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Molecular analysis of retinal photoreceptor development

Research Project

Project/Area Number 18390092
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field General medical chemistry
Research InstitutionOsaka Bioscience Institute

Principal Investigator

TAKAHISA Furukawa  Osaka Bioscience Institute, Developmental Biology, Head (50260609)

Project Period (FY) 2006 – 2007
Project Status Completed (Fiscal Year 2007)
Budget Amount *help
¥16,500,000 (Direct Cost: ¥14,700,000、Indirect Cost: ¥1,800,000)
Fiscal Year 2007: ¥7,800,000 (Direct Cost: ¥6,000,000、Indirect Cost: ¥1,800,000)
Fiscal Year 2006: ¥8,700,000 (Direct Cost: ¥8,700,000)
Keywordsretina / development / Photoreceptor / cell fate / transcription factor / repressor / knock out mouse
Research Abstract

In the central nervous system (CNS) of vertebrates, the retina is an accessible model system to study various issues in the neuroscience field and medical science. The retina is relatively simple, thin layer structure of neural tissue that is located posterior part of the eye. Many things have been learned about the anatomy, physiology, cell metabolism and development of the retina. However, the retina still must solve several important scientific and medical problems. We have been studying to understand the molecular mechanisms of vertebrate retinal development from several aspects, including early eye formation, cell fate determination of photoreceptors, and network formation of the retina.
The establishment of precise synaptic connections between neurons in the developing and mature CNS is crucial for normal nervous system functions, including perception, memory and cognition. Thus, elucidating the mechanisms by which synapses develop and are modified is a central question in neurobi … More ology. Over the past few decades, a large number of protein components that are required for synapse morphogenesis and neurotransmitter release have been -identified. However, the molecules and mechanisms underlying specific synapse connections in the vertebrate CNS are still poorly understood.
In this study we identify pikachurin, a novel dystroglycan ligand, and observe its localization to the synaptic cleft in the photoreceptor ribbon synapse. Pikachurin null mice display improper apposition of the bipolar terminus to the ribbon synapse, resulting in alterations in synaptic signal transmission and visual function. We observed co-localization of pikachurin with DGC molecules and direct binding of pikachurin with a-dystroglycan, an extracellular component of DGC. Our results suggest that pikachurin is the first dystroglycan ligand to interact with the presynaptic DGC, and demonstrate its essential role in precise synapse formation. This may also advance our understanding of the molecular mechanisms underlying the retinal electrophysiological abnormalities observed in muscular dystrophy patients. Less

Report

(3 results)
  • 2007 Annual Research Report   Final Research Report Summary
  • 2006 Annual Research Report
  • Research Products

    (64 results)

All 2008 2007 2006 Other

All Journal Article (33 results) (of which Peer Reviewed: 13 results) Presentation (27 results) Remarks (2 results) Patent(Industrial Property Rights) (2 results)

  • [Journal Article] Elipsa is an early determinant of ciliogenesis that links the IFT particle to membrane-associated small GTPase,Rab8.2008

    • Author(s)
      Omori,Y.
    • Journal Title

      Nature Cell Biology 10

      Pages: 437-444

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] 網膜視細胞の細胞極性と細胞内オルガネラの制御-外節形成、繊毛内輸送、核のポジショニングから網膜変成症まで2008

    • Author(s)
      小池千恵子
    • Journal Title

      生化学 80(3)

      Pages: 224-232

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Elipsa is an early determinant of ciliogenesis that links the IFT particle to membrane-associated small GTPase, Rab8.2008

    • Author(s)
      Omori, Y.
    • Journal Title

      Nature Cell Biology 10

      Pages: 437-444

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Cell polarity of retinal photo receptor cells an regulation of intracellular organella.2008

    • Author(s)
      Koike, C.
    • Journal Title

      Biochemical 80(3)

      Pages: 224-232

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Elipsa is an earlydeterminanat of ciliogenesis that links the IFT particle to membrane-associated small GTPase, Rab82008

