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Molecular evolution of antigen polymoiphism of modem malaria parasite populations

Research Project

Project/Area Number 18390131
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Parasitology (including Sanitary zoology)
Research InstitutionOsaka University

Principal Investigator

TANABE Kazuyuki  Osaka University, Research Instikne for Itrobial Diseass, SA Professor (40047410)

Co-Investigator(Kenkyū-buntansha) HASHIMOTO Tetsuo  Tsukuba University, Institute of Biological Sciences, Professor (50208451)
SAWAI Hiromi  Osaka University, Research Institute for Microbial Diseases, Designated Researcher (60377124)
Project Period (FY) 2006 – 2007
Project Status Completed (Fiscal Year 2007)
Budget Amount *help
¥16,510,000 (Direct Cost: ¥14,800,000、Indirect Cost: ¥1,710,000)
Fiscal Year 2007: ¥7,410,000 (Direct Cost: ¥5,700,000、Indirect Cost: ¥1,710,000)
Fiscal Year 2006: ¥9,100,000 (Direct Cost: ¥9,100,000)
KeywordsMalaria / Antigen / Gene / Infectious disease / Evolution / Plasmodium vivax
Research Abstract

1. Geographic variation in multiplicity of infection
Multiplicity of infection (MOI) was compared among P falciparum populations from diverse geographic areas. MOI as measured by PCR-based mspl- 5' haplotyping was high in Africa, whereas there was no discernible association between MOI and the intensity of malaria transmission in Melanesia. Results suggest that the acquisition of strain specific protective immunity against malaria is associated with not only the intensity of malaria transmission but also the number of genotypes prevalent in local areas and MOI.
2. Origin of and natural selection in mspl polymorphism of P. vivax
To investigate the evolutionary history of mspl polymorphism in P vivax, phylogenetic trees of mspl from P. vivax and related monkey malaria parasite species was constructed. All P vivax mspl alleles cluster in the P vivax lineage and are not distributed among other species. Similarly, all P cynomolgi mspl alleles cluster in the P cynomolgi lineage. This suggests that the origin of P. vivax mspl polymorphism is relatively recent. We observed positive selection_in the P vivax lineage but not in P cynomolgi. This study shows that the evolutionary history of mspl differs greatly among parasite lineages.
3. Phylogeny of the cytosolic SSUrRNA of Plasmodium spp.
To infer the SSUrRNA phylogeny of the genus Plasmodium, sequences of genes encoding paralogous copies of the cyto-SSUrRNA, A-type-like and S-type-like genes, from eight simian Plasmodium species were obtained. The maximum likelihood analyses of these sequences, together with all cyto-SSUrRNA sequences currently available in the database, clearly demonstrated four independent clades in the unrooted Plasmodium tree: a simian Plasmodium + P vivax clade, a rodent Plasmodium clade (P. berghei/P. yoelii), a large clade including P malariae, P. falciparum, P reichnowi, and avian and reptilian Plasmodium species, and a P ovale clade.

Report

(3 results)
  • 2007 Annual Research Report   Final Research Report Summary
  • 2006 Annual Research Report
  • Research Products

    (79 results)

All 2008 2007 2006 Other

All Journal Article (39 results) (of which Peer Reviewed: 21 results) Presentation (38 results) Remarks (2 results)

  • [Journal Article] Diversity and evolution of the highly diverse rhoph1/clag multigene family of Plasmodium falciparum2008

    • Author(s)
      H. Iriko, Kaneko, H. Otsuki, T. Tsuboi, X-z. Su, K. Tanabe, and M. Torii
    • Journal Title

      Molecular and Biochemical Parasitology 158

      Pages: 11-21

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Evolution and phylogeny of the heterogeneous cytosolic SSU rRNA genes in the genus Plasmodium2008

    • Author(s)
      Y. Nishimoto, N. Arisue, S. Kawai, A. A Escalante, T. Horii, K. Tanabe, and T. Hashimoto
    • Journal Title

      Molecular Phylogeny and Evolution 47

      Pages: 45-53

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Diversity and evolution of the highly diverse rhophl/clag multigene family of Plasmodium falciparum2008

    • Author(s)
      H., Iriko, Kaneko, H., Otsuki, T., Tsuboi, X-Z., Su, K., Tanabe, M., Torii
    • Journal Title

      Molecular and Biochemical Parasitology 158

      Pages: 11-21

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Evolution and phylogeny of the heterogeneous cytosolic SSU rRNA genes in the genus Plasmodium2008

