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The role of DOCK2 and its regulatory mechanism in the innate immune system

Research Project

Project/Area Number 18390154
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Immunology
Research InstitutionKyushu University

Principal Investigator

FUKUI Yoshinori  Kyushu University, Medical Institute of Bioregulation, Professor (60243961)

Co-Investigator(Kenkyū-buntansha) TANAKA Yoshihiko  KYUSHU UNIVERSITY, Medical Institute of Bioregulation, Associate Professor (00398083)
NISHIKIMI Akihiko  KYUSHU UNIVERSITY, Medical Institute of Bioregulation, Assistant Professor (70404019)
Project Period (FY) 2006 – 2007
Project Status Completed (Fiscal Year 2007)
Budget Amount *help
¥17,470,000 (Direct Cost: ¥14,500,000、Indirect Cost: ¥2,970,000)
Fiscal Year 2007: ¥12,870,000 (Direct Cost: ¥9,900,000、Indirect Cost: ¥2,970,000)
Fiscal Year 2006: ¥4,600,000 (Direct Cost: ¥4,600,000)
KeywordsImmunology / signal transduction / biomolecule / allerev・asthma / development・differentiation / DOCK2 / Rac / 樹状細胞 / 遊走 / ケモカイン / 細胞内動態
Research Abstract

Neutrophils are highly motile leukocytes and play important roles in the innate immune response to invading pathogens. Neutrophil chemotaxis requires Rac activation, yet the Rac activators functioning downstream of chemoattractant receptors remain to be determined. In this study, we have analyzed the role of DOCK2 in chemotactic response of neutrophils. Although DOCK2-deficient neutrophils moved toward the chemoattractant source, they exhibited abnormal migratory behavior with a marked reduction in translocation speed. In DOCK2-deficient neutrophils, chemoattractant-induced activation of both Rac1 and Rac2 were severely impaired, resulting in the loss of polarized accumulation of F-actin and phosphatidylinositol 3, 4, 5 -triphosphate (PIP3) at the leading edge. On the other hand, we found that DOCK2 associates with PIP3 and translocates to the leading edge of chemotaxing neutrophils in a phosphatidylinositol 3-kinase (PI3K) -dependent manner. These results indicate that during neutrophil chemotaxis DOCK2 regulates leading edge formation through PIP3-dependent membrane translocation and Rac activation. In addition to this, we revealed that DOCK2 is a Rac activator critical for migration of plasmacytoid dendritic cells. Our results thus indicate that DOCK2 plays an important role not only in the acquired, but also in the innate immune system.

Report

(3 results)
  • 2007 Annual Research Report   Final Research Report Summary
  • 2006 Annual Research Report
  • Research Products

    (64 results)

All 2008 2007 2006 Other

All Journal Article (33 results) (of which Peer Reviewed: 16 results) Presentation (29 results) Remarks (2 results)

  • [Journal Article] Differential requirement for DOCK2 in migration of plasmacytoid dendritic cells versus myeloid dendritic cells2008

    • Author(s)
      Gotoh K., et. al.
    • Journal Title

      Blood 111

      Pages: 2973-2976

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Dock2 participates in bone marrow lympho-hematopoiesis2008

    • Author(s)
      Kikuchi T., et. al.
    • Journal Title

      Biochem.Biophys.Res.Common 367

      Pages: 90-96

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Differential requirement for DOCK2 in migration of plasmacytoid dendritic cells versus myeloid dendritic cells.2008

    • Author(s)
      Gotoh K., et. al.
    • Journal Title

      Blood 111

      Pages: 2973-2976

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Dock2 participates in bone marrow lympho-hematopoiesis2008

    • Author(s)
      Kikuchi, T., et. al.
    • Journal Title

      Biochem. Biophys. Res. Commun 367

      Pages: 90-96

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Differential requirement for DOCK2 inmigration of plasmacytoid dendritic cells versus myeloid dendritic cells.2008

