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The study of the mechanism of therapeutic efficacy of novel vaccines on Tuberculosis-infection and the induction of cytotoxic T cells by the vaccines

Research Project

Project/Area Number 18390138
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Bacteriology (including Mycology)
Research InstitutionClinical Research Center, National Hospital Organization, Kinki-Chuo Chest Medical Center

Principal Investigator

OKADA Masaji  Clinical Research Center, National Hospital Organization, Kinki-Chuo Chest Medical Center, 臨床研究センター, 臨床研究センター長 (40160684)

Co-Investigator(Kenkyū-buntansha) YOSHIDA Shigeto  自治医科大学, 医学部, 講師 (10296121)
OHARA Naoya  国立感染症研究所, 免疫部 (70223930)
SUZUKI Katsuhiro  近畿中央胸部疾患センター, 臨床研究センター, 部長 (00206468)
INOUE Yoshikazu  近畿中央胸部疾患センター, 臨床研究センター, 部長 (90240895)
TSUYUGUCHI Kazunari  近畿中央胸部疾患センター, 臨床研究センター, 室長 (00359308)
Project Period (FY) 2006 – 2009
Project Status Completed (Fiscal Year 2009)
Budget Amount *help
¥17,440,000 (Direct Cost: ¥14,500,000、Indirect Cost: ¥2,940,000)
Fiscal Year 2009: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Fiscal Year 2008: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2007: ¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
Fiscal Year 2006: ¥4,700,000 (Direct Cost: ¥4,700,000)
Keywords感染症 / 免疫学 / 細菌 / 遺伝子 / 医療・福祉 / 結核ワクチン / キラーT / 多剤耐性結核菌 / 感染免疫 / キラーT細胞
Research Abstract

(1)We have developed a novel therapeutic tuberculosis (TB) vaccine ; a combination of the DNA vaccines expressing mycobacterial heat shock protein 65 (HSP65) and interleukin 12 (IL-12) delivered by the hemagglutinating virus of Japan (HVJ)-envelope (HSP65+IL-12/HVJ). This vaccine induced CD8^+ cytotoxic T-cell specific for TB antigen.
(2)This vaccine exerted therapeutic efficacy in the TB-infected cynomolgus monkeys as well as mice.
(3)Granulysin augmented in vitro and in vivo induction of CTL. Thus, it was demonstrated that granulysin is CTL differentiation factor. Furthermore, in the presence of IL-6 or IL-2 the in vitro and in vivo induction by granulysin was synergistically enhanced.
(4)We established granulysin transgenic mice.

Report

(6 results)
  • 2009 Annual Research Report   Final Research Report ( PDF )
  • 2008 Annual Research Report   Self-evaluation Report ( PDF )
  • 2007 Annual Research Report
  • 2006 Annual Research Report
  • Research Products

    (175 results)

All 2010 2009 2008 2007 2006 Other

All Journal Article (95 results) (of which Peer Reviewed: 51 results) Presentation (66 results) Book (3 results) Remarks (6 results) Patent(Industrial Property Rights) (5 results)

  • [Journal Article] A Novel Therapeutic and Prophylactic Vaccine (HVJ-Envelope/Hsp65 DNA+IL-12 DNA) against Tuberculosis Using The Cynomolgus Monkey Model2010

    • Author(s)
      Okada M(20人中1番目1/20), Inoue Y(10/20), Nakajima T, Yoshida S(14/20) Tan EV, et al
    • Journal Title

      Procedia in Vaccinology Vol.2(in press)

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] A Novel Therapeutic and Prophylactic Vaccine(HVJ-Envelope/Hsp65 DNA+IL-12 DNA)against Tuberculosis Using The Cynomolgus Monkey Model2010

    • Author(s)
      岡田全司
    • Journal Title

      Procedia in Vaccinology Vol.2(印刷中)

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] (Special Focus on Tuberculosis Prevention and Immunotherapy)Tuberculosis Vaccine Development : The development of novel(preclinical)DNA vaccine2010

    • Author(s)
      岡田全司
    • Journal Title

      Human Vaccines (印刷中)

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] キラーT細胞、granulysin結核免疫とワクチン(HSP65+IL-12DNAワクチン等)開発2010

    • Author(s)
      岡田全司
    • Journal Title

      結核 85

      Pages: 531-538

    • Related Report
      2009 Annual Research Report
  • [Journal Article] 結核免疫(序論)2010

    • Author(s)
      岡田全司
    • Journal Title

      結核 85

      Pages: 501-508

    • NAID

      10030262935

    • Related Report
      2009 Annual Research Report
  • [Journal Article] Identification of MICA as a susceptibility gene for pulmonary Mycobacterium avium complex infection2009

    • Author(s)
      Shojima J, Inoue Y(7/27), Suzuki K(8/27), Okada M(10/27), Inoko H, et al
    • Journal Title

      J Infect Dis 199(11)

      Pages: 1707-15

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Novel prophylactic and therapeutic vaccine against tuberculosis2009

    • Author(s)
      Okada M(1/21), Nakajima T, Yoshida S(8/21), Inoue Y(13/21) Tan EV, et al
    • Journal Title

      Vaccine 27(25-26)

      Pages: 3267-70

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] A novel therapeutic and prophylactic vaccine against tuberculosis2009

    • Author(s)
      Okada M(1/20), Inoue Y(10/20), Nakajima T, Yoshida S(14/20), et al
    • Journal Title

      44th Tuberculosis and Leprosy Research Conference

      Pages: 154-158

    • Related Report
      2009 Final Research Report
  • [Journal Article] Evaluation of the Inno-Lipa Mycobacteria v2 for Mycobacterial identification2009

    • Author(s)
      Yoshida S, Suzuki K, Tsuyuguchi K, Iwamoto T, Tomita M, Okada M, Sakatani M
    • Journal Title

      Kekkaku 84

      Pages: 15-21

    • NAID

      10026402543

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] 遺伝子を用いた抗酸菌鑑別同定試薬INNO-LiPA MYCOBACTERIA v2の有用性の検討2009

    • Author(s)
      吉田志緒美, 鈴木克洋, 露口一成, 岩本朋忠, 富田元久, 岡田全司, 坂谷光則
    • Journal Title

      結核 84(1)

      Pages: 15-21

    • NAID

      10026402543

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] わが国の結核対策の現状と課題結核予防ワクチンの開発状況とその応用の可能性2009

    • Author(s)
      岡田全司
    • Journal Title

      日本公衆衛生雑誌 56巻4号

      Pages: 266-270

    • Related Report
      2009 Final Research Report
  • [Journal Article] Novel prophylactic and therapeutic vaccine against Tuberculosis. Vaccine2009

    • Author(s)
      岡田全司
    • Journal Title

      Vaccine 27

      Pages: 3267-3270

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Evaluation of the Inno-Lipa Mycobacteria v2 for Mycobacterial identification2009