    • Author(s)
      Y., Nishimoto, N., Arisue, S., Kawai, A.A, Escalante, T., Horii, K., Tanabe, T., Hashimoto
    • Journal Title

      Molecular Phvlogenv and Evolution 47

      Pages: 45-53

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Diversity and evolution of the rhophl/clag multigene family of Plasmodium falci parum.2008

    • Author(s)
      Iriko H, Kaneko O, Otsuki H, Tsuboi T, Su XZ, Tanabe K, Torii M.
    • Journal Title

      Mol Biochem Parasitol. 158

      Pages: 11-21

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A comparative study of the genetic diversity of the 42 kDa fragment of the merozoite surface protein 1 in Plasmodium falciparum and P. vivax2007

    • Author(s)
      M. A. Pacheco, A. C. Poe, W. E. Collins, A. A. Lal, K. Tanabe, V. Udhayakumar, and A. E. Escalante
    • Journal Title

      Infection, Genetics and Evolution 7

      Pages: 180-187

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Independent unique evolution of pyrimethamine resistance of P. falciparum in Melanesia2007

    • Author(s)
      T. Mita, K. Tanabe, N. Takahashi, T. Tsukahara, H. Eto, L. Dysoley, H. Ohmae, K. Kita, S. Krudsood, S. Looareesuwan, A. Kaneko, A. Bjorkman, and T. Kobayakawa.
    • Journal Title

      Antimicrobial Agents and Chemotherapy 51

      Pages: 1071-1077

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] High frequency of recombination-drived allelic diversity and temporal variation of Plasmodium falciparum in Tanzania2007

    • Author(s)
      K. Tanabe, N. Sakihama, I. Rooth, A. Bjorkman and A. Farnert
    • Journal Title

      American Journal of Tropical Medicine and Hygiene 76

      Pages: 1037-1045

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Allelic diversity in the merozoite surface protein 1 gene of Plasmodium falciparum on Palawan Island, the Philippines2007

    • Author(s)
      N. Sakihama, M. Nakamura, A. A. Palanca Jr, R. A. Argubano, E. P. Realon, A. L. Larracas, R. L. Espina, and K. Tanabe
    • Journal Title

      Parasitology International 56

      Pages: 185-194

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Progress in the molecular biology of malaria and the immunology of nematode infections.2007

    • Author(s)
      N. Arizono, K. Nakanishi, T. Horii and K. Tanabe
    • Journal Title

      Trends in Parasitology 23

      Pages: 175-181

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Production of High-Affinity Human Monoclonal Antibody Fab Fragments to the 19-Kilodalton C-Terminal Merozoite Surface Protein 1 of Plasmodium falciparum2007

    • Author(s)
      X. Cheng, H. Hayasaka, K. Watanabe, Y. Tao, J. Liu, H. Tsukamoto, T. Horii, K. Tanabe, and H. Tachibana
    • Journal Title

      Infection and Immunity 75

      Pages: 3614-3620

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Allelic dimorphism-associated restriction of recombination in Plasmodium falciparum msp12007

    • Author(s)
      K. Tanabe, N. Sakihama, D. Walliker, H. Babiker, A. A. Abdel-Muhsin, B. Bakote'e, H. Ohmae, N. Arisue, T. Horii, I. Rooth, A. Farnert, A. Bjorkman, and L. Ranford-Cartwright
    • Journal Title

      Gene 397

      Pages: 153-160

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Recent independent evolution of msp1 polymorphism in Plamsodium vivax and related malaria parasites2007

    • Author(s)
      K. Tanabe, A. Escalante, N. Sakihama, M. Honda, N. Arisue, T. Horii, R. Culleton, T. Hayakawa, T. Hashimoto, S. Longacre, S. Pathirana, S. Handunnetti, H. Kishino
    • Journal Title

      Molecular and Biochemical Parasitology 156

      Pages: 74-79

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] A comparative study of the genetic diversity of the 42 kDa fragment of the merozoite surface protein 1 in Plasmodium falciparum and P vivax2007

    • Author(s)
      M.A., Pacheco, A.C., Poe, W.E., Collins, A.A., Lal, IC., Tanabe, V., Udhayakumar, A.E., Escalante
    • Journal Title

      Infection, Genetics and Evolution 7

      Pages: 180-187

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Independent unique evolution of pyrimethamine resistance of P. falciparum in Melanesia2007

