Roles of lipid mediators and receptors in inflammation and immuni

• Project/Area Number: 18390096
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Pathological medical chemistry
• Research Institution: Kyushu University
• Principal Investigator: YOKOMIZO Takehiko Kyushu University, 大学院・医学研究院, 教授 (60302840)
• Co-Investigator(Kenkyū-buntansha): OKUNO Toshiaki 九州大学, 大学院・医学研究院, 助教 (60361466) ; NAKAMURA Takanori 九州大学, 大学院・医学研究院, 技術専門職員 (10380643)
• Project Period (FY): 2006 – 2009
• Project Status: Completed (Fiscal Year 2008)
• Budget Amount: ¥15,480,000 (Direct Cost: ¥13,800,000、Indirect Cost: ¥1,680,000); Fiscal Year 2008: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000); Fiscal Year 2007: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000); Fiscal Year 2006: ¥8,200,000 (Direct Cost: ¥8,200,000)
• Keywords: アラキドン酸カスケード / ロイコトリエン / Gタンパク質共役型受容体 / 遺伝子欠損マウス / 病態モデル / 生理活性脂質 / 受容体 / 脂質 / 免疫学 / 生体分子 / 遺伝子

Research Abstract

LTB4受容体BLT1, BLT2を対象に、受容体の分子解剖、生体内リガンドの同定、遺伝子欠損マウスの表現型解析を行った。BLT1のGタンパク質認識部位の同定、BLT2の形質膜発現におけるヘリックス8の役割の解明、BLT2の生体内リガンドの同定に成功した。遺伝子欠損マウスの解析から、樹状細胞に発現するBLT1がTh1型免疫反応を促進すること、BLT2が腸管炎症に保護的に作用することを見いだした。

Research Products

• [Journal Article] Aromatic D-amino acids act as chemoattractant factors for human leukocytes through a G protein-coupled receptor, GPR109B (2009)
  • Author(s): Irukayama-Tomobe Y, Tanaka H, Yokomizo, T., 他3名
  • Journal Title: Proc. Natl. Acad. Sci. USA 106 Pages: 3930-3934
  • Peer Reviewed
• [Journal Article] ロイコトリエン受容体 (2009)
  • Author(s): 横溝岳彦
  • Journal Title: 日本薬理学会雑誌 133 Pages: 230-232
  • NAID: 10025740562
  • Peer Reviewed
• [Journal Article] Preparation of 2-, 3-, 4-and 7-(2-alkylcarbamoyl-1-alkylvinyl)be nzo[b]furans and their BLT(1) and/or BLT(2) inhibitory activities (2008)
  • Author(s): Ando, K., Kawamura, Y., Akai, Y., Kunitomo, J., Yokomizo, T., 他4名
  • Journal Title: Org. Biomol. Chem. 6 Pages: 296-307
  • Peer Reviewed
• [Journal Article] 12(S)-Hydroxyheptadeca-5Z, 8E, 10E-trienoic acid is a natural ligand for leukotriene B4 receptor 2 (2008)
  • Author(s): Okuno, T, Iizuka Y, Okazaki H, Yokomizo, T., Taguchi R, Shimizu T
  • Journal Title: J.Exp.Med. 205 Pages: 759-766
  • Peer Reviewed
• [Journal Article] Characterization of an orphan G protein-coupled receptor, GPR20, that constitutively activates Gi proteins (2008)
  • Author(s): Hase M, Yokomizo, T., Shimizu T, Nakamura M.
  • Journal Title: J.Biol.Chem. 283 Pages: 12747-12755
  • Peer Reviewed
• [Journal Article] Leukotriene B4/Leukotriene B4 receptor pathway is involved in hepatic microcirculatory dysfunction elicited by endotoxin (2008)
  • Author(s): Ito S, 他4名, Yokomizo, T., Shimizu T, Majima M.
  • Journal Title: Shock 30 Pages: 87-91
  • Peer Reviewed
• [Journal Article] Preparation of leukotriene B(4) inhibitory active 2-and 3-(2-aminothiazol-4-yl)benzo[b]fura n derivatives and their growth inhibitory activity on human pancreatic cancer cells (2008)
  • Author(s): Kuramoto M, 他5名, Yokomizo, T., Takeda S, Tanaka S, Ohishi Y.