    • Author(s)
      Gotoh K., et. al.
    • Journal Title

      Blood 111

      Pages: 2973-2976

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Dock2 participates in bone marrow lympho-hematopoiesis.2008

    • Author(s)
      Kikuchi T., et. al.
    • Journal Title

      Biochem.Biophys.Res.Commun. 367

      Pages: 90-96

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] T helper type 2 differentiation and intracellular trafficking of the interleukin 4 receptor-α subunit controlled by the Rac activator Dock22007

    • Author(s)
      Tanaka Y., et. al.
    • Journal Title

      Nature Immunol 8

      Pages: 1067-1075

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Shignella IpgB1 promotes bacterial entry through the ELMO-Dock180 machinery2007

    • Author(s)
      Handa Y., et. al.
    • Journal Title

      Nature Cell Biol 9

      Pages: 121-128

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] A central role for DOCK2 during interstitial lymphocyte motility and sphingosine-1-phosphate-mediatsd egress2007

    • Author(s)
      Nombela-Arrieta C., et. al.
    • Journal Title

      J.Exp.Med 204

      Pages: 497-510

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] T helper type 2 differentiation and intracellular trafficking of the interleukin 4 receptor-α subunit controlled by the Rac activator Dock22007

    • Author(s)
      Tanaka, Y., et. al.
    • Journal Title

      Nature Immunol 8

      Pages: 1067-1075

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Shignella IpgB1 promotes bacterial entry through the ELMO-Dock180 machinery2007

    • Author(s)
      Handa, Y., et. al.
    • Journal Title

      Nature Cell Biology 9

      Pages: 121-128

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] A central role for DOCK2 during interstitial lymphocyte motility and sphingosine-1-phosphatemediatsd egress2007

    • Author(s)
      Nombela-Arrieta, C., et. al.
    • Journal Title

      J. Exp. Med. 204

      Pages: 497-510

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] T helper type 2 differentiation and intracellular trafficking of the interleukin 4 receptor-α subunit controlled by the Rac activator Dock22007

    • Author(s)
      Tanaka Y., et. al.
    • Journal Title

      Nature Immunol. 8

      Pages: 1067-1075

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Shignella IpgBl promotes bacterial entry through the ELMO-Dock180 machinery.2007

    • Author(s)
      Handa Y., et. al.
    • Journal Title

      Nature Cell Biol. 9

      Pages: 121-128

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A central role for DOCK2 during interstitial lymphocyte motility and sphingosine-1-phosphate-mediatsd egress.2007

    • Author(s)
      Nombela-Arrieta C., et. al.
    • Journal Title

      J.Exp.Med. 204

      Pages: 497-510

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Methylprednisolone injection via the portal vein suppresses inflammation in acute liver failure induced in rats by lipopolysaccharide and d-galactosamine.2007

    • Author(s)
      Higuchi N., et. al.
    • Journal Title

      Liver Int. 27

      Pages: 1342-1348

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A central role for DOCK2 during interstitial Lymphocyte motility and sphingosine-1-phosphate-mediatsd egress.2007

    • Author(s)
      Nombela-Arrieta C et al.
    • Journal Title

      J. Exp. Med. 204

      Pages: 497-510

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Shignella IpgB1 promotes bacterial entry through the ELMO-Dock180 machinery.2007

    • Author(s)
      Handa Y et al.
    • Journal Title

      Nature Cell Biology 9

      Pages: 121-128

    • Related Report
      2006 Annual Research Report
  • [Journal Article] DOCK2 is a Rac activator that regulates motility and polarity during neutrophil chemotaxis2006

    • Author(s)
      Kunisaki Y., et. al.
    • Journal Title

      J.Cell Biology 174

      Pages: 647-652

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] DOCK2 is required in T cell precursors for development of Vα14 natural killar T(NKT)cells2006