    • Author(s)
      T., Mita, K., Tanabe, N., Takahashi, T., Tsukahara, H., Eto, L., Dysoley, H., Ohmae, K., Kita, S., Krudsood, S., Looareesuwan, A., Kaneko, A., Bjarkrnan, T., Kobayakawa
    • Journal Title

      Antimicrobial Agents and Chemotherapy 51

      Pages: 1071-1077

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] High frequency of recombination-drived allelic diversity and temporal variation of Plasmodium falciparum in Tanzania2007

    • Author(s)
      K., Tanabe, N., Sakihama, I., Rooth, A., Bjorkman, A., Famed
    • Journal Title

      American Journal of Tropical Medicine and Hygiene 76

      Pages: 1037-1045

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Allelic diversity in the merozoite surface protein 1 gene of Plasmodium falciparum on Palawan Island, the Philippines2007

    • Author(s)
      N., Sakihama, M., Nakamura, A.A., Palanca, Jr, R.A., Argubano, E.P., Realon, A.L., Larracas, R.L., Espina, K., Tanabe
    • Journal Title

      Parasitology Intemational 56

      Pages: 185-194

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Progress in the molecular biology of malaria and the immunology of nematode Infections2007

    • Author(s)
      N., Arizono, K., Nakanishi, T., Horii, K, Tanabe
    • Journal Title

      Trends in Parasitology 23

      Pages: 175-181

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Production of High-Affinity Human Monoclonal Antibody Fab Fragments to the 19-Kilodalton C-Terminal Merozoite Surface Protein I of Plasmodium falciparum2007

    • Author(s)
      X., Chang, H., Hayasaka, K., Watanabe, Y., Tao, J., Liu, H., Tsukamoto, T., Horii, K., Tanabe, H., Tachibana
    • Journal Title

      Infection and Immunity 75

      Pages: 3614-3620

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Allelic dimorphism-associated restriction of recombination in Plasmodium falciparum mspl2007

    • Author(s)
      K., Tanabe, N., Sakihama, D., Walliker, H., Babiker, A.A., Abdel-Muhsin, B., Bakote'e, H., Ohmae, N., Arisue, T., Horii, I., Rooth, A., Earned, A., BjOrkman, L., Ranford-Cartwrieht
    • Journal Title

      Gene 397

      Pages: 153-160

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Recent independent evolution of mspl polymorphism in Plarnsodium vivax and related malaria parasites2007

    • Author(s)
      K., Tanabe, A., Escalante, N., Sakihama, M., Honda, N., Arisue, T., Horii, R., Culleton, T., Hayakawa, T., Hashimoto, S., Longacre, S., Pathirana, S., Handunnetti, H., Kishino
    • Journal Title

      Molecular and Biochemical Parasitology 156

      Pages: 74-79

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Recent independent evolution of mspl polymorphism in Plasmodium vivax and related simian malaria parasites.2007

    • Author(s)
      Tanabe K, et. al.
    • Journal Title

      Mol Biochem Parasitol. 156

      Pages: 74-79

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Allelic dimorphism-assoicated restriction of recombination in Plasmodium falciparum mspl.2007

    • Author(s)
      Tanabe K, et. al.
    • Journal Title

      Gene 397

      Pages: 153-160

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Production of high-affinity human monoclonal antibody fab fragments to the 19-kilodaltion C-termainal merozoite surface protein 1 of Plasmodium Falciparum.2007

    • Author(s)
      Cheng XJ, Hayashaka H, Watanabe K, Tao YL, Liu JY, Tsukamoto H, Horii T., Tanabe K, Tachibana H.
    • Journal Title

      Infect Immun 75

      Pages: 3614-3620

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Allelic diversity in the merozoite surface protein 1 gene of Plasmodium falciparum on Palawan Island, the Philippines.2007

    • Author(s)
      Sakihama N, Nakamura M, Palanca AA Jr, Argubano RA, Realon EP, Larracas A L, Espina RL, Tanabe K.
    • Journal Title

      Parasitol Int. 56

      Pages: 185-194

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Progress in the molecular biology of malaria and the immunology of nematode infections.2007

    • Author(s)
      Arizono N, Nakanishi K, Horii T., Tanabe K.
    • Journal Title

      Trends Parasitol. 23

      Pages: 175-181

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] High frequency of recombination-drived allelic diversity and temporal variation of Plasmodium falciparum in Tanzania.2007