  • Journal Title: Org. Biomol. Chem. 6 Pages: 2772-2781
  • Peer Reviewed
• [Journal Article] BLT2 is expressed in PanINs, IPMNs, pancreatic cancer and stimulates tumour cell proliferation. (2008)
  • Author(s): Hennig R, 他7名, Yokomizo, T., Friess H, Adrian TE
  • Journal Title: Br.J.Cancer 99 Pages: 1064-1073
  • Peer Reviewed
• [Journal Article] ロイコトリエンB4第二受容体(BLT2)の生体内リガンドは12-HHTである (2008)
  • Author(s): 奥野利明
  • Journal Title: 実験医学 26 Pages: 1752-1753
• [Journal Article] 12(S)-Hydroxyheptadeca-5Z, 8E, 10E-trienoic acid is a natural ligand for leukotriene B4 receptor 2. (2008)
  • Author(s): Okuno, T, 他5名
  • Journal Title: J. Exp. Med. 205 Pages: 759-766
  • Peer Reviewed
• [Journal Article] Characterization of an orphan G protein-coupled receptor, GPR20, that constitutively activates G_i proteins. (2008)
  • Author(s): Hase M, 他3名
  • Journal Title: J. Biol. Cbem. 283 Pages: 12747-55
  • Peer Reviewed
• [Journal Article] Leukotriene B4/Leukotriene B4 receptor pathway is involved in hepatic microcirculatory dysfunction elicited by endotoxin. (2008)
  • Author(s): Ito, S, 他7名
  • Journal Title: Shock 30 Pages: 81-91
  • Peer Reviewed
• [Journal Article] BLT2 is expressed in PanINs, IPMNs, pancreatic cancer and stimulates tumoour cell proliferation. (2008)
  • Author(s): Hennig, R, 他10名
  • Journal Title: Br. J. Cancer 99 Pages: 1064-1073
  • Peer Reviewed
• [Journal Article] Helix 8 of leukotriene B4 type-2 receptor is required for the folding to pass the quality control in the endoplasmic reticulum. (2008)
  • Author(s): Yasuda, D, 他8名
  • Journal Title: Faseb J (印刷中)
  • Peer Reviewed
• [Journal Article] Preparation of 2-,3-,4- and 7-(2-alkylcarbamoyl-1-alkylvinyl)benzo[b]furans and their BLT(1) and/or BLT(2) inhibitory activities. (2008)
  • Author(s): Ando, K, 他8名
  • Journal Title: Org.Biomol.Chem. 6 Pages: 296-307
  • Peer Reviewed
• [Journal Article] 12(S)-Hydroxyheptadeca-5Z, 8E, 10E-trienoic acid is a natural ligand for leukotriene B4 receptor2. (2008)
  • Author(s): Okuno, T, 他5名
  • Journal Title: J.Exp.Med. (印刷中)
  • Peer Reviewed
• [Journal Article] Characterization of an orphan G protein-coupled receptor, GPR20, that constitutively activates G_i proteins. (2008)
  • Author(s): Hase M, 他3名
  • Journal Title: J.Biol.Chem. (印刷中)
  • Peer Reviewed
• [Journal Article] Synthesis and biological activities of novel furo[2,3, 4-jk][2]benzazepin-4(3H)-one derivatives (2007)
  • Author(s): Ando K, Akai Y, Kunitomo J, Yokomizo, T., 他6名
  • Journal Title: Org.Biomol.Chem. 5 Pages: 655-663
  • Peer Reviewed
• [Journal Article] Identification of the Intracellular Region of the Leukotriene B4 receptor type-1 that Specifically Involves in Gi-Activation (2007)
  • Author(s): Kunieda, K., Okuno, T., Terawaki, K., Miyano, M., Yokomizo, T., and Shimizu, T.
  • Journal Title: J.Biol.Chem. 282 Pages: 3998-4006
  • Peer Reviewed
• [Journal Article] Preparation of 3-(4-chlorophenyl)-2-(2-aminothiazo l-4-yl)-5-methoxybenzo[b]furan derivatives and their leukotriene B(4) inhibitory activity (2007)
  • Author(s): Sakata Y, 他5名, Yokomizo, T., Ohishi Y.
