (ROX) as first-line therapy for patients with colorectal cancer2006

    • Author(s)
      Y.Yamada
    • Journal Title

      Jpn.J.Clin.Oncol 36

      Pages: 218-223

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Phase I and pharmacokinetic study of edotecarin, a novel topoisomerase I inhibitor, administered once every 3 weeks in patients with solid tumors2006

    • Author(s)
      Y.Yamada
    • Journal Title

      Cancer Chemother.Pharmacol 58

      Pages: 173-182

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Population pharmacokinetic analysis of micafungin in Japanese patients with fungal infections2006

    • Author(s)
      K.Tabata
    • Journal Title

      Drug Metab.Pharmacokinet 21

      Pages: 324-331

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Linear pharmacokinetics of micafungin and its active metabolites in Japanese pediatric patients with fungal infections2006

    • Author(s)
      K.Tabata
    • Journal Title

      Biol.Pharm.Bull 29

      Pages: 1706-1711

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Phase I study of single-dose oxaliplatin in Japanese patients with malignant tumors2006

    • Author(s)
      K.Shirao
    • Journal Title

      Jpn.J.Clin.Oncol 36

      Pages: 295-300

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] 1173C>T polymorphism in VKORC1 modulates the required warfarin dose2006

    • Author(s)
      K.Kosaki
    • Journal Title

      Pediatr.Cardiol 27

      Pages: 685-688

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Thalidomide for the treatment of leptoningeal multiple myeloma2006

    • Author(s)
      Y., Hattori
    • Journal Title

      Eur. J. Haematol 76

      Pages: 358-359

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Effects of methylene- tetrahydorofolate reductase and reduced folate carrier 1 polymorphisms on high-dose methotrexate-induced toxicities in children with acute lymphoblastic leukemia or lymphoma2006

    • Author(s)
      N., Shimasaki
    • Journal Title

      J. Pediatric Hematol. Oncol 28

      Pages: 64-68

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Novel application of protein chip technology exploring acute rejection markers of rat small bowel transplantation2006

    • Author(s)
      Y., Yamayoshi
    • Journal Title

      Transplantation 82

      Pages: 320-326

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Population pharmacokinetics of arbekacin in patients infected with Methicillin-resistant Staphylococcus aureus2006

    • Author(s)
      Y., Tanigawara
    • Journal Title

      Antimicrobial Agents Chemother 50

      Pages: 3754-3762

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Pharmacokinetic- pharmacodynamic relationship of arbekacin for treatment of patients infected with Methicillin-resistant Staphylococcus aureus2006

    • Author(s)
      R., Sato
    • Journal Title

      Antimicrobial Agents Chemother 50

      Pages: 3763-3769

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Phase I/II study of oxaliplatin with weekly bolus fluorouracil and high-dose leucovorin (ROX) as first-line therapy for patients with colorectal cancer2006

    • Author(s)
      Y., Yamada
    • Journal Title

      Jpn. J. Clin. Oncol 36

      Pages: 218-223

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Phase I and pharmacokinetic study of edotecarin, a novel topoisomerase I inhibitor, administered once every 3 weeks in patients with solid tumors2006

    • Author(s)
      Y., Yamada
    • Journal Title

      Cancer Chemother. Pharmacol 58

      Pages: 173-182

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Population pharmacokinetic analysis of micafungin in Japanese patients with fungal infections2006

    • Author(s)
      K., Tabata
    • Journal Title

      Drug Metab. Pharmacokinet 21

      Pages: 324-331

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Linear pharmacokinetics of micafungin and its active metabolites in Japanese pediatric patients with fungal infections2006

    • Author(s)
      K., Tabata
    • Journal Title

      Biol. Pharm. Bull 29

      Pages: 1706-1711

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Phase I study of single-dose oxaliplatin in Japanese patients with malignant tumors2006

    • Author(s)
      K., Shirao
    • Journal Title

      Jpn. J. Clin. Oncol 36

      Pages: 295-300

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] 1173C>T polymorphism in VKORC1 modulates the required warfarin dose2006