    • Author(s)
      K. Tanabe, N. Sakihama, I. Rooth, A. Bjorkman and Farnert.
    • Journal Title

      Am. J. Trop. Med. Hyg. 76

      Pages: 1037-1045

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Independent unique evolution of pyrimethamine resistance of P. falciparum in Melanesia.2007

    • Author(s)
      T. Mita, K Tanabe, N. Takahashi, L. Dysoley, F. Eto, I. Hwaihwanje, H. Ohmae, K. Kita, S. Looareesuwan, A. Kaneko, A. Bjorkman, and T. Kobayakawa.
    • Journal Title

      Antimicroh. Agents Chemother. 51

      Pages: 1071-1077

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Comparative study of the genetic diversity of the 42 kDa fragment of the merozoite surface protein 1 in Plasmodium falciparum and P. vivax.2007

    • Author(s)
      M. A. Pacheco, A. C. Poe, W. E. Collins, A. A. Lal, K. Tanabe, V. Udhayakumar, and A. E. Escalante.
    • Journal Title

      Inf. Gen. Evol. 7

      Pages: 180-187

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A comparative study of the genetic diversity of the 42 kDa fragment of the merozoite surface protein 1 in Plasmodium falciparum and P. vivax2007

    • Author(s)
      M.A.Pacheco, A.C.Poe, W.E.Collins, A.A.Lal, K.Tanabe, V.Udhayakumar, A.E.Escalante
    • Journal Title

      Infection, Genetics and Evolution 7

      Pages: 180-187

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Independent unique evolution of pyrimethamine resistance of P. falciparum in Melanesia2007

    • Author(s)
      T.Mita, K.Tanabe, et al.
    • Journal Title

      Antimicrobial Agents and Chemotherapy 51

      Pages: 1071-1077

    • Related Report
      2006 Annual Research Report
  • [Journal Article] High frequency of recombination-drived allelic diversity and temporal variation of Plasmodium falciparum in Tanzania2007

    • Author(s)
      K.Tanabe, N.Sakihama, I.Rooth, A.Bjorkman, A.Farnert
    • Journal Title

      American Journal of Tropical Medicine and Hygiene (In press)

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Allelic diversity in the merozoite surface protein 1 gene of Plasmodium falciparum on Palawan Island, the Philippines2007

    • Author(s)
      N.Sakihama, K.Tanabe, et al.
    • Journal Title

      Parasitology International (In press)

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Rapid selection of dhfr mutant allele in P. falciparum isolates after the introduction of sulfadoxine/pyrimethamine in combination with 4-aminoquinolines in Papua New Guninea.2006

    • Author(s)
      T. Mita, A. Kaneko, I. Hwaihawanje, T. Tsukahara, N. Takahashi, H. Osawa, K. Tanabe, T. Kobayakawa, and A. Bjorkman
    • Journal Title

      Infection, Genetics and Evolution 6

      Pages: 447-452

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Plasmodium vivax serine repeat antigen(SERA) multigene family exhibits similar expression patterns in independent infections.2006

    • Author(s)
      N. M. Q. Palacpac, B. W. Y. Leung, N. Aisue, K. Tanabe, J. Sattabongkot, T. Tsuboi, M. Torii, R. Udomsangpetch, T. Horii
    • Journal Title

      Molecular and Biochemical Parasitology 150

      Pages: 353-358

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Rapid selection of dhfr mutant allele in P. falcipanint isolates after the introduction of sulfadoxine/pyrimethamine in combination with 4-aminoquinolines in Papua New Guninea.2006

    • Author(s)
      T., Mita, A., Kaneko, I., Hwaihawanje, T., Tsukahara, N., T0akahashi, H., Osawa, K., Tanabe, T., Kobayakawa, A., Hftirkman
    • Journal Title

      Infection, Genetics and Evolution 6

      Pages: 447-452

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Plasmodium vivax serine repeat antigen (SERA) multigene family exhibits similar expression patterns in independent infections.2006

    • Author(s)
      N.M.Q., Palacpac, B.W.Y., Leung, N., Arisue, K., Tanabe, J., Sattabongkot, T., Tsuboi, M., Torii, R., Udomsangoetch, T., Horii
    • Journal Title

      Molecular and Biochemical Parasitology 150

      Pages: 353-358

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Rapid selection of dhfr mutant allele in P. falciparum isolates after the introduction of sulfadoxine/pyrimethamine in combination with 4-aminoquinolines in Papua New Guninea.2006

