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Comprehensive analysis of TRIM family ubiquitin ligases

Research Project

Project/Area Number 18390079
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field General medical chemistry
Research InstitutionHokkaido University

Principal Investigator

HATAKEYAMA Shigetsugu  Hokkaido University, Graduate School of Medicine, Professor (70294973)

Co-Investigator(Kenkyū-buntansha) TSUKIYAMA Tadasuke  Hokkaido University, Graduate School of Medicine, Assistant Professor (20399819)
Project Period (FY) 2006 – 2007
Project Status Completed (Fiscal Year 2007)
Budget Amount *help
¥16,510,000 (Direct Cost: ¥14,800,000、Indirect Cost: ¥1,710,000)
Fiscal Year 2007: ¥7,410,000 (Direct Cost: ¥5,700,000、Indirect Cost: ¥1,710,000)
Fiscal Year 2006: ¥9,100,000 (Direct Cost: ¥9,100,000)
KeywordsUbiquitin / Proteasome / TRIM protein / Cancer / Ubiquitin ligase / TRIMタンパク質
Research Abstract

Ubiquitination is a versatile post-translational modification mechanism used by eukaryotic cells mainly to control protein levels through proteasome-mediated proteolysis. Ubiquitin conjugation is achieved by several enzymes that act in concert, a ubiquitin-protein ligase (E3). E3 is thought to be the component of the ubiquitin conjugation system that is most directly responsible for substrate recognition. Enzymes belonging to class E3 that have so far been identified include members of the HECT (homologous to E6-AP carboxyl terminus), RING-finger and U-box families of proteins. So far; we have published many articles about ubiquitination and oncogenesis.
Tripartite motif (TRIM) proteins are characterized by the presence of a RING finger, one or two zinc-binding motifs named B-boxes and an associated coiled-coil region (BBRC357: 245, 2007; Mal Cell Biochem 307, 73, 2008; Mol Immunol 45 2045, 2008, Cancer Res, in press).
We found that the putative E3 ubiquitin ligase TRIM68, which is prefe … More rentially expressed in prostate cancer cells, interacts with androgen receptor (AR) and enhances transcriptional activity of the AR in the presence of dihydrotestosterone (DHT). Overexpression of TRIM68 in prostate cancer cells caused an increase in secretion of prostate-specific antigen (PSA), one of the most reliable diagnostic markers for prostate cancer. Moreover, we showed that TRIM68 expression is significantly upregulated in human prostate cancers (Cancer Res, in press).
Furthermore, we found by using yeast two-hybrid screening that TRIM32 binds to Abl-interactor 2 (Abi2), which is known as a tumor suppressor gene and a cell migration inhibitor Overexpression of TRIM32 promoted degradation of Abi2, resulting in enhancement of cell growth, transforming activity and cell motility In addition, we found that TRIM32 suppresses apoptosis induced by cis-diamminedichloroplatinum (II) (cDDP) in HEp2 cell lines. These findings suggest that TRIM32 is a novel oncogene that promotes tumor growth, metastasis and resistance to anti-cancer drugs. Less

Report

(3 results)
  • 2007 Annual Research Report   Final Research Report Summary
  • 2006 Annual Research Report
  • Research Products

    (62 results)

All 2008 2007 2006 Other

All Journal Article (32 results) (of which Peer Reviewed: 18 results) Presentation (29 results) Book (1 results)

  • [Journal Article] Ro52 functionally interacts with IgGl and regulates its quality control via the ERAD system2008

    • Author(s)
      Takahata, M. , et. al.
    • Journal Title

      Mol Immunol 45

      Pages: 2045-2054

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Ubiquitylation of ε-COP by PIRH2 and regulation of the secretion of PSA.2008

    • Author(s)
      Maruyama, S. , et. al.
    • Journal Title

      Mol Cell Biochem 307

      Pages: 73-82

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Ro52 functionally interacts with IgG1 and regulates its quality control via the ERAD system.2008

    • Author(s)
      Takahata, M., Bohgaki, M., Tsukiyama, T., Kondo T., Asaka, M. and Hatakeyama S.
    • Journal Title

      Mol. Immunol 45(7)

      Pages: 2045-2054

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Ro52 functionally interacts with IgG1 and regulates its quality control via the ERAD system2008

    • Author(s)
      Takahata, M., et. al.
    • Journal Title

      Mol Immunol 45

      Pages: 2045-2054

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Ubiquitylation of ε-COP by PIRH2 and regulation of the secretion of PSA2008

