Molecular evolution of antigen polymoiphism of modem malaria parasite populations

• Project/Area Number: 18390131
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Parasitology (including Sanitary zoology)
• Research Institution: Osaka University
• Principal Investigator: TANABE Kazuyuki Osaka University, Research Instikne for Itrobial Diseass, SA Professor (40047410)
• Co-Investigator(Kenkyū-buntansha): HASHIMOTO Tetsuo Tsukuba University, Institute of Biological Sciences, Professor (50208451) ; SAWAI Hiromi Osaka University, Research Institute for Microbial Diseases, Designated Researcher (60377124)
• Project Period (FY): 2006 – 2007
• Project Status: Completed (Fiscal Year 2007)
• Budget Amount: ¥16,510,000 (Direct Cost: ¥14,800,000、Indirect Cost: ¥1,710,000); Fiscal Year 2007: ¥7,410,000 (Direct Cost: ¥5,700,000、Indirect Cost: ¥1,710,000); Fiscal Year 2006: ¥9,100,000 (Direct Cost: ¥9,100,000)
• Keywords: Malaria / Antigen / Gene / Infectious disease / Evolution / Plasmodium vivax

Research Abstract

1. Geographic variation in multiplicity of infection
Multiplicity of infection (MOI) was compared among P falciparum populations from diverse geographic areas. MOI as measured by PCR-based mspl- 5' haplotyping was high in Africa, whereas there was no discernible association between MOI and the intensity of malaria transmission in Melanesia. Results suggest that the acquisition of strain specific protective immunity against malaria is associated with not only the intensity of malaria transmission but also the number of genotypes prevalent in local areas and MOI.
2. Origin of and natural selection in mspl polymorphism of P. vivax
To investigate the evolutionary history of mspl polymorphism in P vivax, phylogenetic trees of mspl from P. vivax and related monkey malaria parasite species was constructed. All P vivax mspl alleles cluster in the P vivax lineage and are not distributed among other species. Similarly, all P cynomolgi mspl alleles cluster in the P cynomolgi lineage. This suggests that the origin of P. vivax mspl polymorphism is relatively recent. We observed positive selection_in the P vivax lineage but not in P cynomolgi. This study shows that the evolutionary history of mspl differs greatly among parasite lineages.
3. Phylogeny of the cytosolic SSUrRNA of Plasmodium spp.
To infer the SSUrRNA phylogeny of the genus Plasmodium, sequences of genes encoding paralogous copies of the cyto-SSUrRNA, A-type-like and S-type-like genes, from eight simian Plasmodium species were obtained. The maximum likelihood analyses of these sequences, together with all cyto-SSUrRNA sequences currently available in the database, clearly demonstrated four independent clades in the unrooted Plasmodium tree: a simian Plasmodium + P vivax clade, a rodent Plasmodium clade (P. berghei/P. yoelii), a large clade including P malariae, P. falciparum, P reichnowi, and avian and reptilian Plasmodium species, and a P ovale clade.

Research Products

• [Journal Article] Diversity and evolution of the highly diverse rhoph1/clag multigene family of Plasmodium falciparum (2008)
  • Author(s): H. Iriko, Kaneko, H. Otsuki, T. Tsuboi, X-z. Su, K. Tanabe, and M. Torii
  • Journal Title: Molecular and Biochemical Parasitology 158 Pages: 11-21
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Evolution and phylogeny of the heterogeneous cytosolic SSU rRNA genes in the genus Plasmodium (2008)
  • Author(s): Y. Nishimoto, N. Arisue, S. Kawai, A. A Escalante, T. Horii, K. Tanabe, and T. Hashimoto
  • Journal Title: Molecular Phylogeny and Evolution 47 Pages: 45-53
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Diversity and evolution of the highly diverse rhophl/clag multigene family of Plasmodium falciparum (2008)
  • Author(s): H., Iriko, Kaneko, H., Otsuki, T., Tsuboi, X-Z., Su, K., Tanabe, M., Torii
  • Journal Title: Molecular and Biochemical Parasitology 158 Pages: 11-21
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Evolution and phylogeny of the heterogeneous cytosolic SSU rRNA genes in the genus Plasmodium (2008)
  • Author(s): Y., Nishimoto, N., Arisue, S., Kawai, A.A, Escalante, T., Horii, K., Tanabe, T., Hashimoto
  • Journal Title: Molecular Phvlogenv and Evolution 47 Pages: 45-53
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Diversity and evolution of the rhophl/clag multigene family of Plasmodium falci parum. (2008)
  • Author(s): Iriko H, Kaneko O, Otsuki H, Tsuboi T, Su XZ, Tanabe K, Torii M.