    • Author(s)
      T.Mita, A.Kaneko, I.Hwaihawanje, T.Tsukahara, N.Takahashi, H.Osawa, K.Tanabe, T.Kobayakawa, A.Bjorkman
    • Journal Title

      Infection, Genetics and Evolution 6

      Pages: 447-452

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Plasmodium vivax serine repeat antigen (SERA) multigene family exhibits similar expression patterns in independent infections.2006

    • Author(s)
      N.M.Q.Palacpac, B.W.Y.Leung, N.Arisue, K.Tanabe, J.Sattabongkot, T.Tsuboi, M.Torii, R.Udomsangpetch, T.Horii
    • Journal Title

      Molecular and Biochemical Parasitology 150

      Pages: 353-358

    • Related Report
      2006 Annual Research Report
  • [Presentation] 複数遺伝子配列データによるマラリア原虫の系統解析2007

    • Author(s)
      有末伸子、橋本哲男、早川敏之、三井英也、先濱直子、賈黙稚、Nirianne Palacpac、田邉和裄、堀井俊宏
    • Organizer
      第30回日本分子生物学会年会
    • Place of Presentation
      横浜、神奈川
    • Year and Date
      2007-12-15
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Annual Research Report 2007 Final Research Report Summary
  • [Presentation] ゲノム多様性が語るマラリア病原体の寄生戦略2007

    • Author(s)
      田邉和裄
    • Organizer
      日本動物学会近畿支部公開講演会
    • Place of Presentation
      橿原、奈良
    • Year and Date
      2007-11-24
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Annual Research Report 2007 Final Research Report Summary
  • [Presentation] 現生マラリア原虫系統の起源における急速な多様化2007

    • Author(s)
      早川敏之、Richrad Culleton, 堀井俊宏、田邉和裄
    • Organizer
      第6回分子寄生虫・マラリア研究フォーラム
    • Place of Presentation
      松山、愛媛
    • Year and Date
      2007-10-27
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Group I. II及びIII SERA遺伝子配列から推定したマラリア原虫の系統関係2007

    • Author(s)
      有末伸子、賈黙稚、Niriann Palacpac、田邉和裄、堀井俊宏
    • Organizer
      第6回分子寄生虫・マラリア研究フォーラム
    • Place of Presentation
      松山、愛媛
    • Year and Date
      2007-10-27
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] マラリア原虫表面抗原msp1における種特異的な自然選択2007

    • Author(s)
      澤井裕美、大谷寛人、田邉和裄
    • Organizer
      第6回分子寄生虫・マラリア研究フォーラム
    • Place of Presentation
      松山、愛媛
    • Year and Date
      2007-10-27
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 現生マラリア原虫系統の起源における急速な多様化2007

    • Author(s)
      早川敏之、Richrad Culleton, 堀井俊宏、田邉和桁
    • Organizer
      第6回分子寄生虫・マラリナ研究フォーラム
    • Place of Presentation
      松山、愛媛
    • Year and Date
      2007-10-27
    • Related Report
      2007 Annual Research Report
  • [Presentation] Group I.II及びIII SERA遺伝子配列から推定したマラリア原虫の系統関係2007

    • Author(s)
      有末伸子、賈黙稚、Niriann Palacpac、田邉和桁、堀井俊宏
    • Organizer
      第6回分子寄生虫・マラリア研究フォーラム
    • Place of Presentation
      松山、愛媛
    • Year and Date
      2007-10-27
    • Related Report
      2007 Annual Research Report
  • [Presentation] マラリア原虫の表面抗原遺伝子msplにおける種特異的な自然選択2007

    • Author(s)
      澤井裕美、大谷寛人、田邉和桁
    • Organizer
      遺伝学会第79回大会
    • Place of Presentation
      岡山、岡山
    • Year and Date
      2007-09-21
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] マラリア原虫の表面抗原遺伝子msp1における種特異的な自然選択2007

    • Author(s)
      澤井裕美、大谷寛人、田邊和裄
    • Organizer
      遺伝学会第79回大会
    • Place of Presentation
      岡山
    • Year and Date
      2007-09-21
    • Related Report
      2007 Annual Research Report
  • [Presentation] Incipient rapid diversification in the evolution of extant malaria parasites.2007

