Estrogen in human lung cancer-intratumoral hormone production and analysis of intracrine mechanisms-
Project/Area Number |
18390109
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Research Category |
Grant-in-Aid for Scientific Research (B)
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Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Human pathology
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Research Institution | Tohoku University |
Principal Investigator |
SASANO Hironobu Tohoku University, 大学院・医学系研究科, 教授 (50187142)
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Co-Investigator(Kenkyū-buntansha) |
SUZUKI Satoshi 東北大学, 病院, 講師 (50344669)
鈴木 貴 東北大学, 医学部, 教授 (10261629)
林 慎一 東北大学, 医学部, 教授 (60144862)
三木 康宏 東北大学, 大学院・医学系研究科, 助教 (50451521)
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Co-Investigator(Renkei-kenkyūsha) |
SUZUKI Takashi 東北大学, 大学院・医学系研究科, 教授 (10261629)
HAYASHI Shin-ichi 東北大学, 大学院・医学系研究科, 教授 (60144862)
MIKI Yasuhiro 東北大学, 医学部, 助教 (50451521)
|
Project Period (FY) |
2006 – 2008
|
Project Status |
Completed (Fiscal Year 2008)
|
Budget Amount *help |
¥12,580,000 (Direct Cost: ¥11,200,000、Indirect Cost: ¥1,380,000)
Fiscal Year 2008: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
Fiscal Year 2007: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
Fiscal Year 2006: ¥6,600,000 (Direct Cost: ¥6,600,000)
|
Keywords | 肺癌 / エストロゲン / アロマタ-ゼ / エストロゲン受容体 / Intracrinology / STS / EST / アンドロゲン / steroid sulfatase / estrogen sulfotransferase / 代謝 / 性ホルモン / 肺 / 腫瘍 / 癌 / 受容体 / ホルモン / 細胞増殖 / アロマターゼ |
Research Abstract |
ヒト肺癌でのE2レベルは腫瘍部位で非腫瘍部位よりも高い濃度で認められ、種々の方法で検討した結果腫瘍細胞でアロマターゼの発現が認められた。次に肺癌培養細胞の検討で肺癌組織内でのE2濃度で有意に細胞増殖を刺激され、種々の受容体拮抗剤でその増殖は抑制された。肺癌における腫瘍内アロマターゼは腫瘍細胞で発現しているERβと有意の相関を示し、特に腺癌ではアロマターゼ及びSTSを中心とした合成酵素により腫瘍局所でエストロゲンが合成され腫瘍細胞核のERβを介して作用している事が考えられた。
|
Report
(4 results)
Research Products
(107 results)
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[Journal Article] Steroid Sulfatase and Estrogen Sulfotransferase in Colon Carcinoma : Regulators of Intratumoral Estrogen Concentrations and Potent Prognostic Factors2009
Author(s)
Sato R, Suzuki T, Katayose Y, Miura K, Shiiba K, Tateno H, Miki Y, Akahira J, Kamogawa Y, Nagasaki S, Yamamoto K, Ii T, Egawa S, Evans DB, Unno M, Sasano H
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Journal Title
Cancer Res 69
Pages: 914-922
Related Report
Peer Reviewed
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[Journal Article] Steroid Sulfatase and Estrogen Sulfotransferase in Colon Carcinoma : Regulators of Intratumoral Estrogen Concentrations and Potent Prognostic Factors2009
Author(s)
Sato R, Suzuki T, Katayose Y, Miura K, Shiiba K, Tateno H, Miki Y, Akahira J, Kamogawa Y, Nagasaki S, Yamamoto K, IiT, Egawa S, Evans DB, Unno M, Sasano H.