    • Author(s)
      Maruyama, S., et. al.
    • Journal Title

      Mol Cell Biochem 307

      Pages: 73-82

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Involvement of Rabring7 in EGF receptor degradation as an E3 ligase2008

    • Author(s)
      Sakane, A., et. al.
    • Journal Title

      Biochem Biophys Res Commun 357

      Pages: 1058-1064

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Establishment of a newly improved detection system for NF-kB activity2008

    • Author(s)
      Matsuda, M., et. al.
    • Journal Title

      Immunol. Lett 109(2)

      Pages: 175-181

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Involvement of Rabring7 in EGF receptor degradation as an E3 Iigase.2007

    • Author(s)
      Sakane, A. , et. al.
    • Journal Title

      Biochem Biophys Res Commun 357

      Pages: 1058-1064

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Establishment of a newly improved detection system for NF-kB activity.2007

    • Author(s)
      Matsuda, M. , et. al.
    • Journal Title

      Immunol. Lett 109(2)

      Pages: 175-181

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Ligand-dependent transcription of estrogen receptor α is mediated by the ubiquitin ligase EFP.2007

    • Author(s)
      Nakajima, A. , et. al.
    • Journal Title

      Biochem. Biophys. Res. Commun 357

      Pages: 245-251

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Protection of vincristine-induced neuropathy by WldS expression and the indepen dence of the activity of Nmnatl.2007

    • Author(s)
      Watanabe, M. , et. al.
    • Journal Title

      Neurosci. Lett 411

      Pages: 228-232

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] APS-mediated Ubiquitination of the Insulin Receptor Enhances its Internalization, but does not Induce its Degradation.2007

    • Author(s)
      Kishi, K. , et. al.
    • Journal Title

      Endocr. J 54

      Pages: 77-78

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Ubiquitylation of s-COP by PIRH2 and regulation of the secretion of PSA.2007

    • Author(s)
      Maruyama, S., Miyajima, N., Bohgaki, M., Tsukiyama, T., Shigemura, M., Nonomura, K. and Hatakevama, S.
    • Journal Title

      Neurosci. Lett 411

      Pages: 228-232

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Protection of vincristine-induced neuropathy by W1dS expression and the independence of the activity of Nmnatl.2007

    • Author(s)
      Watanabe, M., Tsukiyama, T. and Hatakeyama, S.
    • Journal Title

      Neurosci.Lett 411

      Pages: 228-232

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] APS-mediated Ubiquitination of the Insulin Receptor Enhances its Internalization, but does not Induce its Degradation.2007

    • Author(s)
      Kishi, K., Mawatari, K., Sakai-Wakamatsu, K., Yuasa, T., Wang, M., Ogura-Sawa, M., Nakaya, Y., Hatakeyama, S. and Ebina, Y.
    • Journal Title

      Endocr. J 54

      Pages: 77-88

    • NAID

      10019479382

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Establishment of a newly improved detection system for NF-KB activity.2007

    • Author(s)
      Matsuda, M., Tsukiyama, T., Bohgaki, M., Nonomura, K. and Hatakeyama. S.
    • Journal Title

      Immunol. Lett 109

      Pages: 175-181

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Ligand-dependent transcription of estrogen receptor a is mediated by the ubiquitin ligase EFP.2007

    • Author(s)
      Nakajima, A., Maruyama, S., Bohgaki, M., Miyajima, N., Tsukiyama, T., Sakuragi, N. and Hatakevama, S.
    • Journal Title

      Biochem. Biophys. Res. Commun 357

      Pages: 245-251

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Involvement of Rabring7 in EGF receptor degradation as an E3 ligase.2007

    • Author(s)
      Sakane, A., Hatakevama, S. and Sasaki, T.
    • Journal Title

      Biochem. Biophys. Res. Commun 357

      Pages: 1058-1064

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Ligand-dependent transcription of estrogen receptor α is mediated by the ubiquitin ligase EFP2007

    • Author(s)
      Nakajima, A., et. al.
    • Journal Title

      Biochem. Biophys. Res. Commun 357

      Pages: 245-251

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Protection of vincristine-induced neuropathy by Wld^s expression and the independence of the activity of Nmnatl.2007

    • Author(s)
      Watanabe, M.
    • Journal Title

      Neurosci. Lett. 411

      Pages: 228-232

    • Related Report
      2006 Annual Research Report
  • [Journal Article] APS-mediated Ubiquitination of the Insulin Receptor Enhances its Internalization, but does not Induce its Degradation.2007

    • Author(s)
      Kishi, K.
    • Journal Title

      Endocr. J. (In press)

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Establishment of a newly improved detection system for NF-κB activity.2007