    • Author(s)
      Toshiyuki Hayakawa, Richard Culleton, Toshihiro Horii, Kazuyuki Tanabe
    • Organizer
      7th Awaji International Forum on Infection and Immunity
    • Place of Presentation
      Awaji, Hyogo, Japan
    • Year and Date
      2007-09-04
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Phylogenetic relationship of malaria parasites inferred from multiple gene data2007

    • Author(s)
      Nobuko Arisue, Tetso Hashimoto, Toshiyuki Hayakawa, Hideya Mitsui, Naoko Sakihama, Mozhi Jia, Nirianne M. Q. Palacpac, Toshihiro Horii, Kazuyuki Tanabe
    • Organizer
      7th Awaji International Forum on Infection and Immunity
    • Place of Presentation
      Awaji, Hyogo, Japan
    • Year and Date
      2007-09-04
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Plasmodium vivax in Africa2007

    • Author(s)
      Richard Culletion, Toshihito Mita, Mathieu Ndounga, Holger Onger, Pcdro Cravo, Akira Kaneko, Milijaona, Randrianarivelojosia, Shigeyuki Kano, Takafumi Tsuboi, Anjali Yadava, Anna P. Arez, Virgilio, do Rosario, Francine Ntoumi, Richard Carter, Kazuyuki Tanabe.
    • Organizer
      7th Awaji International Forum on Infection and Immunity
    • Place of Presentation
      Awaji, Hyogo, Japan
    • Year and Date
      2007-09-04
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Genetic make-up of Plasmodium vivax populatio in Mae Sot, Thailand2007

    • Author(s)
      Nirianne M. Q. Palacpac, Nobuko Arisue, Tohsihiro Horii, Jetsumon Satabongkt, Takafumi Tsuboi, Motomi Torii, Rachanee Udomsangpetch, Kazuyuki Tanabe
    • Organizer
      7th Awaji International Forum on Infection and Immunity
    • Place of Presentation
      Awaji, Hyogo, Japan
    • Year and Date
      2007-09-04
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Incipient rapid diversification in the evolution of extant malaria parasites.2007

    • Author(s)
      Toshiyuki Hayakawa, Richard Culleton, Toshihiro Horii, Kazuyuki Tanabe
    • Organizer
      7th Awaji International Forum on Infection and Immunity,
    • Place of Presentation
      Awaji, Hyogp, Japan
    • Year and Date
      2007-09-04
    • Related Report
      2007 Annual Research Report
  • [Presentation] Phylogenetic relationship of malaria parasites inferred from multiple gene data.2007

    • Author(s)
      Nobuko Arisue, et. al.
    • Organizer
      7th Awaji International Forum on Infection and Immunity,
    • Place of Presentation
      Awaji, Hyogp, Japan
    • Year and Date
      2007-09-04
    • Related Report
      2007 Annual Research Report
  • [Presentation] Plasmodium vivax in Africa.2007

    • Author(s)
      Richard Culleton, et. al.
    • Organizer
      7th Awaji International Forum on Infection and Immunity
    • Place of Presentation
      Awaji, Hyogp, Japan
    • Year and Date
      2007-09-04
    • Related Report
      2007 Annual Research Report
  • [Presentation] Genetic make-up of Plasmodium vivax populatio in Mae Sot, Thailand.2007

    • Author(s)
      Nirianne M. Q. Palacpac, et. al.
    • Organizer
      7th Awaji International Forum on Infection and Immunity
    • Place of Presentation
      Awaji, Hyogp, Japan
    • Year and Date
      2007-09-04
    • Related Report
      2007 Annual Research Report
  • [Presentation] Recent independent evolution of msp1 polymorphism in Plasmodium vivax and Plasmodium cynomolgi.2007

    • Author(s)
      Kazuyuki Tanabe, Ananias Escalante, Naoko Sakihama, Masanori Honda, Nobuko Arisue, Toshihiro Horii, Richard Culleton, Toshiyuki Hayakawa, Tetsuo Hashimoto, Shirley Longacre, Sisira Pathirana, Shiroma Handunnetti, Hirohisa Kishino.
    • Organizer
      5th European Congress on Tropical Medicien and Internationa Health
    • Place of Presentation
      Amsterdam, Holland
    • Year and Date
      2007-05-26
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Recent independent evolution of mspl polymorphism in Plasmodium vivax and Plasmodium cynomolgi.2007