    • Author(s)
      岡田全司
    • Journal Title

      Kekkaku 84

      Pages: 15-21

    • NAID

      10026402543

    • Related Report
      2009 Annual Research Report
  • [Journal Article] わが国の結核対策の現状と課題 結核予防ワクチンの開発状況とその応用の可能性2009

    • Author(s)
      岡田全司
    • Journal Title

      日本公衆衛生雑誌 56(4)

      Pages: 266-270

    • Related Report
      2009 Annual Research Report
  • [Journal Article] Novelprophylactic and therapeutic vaccineagainst Tuberculosis2009

    • Author(s)
      Okada M,(21人中1番目) Kaneda Y, Yoshida S, Inoue Y, McMurray D.N, Tan E.V, Sakatani M.
    • Journal Title

      Vaccine 27(25-26)

      Pages: 3267-70

    • Related Report
      2008 Self-evaluation Report
    • Peer Reviewed
  • [Journal Article] Novel prophylactic and therapeutic vaccine against Tuberculosis2009

    • Author(s)
      岡田全司
    • Journal Title

      Vaccine 27

      Pages: 3267-3270

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The study of Novel Vaccination using Granulysin transgenic mice2009

    • Author(s)
      岡田全司
    • Journal Title

      Vaccine (印刷中)

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Identification of MICA as a susceptibility gene for pulmonary Mycobacterium avium complex infection2009

    • Author(s)
      岡田全司
    • Journal Title

      J. Infect. Dis (印刷中)

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 遺伝子を用いた抗酸菌鑑別同定試薬INNO-LiPA MYCOBACTERIA v2の有用性の検討2009

    • Author(s)
      岡田全司
    • Journal Title

      Kekkaku 84(1)

      Pages: 15-21

    • NAID

      10026402543

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Research and Development of vaccines against Tuberculosis2008

    • Author(s)
      Kobayashi K, Okada M(3/6), Sadoff J C
    • Journal Title

      Kekkaku 83

      Pages: 635-640

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Neuritogenic Effects of T Cell-Derived IL-3 on Mouse Splenic Sympathetic Neurons In Vivo2008

    • Author(s)
      Kannan-Hayashi Y, Okada M( 9/11), Nakamura Y, et al
    • Journal Title

      The Journal of Immunology 180

      Pages: 4227-4234

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Evaluation of the discrepant Mycobacterium tuberculosis strains between any ordinary susceptibility testing and rpoB gene analysis by the line probe assay2008

    • Author(s)
      Yoshida S, Suzuki K, Tsuyuguchi K, Tomita M, Okada M, Sakatani M
    • Journal Title

      Kekkaku 83

      Pages: 577-583

    • NAID

      10025688875

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] 感染症に対するワクチン開発とその免疫理論2008

    • Author(s)
      岡田全司、喜多洋子、金丸典子、橋元里実、西田泰子、仲谷均、高尾京子、岸上知恵
    • Journal Title

      臨床免疫・アレルギー科 50(5)

      Pages: 533-542

    • Related Report
      2009 Final Research Report
  • [Journal Article] 特異抗原をターゲットとしたImmunotherapy2008

    • Author(s)
      岡田全司
    • Journal Title

      日本臨床免疫学会会誌 31(5)

      Pages: 356-368

    • Related Report
      2009 Final Research Report
  • [Journal Article] 【結核対策の現状を考える】新しい結核ワクチンの開発2008

    • Author(s)
      岡田全司(1/8)
    • Journal Title

      呼吸と循環 56(7)

      Pages: 685-695

    • Related Report
      2009 Final Research Report
  • [Journal Article] BCGと新たな結核ワクチン2008

    • Author(s)
      岡田全司(1/9)
    • Journal Title

      呼吸器科 13

      Pages: 99-106

    • Related Report
      2009 Final Research Report
  • [Journal Article] Development of vaccines against Tuberculosis2008

    • Author(s)
      岡田全司
    • Journal Title

      Kekkaku 83

      Pages: 635-640

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Neuritogenic Effects of T Cell-Derived IL-3 on Mouse Splenic Sympathetic Neurons In Vivo2008

    • Author(s)
      岡田全司
    • Journal Title

      The Journal of Immunology 180

      Pages: 4227-4234

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Evaluation of the discrepant Mycobacterium tuberculosis strains between any ordinary susceptibility testing and rpoB gene analysis by the line probe assay2008

    • Author(s)
      岡田全司
    • Journal Title

      Kekkaku 83

      Pages: 577-583

    • NAID

      10025688875

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] An adolescent case of pulmonary MAC infection, found 3 years later from bone marrow transplantation for myelodysplastic syndrome2008

    • Author(s)
      岡田全司
    • Journal Title

      Kekkaku 83(8)

      Pages: 585-90

    • NAID

      10025688908

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 感染症に対するワクチン開発とその免疫理論2008

    • Author(s)
      岡田全司
    • Journal Title

      臨床免疫・アレルギー科 50(5)

      Pages: 533-542

    • Related Report
      2008 Annual Research Report
  • [Journal Article] 特異抗原をターゲットとした Immunotherapy2008

    • Author(s)
      岡田全司
    • Journal Title

      日本臨床免疫学会会誌 31(5)

      Pages: 356-368

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 新しい結核ワクチンの開発2008

    • Author(s)
      岡田全司
    • Journal Title

      呼吸と循環 56(7)

      Pages: 685-695

    • NAID

      130006948706

    • Related Report
      2008 Annual Research Report
  • [Journal Article] BCGと新たな結核ワクチン2008

    • Author(s)
      岡田全司
    • Journal Title

      呼吸器科 13

      Pages: 99-106

    • Related Report
      2008 Annual Research Report
  • [Journal Article] Evaluation of a novel vaccine (HVJ-liposome / HSP65 DNA + IL-12 DNA) against tuberculosis using the cynomolgus monkey model of TB2007

    • Author(s)
      Okada M(1/27), Nakajima T, Yoshida S(8/27), Tan EV, et al
    • Journal Title

      Vaccine 25(16)

      Pages: 2990-3

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Pulmonary Mycobacterium avium complex infection associated with the IVS8-T5 allele of the CFTR gene2007

    • Author(s)
      Mai HN, Inoue Y(3/20), Suzuki K(4/20), Okada M(6/20), Keicho N, et al
    • Journal Title

      Int J Tuberc Lung Dis 11(7)

      Pages: 808-13

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Development of vaccines and passive immunotherapy against SARS corona virus using SCID-PBL/hu mouse models2007

    • Author(s)
      Okada M(1/26), Yoshida S(18/26), JSM Peiris, Tashiro M
    • Journal Title

      Vaccine 25(16)

      Pages: 3038-40

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Molecular Epidemiology of Mycobacterium tuberculosis-Comparision between Multidrug-Resistant Strains and Pan-Sensitive Strains2007