  • Journal Title: Mol Biochem Parasitol. 158 Pages: 11-21
  • Peer Reviewed
• [Journal Article] A comparative study of the genetic diversity of the 42 kDa fragment of the merozoite surface protein 1 in Plasmodium falciparum and P. vivax (2007)
  • Author(s): M. A. Pacheco, A. C. Poe, W. E. Collins, A. A. Lal, K. Tanabe, V. Udhayakumar, and A. E. Escalante
  • Journal Title: Infection, Genetics and Evolution 7 Pages: 180-187
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Independent unique evolution of pyrimethamine resistance of P. falciparum in Melanesia (2007)
  • Author(s): T. Mita, K. Tanabe, N. Takahashi, T. Tsukahara, H. Eto, L. Dysoley, H. Ohmae, K. Kita, S. Krudsood, S. Looareesuwan, A. Kaneko, A. Bjorkman, and T. Kobayakawa.
  • Journal Title: Antimicrobial Agents and Chemotherapy 51 Pages: 1071-1077
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] High frequency of recombination-drived allelic diversity and temporal variation of Plasmodium falciparum in Tanzania (2007)
  • Author(s): K. Tanabe, N. Sakihama, I. Rooth, A. Bjorkman and A. Farnert
  • Journal Title: American Journal of Tropical Medicine and Hygiene 76 Pages: 1037-1045
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Allelic diversity in the merozoite surface protein 1 gene of Plasmodium falciparum on Palawan Island, the Philippines (2007)
  • Author(s): N. Sakihama, M. Nakamura, A. A. Palanca Jr, R. A. Argubano, E. P. Realon, A. L. Larracas, R. L. Espina, and K. Tanabe
  • Journal Title: Parasitology International 56 Pages: 185-194
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Progress in the molecular biology of malaria and the immunology of nematode infections. (2007)
  • Author(s): N. Arizono, K. Nakanishi, T. Horii and K. Tanabe
  • Journal Title: Trends in Parasitology 23 Pages: 175-181
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Production of High-Affinity Human Monoclonal Antibody Fab Fragments to the 19-Kilodalton C-Terminal Merozoite Surface Protein 1 of Plasmodium falciparum (2007)
  • Author(s): X. Cheng, H. Hayasaka, K. Watanabe, Y. Tao, J. Liu, H. Tsukamoto, T. Horii, K. Tanabe, and H. Tachibana
  • Journal Title: Infection and Immunity 75 Pages: 3614-3620
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Allelic dimorphism-associated restriction of recombination in Plasmodium falciparum msp1 (2007)
  • Author(s): K. Tanabe, N. Sakihama, D. Walliker, H. Babiker, A. A. Abdel-Muhsin, B. Bakote'e, H. Ohmae, N. Arisue, T. Horii, I. Rooth, A. Farnert, A. Bjorkman, and L. Ranford-Cartwright
  • Journal Title: Gene 397 Pages: 153-160
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Recent independent evolution of msp1 polymorphism in Plamsodium vivax and related malaria parasites (2007)
  • Author(s): K. Tanabe, A. Escalante, N. Sakihama, M. Honda, N. Arisue, T. Horii, R. Culleton, T. Hayakawa, T. Hashimoto, S. Longacre, S. Pathirana, S. Handunnetti, H. Kishino
  • Journal Title: Molecular and Biochemical Parasitology 156 Pages: 74-79
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] A comparative study of the genetic diversity of the 42 kDa fragment of the merozoite surface protein 1 in Plasmodium falciparum and P vivax (2007)
  • Author(s): M.A., Pacheco, A.C., Poe, W.E., Collins, A.A., Lal, IC., Tanabe, V., Udhayakumar, A.E., Escalante
  • Journal Title: Infection, Genetics and Evolution 7 Pages: 180-187
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Independent unique evolution of pyrimethamine resistance of P. falciparum in Melanesia (2007)
  • Author(s): T., Mita, K., Tanabe, N., Takahashi, T., Tsukahara, H., Eto, L., Dysoley, H., Ohmae, K., Kita, S., Krudsood, S., Looareesuwan, A., Kaneko, A., Bjarkrnan, T., Kobayakawa