    • Author(s)
      Omori, Y.
    • Journal Title

      Nature Cell Biology 10

      Pages: 437-444

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 網膜視細胞の細胞極性と細胞内オルガネラの制御-外節形成、繊毛内輸送、核のポジショニングから網膜変成症まで2008

    • Author(s)
      小池 千恵子
    • Journal Title

      生化学 80(3)

      Pages: 224-232

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Functional Roles of Otx2 Transcription Factor in Postnatal Mouse Retinal Development.2007

    • Author(s)
      Koike,C.
    • Journal Title

      Molecular Cell Biology 27

      Pages: 8318-8329

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Dkk3-Cre BAC Transgenic Mouse Line: A Tool for Highly Efficient Gene Deletion in Retinal Progenitor Cells.2007

    • Author(s)
      Sato,S.
    • Journal Title

      Genesis 45

      Pages: 502-507

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] 網膜視細胞分化におけるDNA結合ドメインのタンパク質間相互作用2007

    • Author(s)
      佐貫理佳子
    • Journal Title

      生体の科学 59(5)

      Pages: 462-463

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] 脊椎動物の網膜発生の分子制御機構2007

    • Author(s)
      古川 貴久
    • Journal Title

      最新医学 62・2

      Pages: 45-45

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Functional Roles of Otx2 Transcription Factor in Postnatal Mouse Retinal Development.2007

    • Author(s)
      Koike, C.
    • Journal Title

      Molecular Cell Biology 27

      Pages: 8318-8329

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Dkk3-Cre BAC Transgenic Mouse Line : A Tool for Highly Efficient Gene Deletion in Retinal Progenitor Cells.2007

    • Author(s)
      Sato, S.
    • Journal Title

      Genesis 45

      Pages: 502-507

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Protein-protein interaction of DNA binding domain in retinal photoreceptor differentiation2007

    • Author(s)
      Sanuki, R.
    • Journal Title

      Seitai no Kagaku 59(5)

      Pages: 462-463

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Molecular control of vertebrate retinal development.2007

    • Author(s)
      Furukawa, T.
    • Journal Title

      Saishin Igaku 62・2

      Pages: 45-45

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Functional Roleas of Otx2 Transcription Factor in Postnatal Mouse Retinal Development2007

    • Author(s)
      Koike, C.
    • Journal Title

      Molecule Cell Biology 27

      Pages: 8318-8329

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Dkk3-Cre BAC Transgenic Mouse Line:A Tool for Highly Efficient Gene Deletion in Retinal Progenitor Cells2007

    • Author(s)
      Sato, S.
    • Journal Title

      Genesis 45

      Pages: 502-507

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 網膜視細胞分化におけるDNA結合ドメインのタンパク質間相互作用2007

    • Author(s)
      佐貫 理佳子
    • Journal Title

      生体の科学 59(5)

      Pages: 462-463

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 性対動物の網膜発生の分子制御機構2007

    • Author(s)
      古川貴久
    • Journal Title

      最新医学 62・2

      Pages: 45-45

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Ptfla determines horizontal and amacrine cell fates during mouse retinal development.2006

    • Author(s)
      Fujitani,Y.
    • Journal Title

      Development 133・22

      Pages: 4439-4450

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Nucleosome regulator Xhmgb3 is essential for progenitor cell proliferation of the eye and brain.2006

    • Author(s)
      Terada,K.
    • Journal Title

      Developmental Biology 291・2

      Pages: 398-412

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Cloning and characterization of mr-s, a novel SAM domain protein, predominantly expressed in retinal photoreceptor cells.2006

    • Author(s)
      Inoue,T.
    • Journal Title

      BMC Developmental Biology 6・15

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Cloning and regulation of the vertebrate homologue of lin-41 which functions as heterochronic gene in Caenorhabditis elegans.2006