    • Author(s)
      Yoshida S, Suzuki K, Tsuyuguchi K, Okada M, Sakatani M
    • Journal Title

      Kekkaku 82(6)

      Pages: 531-8

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Molecular epidemiological analysis of Mycobacterium kansasii isolates2007

    • Author(s)
      Yoshida S, Suzuki K, Tsuyuguchi K, Iwamoto T, Okada M, Sakatani M
    • Journal Title

      Kekkaku 82(2)

      Pages: 103-10

    • NAID

      130001428405

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] 新しい結核ワクチンの開発2007

    • Author(s)
      岡田全司(1/14)
    • Journal Title

      化学療法の領域 23(3)

      Pages: 447-453

    • NAID

      130006948706

    • Related Report
      2009 Final Research Report
  • [Journal Article] 新しい結核ワクチン2007

    • Author(s)
      岡田全司
    • Journal Title

      感染症 7

      Pages: 14-18

    • NAID

      10018570604

    • Related Report
      2009 Final Research Report 2007 Annual Research Report
  • [Journal Article] 国際ワクチン学会“学会レポート"2007

    • Author(s)
      岡田全司
    • Journal Title

      感染・炎症・免疫(Fifth World Congress on) 37

      Pages: 66-67

    • Related Report
      2009 Final Research Report
  • [Journal Article] 新しい結核ワクチンの新展開2007

    • Author(s)
      岡田全司
    • Journal Title

      最新医学

      Pages: 125-130

    • NAID

      40015697067

    • Related Report
      2009 Final Research Report 2007 Annual Research Report
  • [Journal Article] Novel Vaccination (HVJ-liposome / HSP65 DNA + IL-12 DNA) Against Tuberculosis Using Cynomolgus Monkey2007

    • Author(s)
      Okada M(1/20), Yoshida S(17/20)
    • Journal Title

      Edit Jorge Kalil, Edecio Cunha-Neto, Luiz Viente Rizzo, MEDIMOUD Intern(13th International Congress)

      Pages: 119-122

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Novel vaccines against tuberculosis2007

    • Author(s)
      Okada M
    • Journal Title

      Kekkaku 82(10)

      Pages: 794-797

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] 結核の抗体と細胞性免疫2007

    • Author(s)
      岡田全司
    • Journal Title

      日本時事新報 4351

      Pages: 95-97

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Evaluation of a novel vaccine (HVJ-liposome / HSP65 DNA + IL-12 DNA) against tuberculosis using the cynomolgus monkey model of TB2007

    • Author(s)
      Okada M(1/23), Inoue Y(13/23)
    • Journal Title

      Forty-Second Tuberculosis and Leprosy Research Conference U.S-JAPAN Cooperative Medical Science Program

      Pages: 66-69

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Evaluation of anovel vaccine (HVJ-liposome / HSP65DNA + IL-12 DNA) againsttuberculosis using the cynomolgusmonkey model of TB2007

    • Author(s)
      Okada M(26人中1番目), Kaneda Y, Yoshida S, D N. McMurray, E.V.Tan, R Gelber, Sakatani M.
    • Journal Title

      Vaccine 25(16)

      Pages: 2990-3

    • Related Report
      2008 Self-evaluation Report
    • Peer Reviewed
  • [Journal Article] Evaluation of a novel vaccine(HVJ-liposome/HSP65DNA+IL+12DNA) against tuberculosis using the cynomolgus monkey model of TB.2007

    • Author(s)
      岡田全司
    • Journal Title

      Vaccine 25(16)

      Pages: 2990-2993

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Development of vaccines and passive immunotherapy against SARS coronavirus using SCID-PBL/hu mouse models.2007

    • Author(s)
      岡田全司
    • Journal Title

      Vaccine 25(16):30

      Pages: 38-40

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Molecular Epidemiology of Mycobacterium tuberculosis-Comparison between Multidrug-Resistant Strains and Pan-Sensitive Strains.2007

    • Author(s)
      岡田全司
    • Journal Title

      Kekkaku 82(6)

      Pages: 531-538

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Novel vaccines against tuberculosis.2007

    • Author(s)
      岡田全司
    • Journal Title

      Kekkaku 82(10)

      Pages: 794-797

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 新しい結核ワクチンの開発2007

    • Author(s)
      岡田全司
    • Journal Title

      化学療法の領域 23(3)

      Pages: 447-453

    • NAID

      130006948706

    • Related Report
      2007 Annual Research Report
  • [Journal Article] Neuritogenic Effects of T Cell-Derived IL-3 on Mouse Splenic Sympathetic Neurons In Vivo.2007

    • Author(s)
      岡田全司
    • Journal Title

      The Journal of Immunology 180

      Pages: 4227-4234

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Pulmonary Mycobacterium avium complex infection associated with the IVS8-T5 allele of the CFTR gene.2007

    • Author(s)
      岡田全司
    • Journal Title

      Int J Tuberc Lung Dis 11(7)

      Pages: 808-813

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Molecular epidemiological analysis of Mycobacterium kansasii isolates.2007

    • Author(s)
      岡田全司
    • Journal Title

      Kekkaku 82(2)

      Pages: 103-10

    • NAID

      130001428405

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 平成17年度国立病院機構共同臨床研究「国立病院機構における臨床研究部の活性化と適切な評価法に関する研究」班 : 施設長を対象とした臨床研究部・研究センターに関するアンケート調査.2007

    • Author(s)
      岡田全司
    • Journal Title

      医療 61(8)

      Pages: 546-553

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 国際ワクチン学会"学会レポート".Fifth World Congress on Vaccines, Immunization and Immunotherapy2007

    • Author(s)
      岡田全司
    • Journal Title

      感染・炎症・免疫 37

      Pages: 66-67

    • Related Report
      2007 Annual Research Report
  • [Journal Article] BCGと新たな結核ワクチン2007

    • Author(s)
      岡田全司
    • Journal Title

      呼吸器科 13(1)

      Pages: 99-106

    • Related Report
      2007 Annual Research Report
  • [Journal Article] Novel Vaccination(HVJ-liposome/HSP65 DNA+IL-12DNA)Against Tuberculosis Using Cynomolgus Monkey. "13thInternational Congress of Immunology.2007

    • Author(s)
      岡田全司
    • Journal Title

      MEDIMOND Intern

      Pages: 119-122

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The study of vaccine against Mycobacterium tuberculosis using Aerosol Exposure Chamber system in mice and guinea pig2007

    • Author(s)
      岡田全司
    • Journal Title

      平成18年度 新興・再興感染症研究推進事業研究報告集

      Pages: 5-13

    • Related Report
      2007 Annual Research Report
  • [Journal Article] カニクイザルを用いた、新しい結核治療ワクチン(HVJ/HSP65 DNA+IL-12DNA)による新しい結核治療法の開発2007