  • Journal Title: Antimicrobial Agents and Chemotherapy 51 Pages: 1071-1077
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] High frequency of recombination-drived allelic diversity and temporal variation of Plasmodium falciparum in Tanzania (2007)
  • Author(s): K., Tanabe, N., Sakihama, I., Rooth, A., Bjorkman, A., Famed
  • Journal Title: American Journal of Tropical Medicine and Hygiene 76 Pages: 1037-1045
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Allelic diversity in the merozoite surface protein 1 gene of Plasmodium falciparum on Palawan Island, the Philippines (2007)
  • Author(s): N., Sakihama, M., Nakamura, A.A., Palanca, Jr, R.A., Argubano, E.P., Realon, A.L., Larracas, R.L., Espina, K., Tanabe
  • Journal Title: Parasitology Intemational 56 Pages: 185-194
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Progress in the molecular biology of malaria and the immunology of nematode Infections (2007)
  • Author(s): N., Arizono, K., Nakanishi, T., Horii, K, Tanabe
  • Journal Title: Trends in Parasitology 23 Pages: 175-181
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Production of High-Affinity Human Monoclonal Antibody Fab Fragments to the 19-Kilodalton C-Terminal Merozoite Surface Protein I of Plasmodium falciparum (2007)
  • Author(s): X., Chang, H., Hayasaka, K., Watanabe, Y., Tao, J., Liu, H., Tsukamoto, T., Horii, K., Tanabe, H., Tachibana
  • Journal Title: Infection and Immunity 75 Pages: 3614-3620
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Allelic dimorphism-associated restriction of recombination in Plasmodium falciparum mspl (2007)
  • Author(s): K., Tanabe, N., Sakihama, D., Walliker, H., Babiker, A.A., Abdel-Muhsin, B., Bakote'e, H., Ohmae, N., Arisue, T., Horii, I., Rooth, A., Earned, A., BjOrkman, L., Ranford-Cartwrieht
  • Journal Title: Gene 397 Pages: 153-160
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Recent independent evolution of mspl polymorphism in Plarnsodium vivax and related malaria parasites (2007)
  • Author(s): K., Tanabe, A., Escalante, N., Sakihama, M., Honda, N., Arisue, T., Horii, R., Culleton, T., Hayakawa, T., Hashimoto, S., Longacre, S., Pathirana, S., Handunnetti, H., Kishino
  • Journal Title: Molecular and Biochemical Parasitology 156 Pages: 74-79
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Recent independent evolution of mspl polymorphism in Plasmodium vivax and related simian malaria parasites. (2007)
  • Author(s): Tanabe K, et. al.
  • Journal Title: Mol Biochem Parasitol. 156 Pages: 74-79
  • Peer Reviewed
• [Journal Article] Allelic dimorphism-assoicated restriction of recombination in Plasmodium falciparum mspl. (2007)
  • Author(s): Tanabe K, et. al.
  • Journal Title: Gene 397 Pages: 153-160
  • Peer Reviewed
• [Journal Article] Production of high-affinity human monoclonal antibody fab fragments to the 19-kilodaltion C-termainal merozoite surface protein 1 of Plasmodium Falciparum. (2007)
  • Author(s): Cheng XJ, Hayashaka H, Watanabe K, Tao YL, Liu JY, Tsukamoto H, Horii T., Tanabe K, Tachibana H.
  • Journal Title: Infect Immun 75 Pages: 3614-3620
  • Peer Reviewed
• [Journal Article] Allelic diversity in the merozoite surface protein 1 gene of Plasmodium falciparum on Palawan Island, the Philippines. (2007)
  • Author(s): Sakihama N, Nakamura M, Palanca AA Jr, Argubano RA, Realon EP, Larracas A L, Espina RL, Tanabe K.
  • Journal Title: Parasitol Int. 56 Pages: 185-194
  • Peer Reviewed
• [Journal Article] Progress in the molecular biology of malaria and the immunology of nematode infections. (2007)
  • Author(s): Arizono N, Nakanishi K, Horii T., Tanabe K.