    • Author(s)
      Matsuda, M.
    • Journal Title

      Immunol. Lett. (In press)

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Elmol inhibits ubiquitylation of Dock180.2006

    • Author(s)
      Makino, Y. , et. al.
    • Journal Title

      J. Cell Sci 119

      Pages: 923-932

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Degradation of Tobl mediated by SCF^<skp2->dependentubiquitination.2006

    • Author(s)
      Hiramatsu, Y, et. al.
    • Journal Title

      Cancer Res 66

      Pages: 8477-8483

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Elmol inhibits ubiquitylation of Dock180.2006

    • Author(s)
      Makino, Y., Tsuda, M., Ichihara, S., Watanabe, T., Sawa, H., Nagashima, K., Hatakeyama, S. and Tanaka, S
    • Journal Title

      J. Cell Sci 119

      Pages: 923-932

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Degradation of Tobl mediated by2006

    • Author(s)
      Hiramatsu, Y., Kitagawa, K., Suzuki, T., Uchida, C., Hattori, T., Kikuchi, H., Oda, T., Hatakevama S., Nakayama, K-i., Yamamoto, T., Konno, H. and Kitagawa, M.
    • Journal Title

      Cancer Res 66

      Pages: 8477-8483

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Elmol inhibits ubiquitylation of Dock180.2006

    • Author(s)
      Makino, Y.
    • Journal Title

      J. Cell Sci. 119

      Pages: 923-932

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Degradation of Tobl mediated by SCF^<Skp2->dependent ubiquitination.2006

    • Author(s)
      Hiramatsu, Y.
    • Journal Title

      Cancer Res. 66

      Pages: 8477-8483

    • Related Report
      2006 Annual Research Report
  • [Journal Article] TRIM68 regulates ligand-dependent transcription of androgen receptor in prostate cancer cells.

    • Author(s)
      Miyajima, N. , et. al.
    • Journal Title

      Cancer Reseach (In press)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Involvement of Ymer in suppression of NF-kB activation by regulated interaction with lysine-63-linked polyuquitin chain.

    • Author(s)
      Bohgaki, M. , et. al.
    • Journal Title

      BBA-Mol Cell Res (In press)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] TRIM68 regulates ligand-dependent transcription of androgen receptor in prostate cancer cells

    • Author(s)
      Miyajima, N., et. al.
    • Journal Title

      Cancer Reseach (In press)

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Involvement of Ymer in suppression of NF-kB activation by regulated interaction with lysine-63-linked polyuquitin chain

    • Author(s)
      Bohgaki, M., et. al.
    • Journal Title

      BBA-Mol Cell Res (In press)

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Presentation] Ubiquitin-mediated regulation of coatomer protein complex, subunit epsilon by ARNIP/Pirh2.2007

    • Author(s)
      Maruyama S. , et. al.
    • Organizer
      the 2007 Annual Meeting of the American Urological Association Education and Research Inc.
    • Place of Presentation
      Anaheim Convention Center
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Ubiquitination of e-COP by PIRH2 and regulation of the secretion of PSA2007

    • Author(s)
      Hatakeyama, S., Maruyama, S.
    • Organizer
      International Symposium on Membrane Traffic
    • Place of Presentation
      淡路島夢舞台
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Annual Research Report 2007 Final Research Report Summary
  • [Presentation] Regulation of polarized accumulation of Cdc42p by Gic proteins that specifically interact with the GTP-bound from of Cdc42p in yeast.2007

    • Author(s)
      Fujii, K., Hatakeyama, S., Tanaka, K.
    • Organizer
      International Symposium on Membrane Traffic
    • Place of Presentation
      淡路島夢舞台
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Ubiquitin-mediated regulation of coatomer protein complex, subunit epsilon byARNIP/Pirh2.2007

    • Author(s)
      Maruyama S., Miyajima N., Sato T., Kashiwagi A., Satoshi N., Abe, T., Sazawa A., Harabayashi T., Shinohara N., Hatakevama. S., Nonomura K
    • Organizer
      Annual Meeting of the American Urological Association Education and Research Inc
    • Place of Presentation
      Anaheim
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Ubiquitination of s-COP by PIRH2 and regulation of the secretion of PSA.2007

    • Author(s)
      Hatakevama, S, and Maruyama, S.
    • Organizer
      International Symposium on Membrane Traffic
    • Place of Presentation
      Awajishima
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Regulation of polarized accumulation of Cdc42p by Gic proteins that specifically interact with the GTP-bound form of Cdc42p in yeast.2007