    • Author(s)
      Kunisaki Y., et. al.
    • Journal Title

      J.lmmunol 176

      Pages: 4640-4645

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] DOCK2 regulates chemokine-triggered lateral lymphocyte motility but not transendothelial migration2006

    • Author(s)
      Shulman Z., et. al.
    • Journal Title

      Blood 108

      Pages: 2150-2158

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] DOCK2 is required for chemokine-promoted human T lymphocyte adhesion under shear stress mediated by the integrin α4β12006

    • Author(s)
      Garcia-Bernal D., et. al.
    • Journal Title

      J.lmmunol 177

      Pages: 5215-5225

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] 好中球遊走を制御するRac活性化分子DOCK22006

    • Author(s)
      福井 宣規
    • Journal Title

      実験医学 24

      Pages: 3269-3276

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] DOCK2 is a Rac activator that regulates motility and polarity during neutrophil chemotaxis2006

    • Author(s)
      Kunisaki, Y., et. al.
    • Journal Title

      J. Cell Biology 174

      Pages: 647-652

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] DOCK2 is required in T cell precursors for development of Val4 natural killar T (NKT) cells2006

    • Author(s)
      Kunisaki, Y., et. al.
    • Journal Title

      J. Immunol. 176

      Pages: 4640-4645

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] DOCK2 regulates chemokine-triggered lateral lymphocyte motility but not transendothelial migration2006

    • Author(s)
      Shulman, Z., et. al.
    • Journal Title

      Blood 108

      Pages: 2150-2158

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] DOCK2 is required for chemokine-promoted human T lymphocyte adhesion under shear stress mediated by the integrin α4β1.2006

    • Author(s)
      Garcia-Bernal, D., et. al.
    • Journal Title

      J. Immunol. 177

      Pages: 5215-5225

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] The role of DOCK2 in neutrophil chemotaxis.2006

    • Author(s)
      Y., Fukui
    • Journal Title

      Jikken-igaku 24

      Pages: 3269-3276

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] DOCK2 is required for chemokine-promoted human T lymphocyte adhesion under shear stress mediated by the integrin α4β1.2006

    • Author(s)
      Garcia-Bernal D et al.
    • Journal Title

      J. Immunol. 177

      Pages: 5215-5225

    • Related Report
      2006 Annual Research Report
  • [Journal Article] DOCK2 is a Rac activator that regulates motility and polarity during neutrophil chemotaxis.2006

    • Author(s)
      Kunisaki Y et al.
    • Journal Title

      J. Cell Biology 174

      Pages: 647-652

    • Related Report
      2006 Annual Research Report
  • [Journal Article] DOCK2 regulates chemokine-triggered lateral lymphocyte motility but not transendothelial migration.2006

    • Author(s)
      Shulman Z et al.
    • Journal Title

      Blood 108

      Pages: 2150-2158

    • Related Report
      2006 Annual Research Report
  • [Journal Article] DOCK2 is required in T cell precursors for development of Vα14 natural killar T (NKT) cells.2006

    • Author(s)
      Kunisaki Y et al.
    • Journal Title

      J. Immunol. 176

      Pages: 4640-4645

    • Related Report
      2006 Annual Research Report
  • [Journal Article] 好中球遊走を制御するRac活性化分子DOCK22006

    • Author(s)
      福井宣規
    • Journal Title

      実験医学 24

      Pages: 3269-3276

    • Related Report
      2006 Annual Research Report
  • [Presentation] 免疫系細胞高次機能を司るDOCK2シグナルネットワーク2008

    • Author(s)
      福井 宣規
    • Organizer
      第4回ゲノムネットワークプロジェクト公開シンポジウム
    • Place of Presentation
      東京
    • Year and Date
      2008-02-19
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Annual Research Report 2007 Final Research Report Summary
  • [Presentation] DOCK2 signal network in immure regulation2008