    • Author(s)
      岡田全司
    • Journal Title

      平成18年度 新興・再興感染症研究推進事業研究報告書

      Pages: 146-159

    • Related Report
      2007 Annual Research Report
  • [Journal Article] Evaluation of a novel vaccine(HVJ-liposome/HSP65 DNA+IL-12DNA) against tuberculosis using the cynomolgus monkey model of TB2007

    • Author(s)
      岡田全司
    • Journal Title

      Forty-Second Tuberculosis and Leprosy Research Conference U.S-JAPAN Cooperative Medical Science Program

      Pages: 66-69

    • Related Report
      2007 Annual Research Report
  • [Journal Article] 結核の抗体と細胞性免疫2007

    • Author(s)
      岡田全司
    • Journal Title

      日本医事新報 4351

      Pages: 95-97

    • Related Report
      2007 Annual Research Report
  • [Journal Article] 結核菌の分子疫学的解析 多剤耐性結核菌と全剤感受性結核菌との比較2007

    • Author(s)
      岡田全司
    • Journal Title

      結核 82(6)

      Pages: 531-538

    • NAID

      10019732905

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Evaluation of a novel vaccine (HVJ-liposome / HSP65 DNA + IL-12 DNA) against tuberculosis using the cynomolgus monkey model of TB.2007

    • Author(s)
      岡田全司
    • Journal Title

      Vaccine (In press)

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Development of vaccines and passive immunotherapy against SARS corona virus using SCID-PBL/hu mouse models.2007

    • Author(s)
      岡田全司
    • Journal Title

      Vaccine (In press)

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Molecular Epidemiology of Mycobacterium tuberculosis-Comparision between Multidrug-Resistant Strains and Pan-Sensitive Strains.2007

    • Author(s)
      岡田全司
    • Journal Title

      Kekkaku (In press)

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Novel vaccines against tuberculosis.2007

    • Author(s)
      岡田全司
    • Journal Title

      Kekkaku (In press)

    • Related Report
      2006 Annual Research Report
  • [Journal Article] 新しい結核ワクチンの開発2007

    • Author(s)
      岡田全司
    • Journal Title

      化学療法の領域 (出版中)

    • NAID

      130006948706

    • Related Report
      2006 Annual Research Report
  • [Journal Article] 新しい結核ワクチン2007

    • Author(s)
      岡田全司
    • Journal Title

      感染症 Vol.37 No.1

      Pages: 14-18

    • NAID

      10018570604

    • Related Report
      2006 Annual Research Report
  • [Journal Article] 国際ワクチン学会"学会レポート"2007

    • Author(s)
      岡田全司
    • Journal Title

      感染・炎症・免疫 37巻第1号

      Pages: 66-67

    • Related Report
      2006 Annual Research Report
  • [Journal Article] DNA vaccine using hemagglutinating virus of Japan-liposome encapsulating combination encoding mycobacterial heat shock protein 65 and interleukin-12 confers protection against Mycobacterium tuberculosis by T cell activation2006

    • Author(s)
      Yoshida S(1/12), Okada M(12/12)
    • Journal Title

      Vaccine 24

      Pages: 1191-1204

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Novel vaccination (HVJ-liposome/HSP65 DNA+IL-12 DNA ) against Tuberculosis using cynomolgus monkey2006

    • Author(s)
      Okada M(1/22), Inoue Y(12/22), Yoshida S(16/22)
    • Journal Title

      41st Tuberculosis and Leprosy Research Conference

      Pages: 109-113

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Immunization with dendritic cells retrovirally transduced with mycobacterial antigen 85A gene elicits the specific cellular immunity including cytotoxic T-lymphocyte activity specific to an epitope on antigen 85A2006

    • Author(s)
      Nakano H, Okada M(9/10), Koide Y
    • Journal Title

      Vaccine 24(12)

      Pages: 2110-9

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Development of vaccines and passive immunotherapy against SARS corona virus using mouse and SCID-PBL/hu mouse models2006

    • Author(s)
      Okada M(1/28), Yoshida S(17/28)
    • Journal Title

      Adv. Exp. Med. Biol

      Pages: 581-566

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Chemotherapy for pulmonary M. kansasii disease2006

    • Author(s)
      Suzuki K, Yoshida S, Tuyuguchi K, Minamoto S, Inoue G, Hayashi S, Okada M, Iuchi K, Sakatani M
    • Journal Title

      Kekkaku 81

      Pages: 41-43

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Exogenous re-infection by multidrug-resistant tuberculosis2006

    • Author(s)
      Tuyuguchi K, Yoshida S, Suzuki K, Okada M, Sakatani M
    • Journal Title

      Kekkaku 81

      Pages: 80-81

    • NAID

      10017478948

    • Related Report
      2009 Final Research Report
  • [Journal Article] 結核ワクチン開発の現況と展望“呼吸器6結核・非結核性抗酸菌症;新しい診断と治療のABC 41"2006

    • Author(s)
      岡田全司
    • Journal Title

      最新医学・別冊 170

      Pages: 183-183

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] 多剤耐性結核菌の院内感染の現状と対策2006

    • Author(s)
      鈴木克洋、吉田志緒美、露口一成、岡田全司、坂谷光則
    • Journal Title

      化学療法の領域 22

      Pages: 1691-1695

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] 結核ワクチンの開発(抗酸菌感染症医療の進歩)2006

    • Author(s)
      岡田全司
    • Journal Title

      呼吸 25(5)

      Pages: 477-484

    • Related Report
      2009 Final Research Report 2006 Annual Research Report
    • Peer Reviewed
  • [Journal Article] DNA vaccine usinghemagglutinating virus ofJapan-liposome encapsulatingcombination encoding mycobacterialheat shock protein 65 andinterleukin-12 confers protectionagainst Mycobacterium tuberculosis byT cell activation2006

    • Author(s)
      Yoshida S, Inoue Y, Kaneda Y, Okada M(12人中12番目)
    • Journal Title

      Vaccine 24

      Pages: 1191-1204

    • Related Report
      2008 Self-evaluation Report
    • Peer Reviewed
  • [Journal Article] DNA vaccine using hemagglutinating virus of Japan-liposome encapsulating combination encoding mycobacterial heat shock protein 65 and interleukin-12 confers protection against Mycobacterium tuberculosis by T cell activation.2006

    • Author(s)
      岡田全司
    • Journal Title

      Vaccine 24

      Pages: 1191-1204

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Immunization with dendritic cells retrovirally transduced with mycobacterial antigen 85A gene elicits the specific cellular immunity including cytotoxic T-lymphocyte activity specific to an epitope on antigen 85A.2006

    • Author(s)
      岡田全司
    • Journal Title

      Vaccline 15;24(12)

      Pages: 2110-9

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Development of vaccines and passive immunotherapy against SARS corona virus using mouse and SCID-PBL/hu mouse models.2006