    • Author(s)
      Kazuyuki, Tanabe, Ananias, Escalante, Naoko, Sakihama, Masanori, Honda, Nobuko, Arisue, Toshihiro, Horii, Richard, Culleton, Toshiyuki, Hayakawa, Tetsuo, Hashimoto, Shirley, Longacre, Sisira, Pathirana, Shiroma, Handunnetti, Hirohisa, Kishino
    • Organizer
      5th European Congress on Tropical Medicien and Intemationa Health
    • Place of Presentation
      Amsterdam, Holland
    • Year and Date
      2007-05-26
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Recent independent evolution of mspl polymorphism in Plasmodium vivax and P1asmodium cynomolgi2007

    • Author(s)
      Kazuyuki Tanabe,.
    • Organizer
      5th European Congress on Tropical Medicine and International Health
    • Place of Presentation
      Amsterdam, Netherland
    • Year and Date
      2007-05-26
    • Related Report
      2007 Annual Research Report
  • [Presentation] 三日熱マラリア原虫メロゾイト表面タンパク質1における遺伝子多型の進化2007

    • Author(s)
      田辺和裄, 先濱直子, 早川敏之, Richard Culleton, 有末伸子, 堀井俊宏, 橋本哲男, Sisira Pathirana, Shiroma Handunnetti
    • Organizer
      第76回 日本寄生虫学会大会
    • Place of Presentation
      大阪
    • Year and Date
      2007-03-30
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Polymorphism in malaria antigens and microsatellite markers of Plasmodium vivax: a parasite strategy for survival?2007

    • Author(s)
      N. Palacpac, N. Arisue, K. Tanabe, J. Sattabongkot, T. Tsuboi, M. Torii, R. Udomsangpech, T. Horii
    • Organizer
      第76回 日本寄生虫学会大会
    • Place of Presentation
      大阪
    • Year and Date
      2007-03-30
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] ヒトマラリア原虫を中心とした霊長類マラリア原虫とその宿主の進化2007

    • Author(s)
      早川敏之、リチャード・カレトン, 堀井俊宏、田辺和桁
    • Organizer
      第76回 日本寄生虫学会大会
    • Place of Presentation
      大阪
    • Year and Date
      2007-03-30
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Urbanization and malaria epidemiology in West Africa2007

    • Author(s)
      リチャード・カレトン、ンドンガ・マシュー、田辺和桁
    • Organizer
      第76回 日本寄生虫学会大会
    • Place of Presentation
      大阪
    • Year and Date
      2007-03-30
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] マラリア原虫アピコプラストゲノムの比較解析と分子系統2007

    • Author(s)
      橋本哲男、三井英也、先濱直子、有末伸子、田辺和裄、川合覚、長谷川政美
    • Organizer
      第76回 日本寄生虫学会大会
    • Place of Presentation
      大阪
    • Year and Date
      2007-03-30
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Recent evolution of msp1 polymorphism in Plasmodium vivax2007

    • Author(s)
      Kazuyuki Tanabe
    • Organizer
      40th Japan-US Joint Conference on Parasitic Diseases
    • Place of Presentation
      Tokyo, Japan
    • Year and Date
      2007-02-02
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Genetic polymorphisms of drug resistant gene in Southeast Asia throughimported isolates of Plasmodium falciparum in Japan2007

    • Author(s)
      Y. Saito-Nakano, K. Kamei, M. Iwagami, K. Komaki-Yasuda, S. Kawazu, S. Kano, K. Tanabe, H. Ohmae, T. Endo
    • Organizer
      The 1st Thailand-Japan Joint Forum on Infectious Diseases
    • Place of Presentation
      Bangkok, Thailand
    • Year and Date
      2007-01-30
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Stable antigen polymorphism in modern Plasmodium falciparum populations2007

    • Author(s)
      Kazuyuki Tanabe, Naoko Sakihama, Ingegerd Rooth, Anna Farnert, Anders Bjorkman, Marcelo M. Ferreira, Hiroshi Ohmae, and Kenji Hirayama
    • Organizer
      Asian Research Forum on Emerging and Reemerging Infections-2007
    • Place of Presentation
      Nagasaki, Japan
    • Year and Date
      2007-01-16
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Stable antigen polymorphism in modem Plasmodium falciparum populations2007

    • Author(s)
      Kazuyuki, Tanabe, Naoko, Sakihama, Ingegerd, Rooth, Anna, Farnert, Anders, BjOrkman, Marcelo, M., Ferreira, Hiroshi, Ohmae, Kenji, Himyama
    • Organizer
      Asian Research Forum on Emerging and Reemerging Infections-2007
    • Place of Presentation
      Nagasaki, Japan
    • Year and Date
      2007-01-16
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Plasmodium vivax in Africa2006