    • Author(s)
      Fukui, Y
    • Organizer
      The 4th GNP Symposium
    • Place of Presentation
      Tokyo
    • Year and Date
      2008-02-19
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 免疫系細胞高次機能を司るCDMファミリー分子DOCK22007

    • Author(s)
      福井 宣規
    • Organizer
      第18回フォーラム・イン・ドージン
    • Place of Presentation
      熊本
    • Year and Date
      2007-11-30
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] The role of the CDM family protein DOCK2 in the immure system2007

    • Author(s)
      Fukui, Y
    • Organizer
      The 18th Forum in Dojin
    • Place of Presentation
      Kumamoto
    • Year and Date
      2007-11-30
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 免疫系細胞高次機能を司るCDMファミリー分子DOCK22007

    • Author(s)
      福井 宣規
    • Organizer
      第18回フォーラム・イン・ドージン
    • Place of Presentation
      熊木
    • Year and Date
      2007-11-30
    • Related Report
      2007 Annual Research Report
  • [Presentation] Dock2-Rac signaling pathway controls lineage commitment of CD4^+ T cells via intracelluar trafficking of the interleukin 4 receptor-α subunit2007

    • Author(s)
      Tanaka Y, et. al.
    • Organizer
      International Symposiumon Membrane Traffic
    • Place of Presentation
      淡路
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] IL-4受容体のメンブレントラフィックを介したDOCK2-RacシグナルによるCD4^+T細胞Iineage commitment制御機構の解明2007

    • Author(s)
      田中 芳彦, 他
    • Organizer
      第37回日本免疫学会総会
    • Place of Presentation
      東京
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] B細胞分化・増殖におけるDOCK2の機能2007

    • Author(s)
      川口 真喜子, 他
    • Organizer
      第37回日本免疫学会総会
    • Place of Presentation
      東京
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] DOCK2 links TCR signals to IL-4 receptor downregulation to control lineage commitment of CD4^+ T cells2007

    • Author(s)
      TanakaY., et. al.
    • Organizer
      The AWAJI International Forum on Infection and Immunity
    • Place of Presentation
      淡路
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Dock2-Rac signaling pathway controls lineage commitment of CD^4+ T cells via intracellular trafficking of the interleukin 4 receptor-α subunit2007

    • Author(s)
      Tanaka, Y., et. al.
    • Organizer
      International Sympopsium on Membrane Traffic
    • Place of Presentation
      Awaji
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Dock2-Rac signaling pathway controls lineage commitment of CD^4+ T cells via intracellular trafficking of the interleukin 4 receptor-α subunit2007

    • Author(s)
      Tanaka, Y., et. al.
    • Organizer
      The 37th JSI annual meeting
    • Place of Presentation
      Tokyo
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] The role of DOCK2 in B cell functions2007

    • Author(s)
      Kawaguchi, M., et. al.
    • Organizer
      The 37th JSI annual meeting
    • Place of Presentation
      Tokyo
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] DOCK2 links TCR signals to IL-4 receptor downregulation to controllineage commitment of CD^4+ T cells2007

    • Author(s)
      Tanaka, Y., et. al.
    • Organizer
      The AWAJI International Forum on Infection and Immunity
    • Place of Presentation
      Awaji
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Dock2-Rac signaling pathway controls lineage commitment of CD4^+ T cells via intracellular trafficking of the interleukin 4 receptor-α subunit.2007

    • Author(s)
      Tanaka Y, et. al.
    • Organizer
      International Symposium on Membrane Traffic
    • Place of Presentation
      淡路
    • Related Report
      2007 Annual Research Report
  • [Presentation] IL-4受容体のメンブレントラフィックを介したDOCK2-RacシグナルによるCD4^+T細胞lineage commitment制御機構の解明2007

    • Author(s)
      田中 芳彦, 他
    • Organizer
      第37回日本免疫学会総会
    • Place of Presentation
      東京
    • Related Report
      2007 Annual Research Report
  • [Presentation] B細胞文化・増殖におけるDOCK2の機能2007