    • Author(s)
      K., Kosaki
    • Journal Title

      Pediatr. Cardiol 27

      Pages: 685-688

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Population Pharmacokinetics of Arbekacin in Patients Infected with Methicillin-Resistant Stapylococcus Aureus.2006

    • Author(s)
      Y.Tanigawara
    • Journal Title

      Antimicrobial Agents Chemother. 50(11)

      Pages: 3754-3762

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Novel Application of ProteinChip Technology Exploring Acute Rejection Markers of Rat Small Bowel Transplantation.2006

    • Author(s)
      Y.Yamayoshi
    • Journal Title

      Transplantation 82(3)

      Pages: 320-326

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Phase I and pharmacokinetic study of edotecarin, a novel topoisomerase I inhibitor, administered once every 3 weeks in patients with solid tumors.2006

    • Author(s)
      Y.Yamayoshi
    • Journal Title

      Cancer Chemother Pharmacol. 58

      Pages: 173-182

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Phase I/II Study of Oxaliplatin with Weekly Bolus Fluorouracil and High-Dose Leucovorin (ROX) as First-Line Therapy for Patients with Colorectal Cancer.2006

    • Author(s)
      Y.Yamada
    • Journal Title

      Jpn J Clin Oncol. 36(4)

      Pages: 218-223

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Thalidomide for the treatment of leptoningeal multiple myeloma.2006

    • Author(s)
      Y.Hattori
    • Journal Title

      Eur. J. Haematol. 76

      Pages: 358-359

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Effects of methylenetetrahydrofolate reductase and reduced folate carrier 1 polymorphisms on high-dose methotrexate-induced toxicities in children with acute lymphoblastic leukimia or lymphoma.2006

    • Author(s)
      N.Shimasaki
    • Journal Title

      J. Pediatric. Hematol. Oncol. 28(2)

      Pages: 64-68

    • Related Report
      2006 Annual Research Report
  • [Presentation] CE-TOFMSメタボローム解析による5-FU曝露後の細胞内代謝物動態2008

    • Author(s)
      西牟田 章戸
    • Organizer
      日本薬学会第128年会
    • Place of Presentation
      横浜
    • Year and Date
      2008-03-28
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Metabolome analysis of intracellular metabolite kinetics after 5-FU exposure by CE-TOFMS2008

    • Author(s)
      A., Nishimuta
    • Organizer
      The 128th Japanese Meeting of the Pharmaceutical Society of Japan
    • Place of Presentation
      Yokohama, Japan
    • Year and Date
      2008-03-28
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] CE-TOFMSメタボローム解析による5-FU曝露後の細胞内代施物動態2008

    • Author(s)
      西牟田 章戸
    • Organizer
      日本薬学会第128年会
    • Place of Presentation
      横浜
    • Year and Date
      2008-03-28
    • Related Report
      2007 Annual Research Report
  • [Presentation] プロテオミクスによるオキサリプラチン感受性予測バイオマーカーの探索2008

    • Author(s)
      鈴木 小夜
    • Organizer
      日本薬学会第128年会
    • Place of Presentation
      横浜
    • Year and Date
      2008-03-27
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Annual Research Report 2007 Final Research Report Summary
  • [Presentation] CE-TOFMSメタボローム解析による大腸癌のイリノテカンに対する感受性バイオマーカーの探索2008

    • Author(s)
      有田 惠理
    • Organizer
      日本薬学会第128年会
    • Place of Presentation
      横浜
    • Year and Date
      2008-03-27
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Annual Research Report 2007 Final Research Report Summary
  • [Presentation] Search for new biomarkers to predict Oxaliplatin sensitivity by SELDI-TOF MS proteomic screening2008

    • Author(s)
      S., Suzuki
    • Organizer
      The 128th Japanese Meeting of the Pharmaceutical Society of Japan
    • Place of Presentation
      Yokohama, Japan
    • Year and Date
      2008-03-27
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Blood biomarkers to predict sensitivity to CPT-11 using CE-TOFMS metabolomic screening2008

