Comprehensive analyses of the type III effectors in pathogenic Escherichia coli
| Project/Area Number |
18390136
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (B)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Bacteriology (including Mycology)
|
|---|
| Research Institution | Kitasato University |
|---|
Principal Investigator |
ABE Akio Kitasato University, 大学院・感染制御科学府, 教授 (50184205)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
NAGAMATSU Kanna 北里大学, 北里生命科学研究所, 助手 (90458745)
KUWAE Asaomi 北里大学, 大学院・感染制御科学府, 講師 (60337996)
|
|---|
| Project Period (FY) |
2006 – 2008
|
| Project Status |
Completed (Fiscal Year 2008)
|
| Budget Amount *help |
¥16,980,000 (Direct Cost: ¥14,100,000、Indirect Cost: ¥2,880,000)
Fiscal Year 2008: ¥7,020,000 (Direct Cost: ¥5,400,000、Indirect Cost: ¥1,620,000)
Fiscal Year 2007: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2006: ¥4,500,000 (Direct Cost: ¥4,500,000)
|
|---|
| Keywords | 腸管病原性大腸菌 / 腸管出血性大腸菌 / 下痢 / III 型分泌装置 / エフェクター / 網羅的解析 / III型分泌装置 / siRNA |
|---|
| Research Abstract |
病原性大腸菌である腸管出血性大腸菌(EHEC), 腸管病原性大腸菌(EPEC)は, 共にIII 型分泌装置を介してエフェクターと呼ばれる病原因子を宿主細胞内に注入することが知られている。これら病原性大腸菌の機能未知なエフェクターについて網羅的な解析を行った結果, NleC はリボソームタンパク質S10 と相互作用することで, 宿主翻訳系を阻害するエフェクターであることを明らかにした。さらに, EspJ の宿主内での機能は精査中であるが, このエフェクターは感染時にミトコンドリアに局在することを明らかにした。
|
Report
(4 results)
Research Products
(46 results)
-
-
-
-
[Journal Article] Guadinomines, type III secretion system inhibitors, produced by Streptomyces sp. K01-0509 (II. Physico-chemical properties and structure elucidation)2008
Author(s)
Masato Iwatsuki, Ryuji Uchida, Hitomi Yoshijima, Hideaki Ui, Kazuro Shiomi, Yong-Pil Kim, Tomoyasu Hirose, Toshiaki Sunazuka, Akio Abe, Hiroshi Tomoda, and Satoshi Omura
-
Journal Title
J. Antibiot 61
Pages: 230-236
NAID
Related Report
Peer Reviewed
-
[Journal Article] Guadinomines, type III secretion system inhibitors, produced by Streptomyces sp. K01-0509 (I. Taxonomy, fermentation, isolation and biological properties)2008
Author(s)
Masato Iwatsuki, Ryuji Uchida, Hitomi Yoshijima, Hideaki Ui, Kazuro Shiomi, Atsuko Matsumoto, Yoko Takahashi, Akio Abe, Hiroshi Tomoda, Satoshi Omura
-
Journal Title
J.Antibiot. 61(4)
Pages: 222-229
NAID
Related Report
Peer Reviewed
-
-
-
-
-
-
[Journal Article] Helicobacter pylori dampens gut epithelial self-renewal by inhibiting apoptosis, a bacterial strategy to enhance colonization of the stomach2007
Author(s)
Hitomi Mimuro, Toshihiko Suzuki, Shigenori Nagai, Gabriele Rieder, Masato Suzuki, Takeshi Nagai,Yukihiro Fujita, Kanna Nagamatsu, Nozomi Ishijima,Shigeo Koyasu, ainer Haas, and Chihiro Sasakawa
-
Journal Title
Cell Host and Microbe 2
Pages: 250-263
Related Report
Peer Reviewed
-
-
-
[Journal Article] Enteropathogenic Escherichia coli, Shigella flexneri, and Listeria monocytogenes recruit a junctional protein, zonula occludens-1, to actin tails and pedestals2007
Author(s)
Miyuki Hanajima-Ozawa, Takeshi Matsuzawa, Aya Fukui, Shigeki Kamitani, Hiroe Ohnishi, Akio Abe, Yasuhiko Horiguchi, and Masami Miyake
-
Journal Title
Infection and Immunity 75
Pages: 565-573
Related Report
Peer Reviewed
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