  • Journal Title: Trends Parasitol. 23 Pages: 175-181
  • Peer Reviewed
• [Journal Article] High frequency of recombination-drived allelic diversity and temporal variation of Plasmodium falciparum in Tanzania. (2007)
  • Author(s): K. Tanabe, N. Sakihama, I. Rooth, A. Bjorkman and Farnert.
  • Journal Title: Am. J. Trop. Med. Hyg. 76 Pages: 1037-1045
  • Peer Reviewed
• [Journal Article] Independent unique evolution of pyrimethamine resistance of P. falciparum in Melanesia. (2007)
  • Author(s): T. Mita, K Tanabe, N. Takahashi, L. Dysoley, F. Eto, I. Hwaihwanje, H. Ohmae, K. Kita, S. Looareesuwan, A. Kaneko, A. Bjorkman, and T. Kobayakawa.
  • Journal Title: Antimicroh. Agents Chemother. 51 Pages: 1071-1077
  • Peer Reviewed
• [Journal Article] Comparative study of the genetic diversity of the 42 kDa fragment of the merozoite surface protein 1 in Plasmodium falciparum and P. vivax. (2007)
  • Author(s): M. A. Pacheco, A. C. Poe, W. E. Collins, A. A. Lal, K. Tanabe, V. Udhayakumar, and A. E. Escalante.
  • Journal Title: Inf. Gen. Evol. 7 Pages: 180-187
  • Peer Reviewed
• [Journal Article] A comparative study of the genetic diversity of the 42 kDa fragment of the merozoite surface protein 1 in Plasmodium falciparum and P. vivax (2007)
  • Author(s): M.A.Pacheco, A.C.Poe, W.E.Collins, A.A.Lal, K.Tanabe, V.Udhayakumar, A.E.Escalante
  • Journal Title: Infection, Genetics and Evolution 7 Pages: 180-187
• [Journal Article] Independent unique evolution of pyrimethamine resistance of P. falciparum in Melanesia (2007)
  • Author(s): T.Mita, K.Tanabe, et al.
  • Journal Title: Antimicrobial Agents and Chemotherapy 51 Pages: 1071-1077
• [Journal Article] High frequency of recombination-drived allelic diversity and temporal variation of Plasmodium falciparum in Tanzania (2007)
  • Author(s): K.Tanabe, N.Sakihama, I.Rooth, A.Bjorkman, A.Farnert
  • Journal Title: American Journal of Tropical Medicine and Hygiene (In press)
• [Journal Article] Allelic diversity in the merozoite surface protein 1 gene of Plasmodium falciparum on Palawan Island, the Philippines (2007)
  • Author(s): N.Sakihama, K.Tanabe, et al.
  • Journal Title: Parasitology International (In press)
• [Journal Article] Rapid selection of dhfr mutant allele in P. falciparum isolates after the introduction of sulfadoxine/pyrimethamine in combination with 4-aminoquinolines in Papua New Guninea. (2006)
  • Author(s): T. Mita, A. Kaneko, I. Hwaihawanje, T. Tsukahara, N. Takahashi, H. Osawa, K. Tanabe, T. Kobayakawa, and A. Bjorkman
  • Journal Title: Infection, Genetics and Evolution 6 Pages: 447-452
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Plasmodium vivax serine repeat antigen(SERA) multigene family exhibits similar expression patterns in independent infections. (2006)
  • Author(s): N. M. Q. Palacpac, B. W. Y. Leung, N. Aisue, K. Tanabe, J. Sattabongkot, T. Tsuboi, M. Torii, R. Udomsangpetch, T. Horii
  • Journal Title: Molecular and Biochemical Parasitology 150 Pages: 353-358
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Rapid selection of dhfr mutant allele in P. falcipanint isolates after the introduction of sulfadoxine/pyrimethamine in combination with 4-aminoquinolines in Papua New Guninea. (2006)