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Journal Title
Cancer Res. 69
Pages: 914-922
Related Report
Peer Reviewed
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[Journal Article] Intratumoral estrogen and estrogen receptors in human non-small cell lung carcinoma2008
Author(s)
Niikawa H, Suzuki T, Miki Y, Suzuki S, Nagasaki S, Akahira J-I, Honma S, D.B. Evans, Hayashi S-I, Kondo T, Sasano H
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Journal Title
Clinical Cancer Research 14
Pages: 4417-4426
Related Report
Peer Reviewed
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[Journal Article] Intratumoral estrogen and estrogen receptors in human non-small cell lung carcinoma2008
Author(s)
H. Niikawa, T. Suzuki, Y. Miki, S. Suzuki, S. Nagasaki, J-I. Akahira, S. Honma, D. B. Evans, S-I. Hayashi, T. Kondo, H. Sasano
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Journal Title
Clinical Cancer Research (in press)
Related Report
Peer Reviewed
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[Journal Article] Primary aldosteronism due to unilateral adrenal microadenoma in an elderly patient: efficacy of selective adrenal venous sampling.2008
Author(s)
Tamura Y, Adachi J, Chiba Y, Mori S, Takeda K, Kasuya Y, Murayama T, Sawabe M, Sasano H, Araki A, Ito H, Horiuchi T.
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Journal Title
Intern Med 47
Pages: 37-42
NAID
Related Report
Peer Reviewed
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[Journal Article] Hormonal markers in breast cancer : coexpression, relationship with pathologic characteristics, and risk factor associations in a population-based study2007
Author(s)
Yang XR, Pfeiffer RM, Garcia-Closas M, Rimm DL, Lissowska J,Brinton LA, Peplonska B, Hewitt SM, Cartun RW, Mandich D, Sasano H, Evans DB, Sutter TR, Sherman ME
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Journal Title
Cancer Research 67
Pages: 10608-10617
Related Report
Peer Reviewed
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[Journal Article] Aromatase localization in human breast cancer tissues-possible interactions between intratumoral stromal and parenchymal cells2007
Author(s)
Miki Y, Suzuki T, Tazawa C, Yamaguchi Y, Kitada K, Honma S, Moriya T, Hirakawa H, Evans D B, Hayashi S, Ohuchi N, Sasano H
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Journal Title
Cancer Research 67
Pages: 3945-3954
Related Report
Peer Reviewed
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[Journal Article] Expression of the steroid and xenobiotic receptor and its possible target gene, organic anion transporting polypeptide-A, in human breast carcinoma2007
Author(s)
Miki Y, Suzuki T, Kitada K, Yabuki N, Shibuya R, Moriya T, Ishida T, Ohuchi N, Blumberg B, Sasano H
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Journal Title
Cancer Research 66
Pages: 535-542
Related Report
Peer Reviewed
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[Journal Article] Endogenous Secretory Receptor for Advanced Glycation Endproducts in Non-Small Cell Lung Carcinoma.2007
Author(s)
Kobayashi S, Kubo H, Suzuki T, Ishizawa K, Yamada M, He M, Yamamoto Y, Yamamoto H, Sasano H, Sasaki H, Suzuki S.
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Journal Title
American journal of respiratory and critical care medicine. 175
Pages: 184-189
Related Report
Peer Reviewed
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[Journal Article] Bone Marrow(BM)Transplantation Promotes{beta}Cell Regeneration after Acute Injury through BM Cell Mobilization.2007
Author(s)
Hasegawa Y, Ogihara T, Yamada T, Ishigaki Y, Imai J, Uno K, Gao J, Kaneko K, Ishihara H, Sasano H, Nakauchi H, Oka Y, Katagir
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Journal Title
Endocrinology 148
Pages: 2006-2015
Related Report
Peer Reviewed
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[Journal Article] Benign cortisol-secreting adrenocortical adenomas produce small amounts of androgens.2007
Author(s)
Kamenicky P, Houdoin L, Ferlicot S, Salenave S, Brailly S, Droupy S, Meduri G, Sasano H, Suzuki T, Young J, Chanson P.