  • Journal Title: Org.Biomol.Chem 5 Pages: 3083-3086
  • Peer Reviewed
• [Journal Article] ロイコトリエンB4と呼吸器疾患 (2007)
  • Author(s): 奥野利明, 横溝岳彦
  • Journal Title: 呼吸と循環 55 Pages: 423-428
  • NAID: 40015403703
• [Journal Article] 臨床検査と脂質 : これからの脂質研究への期待 (2007)
  • Author(s): 横溝岳彦
  • Journal Title: 臨床検査 51 Pages: 457-458
• [Journal Article] 細胞膜受容体の脂質性リガン : エイコサノイド, スフィンゴ脂質と新規抗炎症脂質 (2007)
  • Author(s): 横溝岳彦
  • Journal Title: 臨床検査 51 Pages: 459-468
• [Journal Article] ロイコトリエンB4と免疫・アレルギー反応 (2007)
  • Author(s): 横溝岳彦
  • Journal Title: 日本アレルギー協会支部ニュース 12号
• [Journal Article] LTB4受容体の同定とその後の進展 (2007)
  • Author(s): 横溝岳彦
  • Journal Title: 日本薬理学会雑誌 130 Pages: 29-33
  • Peer Reviewed
• [Journal Article] ロイコトリエンによる免疫制御 (2007)
  • Author(s): 横溝岳彦
  • Journal Title: 細胞工学 26 Pages: 1236-1240
• [Journal Article] Synthesis and biological activities of novel furo[2,3,4-jk][2]benzazepin-4(3H)-one derivatives. (2007)
  • Author(s): Ando, K, 他9名
  • Journal Title: Org.Biomol.Chem. 5 Pages: 655-663
  • Peer Reviewed
• [Journal Article] Preparation of 3-(4-chlorophenyl)-2-(2-aminothiazol-4-yl)-5-methoxybenzo[b]furan derivatives and their leukotriene B(4) inhibitory activity. (2007)
  • Author(s): Sakata, Y, 他7名
  • Journal Title: Org.Biomol.Chem. 5 Pages: 3083-3086
  • Peer Reviewed
• [Journal Article] ロイコトリエンによる免疫制御 (2007)
  • Author(s): 横溝 岳彦
  • Journal Title: 細胞工学 26 Pages: 1236-1240
• [Journal Article] 細胞膜受容体の脂質性リガンド: エイコサノイド、スフィンゴ脂質と新規抗炎症脂質 (2007)
  • Author(s): 横溝 岳彦
  • Journal Title: 臨床検査 51 Pages: 459-468
• [Journal Article] LTB4受容体の同定とその後の進展 (2007)
  • Author(s): 横溝 岳彦
  • Journal Title: 日本薬理学会雑誌 130 Pages: 29-33
• [Journal Article] Identification of the Intracellular Region of the Leukotriene B4 receptor type-1 that Specifically Involves in Gi-Activation. (2007)
  • Author(s): Kunieda, K., 他5名
  • Journal Title: J. Biol. Chem. 282 Pages: 3998-4006
• [Journal Article] The Lipoxin receptor ALX : Potent ligand-specific and stereoselective actions in vivo (2006)
  • Author(s): Chiang N, 他6名, Yokomizo, T., Brink, C.
  • Journal Title: Pharmacol. Rev. 58 Pages: 463-487
  • Peer Reviewed
• [Journal Article] Attenuation of folic acid-induced renal inflammatory injury in platelet-activating factor receptor deficient mice (2006)
  • Author(s): Doi, K., 他6名, Yokomizo, T., 他5名
  • Journal Title: Am.J.Pathol. 168 Pages: 1413-1424
  • Peer Reviewed
• [Journal Article] Crystal structure of anti-configuration of indomethacin and leukotriene B-4 12-hydroxydehydrogenase/15-oxo-pros taglandin 13-reductase complex reveals the structural basis of broad spectrum indomethacin efficacy (2006)
  • Author(s): Hori, T., Ishijima, J., Yokomizo, T.,他3名
  • Journal Title: J.Biochem 140 Pages: 457-466
  • Peer Reviewed
• [Journal Article] T. Charaterization of mouse second leukotriene B4 receptor, mBLT2 (2006)
