The regulatory mechanism of sensor-type transcription factor during mitosis
| Project/Area Number |
18390083
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
General medical chemistry
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| Research Institution | Shimane University (2007-2008)
Nagoya University (2006) |
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Principal Investigator |
URANO Takeshi Shimane University, 医学部, 教授 (70293701)
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| Project Period (FY) |
2006 – 2008
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| Project Status |
Completed (Fiscal Year 2008)
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| Budget Amount *help |
¥15,470,000 (Direct Cost: ¥13,400,000、Indirect Cost: ¥2,070,000)
Fiscal Year 2008: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2007: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2006: ¥6,500,000 (Direct Cost: ¥6,500,000)
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| Keywords | 分裂期キナーゼ / Aurora / p53 / リン酸化モノクローナル抗体 / EB3 / SIAH-1 / ユビキチン化 / タンパク質分解 / リン酸化 / 基質特異性 / セリン / スレオニンキナーゼ / p21 / WAF1 |
|---|
| Research Abstract |
細胞分裂期の染色体分配など複雑な物理的ストレスをがん細胞が回避する機構を解明する端緒として,様々なストレスに反応する転写因子であるp53 およびその下流の実働分子であるp21/WAF1 が細胞分裂期にAurora によりリン酸化され,それらの機能が細胞分裂期特異的に不活性化されていることを見出した。
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Report
(4 results)
Research Products
(64 results)
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[Journal Article] Gene silencing in cancer by histone H3 lysine 27 trimethylation independent of promoter DNA methylation.2008
Author(s)
Kondo Y, Shen L, Cheng AS, Ahmed S,Boumber Y, Charo C, Yamochi T, Urano T,Furukawa K, Kwabi-Addo B, Gold DL,Sekido Y, Huang TH and Issa JP
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Journal Title
Nature Genet 40
Pages: 741-750
Related Report
Peer Reviewed
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[Journal Article] Gene amplification and overexpression of PRDM14 in breast cancers.2007
Author(s)
Nishikawa N, Toyota M, Suzuki H,Honma T, Fujikane T, Ohmura T,Nishidate T, Ohe-Toyota M, Maruyama R,Sonoda T, Sasaki Y, Urano T, Imai K,Hirata K, and Tokino T
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Journal Title
Cancer Res 67
Pages: 9649-9657
Related Report
Peer Reviewed
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[Journal Article] Role of DNA methylation and histone H3 Lysine 27 methylation in tissue-specific imprinting of mouse Grb10.2007
Author(s)
Yamasaki-Ishizaki Y, Kayashima T,Mapendano CK, Soejima H, Ohta T,Masuzaki H, Kinoshita A, Urano T,Yoshiura KI, Matsumoto N, Ishimaru T,Mukai T, Niikawa N and Kishino T
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Journal Title
Mol. Cell. Biol. 27
Pages: 732-742
Related Report
Peer Reviewed
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[Journal Article] Overexpression of caveolin-1 in a human melanoma cell line results in dispersion of ganglioside GD3 from lipid rafts and alteration of leading edges, leading to attenuation of malignant properties.2007
Author(s)
Nakashima H, Hamamura K, Houjou T,Taguchi R, Yamamoto N, Mitsudo K,Tohnai I, Ueda M, Urano T, Furukawa K,Furukawa K
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Journal Title
Cancer Sci 98
Pages: 512-520
Related Report
Peer Reviewed
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