    • Author(s)
      Kanamoto,T.
    • Journal Title

      Developmental Dynamics 235・4

      Pages: 1142-1149

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Cloning and expression pattern of lbx3, a novel chick homeobox gene.2006

    • Author(s)
      Kanamoto,T.
    • Journal Title

      Mechanisms of Development/Gene Expression Patterns 6・3

      Pages: 241-246

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Ptf1a determines horizontal and amacrine cell fates during mouse retinal development.2006

    • Author(s)
      Fujitani, Y.
    • Journal Title

      Development 133

      Pages: 4439-4450

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Nucleosome regulator Xhmgb3 is essential for progenitor cell proliferation of the eye and brain.2006

    • Author(s)
      Terada, K.
    • Journal Title

      Developmental Biology 291

      Pages: 398-412

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Cloning and characterization of mr-s, a novel SAM domain protein, predominantly expressed in retinal photoreceptor cells2006

    • Author(s)
      Inoue, T.
    • Journal Title

      BMC Developmental Biology 6

      Pages: 15-15

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Cloning and regulation of the vertebrate homologue of lin-41 which functions as heterochronic gene in Caenorbabditis elegans.2006

    • Author(s)
      Kanamoto, T.
    • Journal Title

      Developmental Dynamics 235

      Pages: 1142-1149

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Cloning and expression pattern of Ibx3, a novel chick homeobox gene.2006

    • Author(s)
      Kanamoto, T.
    • Journal Title

      Mechanisms of Development/Gene Expression Patterns 6

      Pages: 241-246

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Ptfla determines horizonta and amacrine cell fates during mouse retinal development.2006

    • Author(s)
      Fujitani, Y.
    • Journal Title

      Development 133・22

      Pages: 4439-4450

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Nucleosome regulator Xhmgb3 is essential for progenitor cell proliferation of the eye and brain.2006

    • Author(s)
      Terada, K.
    • Journal Title

      Developmental Biology 291・2

      Pages: 298-412

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Cloning and characterization of mr-s, a novel SAM domain protein, predominantly expressed in retinal photoreceptor cells.2006

    • Author(s)
      Inoue, T.
    • Journal Title

      BMC Developmental biology 6・15

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Cloning and regulation of the vertebrate homologue of lin-41 which functions as heterochronic gene in Caenorhabditis elegans.2006

    • Author(s)
      Kanamoto, T.
    • Journal Title

      Developmental Dynamics 235・4

      Pages: 1142-1149

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Cloning and expression pattern of lbx3,a novel chick homeobox gene.2006

    • Author(s)
      Kanamoto, t.
    • Journal Title

      Mechanisms of Development/Gene expression Patterns 6・3

      Pages: 241-246

    • Related Report
      2006 Annual Research Report
  • [Presentation] An Essential Role of Pikachurin, a Novel Dystroglycan Ligand Protein, in Bipolar Terminus Apposition to Photoreceptor Ribbon Synapse in the Retina.2008

    • Author(s)
      Furukawa,T.
    • Organizer
      CDB Symposium 2008
    • Place of Presentation
      Kobe,Japan
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] An Essential Role of Pikachurin, a Novel Dystroglycan Ligand Protein, in Bipolar Terminus Apposition to Photoreceptor Ribbon Synapse in the Retina.2008

    • Author(s)
      Furukawa, T.
    • Organizer
      CDB Symposium 2008
    • Place of Presentation
      Kobe, Japan
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] An Essential Role of Pikachurin, a Novel Dystroglycan Ligand Protein,in Bipolar Terminus Apposition to Photoreceptor Ribbon Synapse in the Retina2008

    • Author(s)
      Furukawa, T.
    • Organizer
      CDB Symposium 2008
    • Place of Presentation
      Kobe,Japan
    • Related Report
      2007 Annual Research Report
  • [Presentation] Cloning and functional analysis of Pikachurin: a novel Agrin/Perlecan-related protein localized at the active zone of retinal photoreceptor ribbon synapse.2007