  • Author(s): Iizuka, Y., Yokomizo, T., 他4名
  • Journal Title: Prostaglandins & other lipid mediators 79 Pages: 163-164
  • Peer Reviewed
• [Journal Article] 進展する脂質膜受容体研究-最近のトピックス (2006)
  • Author(s): 横溝岳彦
  • Journal Title: シグナル受容機構と生理機能の解明(実験医学増刊号) 24 Pages: 624-629
• [Journal Article] 生理活性脂質ロイコトリエンB4とその受容体 (2006)
  • Author(s): 横溝岳彦
  • Journal Title: 福岡医学 97 Pages: 183-191
  • NAID: 120002548749
• [Journal Article] 脂質因子による免疫反応の制御 (2006)
  • Author(s): 横溝岳彦
  • Journal Title: 感染・炎症・免疫 36 Pages: 196-205
• [Journal Article] Attenuation of folic acid-induced renal inflammatory injury in platelet-activating factor receptor-deficient mice. (2006)
  • Author(s): Doi, K., 他12名
  • Journal Title: Am. J. Pathol. 168 Pages: 1413-1424
• [Journal Article] Crystal structure of anti-configuration of indomethacin and leukotriene B-4 12-hydroxydrogenase /15-oxo-prostaglandin 13-reductase complex reveals the structural basis of broad spectrum indomethacin efficacy. (2006)
  • Author(s): Hori, T., 他5名
  • Journal Title: J. Biochem. 140 Pages: 457-466
• [Journal Article] The Lipoxin receptor ALX : Potent ligand-specific and stereoselective actions in vivo. (2006)
  • Author(s): Chiang N, 他7名
  • Journal Title: Pharmacol. Rev. 58 Pages: 463-487
• [Journal Article] 生理活性脂質ロイコトロエンB4とその受容体 (2006)
  • Author(s): 横溝岳彦
  • Journal Title: 福岡医学 97 Pages: 183-191
• [Journal Article] 脂質因子による免疫反応の制御 (2006)
  • Author(s): 横溝岳彦
  • Journal Title: 感染 炎症 免疫 36 Pages: 196-205
• [Journal Article] Helix 8 of leukotriene B4 type-2 receptor is required for the folding to pass the quality control in the endoplasmic reticulum
  • Author(s): Yasuda D, Okuno, T, Yokomizo, T., 他6名
  • Journal Title: Faseb J (In press)
  • Peer Reviewed
• [Presentation] ロイコトリエンB4第二受容体BLT2の内在性リガンドの同定 (2009)
  • Author(s): 横溝岳彦
  • Organizer: 日本薬学会第129年会シンポジウム
  • Place of Presentation: 京都
  • Year and Date: 2009-03-26
• [Presentation] Gタンパク質共役型受容体の構造機能相関とリガンド探索 (2009)
  • Author(s): 横溝岳彦
  • Organizer: Gタンパク質シグナル公開シンポジウム
  • Place of Presentation: 福岡
  • Year and Date: 2009-03-14
• [Presentation] ロイコトリエンB4第2受容体BLT2の内在性リガンドの同定 (2009)
  • Author(s): 奥野利明
  • Organizer: 生命科学系GCOEネットワーク・フォーラム2009
  • Place of Presentation: 東京
  • Year and Date: 2009-02-14
• [Presentation] ロイコトリエンB4第二受容体BLT2の生体内リガンドの同定 (2009)
  • Author(s): 奥野利明
  • Organizer: Gタンパク質特定領域・膜輸送複合体特定領域合同若手ワークショップ
  • Place of Presentation: 神戸
  • Year and Date: 2009-01-30
• [Presentation] GPCRが有するHelix8の小胞体搬出における意義 (2009)
  • Author(s): 安田大恭
  • Organizer: Gタンパク質特定領域・膜輸送複合体特定領域合同若手ワークショップ
  • Place of Presentation: 神戸
  • Year and Date: 2009-01-30
• [Presentation] 12-HHT, a Metabolite of Cyclooxygenase, is a Natural Ligand for Leukotriene B4 Receptor 2 (2008)
  • Author(s): Okuno, T.