    • Author(s)
      岡田全司
    • Journal Title

      Adv. Exp. Med. Biol. 581

      Pages: 561-566

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Chemotherapy for pulmonary M.kansasii disease.2006

    • Author(s)
      岡田全司
    • Journal Title

      Kekkaku 81

      Pages: 41-43

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Exogenous re-infection by multidrug-resistant tuberculosis.2006

    • Author(s)
      岡田全司
    • Journal Title

      Kekkaku 81

      Pages: 80-81

    • NAID

      10017478948

    • Related Report
      2006 Annual Research Report
  • [Journal Article] 結核ワクチン開発の現況と展望"呼吸器6 結核・非結核性抗酸菌症新しい診断と治療のABC 412006

    • Author(s)
      岡田全司
    • Journal Title

      最新医学・別冊 170

      Pages: 183-183

    • Related Report
      2006 Annual Research Report
  • [Journal Article] 多剤耐性結核菌の院内感染の現状と対策2006

    • Author(s)
      岡田全司
    • Journal Title

      化学療法の領域 22

      Pages: 1691-1695

    • Related Report
      2006 Annual Research Report
  • [Journal Article] 培養陰性,非結核性抗酸菌混在時における結核菌薬剤耐性遺伝子検査キットの有用性2006

    • Author(s)
      岡田全司
    • Journal Title

      臨床検査 50巻・8号

      Pages: 934-939

    • NAID

      40007426521

    • Related Report
      2006 Annual Research Report
  • [Journal Article] リファンピシン耐性Mycobacterium kansasiiにおけるrpoB変異の解明2006

    • Author(s)
      岡田全司
    • Journal Title

      結核 81巻・7号

      Pages: 475-479

    • NAID

      10018335804

    • Related Report
      2006 Annual Research Report
  • [Journal Article] キラーT細胞、granulysin結核免疫とワクチン(HSP65 + IL-12 DNAワクチン等)開発

    • Author(s)
      岡田全司、喜多洋子
    • Journal Title

      結核 (出版中)

    • Related Report
      2009 Final Research Report
  • [Journal Article] 結核免疫(序論)

    • Author(s)
      岡田全司
    • Journal Title

      結核 (出版中)

    • NAID

      10030262935

    • Related Report
      2009 Final Research Report
  • [Journal Article] (Special Focus on Tuberculosis Prevention and Immunotherapy) Tuberculosis Vaccine Development: The development of novel (preclinical) DNA vaccine

    • Author(s)
      Okada M, Kita Y
    • Journal Title

      Human Vaccines (in press)

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] 新しい結核ワクチンの開発

    • Author(s)
      岡田全司
    • Journal Title

      呼吸と循環 (掲載確定)

    • NAID

      130006948706

    • Related Report
      2007 Annual Research Report
  • [Presentation] Activation of CD8 positive cytotoxic T-cells by a novel vaccine (HSP65 DNA+ IL-12 DNA) against tuberculosis in vivo2009

    • Author(s)
      Okada M
    • Organizer
      第39回日本免疫学会総会・学術集会
    • Place of Presentation
      大阪
    • Year and Date
      2009-12-04
    • Related Report
      2009 Final Research Report
  • [Presentation] 新しい結核治療ワクチン(HVJ-エンベロープ/Hsp65+IL-12 DNA)の開発2009

    • Author(s)
      岡田全司
    • Organizer
      第84回結核病学会総会
    • Place of Presentation
      北海道
    • Year and Date
      2009-07-23
    • Related Report
      2009 Final Research Report
  • [Presentation] Novel therapeutic and prophylactic vaccine (HVJ-Envelope /Hsp65DNA+IL-12DNA) against tuberculosis using cynomolgus monkey2009

    • Author(s)
      Okada M
    • Organizer
      第15回遺伝子治療学会
    • Place of Presentation
      大阪
    • Year and Date
      2009-07-09
    • Related Report
      2009 Final Research Report
  • [Presentation] 新しい結核治療ワクチン(HVJ-エンベロープ/Hsp65+IL-12 DNA)の開発(マウス感染系を用いて)2009

    • Author(s)
      岡田全司
    • Organizer
      第79回実験結核研究会
    • Place of Presentation
      札幌
    • Year and Date
      2009-07-01
    • Related Report
      2009 Annual Research Report
  • [Presentation] A Novel Therapeutic and Prophylactic Vaccine (HVJ-Envelope/Hsp65 DNA+ IL-12 DNA) against Tuberculosis Using The Cynomolgus Monkey Model2009

    • Author(s)
      Okada M
    • Organizer
      3rd World Vaccine Meeting
    • Place of Presentation
      Singapole
    • Related Report
      2009 Final Research Report
  • [Presentation] A novel therapeutic vaccine (HVJ-Envelope/HSP65 DNA+IL-12 DNA) against Tuberculosis using the Cynomolgus monkey model2009

    • Author(s)
      M Okada
    • Organizer
      49th ICCAC (Interscience Conference on Antimicobial Agents and Chemotherapy)
    • Place of Presentation
      San Francisco
    • Related Report
      2009 Final Research Report
  • [Presentation] 結核に対する新しい治療ワクチン(Hsp65+IL-12 DNA)の開発2009

    • Author(s)
      岡田全司
    • Organizer
      第49回日本呼吸器学会学術講演会
    • Place of Presentation
      東京
    • Related Report
      2009 Annual Research Report 2009 Final Research Report
  • [Presentation] A novel Prophylactic and Therapeutic vaccine (HVJ-envelope/HSP65 DNA+ IL-12 DNA) against tuberculosis using the cynomolgus monkey model2009

    • Author(s)
      Okada M
    • Organizer
      6th ICWO
    • Place of Presentation
      Italia, Milan
    • Related Report
      2009 Final Research Report
  • [Presentation] A novel therapeutic vaccine(HVJ-Envelope/HSP65 DNA+IL-12 DNA)against Tuberculosis using the Cynomolgus monkey model2009

    • Author(s)
      岡田全司
    • Organizer
      49th ICCAC
    • Place of Presentation
      San Francisco, USA
    • Related Report
      2009 Annual Research Report
  • [Presentation] A Novel Therapeutic and Prophylactic Vaccine(HVJ-Envelope/Hsp65 DNA+IL-12 DNA)against Tuberculosis Using The Cynomolgus Monkey Model2009

    • Author(s)
      岡田全司
    • Organizer
      3rd World Vaccine Meeting 2009
    • Place of Presentation
      Singapole
    • Related Report
      2009 Annual Research Report
  • [Presentation] Novel therapeutic and prophylactic vaccine(HVJ-Envelope/HSP65 DNA+IL-12 DNA)against tuberculosis using cynomolgus monkey2009

    • Author(s)
      岡田全司
    • Organizer
      The Japan Society of Gene Therapy
    • Place of Presentation
      大阪
    • Related Report
      2009 Annual Research Report
  • [Presentation] Activation of CD8 positive cytotoxic T-cells by a novel vaccine(HSP65 DNA+IL-12 DNA)against tuberculosis in vivo2009