  • Author(s): T., Mita, A., Kaneko, I., Hwaihawanje, T., Tsukahara, N., T0akahashi, H., Osawa, K., Tanabe, T., Kobayakawa, A., Hftirkman
  • Journal Title: Infection, Genetics and Evolution 6 Pages: 447-452
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Plasmodium vivax serine repeat antigen (SERA) multigene family exhibits similar expression patterns in independent infections. (2006)
  • Author(s): N.M.Q., Palacpac, B.W.Y., Leung, N., Arisue, K., Tanabe, J., Sattabongkot, T., Tsuboi, M., Torii, R., Udomsangoetch, T., Horii
  • Journal Title: Molecular and Biochemical Parasitology 150 Pages: 353-358
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Rapid selection of dhfr mutant allele in P. falciparum isolates after the introduction of sulfadoxine/pyrimethamine in combination with 4-aminoquinolines in Papua New Guninea. (2006)
  • Author(s): T.Mita, A.Kaneko, I.Hwaihawanje, T.Tsukahara, N.Takahashi, H.Osawa, K.Tanabe, T.Kobayakawa, A.Bjorkman
  • Journal Title: Infection, Genetics and Evolution 6 Pages: 447-452
• [Journal Article] Plasmodium vivax serine repeat antigen (SERA) multigene family exhibits similar expression patterns in independent infections. (2006)
  • Author(s): N.M.Q.Palacpac, B.W.Y.Leung, N.Arisue, K.Tanabe, J.Sattabongkot, T.Tsuboi, M.Torii, R.Udomsangpetch, T.Horii
  • Journal Title: Molecular and Biochemical Parasitology 150 Pages: 353-358
• [Presentation] 複数遺伝子配列データによるマラリア原虫の系統解析 (2007)
  • Author(s): 有末伸子、橋本哲男、早川敏之、三井英也、先濱直子、賈黙稚、Nirianne Palacpac、田邉和裄、堀井俊宏
  • Organizer: 第30回日本分子生物学会年会
  • Place of Presentation: 横浜、神奈川
  • Year and Date: 2007-12-15
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] ゲノム多様性が語るマラリア病原体の寄生戦略 (2007)
  • Author(s): 田邉和裄
  • Organizer: 日本動物学会近畿支部公開講演会
  • Place of Presentation: 橿原、奈良
  • Year and Date: 2007-11-24
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] 現生マラリア原虫系統の起源における急速な多様化 (2007)
  • Author(s): 早川敏之、Richrad Culleton, 堀井俊宏、田邉和裄
  • Organizer: 第6回分子寄生虫・マラリア研究フォーラム
  • Place of Presentation: 松山、愛媛
  • Year and Date: 2007-10-27
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Group I. II及びIII SERA遺伝子配列から推定したマラリア原虫の系統関係 (2007)
  • Author(s): 有末伸子、賈黙稚、Niriann Palacpac、田邉和裄、堀井俊宏
  • Organizer: 第6回分子寄生虫・マラリア研究フォーラム
  • Place of Presentation: 松山、愛媛
  • Year and Date: 2007-10-27
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] マラリア原虫表面抗原msp1における種特異的な自然選択 (2007)
  • Author(s): 澤井裕美、大谷寛人、田邉和裄
  • Organizer: 第6回分子寄生虫・マラリア研究フォーラム
  • Place of Presentation: 松山、愛媛
  • Year and Date: 2007-10-27
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] 現生マラリア原虫系統の起源における急速な多様化 (2007)
  • Author(s): 早川敏之、Richrad Culleton, 堀井俊宏、田邉和桁
  • Organizer: 第6回分子寄生虫・マラリナ研究フォーラム
  • Place of Presentation: 松山、愛媛
  • Year and Date: 2007-10-27
• [Presentation] Group I.II及びIII SERA遺伝子配列から推定したマラリア原虫の系統関係 (2007)
  • Author(s): 有末伸子、賈黙稚、Niriann Palacpac、田邉和桁、堀井俊宏
  • Organizer: 第6回分子寄生虫・マラリア研究フォーラム
  • Place of Presentation: 松山、愛媛
  • Year and Date: 2007-10-27
• [Presentation] マラリア原虫の表面抗原遺伝子msplにおける種特異的な自然選択 (2007)
  • Author(s): 澤井裕美、大谷寛人、田邉和桁
  • Organizer: 遺伝学会第79回大会
  • Place of Presentation: 岡山、岡山
  • Year and Date: 2007-09-21
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] マラリア原虫の表面抗原遺伝子msp1における種特異的な自然選択 (2007)
  • Author(s): 澤井裕美、大谷寛人、田邊和裄
  • Organizer: 遺伝学会第79回大会
  • Place of Presentation: 岡山
  • Year and Date: 2007-09-21