    • Author(s)
      Richrad Culleton, Matthieu Ndounga, Holger Unger, Richard Carter, Kazuyuki Tanabe
    • Organizer
      第5回分子寄生虫・マラリア研究フォーラム
    • Place of Presentation
      東京
    • Year and Date
      2006-10-28
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Independent unique evolution of pyrimethamine resistance of P. falciparum in Melanesia2006

    • Author(s)
      美田敏宏、田辺和裄、大前比呂思、北潔、小早川隆敏
    • Organizer
      第5回分子寄生虫・マラリア研究フォーラム
    • Place of Presentation
      東京
    • Year and Date
      2006-10-28
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 核コード細胞質SSUrRNA遺伝子に基づくマラリア原虫Plasmodium属の系統解析2006

    • Author(s)
      西本由利子、有末伸子、川合覚、田辺和裄、橋本哲男
    • Organizer
      第5回分子寄生虫・マラリア研究フォーラム
    • Place of Presentation
      東京
    • Year and Date
      2006-10-28
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 霊長類マラリア原虫とその宿主の進化2006

    • Author(s)
      早川敏之、Richrad Culleton, 堀井俊宏、田辺和桁
    • Organizer
      第5回分子寄生虫・マラリア研究フォーラム
    • Place of Presentation
      東京
    • Year and Date
      2006-10-28
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] The evolution of antigen polymorphism in 'modern' P. falciparum populations2006

    • Author(s)
      Kazuyuki Tanabe, Naoko Sakihama, Ingegerd Rooth, Anna Farnert, Anders Bjorkman, Hiroshi Ohmae, and Kenji Hirayama
    • Organizer
      The 15th Japanese-German Symposium on Protozoan Diseases
    • Place of Presentation
      Obihiro, Hokkaido, Japan
    • Year and Date
      2006-09-18
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] The Plasmodium vivax serine rgpeat antigen(SERA)multigene family: expression pattern and genetic diversity in independent infections2006

    • Author(s)
      Nirianne M. Q. Palacpac, Betty W. Y. Leung, Nobuko Arisue, Kazuyuki Tanabe, Jetsumon Sattabongkot, Takafumi Tsuboi, Motomi Torii, Rachanee Udomsangpetch and Toshiriho Horii
    • Organizer
      6th Awaji International Forum on Infection and Immunity
    • Place of Presentation
      Awaji, Hyogo, Japan
    • Year and Date
      2006-09-06
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Evolution of msp1 polymorphism after speciation of Plasmodium vivax and Plasmodium cynomolgi2006

    • Author(s)
      Kazuyuki Tanabe, Naoko Sakihma, Ananias Escalante, Sisira Pathirana, Shiroma Handunnetti, Masanori Honda, and Hirohisa Kishino
    • Organizer
      6th Awaji International Forum on Infection and Immunity
    • Place of Presentation
      Awaji, Hyogo, Japan
    • Year and Date
      2006-09-06
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Evolution of mspl polymorphism after speciation of Plasmodium vivax and Plasmodium cvnomolai2006

    • Author(s)
      Kazuvuki, Tanabe, Naoko, Sakihma, Ananias, Escalante, Sisira, Pathirana, Shiroma, Handunnetti, Masanori, Honda, Hirohisa, Kishino
    • Organizer
      6th Awaji International Forum on Infection and Immunity
    • Place of Presentation
      Awaji, Hyogo,Japan
    • Year and Date
      2006-09-06
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Evolution of antigen polymorphism in the world populations of Plasmodium falciparum, the human malaria parasite2006

    • Author(s)
      Kazuyuki Tanabe
    • Organizer
      20th International Congress of Biochemistry and Molecular Biology
    • Place of Presentation
      Kyoto, Japan
    • Year and Date
      2006-06-19
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Remarks] 「研究成果報告書概要(和文)」より

    • URL

      http://www.biken.osaka-u.ac.ip/act/act_tanabe.php

    • Related Report
      2007 Final Research Report Summary
  • [Remarks]

    • URL

      http://www.biken.osaka-u.ac.jp/act/act_tanabe.php

    • Related Report
      2007 Annual Research Report

URL: 

Published: 2006-04-01   Modified: 2016-04-21  

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