| Project/Area Number |
18390145
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Virology
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| Research Institution | National Institute of Infectious Diseases |
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Principal Investigator |
YAMAMOTO Naoki National Institute of Infectious Diseases, AIDS Research Center, Director (00094053)
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| Co-Investigator(Kenkyū-buntansha) |
YAMAMOTO Norio Tokyo Medical and Dental University, Department of Molecular Virology, Assistant Professor (40323703)
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| Project Period (FY) |
2006 – 2007
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| Project Status |
Completed (Fiscal Year 2007)
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| Budget Amount *help |
¥16,700,000 (Direct Cost: ¥14,600,000、Indirect Cost: ¥2,100,000)
Fiscal Year 2007: ¥9,100,000 (Direct Cost: ¥7,000,000、Indirect Cost: ¥2,100,000)
Fiscal Year 2006: ¥7,600,000 (Direct Cost: ¥7,600,000)
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| Keywords | cell therapy / persistent infections / cancer / virus / humanized mice / NOG mice |
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| Research Abstract |
Our efforts have been made regarding morphological, genetic and molecular studies on virally-induced diseases (HTLV-I/ATL, HIV-I/AIDS, and EBV/AIDS-associated lymphoma) and non-virally induced cancers using newly developed NOG mice. We initially established a novel animal model for ATL using unconditional NOG mice. We also showed the effect of several newly developed NF-kB inhibitors. We proved efficacy and safety of NK cells in NOG mice as well as in the breast tumor-bearing patients. We also constructed humanized NOG mice by transplanting human cord blood-derived hematopoietic stem cells that eventually developed into human B cells, T cells and other monocytes/macrophages and dendritic cells associated with the generation of lymphoid follicle-like structures in lymphoid tissues. This system allows a long-lasting infection of both HIV-1 and EBV with human immune responses. All these data suggest that NOG mice may have potential as a useful animal model for the development of new regimen against various infectious diseases and cancers of human origin.
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