|Budget Amount *help
¥15,580,000 (Direct Cost: ¥13,900,000、Indirect Cost: ¥1,680,000)
Fiscal Year 2009: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2008: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Fiscal Year 2007: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Fiscal Year 2006: ¥8,300,000 (Direct Cost: ¥8,300,000)
While cytosine methylation in CpG-island, located usually regulatory region of many genes, is well recognized as an inhibitory epigenetic regulator, biological significance of the cytosine methylation other than CpG-island is unclear. By focusing morphology-oriented microscopic dissection methods, we investigated cytosine methylation status in the gene promoter, and found that some of the cytosine methylation outside of the CpG-island have major contributions during cancer progression.