• [Presentation] Incipient rapid diversification in the evolution of extant malaria parasites. (2007)
  • Author(s): Toshiyuki Hayakawa, Richard Culleton, Toshihiro Horii, Kazuyuki Tanabe
  • Organizer: 7th Awaji International Forum on Infection and Immunity
  • Place of Presentation: Awaji, Hyogo, Japan
  • Year and Date: 2007-09-04
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Phylogenetic relationship of malaria parasites inferred from multiple gene data (2007)
  • Author(s): Nobuko Arisue, Tetso Hashimoto, Toshiyuki Hayakawa, Hideya Mitsui, Naoko Sakihama, Mozhi Jia, Nirianne M. Q. Palacpac, Toshihiro Horii, Kazuyuki Tanabe
  • Organizer: 7th Awaji International Forum on Infection and Immunity
  • Place of Presentation: Awaji, Hyogo, Japan
  • Year and Date: 2007-09-04
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Plasmodium vivax in Africa (2007)
  • Author(s): Richard Culletion, Toshihito Mita, Mathieu Ndounga, Holger Onger, Pcdro Cravo, Akira Kaneko, Milijaona, Randrianarivelojosia, Shigeyuki Kano, Takafumi Tsuboi, Anjali Yadava, Anna P. Arez, Virgilio, do Rosario, Francine Ntoumi, Richard Carter, Kazuyuki Tanabe.
  • Organizer: 7th Awaji International Forum on Infection and Immunity
  • Place of Presentation: Awaji, Hyogo, Japan
  • Year and Date: 2007-09-04
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Genetic make-up of Plasmodium vivax populatio in Mae Sot, Thailand (2007)
  • Author(s): Nirianne M. Q. Palacpac, Nobuko Arisue, Tohsihiro Horii, Jetsumon Satabongkt, Takafumi Tsuboi, Motomi Torii, Rachanee Udomsangpetch, Kazuyuki Tanabe
  • Organizer: 7th Awaji International Forum on Infection and Immunity
  • Place of Presentation: Awaji, Hyogo, Japan
  • Year and Date: 2007-09-04
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Incipient rapid diversification in the evolution of extant malaria parasites. (2007)
  • Author(s): Toshiyuki Hayakawa, Richard Culleton, Toshihiro Horii, Kazuyuki Tanabe
  • Organizer: 7th Awaji International Forum on Infection and Immunity,
  • Place of Presentation: Awaji, Hyogp, Japan
  • Year and Date: 2007-09-04
• [Presentation] Phylogenetic relationship of malaria parasites inferred from multiple gene data. (2007)
  • Author(s): Nobuko Arisue, et. al.
  • Organizer: 7th Awaji International Forum on Infection and Immunity,
  • Place of Presentation: Awaji, Hyogp, Japan
  • Year and Date: 2007-09-04
• [Presentation] Plasmodium vivax in Africa. (2007)
  • Author(s): Richard Culleton, et. al.
  • Organizer: 7th Awaji International Forum on Infection and Immunity
  • Place of Presentation: Awaji, Hyogp, Japan
  • Year and Date: 2007-09-04
• [Presentation] Genetic make-up of Plasmodium vivax populatio in Mae Sot, Thailand. (2007)
  • Author(s): Nirianne M. Q. Palacpac, et. al.
  • Organizer: 7th Awaji International Forum on Infection and Immunity
  • Place of Presentation: Awaji, Hyogp, Japan
  • Year and Date: 2007-09-04
• [Presentation] Recent independent evolution of msp1 polymorphism in Plasmodium vivax and Plasmodium cynomolgi. (2007)
  • Author(s): Kazuyuki Tanabe, Ananias Escalante, Naoko Sakihama, Masanori Honda, Nobuko Arisue, Toshihiro Horii, Richard Culleton, Toshiyuki Hayakawa, Tetsuo Hashimoto, Shirley Longacre, Sisira Pathirana, Shiroma Handunnetti, Hirohisa Kishino.