    • Author(s)
      E., Arita
    • Organizer
      The 128th Japanese Meeting of the Pharmaceutical Society of Japan
    • Place of Presentation
      Yokohama, Japan
    • Year and Date
      2008-03-27
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] UGT1A1の遺伝子多型と塩酸イリノテカンのPPKおよびPK/PD2008

    • Author(s)
      田村 研治
    • Organizer
      第6回日本臨床腫瘍学会学術集会
    • Place of Presentation
      福岡
    • Year and Date
      2008-03-21
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Annual Research Report 2007 Final Research Report Summary
  • [Presentation] Association between UGT1A1 genotypes and pharmacokinetics / pharmacodynamics (PK/PD) of Irinotecan (CPT-11)2008

    • Author(s)
      K., Tamura
    • Organizer
      The 6th Annual Meeting of Japanese Society of Medical Oncology
    • Place of Presentation
      Fukuoka, Japan
    • Year and Date
      2008-03-21
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] プロテインチップシステムによる生体小腸移植後の拒絶マーカー探索2008

    • Author(s)
      山吉 康子
    • Organizer
      第20回日本小腸移植研究会
    • Place of Presentation
      大阪
    • Year and Date
      2008-03-01
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Annual Research Report 2007 Final Research Report Summary
  • [Presentation] Clinical applicaion of ProteinChip system for develop acute rejection marker after living-donor small bowel transplantation2008

    • Author(s)
      Y., Yamayoshi
    • Organizer
      20th Annual meeting of The Japanese Society for Small Bowel Transplantation
    • Place of Presentation
      Yokohama, Japan
    • Year and Date
      2008-03-01
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 血管新生阻害剤bevacizumabの薬効指標となるバイオマーカーの探索2007

    • Author(s)
      福田 八寿絵
    • Organizer
      日本薬学会第127年会
    • Place of Presentation
      富山
    • Year and Date
      2007-03-29
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] DNA microarray analysis for novel genes associated with the response to bevacizumab treatment2007

    • Author(s)
      Y., Hukuda
    • Organizer
      The '127th Japanese Meeting of the Pharmaceutical Society of Japan
    • Place of Presentation
      Toyama, Japan
    • Year and Date
      2007-03-29
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 小腸移植後の急性拒絶反応の早期診断をめざしたマルチマーカー解析の検討2006

    • Author(s)
      山吉 康子
    • Organizer
      第23日本TDM学会学術大会
    • Place of Presentation
      東京
    • Year and Date
      2006-07-16
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 末梢血液を用いた拒絶の遺伝子マーカーAIF1のラット移植モデルおよび生体肝移植症例における検討2006

    • Author(s)
      石川 春樹
    • Organizer
      第23日本TDM学会学術大会
    • Place of Presentation
      東京
    • Year and Date
      2006-07-16
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] ProteinChip analysis for development of acute rejection markers after small bowel transplantation2006

    • Author(s)
      Y., Yamayoshi
    • Organizer
      23th The Japanese Society of Therapeutic Drug Monitoring
    • Place of Presentation
      Tokyo, Japan
    • Year and Date
      2006-07-16
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Noninvasive diagnosis of allograft rejection after human liver transplantation by measurement of mRNA for AIF1 gene in peripheral blood2006

    • Author(s)
      H., Ishikawa
    • Organizer
      23th The Japanese Society of Therapeutic Drug Monitoring
    • Place of Presentation
      Tokyo, Japan
    • Year and Date
      2006-07-16
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Novel Application of ProteinChip Technology Exploring Acute Rejection Markers of Rat Small Bowel Transplantation2006

    • Author(s)
      Yasuko Yamayoshi
    • Organizer
      5th International Symposium on MEASUREMENT AND KINETICS OF IN VWO DRUG EFFECTS
    • Place of Presentation
      Noordwijkerhout (Netherlands)
    • Year and Date
      2006-04-27
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Novel application of ProteinChip technology exploring acute rejection markers of rat small bowel transplantation2006