    • Author(s)
      川口 真喜子, 他
    • Organizer
      第37回日本免疫学会総会
    • Place of Presentation
      東京
    • Related Report
      2007 Annual Research Report
  • [Presentation] DOCK2 links TCR signals to IL-4 receptor downregulation to control lineage commitment of CD4^+ T cells.2007

    • Author(s)
      Tanaka Y., et. al.
    • Organizer
      The AWAJI International Forum on Infection and Immunity
    • Place of Presentation
      淡路
    • Related Report
      2007 Annual Research Report
  • [Presentation] DOCK2 is a Rac activator critical for neutrophil chemotaxis2006

    • Author(s)
      福井 宣規, 他
    • Organizer
      第36回日本免疫学会総会
    • Place of Presentation
      大阪
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] アレルギー性免疫応答制御における細胞骨格制御分子DOCK2の役割2006

    • Author(s)
      田中 芳彦, 他
    • Organizer
      第36回日本免疫学会総会
    • Place of Presentation
      大阪
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 細胞骨格制御分子DOCK2は形質細胞様樹状細胞の遊走を制御する2006

    • Author(s)
      後藤 和人, 他
    • Organizer
      第36回日本免疫学会総会
    • Place of Presentation
      大阪
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] CDMファミリー分子DOCK2による好中球遊走の制御機構2006

    • Author(s)
      福井 宣規
    • Organizer
      日本分子生物学会2006フォーラム
    • Place of Presentation
      名古屋
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] DOCK2 is a Rac activator that regulates motility and polarity during neutronhil chemotaxis2006

    • Author(s)
      Akihiko Nishikimi, et. al.
    • Organizer
      日本分子生物学会2006フォーラム
    • Place of Presentation
      名古屋
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] DOCK2 is critical for alloreactive T cell homhlg,activation,and intragraft infiltration during transplant rejection2006

    • Author(s)
      Fan Pan, et. al.
    • Organizer
      World Transplantarion Congress
    • Place of Presentation
      Boston,USA
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] DOCK2 is a Rac activator critical for neutrophil chemotaxis2006

    • Author(s)
      Fukui, Y., et. al.
    • Organizer
      The 36th JSI annual meeting
    • Place of Presentation
      Osaka
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] The role of DOCK2 in helper T cell differentiation2006

    • Author(s)
      Tanaka, Y., et. al.
    • Organizer
      The 36th JSI annual meeting
    • Place of Presentation
      Osaka
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] The role of DOCK2 in plasmacytoid DC migration2006

    • Author(s)
      Gotoh, K., et. al.
    • Organizer
      The 36th JSI annual meeting
    • Place of Presentation
      Osaka
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Regulation for neutrophil chemotaxis by the CDM family protein DOCK22006

    • Author(s)
      Y., Fukui
    • Organizer
      MBSJ Forum 2006
    • Place of Presentation
      Nagoya
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] DOCK2 is a Rac activator that regulates motility and polarity during neutrophil chemotaxis2006

    • Author(s)
      Nishikimi, A., et. al.
    • Organizer
      MBSJ Forum 2006
    • Place of Presentation
      Nagoya
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] DOCK2 is critical for alloreactive T cell homing, activation, and intragraft infiltration during transplant reiection2006

    • Author(s)
      Fan, Pan, et. al.
    • Organizer
      World Transplantation Congress
    • Place of Presentation
      Boston, USA
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Remarks] 「研究成果報告書概要(和文)」より

    • URL

      http://www.bioreg.kyushu-u.ac.jp/iden/

    • Related Report
      2007 Final Research Report Summary
  • [Remarks]

    • URL

      http://www.bioreg.kyushu-u.ac.jp/iden/

    • Related Report
      2007 Annual Research Report

URL: 

Published: 2006-04-01   Modified: 2016-04-21  

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