  • Organizer: 5th European Congress on Tropical Medicien and Internationa Health
  • Place of Presentation: Amsterdam, Holland
  • Year and Date: 2007-05-26
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Recent independent evolution of mspl polymorphism in Plasmodium vivax and Plasmodium cynomolgi. (2007)
  • Author(s): Kazuyuki, Tanabe, Ananias, Escalante, Naoko, Sakihama, Masanori, Honda, Nobuko, Arisue, Toshihiro, Horii, Richard, Culleton, Toshiyuki, Hayakawa, Tetsuo, Hashimoto, Shirley, Longacre, Sisira, Pathirana, Shiroma, Handunnetti, Hirohisa, Kishino
  • Organizer: 5th European Congress on Tropical Medicien and Intemationa Health
  • Place of Presentation: Amsterdam, Holland
  • Year and Date: 2007-05-26
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Recent independent evolution of mspl polymorphism in Plasmodium vivax and P1asmodium cynomolgi (2007)
  • Author(s): Kazuyuki Tanabe,.
  • Organizer: 5th European Congress on Tropical Medicine and International Health
  • Place of Presentation: Amsterdam, Netherland
  • Year and Date: 2007-05-26
• [Presentation] 三日熱マラリア原虫メロゾイト表面タンパク質1における遺伝子多型の進化 (2007)
  • Author(s): 田辺和裄, 先濱直子, 早川敏之, Richard Culleton, 有末伸子, 堀井俊宏, 橋本哲男, Sisira Pathirana, Shiroma Handunnetti
  • Organizer: 第76回 日本寄生虫学会大会
  • Place of Presentation: 大阪
  • Year and Date: 2007-03-30
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Polymorphism in malaria antigens and microsatellite markers of Plasmodium vivax: a parasite strategy for survival? (2007)
  • Author(s): N. Palacpac, N. Arisue, K. Tanabe, J. Sattabongkot, T. Tsuboi, M. Torii, R. Udomsangpech, T. Horii
  • Organizer: 第76回 日本寄生虫学会大会
  • Place of Presentation: 大阪
  • Year and Date: 2007-03-30
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] ヒトマラリア原虫を中心とした霊長類マラリア原虫とその宿主の進化 (2007)
  • Author(s): 早川敏之、リチャード・カレトン, 堀井俊宏、田辺和桁
  • Organizer: 第76回 日本寄生虫学会大会
  • Place of Presentation: 大阪
  • Year and Date: 2007-03-30
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Urbanization and malaria epidemiology in West Africa (2007)
  • Author(s): リチャード・カレトン、ンドンガ・マシュー、田辺和桁
  • Organizer: 第76回 日本寄生虫学会大会
  • Place of Presentation: 大阪
  • Year and Date: 2007-03-30
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] マラリア原虫アピコプラストゲノムの比較解析と分子系統 (2007)
  • Author(s): 橋本哲男、三井英也、先濱直子、有末伸子、田辺和裄、川合覚、長谷川政美
  • Organizer: 第76回 日本寄生虫学会大会
  • Place of Presentation: 大阪
  • Year and Date: 2007-03-30
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Recent evolution of msp1 polymorphism in Plasmodium vivax (2007)
  • Author(s): Kazuyuki Tanabe
  • Organizer: 40th Japan-US Joint Conference on Parasitic Diseases
  • Place of Presentation: Tokyo, Japan
  • Year and Date: 2007-02-02
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Genetic polymorphisms of drug resistant gene in Southeast Asia throughimported isolates of Plasmodium falciparum in Japan (2007)
  • Author(s): Y. Saito-Nakano, K. Kamei, M. Iwagami, K. Komaki-Yasuda, S. Kawazu, S. Kano, K. Tanabe, H. Ohmae, T. Endo
  • Organizer: The 1st Thailand-Japan Joint Forum on Infectious Diseases
  • Place of Presentation: Bangkok, Thailand
  • Year and Date: 2007-01-30
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Stable antigen polymorphism in modern Plasmodium falciparum populations (2007)
  • Author(s): Kazuyuki Tanabe, Naoko Sakihama, Ingegerd Rooth, Anna Farnert, Anders Bjorkman, Marcelo M. Ferreira, Hiroshi Ohmae, and Kenji Hirayama
  • Organizer: Asian Research Forum on Emerging and Reemerging Infections-2007
  • Place of Presentation: Nagasaki, Japan
  • Year and Date: 2007-01-16
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Stable antigen polymorphism in modem Plasmodium falciparum populations (2007)