    • Author(s)
      Furukawa,T.
    • Organizer
      NEUROSCIENCE
    • Place of Presentation
      San Diego,USA
    • Year and Date
      2007-11-04
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Cloning and functional analysis of Pikachurin : a novel Agrin/Perlecan-related protein localized at the active zone of retinal photoreceptor ribbon synapse.2007

    • Author(s)
      Furukawa, T.
    • Organizer
      NEUROSCIENCE
    • Place of Presentation
      San Diego, USA.
    • Year and Date
      2007-11-04
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Cloning and functional analysis of Pikachurin:a novel Agrin/Perlecan-related protein localized at the active zone of retinal photoreceptor ribbon synapse2007

    • Author(s)
      Furukawa, T.
    • Organizer
      NEUROSCIENCE
    • Place of Presentation
      San Diego,USA
    • Year and Date
      2007-11-04
    • Related Report
      2007 Annual Research Report
  • [Presentation] 網膜視細胞のリボンシナプスに局在しAgrin/Perlecanにホモロジーのある新規タンパク質pikachurinの同定と機能解析2007

    • Author(s)
      古川貴久
    • Organizer
      Neuro 2007
    • Place of Presentation
      横浜
    • Year and Date
      2007-09-10
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Annual Research Report 2007 Final Research Report Summary
  • [Presentation] 細胞外マトリックスによる細胞運命制御2007

    • Author(s)
      古川貴久
    • Organizer
      発生細胞合同学会 ミニシンポジウム
    • Place of Presentation
      福岡
    • Year and Date
      2007-05-29
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 細胞外マトリックスによる細胞運命制御2007

    • Author(s)
      古川 貴久
    • Organizer
      発生細胞合同学会ミニシンポジウム
    • Place of Presentation
      福岡
    • Year and Date
      2007-05-29
    • Related Report
      2007 Annual Research Report
  • [Presentation] 網膜幹細胞の増殖におけるSUMO結合酵素Ubc9の役割2007

    • Author(s)
      寺田晃士
    • Organizer
      BMB2007
    • Place of Presentation
      横浜
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] ON型網膜双極細胞に局在するTRPM1の機能解析2007

    • Author(s)
      小池千恵子
    • Organizer
      BMB2007
    • Place of Presentation
      横浜
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Annual Research Report 2007 Final Research Report Summary
  • [Presentation] 網膜視細胞特異的転写抑制因子mr-sの機能解析2007

    • Author(s)
      井上達也
    • Organizer
      BMB2007
    • Place of Presentation
      横浜
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 新規膜蛋白質Obifの間葉系細胞凝集および骨芽細胞分化における機能解析2007

    • Author(s)
      金本隆司
    • Organizer
      BMB2007
    • Place of Presentation
      横浜
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Annual Research Report 2007 Final Research Report Summary
  • [Presentation] 網膜視細胞のリボンシナプスに局在しAgrin/Perlecanにホモロジーのある新規タンパク質pikachurinの同定と機能解析2007

    • Author(s)
      佐藤茂
    • Organizer
      BMB2007
    • Place of Presentation
      横浜
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Annual Research Report 2007 Final Research Report Summary
  • [Presentation] Cayman型小脳性運動失調症の原因遺伝子Atcayの作用機構2007

    • Author(s)
      青山貴音
    • Organizer
      BMB2007
    • Place of Presentation
      横浜
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Annual Research Report 2007 Final Research Report Summary
  • [Presentation] 網膜幹細胞の増殖におけるSUM0結合酵素Ubc9の役割2007

    • Author(s)
      寺田 晃士
    • Organizer
      BMB2007
    • Place of Presentation
      横浜
    • Related Report
      2007 Annual Research Report
  • [Presentation] 網膜視細胞特異的転写抑制因子mrsの機能解析2007

    • Author(s)
      井上 達也
    • Organizer
      BMB2007
    • Place of Presentation
      横浜
    • Related Report
      2007 Annual Research Report
  • [Presentation] Cooperative roles of Otx2 and Crx in the development of retinal photoreceptor and bipolar cells.2006