  • Organizer: BLT2, Japan/Korea Conference on Cellular Signaling
  • Place of Presentation: 福岡
  • Year and Date: 2008-12-19
• [Presentation] ロイコトリエンB4第一受容体BLT1と血小板活性化因子受容体PAFRの脱感作機構 (2008)
  • Author(s): 荒武良総
  • Organizer: 第81回日本生化学会大会合同大会
  • Place of Presentation: 神戸
  • Year and Date: 2008-12-12
• [Presentation] Generation and characterization of a novel high-affinity monoclonal antibody for FLAG tag. (2008)
  • Author(s): 佐々木文之, 他3名
  • Organizer: 第81回日本生化学会大会合同大会
  • Place of Presentation: 神戸
  • Year and Date: 2008-12-12
• [Presentation] ロイコトリエンB4第一受容体BLTIと血小板活性化因子受容体PAFRの脱感作機構 (2008)
  • Author(s): 荒武良総, 奥野利明, 横溝岳彦
  • Organizer: 第81回日本生化学会大会合同大会
  • Place of Presentation: 神戸
  • Year and Date: 2008-12-12
• [Presentation] ロイコトリエンB4第二受容体BLT2の生体内リガンドの同定 (2008)
  • Author(s): 奥野利明
  • Organizer: 第81回日本生化学会大会合同大会シンポジウム
  • Place of Presentation: 神戸
  • Year and Date: 2008-12-11
• [Presentation] ロイコトリエンB4第二受容体BLT2の生体内リガンドの同定 (2008)
  • Author(s): 奥野利明, 横溝岳彦, 他2名
  • Organizer: 第81回日本生化学会大会合同大会(シンポジウム)
  • Place of Presentation: 神戸
  • Year and Date: 2008-12-11
• [Presentation] Generation and characterization of a novel high-affinity monoclonal antibody for FLAG tag (2008)
  • Author(s): Sasaki, F
  • Organizer: 第81回日本生化学会大会合同大会
  • Place of Presentation: 神戸
  • Year and Date: 2008-12-09
• [Presentation] シクロオキシゲナーゼ代謝物12-HHT はBLT2の内在性リガンドである (2008)
  • Author(s): Okuno, T
  • Organizer: 日本免疫学会
  • Place of Presentation: 京都
  • Year and Date: 2008-12-02
• [Presentation] Receptors for bioactive lipid mediators (2008)
  • Author(s): Yokomizo, T.
  • Organizer: G-COE International symposium
  • Place of Presentation: Fukuoka
  • Year and Date: 2008-11-09
• [Presentation] DIFICIENCY OF LEUKOTRIENE B4 RECEPTORS AFFECTS TUMOR METASTASIS (2008)
  • Author(s): Okazaki
  • Organizer: G-COE International symposium
  • Place of Presentation: Fukuoka
  • Year and Date: 2008-11-09
• [Presentation] ロイコトリエンB4第二受容体(BLT2)の生体内リガンドの同定 (2008)
  • Author(s): 奥野利明
  • Organizer: 第5回東京呼吸器リサーチフォーラム
  • Place of Presentation: 東京
  • Year and Date: 2008-11-01
• [Presentation] ロイコトリエンB4第二受容体の内因性リガンドの同定 (2008)
  • Author(s): 横溝岳彦
  • Organizer: 第30回薬学会九州支部コロキウム「生命機能をつかさどるGタンパク質シグナリング」
  • Place of Presentation: 福岡
  • Year and Date: 2008-10-25
• [Presentation] ロイコトリエンB4第二受容体(BLT2)の生体内リガンドはシクロオキシゲナーゼ産物12-HHTである (2008)
  • Author(s): 奥野利明
  • Organizer: 第2回G-COE理医連携リトリート
  • Place of Presentation: 熊本
  • Year and Date: 2008-08-10
• [Presentation] 2つのLeukotrieneB4受容体と癌の転移・浸潤, 九州大学G-COEプログラム (2008)
  • Author(s): 岡崎寛士
  • Organizer: 平成20年度若手研究者発表会
  • Place of Presentation: 熊本
  • Year and Date: 2008-08-09
• [Presentation] Gタンパク質共役型受容体の脱感作と細胞内移行の分子機序 (2008)
  • Author(s): 荒武良総
  • Organizer: 第2回G-COE理医連携リトリート
  • Place of Presentation: 熊本
  • Year and Date: 2008-08-09
• [Presentation] ロイコトリエンB4第二受容体(BLT2)の生体内リガンドは12-HHTである (2008)
  • Author(s): 奥野利明
  • Organizer: 第50回日本脂質生化学会
  • Place of Presentation: 徳島
  • Year and Date: 2008-06-06