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Journal Title
Clinical Endocrinology 66
Pages: 778-788
Related Report
Peer Reviewed
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[Journal Article] Aromatase localization in human breast cancer tissues: possible interactions between intratumoral stromal and parenchymal cel2007
Author(s)
Miki Y, Suzuki T, Tazawa C, Yamaguchi Y, Kitada K, Honma S, Moriya T, Hirakawa H, Evans DB, Hayashi S, Ohuchi N, Sasano H.
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Journal Title
Cancer Research 67
Pages: 3945-3954
Related Report
Peer Reviewed
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[Journal Article] Medicolegal Liability in pathology: an international perspective.2007
Author(s)
Wick MR, Foucar E, Allen PW, Alves VA, . Bjornsson J, Bosman F, Churg AW, Drut R, Foster CS, Hauptmann S, Hytiroglou P, Kuo TT, Matsubara O, Nappi O, Pervez S, Rosai J, Sasano H, Vielh P, Zelger B.
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Journal Title
Seminars in Diagnostic Pathology 24
Pages: 65-76
Related Report
Peer Reviewed
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[Journal Article] Prognoses and Prognostic Factors of Carcinosarcoma, Endometrial Stromal Sarcoma and Uterine Leiomyosarcoma: A Comparison with Uterine Endometrial Adenocarcinoma.2007
Author(s)
Akahira JI, Tokunaga H, Toyoshima M, Takano T, Nagase S, Yoshinaga K, Tase T, Wada Y, Ito K, Niikura H, Yamada H, Sato A, Sasano H, Yaegashi N.
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Journal Title
Oncology 71
Pages: 333-340
Related Report
Peer Reviewed
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[Journal Article] Hormonal markers in breast cancer: coexpression, relationship with pathologic characteristics, and risk factor associations in a population-basedstudy.2007
Author(s)
Yang XR, Pfeiffer RM, Garcia-Closas M, Rimm DL, Lissowska J, Brinton LA, Peplonska B, Hewitt SM, Cartun RW, Mandich D, Sasano H, Evans DB, Sutter TR, Sherman ME.
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Journal Title
Cancer Research 67
Pages: 10608-10617
Related Report
Peer Reviewed
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[Journal Article] Aromatase localization in human breast cancer tissues-possible interactions between intratumoral stromal and parenchymal cells2007
Author(s)
Miki Y, Suzuki T, Tazawa C, Yamaguchi Y, Kitada K, Honma S, Moriya T, Hirakawa H, Evans D B, Havashi S, Ohuchi N, Sasano H
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Journal Title
Cancer Research (in press)
Related Report
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[Journal Article] Endogenous Secretory Receptor for Advanced Glycation Endproducts in Non-Small Cell Lung Carcinoma2007
Author(s)
Kobayashi S, Kubo H, Suzuki T, Ishizawa K, Yamada M, He M, Yamamoto Y, Yamamoto H, Sasano H, Sasaki H, Suzuki S
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Journal Title
American journal of respiratory and critical care medicine 175
Pages: 184-189
Related Report
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[Journal Article] lmmunolocalization of liver receptor homologue-1 (LRH-1) in human breast carcinoma : Possible regulator of insitu steroidogenesis.2006
Author(s)
Miki Y, Clyne CD, Suzuki T, Moriya T, Shibuya R, Nakamura Y, Ishida T, Yabuki N, Kitada K, Hayashi SI, Sasao H
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Journal Title
Cancer Letters 244
Pages: 24-33
Related Report
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[Journal Article] Expression of the steroid and xenobiotic receptor and its possible target gene, Organic anion transporting polypeptide-A, in human breast carcinoma2006
Author(s)
Miki Y, Suzuki T, Kitada K, Yabuki N, Shibuya R, Moriya T, Ishida T, Ohuchi N, Blumberg B, Sasano H
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Journal Title
Cancer Research 66
Pages: 535-542
Related Report
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