    • Author(s)
      Fujii, K., Hatakeyama, S. and Tanaka, K.
    • Organizer
      International Symposium on Membrane Traffic
    • Place of Presentation
      Awajishima
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Ubiquitin-mediated regulation of coatomer protein complex, subunit epsilon by APNIP/Pirh22007

    • Author(s)
      Maruyama S., et. al.
    • Organizer
      the 2007 Annual Meeting of the American Urological Association Education and Research Inc.
    • Place of Presentation
      Anaheim Convention Center
    • Related Report
      2007 Annual Research Report
  • [Presentation] Regulation of polarized accumulation of Cdc42p by Gic proteins that specifically interact with the GTP-bound from of Cdc42p in yeast2007

    • Author(s)
      Fujii, K., Hatakeyama, S., Tanaka, K.
    • Organizer
      International Symposium on Membrane Traffic
    • Place of Presentation
      淡路島夢舞台
    • Related Report
      2007 Annual Research Report
  • [Presentation] 新規ユビキチン様修飾分子GdXによるcyclin Fと細胞周期M期の制御2007

    • Author(s)
      石田典子、畠山鎮次、中山啓子、中山敬一
    • Organizer
      第30回日本分子生物学会年会・第80回日本生化学会大会・合同大会
    • Place of Presentation
      パシフィコ横浜
    • Related Report
      2007 Annual Research Report
  • [Presentation] TRIM68 is required for androgen-dependent transcription and regulates prostate cancer cell growth2007

    • Author(s)
      Miyajima, N., Maruyama, S., Tsukiyama, T., Nonomura, K., Hatakeyama, S.
    • Organizer
      第30回日本分子生物学会年会・第80回日本生化学会大会・合同大会
    • Place of Presentation
      パシフィコ横浜
    • Related Report
      2007 Annual Research Report
  • [Presentation] ユビキチンリガーゼTripartite motif protein32(TRIM32)による癌細胞増殖制御2007

    • Author(s)
      加納里志、築山忠維、福田 諭、畠山鎮次
    • Organizer
      第30回日本分子生物学会年会・第80回日本生化学会大会・合同大会
    • Place of Presentation
      パシフィコ横浜
    • Related Report
      2007 Annual Research Report
  • [Presentation] ユビキチン統合酵素E2Q2の結合タンパク質の同定と機能的解析2007

    • Author(s)
      真栄田裕行、築山忠維、畠山鎮次
    • Organizer
      第30回日本分子生物学会年会・第80回日本生化学会大会・合同大会
    • Place of Presentation
      パシフィコ横浜
    • Related Report
      2007 Annual Research Report
  • [Presentation] 改良型NF-kB活性検出システムの構築2007

    • Author(s)
      築山忠維、松田真由子、畠山鎮次
    • Organizer
      第30回日本分子生物学会年会・第80回日本生化学会大会・合同大会
    • Place of Presentation
      パシフィコ横浜
    • Related Report
      2007 Annual Research Report
  • [Presentation] A novel protein interacts with ubiquitin modifying protein A20.2006

    • Author(s)
      Bohgaki, M., et. al
    • Organizer
      20th IUBMB International Congress of Biochemistry and Molecular Biology and llth FAOBMB Congress., Kyoto
    • Place of Presentation
      Kyoto International Conference Hall
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Wnt5a is a haploinsufficient tumor suppressor that cooperates with Tcfl to suppress T cell lymphomas.2006

    • Author(s)
      Tsukiyama, T., et. al
    • Organizer
      20th IUBMB International Congress of Biochemistry and Molecular Biology and llth FAOBMB Congress., Kyoto
    • Place of Presentation
      Kyoto International Conference Hall
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Systematic analysis of phosphotyrosine-related proteome provides novel insights into signal transduction.2006

    • Author(s)
      Matsumoto, M., et. al
    • Organizer
      20th IUBMB International Congress of Biochemistry and Molecular Biology and 11th FAOBMB Congress., Kyoto
    • Place of Presentation
      Kyoto International Conference Hall
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Ubiquitin ligase EFP as a regulator for estrogen receptor.2006

    • Author(s)
      Nakajima, A., et. al
    • Organizer
      20th IUBMB International Congress of Biochemistry and Molecular Biology and 11th FAOBMB Congress., Kyoto
    • Place of Presentation
      Kyoto International Conference Hall
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] RING-finger protein Ro52/TRIM21 functionally interacts with IgGl heavy chain and p97/valosin-containing protein.2006

    • Author(s)
      Takahata, M., et. al
    • Organizer
      20th lUBMB International Congress of Biochemistry and Molecular Biology and 11th FAOBMB Congress., Kyoto
    • Place of Presentation
      Kyoto International Conference Hall
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Ring-finger protein Trim32 interacts with Abl interactor protein 2 and enhances its degradation.2006