• [Presentation] ロイコトリエンB4第二受容体(BLT2)の生体内リガンドはシクロオキシゲナーゼ産物12-HHTである (2008)
  • Author(s): 奥野利明
  • Organizer: 日本生化学会九州支部例会
  • Place of Presentation: 福岡
  • Year and Date: 2008-05-18
• [Presentation] 生理活性脂質研究のこれまでとこれから (2008)
  • Author(s): 横溝岳彦
  • Organizer: 第49回日本生化学会中国四国支部例会
  • Place of Presentation: 高松
  • Year and Date: 2008-05-16
• [Presentation] ロイコトリエンB4受容体(BLT1)の細胞内ループとC末端の役割 (2008)
  • Author(s): 奥野利明
  • Organizer: グローバルCOE若手研究者発表会
  • Place of Presentation: 別府
  • Year and Date: 2008-02-01
• [Presentation] ロイコトリエンB4受容体の細胞内領域の役割 (2008)
  • Author(s): 奥野利明
  • Organizer: Gタンパク質特定領域・膜輸送複合体特定領域合同若手ワークショップ
  • Place of Presentation: 箱根
  • Year and Date: 2008-01-26
• [Presentation] Gタンパク質共役型受容体の細胞内移行のメカニズムに関する研究, 九州大学21世紀COEプログラム (2008)
  • Author(s): 荒武良総
  • Organizer: 平成19年度若手研究者研究成果発表会
  • Place of Presentation: 福岡
  • Year and Date: 2008-01-25
• [Presentation] 癌転移におけるLTB4及びその受容体BLT1, BLT2の意義に関する研究, 九州大学21世紀COEプログラム (2008)
  • Author(s): 岡崎寛士
  • Organizer: 平成19年度若手研究者研究成果発表会
  • Place of Presentation: 福岡
  • Year and Date: 2008-01-25
• [Presentation] Screening of a natural lipid ligand of orphan GPCR (2008)
  • Author(s): Okuno,T
  • Organizer: Keystone Symposia
  • Place of Presentation: Montana
  • Year and Date: 2008-01-09
• [Presentation] マウス下肢虚血再灌流後の肝障害におけるロイコトリエンB4受容体の役割 (2007)
  • Author(s): 伊藤伸子
  • Organizer: BMB2007
  • Year and Date: 2007-12-13
• [Presentation] LTB4-12水酸基脱水素酵素に結合する新規タンパク質の同定 (2007)
  • Author(s): 吉本瑛梨
  • Organizer: BMB2007
  • Place of Presentation: 横浜
  • Year and Date: 2007-12-13
• [Presentation] オーファンGPCR, GPR20の機能解析 (2007)
  • Author(s): 馳桃子
  • Organizer: BMB2007
  • Year and Date: 2007-12-11
• [Presentation] 脂質認識GPCRに近縁なオーファンGPCR, GPR20の細胞内シグナル伝達解析 (2007)
  • Author(s): 馳桃子
  • Organizer: 東京大学生命科学研究ネットワークシンポジウム
  • Year and Date: 2007-09-15
• [Presentation] ロイコトリエンB4受容体と免疫・炎症反応 (2007)
  • Author(s): 横溝岳彦
  • Organizer: 第16回日本脂質栄養食糧学会
  • Place of Presentation: 島根
  • Year and Date: 2007-09-01
• [Presentation] ロイコトリエンB4受容体の生体内での役割 (2007)
  • Author(s): 横溝岳彦
  • Organizer: 第27回日本炎症・再生医学会
  • Place of Presentation: 東京
  • Year and Date: 2007-08-02
• [Presentation] ロイコトリエンB4受容体のヘリックス8の役割 (2007)
  • Author(s): 奥野利明
  • Organizer: 九州大学第11回感染症リサーチコアセミナー
  • Place of Presentation: 福岡
  • Year and Date: 2007-06-15
• [Presentation] Leukotriene B4 receptors: from cloning to clinic (2007)
  • Author(s): 横溝 岳彦
  • Organizer: 5th Korea-Japan Conference on Cell Signaling for Young Scientists
  • Place of Presentation: 韓国・Geongju
  • Year and Date: 2007-06-10
• [Presentation] Leukotriene B4 receptors (2007)
  • Author(s): Yokomizo, T
  • Organizer: 3rd International Conference on Phospholipase A2 and Lipid Mediators
  • Place of Presentation: Sorrento
  • Year and Date: 2007-05-10
• [Presentation] Leukotriene B4 receptors (2007)
  • Author(s): 横溝 岳彦
  • Organizer: 3rd International Conference on Phospholipase A2 and Lipid Mediators
  • Place of Presentation: 中国・北京
  • Year and Date: 2007-05-10
