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Clock gene response against skelton type entrainment stimulation in mice

Research Project

Project/Area Number 18390071
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Environmental physiology (including Physical medicine and Nutritional physiology)
Research InstitutionWaseda University

Principal Investigator

SHIBATA Shigenobu  Waseda University, Faculty of Science and Engineering, Professor (10162629)

Co-Investigator(Kenkyū-buntansha) HORIKAWA Kazumasa  Waseda University, Faculty of Human Sciences, Assistant professor (80386664)
KUDO Takashi  Waseda University, Faculty of Science and Engineering, Assistant Professor (10434284)
Project Period (FY) 2006 – 2007
Project Status Completed (Fiscal Year 2007)
Budget Amount *help
¥15,950,000 (Direct Cost: ¥14,900,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2007: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2006: ¥11,400,000 (Direct Cost: ¥11,400,000)
Keywordscircadian / clock gene / food anticipation / liver / light entrainment / nutrition / chrononutrition / circadian / entrainment / food anticipation / dexamethasone / mouse
Research Abstract

The aim of this experiment is to elucidate the mechanism of skeleton-type photic and non-photic entrainment like food entrainment in mice. First we examined the circadian pattern of clock gene expression in the liver under one-hr light stimulation in the morning and one-hr light stimulation in the evening. This lighting schedule could entrain the locomotor activity rhythm and also liver dock gene expression rhythm. Thus, skeleton lighting schedule can entrain the circadian dock just like usual 12-hr light-dark schedule. Next, we examined the circadian pattern of clock gene expression in the liver under 2-hr feeding in the morning and 2-hr feeding in the evening. This feeding schedule could entrain the liver clock gene expression rhythm, and its pattern was very similar to adlib feeding group. Thus, two feeding times per day with morning and evening could entrain the peripheral circadian rhythm. In the third experiment, we changed the ratio of feeding volume in the morning and evening. If the more feeding volume was applied in the morning, there was little effect on the phase of dock gene expression. However, if the more feeding volume was applied in the evening, phase of dock gene expression rhythm was strongly delayed. Taken together these results suggest that food intake in the morning is important to keep the phase of dock gene expression the peripheral organs.

Report

(3 results)
  • 2007 Annual Research Report   Final Research Report Summary
  • 2006 Annual Research Report
  • Research Products

    (16 results)

All 2008 2007

All Journal Article (16 results) (of which Peer Reviewed: 10 results)

  • [Journal Article] Gonadectomy reveals sex differences in circadian rhythms and suprachiasmatic nucleus androgen receptors in mice2008

    • Author(s)
      Iwahana E, Karatsoreos I, Shibata S, Silver R.
    • Journal Title

      Hormone behavior 53

      Pages: 422-430

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Clock mutation facilitates accumulation of cholesterol in the liver of mice fed a cholesterol and/or cholic acid diet2008

    • Author(s)
      Kudo T, Kawashima M, Tamagawa T, Shibata S.
    • Journal Title

      Am J Physiol Endocrinol Metab 294

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Gonadectomy reveals sex differences in circadian rhythms and suprachiasmatic nucleus androgen receptors in mice.2008

    • Author(s)
      Iwahana E, Karatsoreos I, Shibata S, Silver R.
    • Journal Title

      Hormone and behavior 53

      Pages: 422-430

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Clock mutation facilitates accumulation of cholesterol in the liver of mice fed a cholesterol and/or cholic acid diet.2008

    • Author(s)
      Kudo T, Kawashima M, Tamagawa T, Shibata S.
    • Journal Title

      Am J. Physiol. Endocrinol. Metab. 294

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Gonadectomy reveals sex differences in circadian rhythms and suprachiasmatic nucleus androgen receptors in mice.2008

    • Author(s)
      Iwahana E, Karatsoreos I, Shibata S, Silver R.
    • Journal Title

      Horm behav 53

      Pages: 422-430

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Clock mutation facilitates accumulation of cholesterol in the liver of mice fed a cholesterol and/or cholic acid diet.2008

    • Author(s)
      Kudo T, Kawashima M, Tamagawa T, Shibata S.
    • Journal Title

      Am J Physiol Endocrinol Metab. 294

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Attenuating effect of clock mutation on triglyceride contentd in the ICR mouse liver under a high-fat diet2007

    • Author(s)
      Kudo T, Tamagawa T, Kawashima M, Mito N, Shibata S.
    • Journal Title

      J Biol Rhythms 22

      Pages: 312-323

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Multifactorial rugulation of daily rhythms in expression of the metabolically responsive gene spot14 in the mouse liver2007

    • Author(s)
      Ishihara A, Matsumoto E, Horikawa K, Kudo T, Shibata S, Takiguchi M.
    • Journal Title

      J Biol Rhythms 22

      Pages: 324-334

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] PPARalpha is a potential therapeutic target of drugs to treat circadian rhythm sleep disorders2007

    • Author(s)
      Shirai H, Oishi K, Kudo T, Shibata S, Ishida N.
    • Journal Title

      Biochem Biophys Res Commun 357

      Pages: 679-682

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Attenuating effect of clock mutation on triglyceride contents in the ICR mouse liver under a high-fat diet.2007

    • Author(s)
      Kudo T, Tamagawa T, Kawashima M, Mito N, Shibata S.
    • Journal Title

      J Biol. Rhythms. 22

      Pages: 312-323

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Multifactorial regulation of daily rhythms in expression of the metabolically responsive gene spotl4 in the mouse liver.2007

    • Author(s)
      Ishihara A, Tamura Y, Shibata S, Takiguchi M.
    • Journal Title

      J Biol. Rhythms. 22

      Pages: 324-334

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] PPARalpha is a potential therapeutic target of drugs to treat circadian rhythm sleep disorders.2007

    • Author(s)
      Shirai H, Oishi K, Kudo T, Shibata S, Ishida N.
    • Journal Title

      Biochem. Biophys. Res. Commun. 357

      Pages: 679-682

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Attenuating effect of clock mutation on triglyceride contents in the ICR mouse liver under a high-fat diet.2007

    • Author(s)
      Kudo T, Tamagawa T, Kawashima M, Mito.N, Shibata S.
    • Journal Title

      J Biol Rhythms. 22

      Pages: 312-323

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Multifactorial regulation of daily rhythms in expression of the metabolically responsive gene spot14 in the mouse liver.2007

    • Author(s)
      Ishihara A, Tamura Y, Shibata S, Takiguchi M.
    • Journal Title

      J Biol Rhythms. 22

      Pages: 324-334

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] PPARalpha is a potential therapeutic target of drugs to treat circadian rhythm sleep disorders.2007

    • Author(s)
      Shirai H, Oishi K, Kudo T, Shibata S, Ishida N.
    • Journal Title

      Biochem Biophys Res Commun. 357

      Pages: 679-682

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Phase-shifting of Clock Gene Expression Rhythm in the Lungs of the Asthma Mouse Model2007

    • Author(s)
      Hayasaka, Yaita, Kuwaki, Honma, Honma, Kudo, Shibata
    • Journal Title

      Endocrinology in press

    • Related Report
      2006 Annual Research Report

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Published: 2006-04-01   Modified: 2016-04-21  

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