    • Author(s)
      Kano, S., et. al
    • Organizer
      20th IUBMB International Congress of Biochemistry and Molecular Biology and 11th FAOBMB Congress., Kyoto
    • Place of Presentation
      Kyoto International Conference Hall
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Ubiquitin-mediated regulation of coatomer protein complex, subunit epsilon by ARNIP/Pirh2.2006

    • Author(s)
      Maruyama, S., et. al
    • Organizer
      20th IUBMB International Congress of Biochemistry and Molecular Biology and 11th FAOBMB Congress., Kyoto
    • Place of Presentation
      Kyoto International Conference Hall
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] GdX, an X-linked ubiuitin-like modifier, is conjugated to cyclin F and regulates mitotic exit.2006

    • Author(s)
      Ishida, N., et. al
    • Organizer
      20th IUBMB International Congress of Biochemistry and Molecular Biology and 11th FAOBMB Congress., Kyoto
    • Place of Presentation
      Kyoto International Conference Hall
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] A novel protein interacts with ubiquitin modifying protein A20.2006

    • Author(s)
      Bohgaki, M., Tsukiyama, T. and Hatakeyama. S.
    • Organizer
      20th IUBMB International Congress of Biochemistry and Molecular Biology and 11th FSOBMO Congress
    • Place of Presentation
      Kyoto
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Wnt5a is a haploinsufficient tumor suppressor that cooperates with Tcfl to suppress T cell lymphomas.2006

    • Author(s)
      Tsukiyama, T., Dunty, W., Hatakeyama. S., Clevers, H. and Yamaguchi, T.
    • Organizer
      20th IUBMB International Congress of Biochemistry and Molecular Biology and 11th FAOBMB Congress
    • Place of Presentation
      Kyoto
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Systematic analysis of phosphotyrosine-related proteome provides novel insights into signal transduction.2006

    • Author(s)
      Matsumoto, M., Oyamada, K., Hatakevama. S. and Nakayama, KI.
    • Organizer
      20th IUBMB International Congress of Biochemistry and Molecular Biology and 11th FAOBMB Congress
    • Place of Presentation
      Kyoto
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Ubiquitin ligase EFP as a regulator for estrogen receptor.2006

    • Author(s)
      Nakajima, A. and Hatakeyama. S.
    • Organizer
      20th IUBMB International Congress of Biochemistry and Molecular Biology and 11th FAOBMB Congress
    • Place of Presentation
      Kyoto
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] RING-finger protein R052/TRIM21 -functionally interacts with IgGl heavy chain and p97/valosin-containing protein.2006

    • Author(s)
      Takahata, M., Bohgaki, M., Tsukiyama, T., Asaka, M. and Hatakeyama. S.
    • Organizer
      20th IUBMB International Congress of Biochemistry and Molecular Biology and 11th FAOBMB Congress
    • Place of Presentation
      Kyoto
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Rin; finger protein Trim32 interacts with Abl interactor protein 2 and enhances its degradation2006

    • Author(s)
      Kano, S., Tsukiyama, T., Tsukiyama, T. Fukuda, S and Hatakeyama. S.
    • Organizer
      20th IUBMB International Congress of BIochemistry and Molecular Biology and 11th FAOBMB Congress
    • Place of Presentation
      Kyoto
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Ubiquitin-mediated regulation of coatomer protein complex, subunit epsilon by ARNIP/Pirh2.2006

    • Author(s)
      Maruyama, S., Miyajima, S., Tsukiyama, T., Nonomura, K. and Hatakeyama. S.
    • Organizer
      20th IUBMB International Congress of Biochemistry and Molecular Biology and 11th FAOBMB Congress
    • Place of Presentation
      Kyoto
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] GdX, an X-linked ubiuitin-like modifier, is conjugated to cyclin F and regulates mitotic exit.2006

    • Author(s)
      Ishida, N., Hatakeyama, S.. Iemura, S., Natsume, T., Nakayama, K. and Nakayama, KI.
    • Organizer
      20th IUBMB International Congress of Biochemistry and Molecular Biology and 11th FAOBMB Congress
    • Place of Presentation
      Kyoto
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Book] The Frontiers in Medical Sciences「神経変性疾患のサイエンス」2007

    • Author(s)
      畠山鎮次
    • Total Pages
      247
    • Publisher
      南山堂
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Annual Research Report 2007 Final Research Report Summary

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Published: 2006-04-01   Modified: 2016-04-21  

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