  • Author(s): Kazuyuki, Tanabe, Naoko, Sakihama, Ingegerd, Rooth, Anna, Farnert, Anders, BjOrkman, Marcelo, M., Ferreira, Hiroshi, Ohmae, Kenji, Himyama
  • Organizer: Asian Research Forum on Emerging and Reemerging Infections-2007
  • Place of Presentation: Nagasaki, Japan
  • Year and Date: 2007-01-16
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Plasmodium vivax in Africa (2006)
  • Author(s): Richrad Culleton, Matthieu Ndounga, Holger Unger, Richard Carter, Kazuyuki Tanabe
  • Organizer: 第5回分子寄生虫・マラリア研究フォーラム
  • Place of Presentation: 東京
  • Year and Date: 2006-10-28
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Independent unique evolution of pyrimethamine resistance of P. falciparum in Melanesia (2006)
  • Author(s): 美田敏宏、田辺和裄、大前比呂思、北潔、小早川隆敏
  • Organizer: 第5回分子寄生虫・マラリア研究フォーラム
  • Place of Presentation: 東京
  • Year and Date: 2006-10-28
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] 核コード細胞質SSUrRNA遺伝子に基づくマラリア原虫Plasmodium属の系統解析 (2006)
  • Author(s): 西本由利子、有末伸子、川合覚、田辺和裄、橋本哲男
  • Organizer: 第5回分子寄生虫・マラリア研究フォーラム
  • Place of Presentation: 東京
  • Year and Date: 2006-10-28
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] 霊長類マラリア原虫とその宿主の進化 (2006)
  • Author(s): 早川敏之、Richrad Culleton, 堀井俊宏、田辺和桁
  • Organizer: 第5回分子寄生虫・マラリア研究フォーラム
  • Place of Presentation: 東京
  • Year and Date: 2006-10-28
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] The evolution of antigen polymorphism in 'modern' P. falciparum populations (2006)
  • Author(s): Kazuyuki Tanabe, Naoko Sakihama, Ingegerd Rooth, Anna Farnert, Anders Bjorkman, Hiroshi Ohmae, and Kenji Hirayama
  • Organizer: The 15th Japanese-German Symposium on Protozoan Diseases
  • Place of Presentation: Obihiro, Hokkaido, Japan
  • Year and Date: 2006-09-18
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] The Plasmodium vivax serine rgpeat antigen(SERA)multigene family: expression pattern and genetic diversity in independent infections (2006)
  • Author(s): Nirianne M. Q. Palacpac, Betty W. Y. Leung, Nobuko Arisue, Kazuyuki Tanabe, Jetsumon Sattabongkot, Takafumi Tsuboi, Motomi Torii, Rachanee Udomsangpetch and Toshiriho Horii
  • Organizer: 6th Awaji International Forum on Infection and Immunity
  • Place of Presentation: Awaji, Hyogo, Japan
  • Year and Date: 2006-09-06
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Evolution of msp1 polymorphism after speciation of Plasmodium vivax and Plasmodium cynomolgi (2006)
  • Author(s): Kazuyuki Tanabe, Naoko Sakihma, Ananias Escalante, Sisira Pathirana, Shiroma Handunnetti, Masanori Honda, and Hirohisa Kishino
  • Organizer: 6th Awaji International Forum on Infection and Immunity
  • Place of Presentation: Awaji, Hyogo, Japan
  • Year and Date: 2006-09-06
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Evolution of mspl polymorphism after speciation of Plasmodium vivax and Plasmodium cvnomolai (2006)
  • Author(s): Kazuvuki, Tanabe, Naoko, Sakihma, Ananias, Escalante, Sisira, Pathirana, Shiroma, Handunnetti, Masanori, Honda, Hirohisa, Kishino
  • Organizer: 6th Awaji International Forum on Infection and Immunity
  • Place of Presentation: Awaji, Hyogo,Japan
  • Year and Date: 2006-09-06
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Evolution of antigen polymorphism in the world populations of Plasmodium falciparum, the human malaria parasite (2006)
  • Author(s): Kazuyuki Tanabe
  • Organizer: 20th International Congress of Biochemistry and Molecular Biology
  • Place of Presentation: Kyoto, Japan
  • Year and Date: 2006-06-19
  • Description: 「研究成果報告書概要(和文)」より
• [Remarks] 「研究成果報告書概要(和文)」より
  • URL: http://www.biken.osaka-u.ac.ip/act/act_tanabe.php
• [Remarks]
  • URL: http://www.biken.osaka-u.ac.jp/act/act_tanabe.php