    • Author(s)
      Furukawa,T.
    • Organizer
      Gordon research conference
    • Place of Presentation
      Barga,Italy
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Function of aPKCλ in differentiating photoreceptors is required for proper lamination of mouse retina.2006

    • Author(s)
      Koike,C.
    • Organizer
      20th IUBMB International Congress of Biochemistry and Molecular Biology and 11th FAOBMB Congress
    • Place of Presentation
      Kyoto,Japan
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Cloning and characterization of mr-s, a novel SAM domain protein, predominantly expressed in retinal photoreceptor cells.2006

    • Author(s)
      Inoue,T.
    • Organizer
      20th IUBMB International Congress of Biochemistry and Molecular Biology and 11th FAOBMB Congress
    • Place of Presentation
      Kyoto,Japan
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Cloning and regulation of the vertebrate homologue of lin-41 which is a target of microRNA let-7 and functions as heterochronic gene in Caenorhabditis elegans.2006

    • Author(s)
      Kanamoto,T.
    • Organizer
      20th IUBMB International Congress of Biochemistry and Molecular Biology and 11th FAOBMB Congress
    • Place of Presentation
      Kyoto,Japan
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Nucleosome regulator Xhmgb3 is required for cell proliferation of the eye and brain as a downstream target of Xenopus rax/Rxl.2006

    • Author(s)
      Terada,K.
    • Organizer
      20th IUBMB International Congress of Biochemistry and Molecular Biology and 11th FAOBMB Congress
    • Place of Presentation
      Kyoto,Japan
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Roles of Otx2 homeobox gene in vertebrate retinal development.2006

    • Author(s)
      Furukawa,T.
    • Organizer
      XVII International Congress of Eye Research
    • Place of Presentation
      Buenos Aires,Argentina
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Otx2とCrxは網膜視細胞および双極細胞発生過程において協同的に作用する2006

    • Author(s)
      古川貴久
    • Organizer
      日本発生生物学会第39回大会
    • Place of Presentation
      広島
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 光感覚受容器である網膜視細胞の発生の分子メカニズム2006

    • Author(s)
      古川貴久
    • Organizer
      第29回日本神経科学大会
    • Place of Presentation
      京都
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 内軟骨骨化における転写因子Stat3の機能解析2006

    • Author(s)
      古川貴久
    • Organizer
      第21回日本整形外科学会基礎学術集会
    • Place of Presentation
      長崎
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Cooperative roles of Otx2 and Crx in the development of retinal photoreceptor and bipolar cells.2006

    • Author(s)
      Furukawa, T.
    • Organizer
      Gordon research conference
    • Place of Presentation
      Barga, Italy
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Remarks] 「研究成果報告書概要(和文)」より

    • URL

      http://www.obi.or.jp/japanese/introduction/set_developmental.html

    • Related Report
      2007 Final Research Report Summary
  • [Remarks]

    • URL

      http://www.obi.or.jp/japanese/introduction/set_developmental.html

    • Related Report
      2007 Annual Research Report
  • [Patent(Industrial Property Rights)] 骨芽細胞分化誘導因子obifの利用2007

    • Inventor(s)
      古川貴久, 金本隆司
    • Industrial Property Rights Holder
      (財)大阪バイオサイエンス研究所
    • Industrial Property Number
      2007-228333
    • Filing Date
      2007-09-03
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Patent(Industrial Property Rights)] 骨芽細胞分化誘導因子obifの利用2007

    • Inventor(s)
      古川 貴久, 金本 隆司
    • Industrial Property Rights Holder
      (財)大阪バイオサイエンス研究所
    • Industrial Property Number
      2007-228333
    • Filing Date
      2007-09-03
    • Related Report
      2007 Annual Research Report

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Published: 2006-04-01   Modified: 2016-04-21  

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