• [Presentation] 生理活性脂質受容体の解析 : in vitroとin vivo (2007)
  • Author(s): 横溝岳彦
  • Organizer: 第80回日本薬理学会年会シンポジウム
  • Place of Presentation: 名古屋
  • Year and Date: 2007-03-14
• [Presentation] Gタンパク質共役型受容体-ラボベンチから創薬へ (2007)
  • Author(s): 横溝岳彦
  • Organizer: 「魅力ある大学院教育」イニシアティブ事業シンポジウム
  • Place of Presentation: 北九州
  • Year and Date: 2007-03-03
• [Presentation] 生理活性脂質受容体の構造と機能 (2007)
  • Author(s): 横溝岳彦
  • Organizer: 第32回日本微小循環学会総会特別講演
  • Place of Presentation: 京都
  • Year and Date: 2007-02-23
• [Presentation] ロイコトリエンB4 12水酸基脱水素酵素に結合する新規タンパク質の同定 (2007)
  • Author(s): 吉本瑛梨
  • Organizer: 平成19年度日本生化学会九州支部例会
  • Place of Presentation: 宮崎
• [Presentation] ロイコトリエンB4受容体(BLT1)のヘリックス8の機能解明とGi タンパク質選択的共役部位の同定 (2007)
  • Author(s): 奥野利明
  • Organizer: 平成19年度日本生化学会九州支部例会
  • Place of Presentation: 宮崎
• [Presentation] Leukotriene B4 receptors : from cloning to clinic (2007)
  • Author(s): Yokomizo, T
  • Organizer: 5th Korea-Japan Conference on Cell Signaling for Young Scientists
  • Place of Presentation: Geongju (Korea)
• [Presentation] Roles of helix 8 and intracellular regions of the leukotriene B4 receptor type 1 (2007)
  • Author(s): Okuno, T.
  • Organizer: 5th Korea-Japan Conference on Cell Signaling for Young Scientists
  • Place of Presentation: Geongju (Korea)
• [Presentation] Diacylglycerol-induced Ca2+ influx mediates NFAT activation. Role of TRPC3 and TRPC6 (2007)
  • Author(s): Onohara N.
  • Organizer: 5th Korea-Japan Conference on Cell Signaling for Young Scientists
  • Place of Presentation: Geongju (Korea)
• [Presentation] Identification of binding proteins of leukotriene B4 12-hydroxydehydrogenase (2007)
  • Author(s): Yoshimoto, E.
  • Organizer: 5th Korea-Japan Conference on Cell Signaling for Young Scientists
  • Place of Presentation: Geongju (Korea)
• [Presentation] Rapid and convenient method for isolating cells overexpressing orphan GPCRs using autoMACS (2007)
  • Author(s): Moroishi K.
  • Organizer: 5th Korea-Japan Conference on Cell Signaling for Young Scientists
  • Place of Presentation: Geongju (Korea)
• [Presentation] Roles of leukotriene B4 receptor, BLT1 in chronic asthma model (2006)
  • Author(s): Hase, M
  • Organizer: 20th IUBMB International Congress of Biochemistry and Molecular Biology
  • Place of Presentation: Kyoto
  • Year and Date: 2006-06-21
• [Presentation] Roles of leukotriene B4 receptors in immunological reactions (2006)
  • Author(s): Yokomizo, T
  • Organizer: 15th World Congress of Pharmacology
  • Place of Presentation: Beijing
• [Book] 実験医学増刊・シグナル受容機構と生理機能の解明 (2006)
  • Author(s): 横溝岳彦
  • Total Pages: 222
  • Publisher: 羊土社
• [Book] プロスタグランジン・トロンボキサン・ロイコトリエン, 炎症・再生医学事典
  • Author(s): 横溝岳彦
  • Publisher: 朝倉書店(印刷中)
• [Book] 炎症・再生医学事典(プロスタグランジン・トロンボキサン・ロイコトリエンの章を担当)
  • Author(s): 横溝岳彦
  • Publisher: 朝倉書店(印刷中)
• [Remarks]
  • URL: http://www.med.kyushu-u.ac.jp/biochem1/
• [Remarks]
  • URL: http://www.med.kyushu-u.ac.jp/biocheml/publlcation.Html
• [Remarks]
  • URL: http://www.med.kyushu-u.ac.jp/biochem1/index.html