    • Author(s)
      岡田全司
    • Organizer
      第39回日本免疫学会総会
    • Place of Presentation
      大阪
    • Related Report
      2009 Annual Research Report
  • [Presentation] 新しい結核治療ワクチン(HVJ-エンベロープ/Hsp65+IL-12 DNA)の開発2009

    • Author(s)
      岡田全司
    • Organizer
      第84回日本結核病学会
    • Place of Presentation
      札幌
    • Related Report
      2009 Annual Research Report
  • [Presentation] ヒト結核感染モデルに最も近いカニクイザルを用いた結核に対する新しい治療ワクチン開発:HSP65 DNA+IL-12 DNAワクチン2009

    • Author(s)
      岡田全司
    • Organizer
      第84回日本結核病学会
    • Place of Presentation
      札幌
    • Related Report
      2009 Annual Research Report
  • [Presentation] ヒト結核感染モデルに最も近いカニクイザルを用いた新しい結核治療ワクチン開発:HSP65 DNA+IL-12 DNAワクチン2009

    • Author(s)
      岡田全司
    • Organizer
      第49回日本呼吸器学会学術講演会
    • Place of Presentation
      東京
    • Related Report
      2009 Annual Research Report
  • [Presentation] 超薬剤耐性結核に対する新しい結核治療ワクチン(HVJ-エンベロープ/HSP65 DNA+IL-12DNAワクチン)開発2009

    • Author(s)
      岡田全司
    • Organizer
      第63回国立病院総合医学会
    • Place of Presentation
      仙台
    • Related Report
      2009 Annual Research Report
  • [Presentation] ヒト結核感染に最も近いカニクイザルを用いた、新しい結核治療ワクチン(HSP65 DNA+IL-12DNA)開発研究2009

    • Author(s)
      岡田全司
    • Organizer
      第63回国立病院総合医学会
    • Place of Presentation
      仙台
    • Related Report
      2009 Annual Research Report
  • [Presentation] 結核におけるサイトカインの関与2008

    • Author(s)
      岡田全司
    • Organizer
      日本臨床免疫学会イブニングセミナー
    • Place of Presentation
      東京
    • Year and Date
      2008-10-17
    • Related Report
      2009 Final Research Report
  • [Presentation] 特異抗原をターゲットとしたImmunotherapy2008

    • Author(s)
      岡田全司
    • Organizer
      日本臨床免疫学会シンポジウム
    • Place of Presentation
      東京
    • Year and Date
      2008-10-17
    • Related Report
      2009 Final Research Report
  • [Presentation] 結核におけるサイトカインの関与2008

    • Author(s)
      岡田全司
    • Organizer
      第36回日本臨床免疫学会イブニングセミナー
    • Place of Presentation
      東京
    • Year and Date
      2008-10-17
    • Related Report
      2008 Annual Research Report
  • [Presentation] Novel therapeutic vaccine against tuberculosis using mice and cynomolgus monkeys2008

    • Author(s)
      Okada M
    • Organizer
      6th World Congress on Vaccine, (WCVII2008)
    • Place of Presentation
      Milan, Italy(招待講演)
    • Year and Date
      2008-09-23
    • Related Report
      2008 Self-evaluation Report
  • [Presentation] 新しい結核治療ワクチン(HVJ-エンベロープ/Hsp65+IL-12 DNA)の開発2008

    • Author(s)
      岡田全司
    • Organizer
      日本結核病学会
    • Place of Presentation
      東京
    • Related Report
      2009 Final Research Report
  • [Presentation] 結核に対する新しいワクチン(Hsp65+IL-12 DNA)の効果とCD8陽性T細胞の重要性2008

    • Author(s)
      岡田全司
    • Organizer
      日本呼吸器学会
    • Place of Presentation
      神戸
    • Related Report
      2009 Final Research Report
  • [Presentation] Activation of CD8 positive T-cells by a novel vaccine (HSP65 DNA+ IL-12 DNA) against tuberculosis using the cynomolgus monkey and mice2008

    • Author(s)
      Okada M
    • Organizer
      日本免疫学会
    • Place of Presentation
      京都
    • Related Report
      2009 Final Research Report
  • [Presentation] Evaluation of a novel vaccine (HVJ-liposome/HSP65 DNA+ IL-12 DNA) against tuberculosis using the cynomolgus monkey model of TB2008

    • Author(s)
      Okada M
    • Organizer
      TBV (TB vaccines for the world, TBV 2008)
    • Place of Presentation
      Atlanta, USA
    • Related Report
      2009 Final Research Report
  • [Presentation] 新しい結核治療ワクチン(HVJ-エンベロープ/Hsp65+IL-12DNA)の開発2008

    • Author(s)
      岡田全司
    • Organizer
      第83回日本結核病学会
    • Place of Presentation
      東京
    • Related Report
      2008 Annual Research Report
  • [Presentation] ヒト結核感染モデルに最も近いカニクイザルを用いた結核に対する新しい治療ワクチン開発:HSP65 DNA+IL-12DNAワクチン2008

    • Author(s)
      岡田全司
    • Organizer
      第83回日本結核病学会
    • Place of Presentation
      東京
    • Related Report
      2008 Annual Research Report
  • [Presentation] 結核に対する新しいワクチン(Hsp65+IL-12 DNA)の効果とCD8陽性T細胞の重要性2008

    • Author(s)
      岡田全司
    • Organizer
      第48回日本呼吸器学会
    • Place of Presentation
      東京
    • Related Report
      2008 Annual Research Report
  • [Presentation] Activation of CD8 positive T-cells by a novel vaccine (HSP65 DNA+IL-12 DNA) against tuberculosis using the cynomolgus monkey and mice2008

    • Author(s)
      岡田全司
    • Organizer
      第38回日本免疫学会
    • Place of Presentation
      京都
    • Related Report
      2008 Annual Research Report
  • [Presentation] ポリオウイルスベクターを用いた新規結核ワクチンの開発/Expression of Mycobacterium tuberculosis antigens in poliovirus vector2008

    • Author(s)
      岡田全司
    • Organizer
      第38回日本免疫学会
    • Place of Presentation
      京都
    • Related Report
      2008 Annual Research Report
  • [Presentation] Evaluation of a novel vaccine (HVJ-liposome/HSP65 DNA+IL-12 DNA) against tuberculosis using the cynomolgus monkey model of TB2008

    • Author(s)
      岡田全司
    • Organizer
      TBV (TB vaccines for the world, TBV 2008)
    • Place of Presentation
      Atlanta, USA
    • Related Report
      2008 Annual Research Report
  • [Presentation] A novel PROPHYLATIC AND THERAPEUTIC vaccine (HVJ- envelope/HSP65 DNA+IL-12 DNA) against tuberculosis using the cynomolgus monkey model2008