    • Author(s)
      Y., Yamayoshi
    • Organizer
      5th International Symposium on MEASUREMENT AND KINETICS OF IN VIVO DRUG EFFECTS
    • Place of Presentation
      Noordwijkerhout, Netherlands
    • Year and Date
      2006-04-27
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Book] がん化学療法副作用グレード評価シート2008

    • Author(s)
      谷川原 祐介
    • Total Pages
      128
    • Publisher
      南山堂
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Annual Research Report 2007 Final Research Report Summary
  • [Book] これからの乳癌診療2008-20092008

    • Author(s)
      鈴木 小夜
    • Publisher
      金原出版
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Annual Research Report 2007 Final Research Report Summary
  • [Book] 今日の治療指針20082008

    • Author(s)
      谷川原 祐介
    • Publisher
      医学書院
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Book] 薬剤師のための感染制御標準テキスト2008

    • Author(s)
      池谷 修
    • Publisher
      じほう
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Annual Research Report 2007 Final Research Report Summary
  • [Book] 今日の治療指針 20082008

    • Author(s)
      谷川原 祐介
    • Publisher
      医学書院
    • Related Report
      2007 Annual Research Report
  • [Book] 生物薬剤学改訂第2版2007

    • Author(s)
      谷川原 祐介(編)
    • Total Pages
      261
    • Publisher
      南江堂
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Book] 安全で有効な外来がん化学療法の実践2007

    • Author(s)
      谷川原 祐介
    • Publisher
      先端医学社
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Annual Research Report 2007 Final Research Report Summary
  • [Book] スタンダード薬学シリーズ10実務事前実習病院、薬局に行く前に2006

    • Author(s)
      谷川原 祐介
    • Publisher
      東京化学同人
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Book] 最新臨床検査のABC2006

    • Author(s)
      鈴木 小夜
    • Publisher
      日本医師会
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Book] 乳がん標準化学療法の実際2006

    • Author(s)
      今村 知世
    • Publisher
      金原出版
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Patent(Industrial Property Rights)] 抗がん剤感受性の判定方法2008

    • Inventor(s)
      谷川原 祐介, 鈴木 小夜, 杉本 伸二
    • Industrial Property Rights Holder
      学校法人慶應義塾 株式会社ヤクルト本社
    • Industrial Property Number
      2008-021124
    • Filing Date
      2008-01-31
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Patent(Industrial Property Rights)] 抗がん剤感受性判定マーカー2008

    • Inventor(s)
      谷川原 祐介, 渡辺 光博, 有田 惠理, 西牟田 章戸, 山吉 康子, 松崎 健, 杉本 伸二
    • Industrial Property Rights Holder
      学校法人慶應義塾 株式会社ヤクルト本社
    • Industrial Property Number
      2008-021123
    • Filing Date
      2008-01-31
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Patent(Industrial Property Rights)] 抗がん剤感受性の判定方法2008

    • Inventor(s)
      谷川 原祐介, 鈴木 小夜, 杉本 伸二
    • Industrial Property Rights Holder
      学校法人慶應義塾株式会社ヤクルト本社
    • Industrial Property Number
      2008-021124
    • Filing Date
      2008-01-31
    • Related Report
      2007 Annual Research Report
  • [Patent(Industrial Property Rights)] 抗がん剤感受性判定マーカー2008

    • Inventor(s)
      谷川 原祐介, 渡辺 光博, 有田 恵理, 西牟 田章戸, 山吉 康子, 松崎 健, 杉本 伸二
    • Industrial Property Rights Holder
      学校法人慶應義塾株式会社ヤクルト本社
    • Industrial Property Number
      2008-021123
    • Filing Date
      2008-01-31
    • Related Report
      2007 Annual Research Report

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Published: 2006-04-01   Modified: 2016-04-21  

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