| Budget Amount *help |
¥16,260,000 (Direct Cost: ¥13,800,000、Indirect Cost: ¥2,460,000)
Fiscal Year 2008: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2007: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2006: ¥5,600,000 (Direct Cost: ¥5,600,000)
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| Research Abstract |
A tissue-engineered artificial lymphoid tissue (aLT) can be constructed by introducing stromal cells embedded in a collagenous scaffold. In this study, we confirmed functional efferent lymphatic vessel formation in aLTs. It was revealed aLTs had specialized blood vessels distinct from ordinary blood vessels or high endothelial venules. Further, we found that activated lymphocytes were concentrated in aLTs, which enabled aLTs to introduce effective cytotoxic T cell activities in severe-combined immunodeficient mice. Our data suggested that possible therapeutic application of aLTs for adaptive immunity activation against intractable infectious diseases or cancer.
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