    • Author(s)
      岡田全司
    • Organizer
      6^<th> ICWO
    • Place of Presentation
      Italia, Milan
    • Related Report
      2008 Annual Research Report
  • [Presentation] The study of Novel Vaccination using Granulysin transgenic mice2008

    • Author(s)
      岡田全司
    • Organizer
      6^<th> ICWO
    • Place of Presentation
      Italia, Milan
    • Related Report
      2008 Annual Research Report
  • [Presentation] 新しい結核ワクチン開発の実験動物2008

    • Author(s)
      岡田全司
    • Organizer
      第8回 日本バイオセーフティ学会総会
    • Place of Presentation
      大阪
    • Related Report
      2008 Annual Research Report
  • [Presentation] 最新の結核ワクチン・SARSワクチン及び肺癌ワクチンについて2007

    • Author(s)
      岡田全司
    • Organizer
      箕面医師会特別講演
    • Place of Presentation
      箕面医師会
    • Year and Date
      2007-06-20
    • Related Report
      2007 Annual Research Report
  • [Presentation] 抗酸菌研究の最前線2007

    • Author(s)
      岡田全司、小林和夫
    • Organizer
      第82回日本結核病学会総会
    • Place of Presentation
      大阪
    • Related Report
      2009 Final Research Report
  • [Presentation] 新しいワクチン開発2007

    • Author(s)
      岡田全司
    • Organizer
      第82回日本結核病学会総会
    • Place of Presentation
      大阪
    • Related Report
      2009 Final Research Report
  • [Presentation] Immunological enhancement of a novel vaccine (HSP65 DNA + IL-12 DNA) against tuberculosis using the cynomolgus monkey model of TB2007

    • Author(s)
      Okada M
    • Organizer
      日本免疫学会総会・学術集会記録
    • Place of Presentation
      東京
    • Related Report
      2009 Final Research Report
  • [Presentation] 新しい結核ワクチン.(特別講演未来に繋がる結核対策)2007

    • Author(s)
      岡田全司
    • Organizer
      .第47回日本呼吸器病学会
    • Place of Presentation
      東京
    • Related Report
      2009 Final Research Report
  • [Presentation] ワクチン開発2007

    • Author(s)
      岡田全司
    • Organizer
      第82回日本結核病学会
    • Place of Presentation
      大阪
    • Related Report
      2009 Final Research Report
  • [Presentation] 抗酸菌研究の最前線2007

    • Author(s)
      岡田全司
    • Organizer
      第82回 日本結核病学会総会
    • Place of Presentation
      大阪
    • Related Report
      2007 Annual Research Report
  • [Presentation] ワクチン開発.(特別講演 抗酸菌研究の最前線)2007

    • Author(s)
      岡田全司
    • Organizer
      第82回 日本結核病学会総会
    • Place of Presentation
      大阪
    • Related Report
      2007 Annual Research Report
  • [Presentation] ヒト結核感染モデルに最も近いカニクイザルを用いた結核に対する新しいDNAワクチン開発 : HSP65DNA+IL-12DNAワクチン(4)2007

    • Author(s)
      岡田全司
    • Organizer
      第82回 日本結核病学会総会
    • Place of Presentation
      大阪
    • Related Report
      2007 Annual Research Report
  • [Presentation] 結核に対する新しいワクチン(HVJ-liposome/HSP65+IL-12DNA)の開発とT細胞分化誘導作用2007

    • Author(s)
      岡田全司
    • Organizer
      第82回 日本結核病学会総会
    • Place of Presentation
      大阪
    • Related Report
      2007 Annual Research Report
  • [Presentation] プライム・ブースター法を用いた新しいワクチン(HVJ-liposome/HSP65+IL-12DNA)による肺結核病理像作用2007

    • Author(s)
      岡田全司
    • Organizer
      第82回 日本結核病学会総会
    • Place of Presentation
      大阪
    • Related Report
      2007 Annual Research Report
  • [Presentation] HSP65遺伝子導入マウス及びIL-12遺伝子導入マウスを用いた結核感染防御機構の解析モデルの開発2007

    • Author(s)
      岡田全司
    • Organizer
      第82回 日本結核病学会総会
    • Place of Presentation
      大阪
    • Related Report
      2007 Annual Research Report
  • [Presentation] 気道内投与・鼻腔内投与による新規結核ワクチン効果解析(エアゾル吸入感染系を用いた)2007

    • Author(s)
      岡田全司
    • Organizer
      第82回 日本結核病学会総会
    • Place of Presentation
      大阪
    • Related Report
      2007 Annual Research Report
  • [Presentation] 国立病院機構(NHO)呼吸器ネットにおける2004年結核死亡調査と死亡推移の検討2007

    • Author(s)
      岡田全司
    • Organizer
      第82回 日本結核病学会総会
    • Place of Presentation
      大阪
    • Related Report
      2007 Annual Research Report
  • [Presentation] 神戸市で結核定期外健康診断時に実施したQFT-2G検査の有用性と接触度について2007

    • Author(s)
      岡田全司
    • Organizer
      第82回 日本結核病学会総会
    • Place of Presentation
      大阪
    • Related Report
      2007 Annual Research Report
  • [Presentation] Induction of CTL by using granulysin, IL-6 related genes and IL-2 Receptor disrupted SCID mouse2007

    • Author(s)
      岡田全司
    • Organizer
      Proceedings 66th Annual Meeting of the Japanese Cancer Association
    • Place of Presentation
      横浜
    • Related Report
      2007 Annual Research Report
  • [Presentation] Immunological enhancement of a novel vaccine(HSP65DNA+IL-12DNA) against tuberculosis using the cynomolgus monkey model of TB2007

    • Author(s)
      岡田全司
    • Organizer
      第37回日本免疫学会総会
    • Place of Presentation
      東京
    • Related Report
      2007 Annual Research Report
  • [Presentation] INHの予防内服によりINH耐性が誘導されたと考えられた結核の1症例2007

    • Author(s)
      岡田全司
    • Organizer
      第82回 日本結核病学会総会
    • Place of Presentation
      大阪
    • Related Report
      2007 Annual Research Report
  • [Presentation] Line Probe Assayを用いた抗酸菌同定キットの有用性の検討2007

    • Author(s)
      岡田全司
    • Organizer
      第82回 日本結核病学会総会
    • Place of Presentation
      大阪
    • Related Report
      2007 Annual Research Report
  • [Presentation] 神戸市でのVNTR法による結核菌の遺伝子型別データベースが有用であり、QFTも併用した接触者健康診断事例について2007

    • Author(s)
      岡田全司
    • Organizer
      第82回 日本結核病学会総会
    • Place of Presentation
      大阪
    • Related Report
      2007 Annual Research Report
  • [Presentation] 特異抗原をターゲットとしたImmunotherapy新しい結核ワクチンの開発2007

    • Author(s)
      岡田全司
    • Organizer
      第35回日本臨床免疫学会
    • Place of Presentation
      大阪
    • Related Report
      2007 Annual Research Report
  • [Presentation] 薬剤感受性試験でRFP感受性、耐性遺伝子検査でRFP耐性となる結核菌の検討2007

    • Author(s)
      岡田全司
    • Organizer
      第82回 日本結核病学会総会
    • Place of Presentation
      大阪
    • Related Report
      2007 Annual Research Report
  • [Presentation] SCID-PBL/huモデルマウスを用いたSARSウイルスM蛋白に対するヒト中和抗体誘導DNAワクチンの開発2007

    • Author(s)
      岡田全司
    • Organizer
      第47回日本呼吸器学会
    • Place of Presentation
      東京
    • Related Report
      2007 Annual Research Report
  • [Presentation] HSP65遺伝子導入マウス及びIL-12遺伝子導入マウスを用いた結核感染防御機構の解明2007

    • Author(s)
      岡田全司
    • Organizer
      第47回日本呼吸器学会
    • Place of Presentation
      東京
    • Related Report
      2007 Annual Research Report
  • [Presentation] 結核に対する新しいワクチン(Hsp65+IL-12DNA)の開発とキラーT細胞分化誘導効果2007

    • Author(s)
      岡田全司
    • Organizer
      第47回日本呼吸器学会
    • Place of Presentation
      東京
    • Related Report
      2007 Annual Research Report
  • [Presentation] 肺感染症の病態と診療の研究における進歩 ヒト結核感染モデルに最も近いカニクイザルを用いた新しい結核ワクチン開発2007

    • Author(s)
      岡田全司
    • Organizer
      第47回日本呼吸器学会
    • Place of Presentation
      東京
    • Related Report
      2007 Annual Research Report
  • [Presentation] 新しい結核ワクチン(特別講演 未来に繋がる結核対策)2007

    • Author(s)
      岡田全司
    • Organizer
      第47回日本呼吸器学会
    • Place of Presentation
      東京
    • Related Report
      2007 Annual Research Report
  • [Presentation] Novel Vaccination(HVJ-Liposome/HSP65DNA+IL-12DNA) Against Tuberculosis Using Cynomolgus Monkey2007

    • Author(s)
      岡田全司
    • Organizer
      Leonard Wood Memorial International Meeting
    • Place of Presentation
      Leonard Wood Memorial研究所(Philippines)
    • Related Report
      2007 Annual Research Report
  • [Presentation] Evaluation of a novel vaccine (HVJ-liposome / HSP65 DNA + IL-12 DNA) against tuberculosis using the cynomolgus monkey model of TB2006

    • Author(s)
      Okada M(Symposist)
    • Organizer
      Fifth World Congress on Vaccines, Immunization and Immunotherapy (WCVII)
    • Place of Presentation
      Montreal, Canada
    • Related Report
      2009 Final Research Report
  • [Presentation] Novel Vaccines Against Tuberculosis; Non-antibiotic Strategy for Pulmonary Infection2006

    • Author(s)
      Okada M(Symposist)
    • Organizer
      46th JRS-International Symposium (Japanese Respiratory Society)
    • Place of Presentation
      Tokyo, JAPAN
    • Related Report
      2009 Final Research Report
  • [Presentation] 新しい結核ワクチン(教育講演)2006

    • Author(s)
      岡田全司
    • Organizer
      第81回日本結核病学会総会
    • Place of Presentation
      仙台
    • Related Report
      2009 Final Research Report
  • [Presentation] (第80回記念企画講演)新しい結核ワクチンの開発:新世代ワクチン・ストラテジー2006

    • Author(s)
      岡田全司
    • Organizer
      (第80回記念企画:感染症学のBreak-Throughを目指して)第80回日本感染症学会総会
    • Place of Presentation
      東京
    • Related Report
      2009 Final Research Report
  • [Book] 結核ワクチン2006

    • Author(s)
      岡田全司
    • Publisher
      医学書院
    • Related Report
      2009 Final Research Report
  • [Book] 結核ワクチン. "結核第4版"2006

    • Author(s)
      岡田全司, 泉孝英, 富岡洋海
    • Publisher
      医学書院
    • Related Report
      2008 Self-evaluation Report
  • [Book] 結核 第4版2006

    • Author(s)
      岡田全司
    • Total Pages
      20
    • Publisher
      医学書院
    • Related Report
      2006 Annual Research Report
  • [Remarks] 新聞掲載2件(朝日新聞)ラジオ講演1件(ニッケイ)

    • URL

      http://www.hosp.go.jp/~kch/

    • Related Report
      2009 Final Research Report
  • [Remarks] 新聞掲載

    • Related Report
      2008 Self-evaluation Report
  • [Remarks] 2件(朝日新聞)

    • Related Report
      2008 Self-evaluation Report
  • [Remarks] ラジオ講演

    • Related Report
      2008 Self-evaluation Report
  • [Remarks] 1件(ニッケイ)

    • Related Report
      2008 Self-evaluation Report
  • [Remarks]

    • URL

      http://www.hosp.go.jp/~kch/

    • Related Report
      2008 Self-evaluation Report
  • [Patent(Industrial Property Rights)] 感染症治療剤15K granulysin2008

    • Inventor(s)
      岡田全司、高森靖、安井正文
    • Industrial Property Rights Holder
      岡田全司、高森靖、安井正文
    • Filing Date
      2008-07-04
    • Related Report
      2009 Final Research Report
  • [Patent(Industrial Property Rights)] 感染症治療剤15K granulysin2008

    • Inventor(s)
      岡田全司、高森靖、安井正文
    • Acquisition Date
      2008-07-04
    • Related Report
      2008 Self-evaluation Report
  • [Patent(Industrial Property Rights)] キラーT細胞の誘導抑制剤2006

    • Inventor(s)
      岡田全司、大杉義征、三原昌彦、高橋将文、伊澤淳
    • Industrial Property Rights Holder
      岡田全司、大杉義征、三原昌彦、高橋将文、伊澤淳
    • Filing Date
      2006-11-15
    • Related Report
      2009 Final Research Report
  • [Patent(Industrial Property Rights)] キラーT 細胞の誘導抑制剤2006

    • Inventor(s)
      岡田全司、大杉義征、三原昌彦、高橋将文、伊澤淳
    • Filing Date
      2006-11-15
    • Related Report
      2008 Self-evaluation Report
  • [Patent(Industrial Property Rights)] キラーT細胞の誘導抑制剤2006

    • Inventor(s)
      岡田全司, 大杉義征, 三原昌彦, 高橋将文, 伊澤淳
    • Industrial Property Rights Holder
      国立病院機構, 信州大学, 中外製薬
    • Filing Date
      2006-11-15
    • Related Report
      2006 Annual Research Report

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Published: 2006-04-01   Modified: 2016-04-21  

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