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Tailor-made cancer diagnosis by systematically detecting alterations of miRNA and protein expressions

Research Project

Project/Area Number 18390171
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Laboratory medicine
Research InstitutionNagoya University

Principal Investigator

TAKASHI Takahashi  Nagoya University, 大学院・医学系研究科, 教授 (50231395)

Co-Investigator(Kenkyū-buntansha) YANAGISAWA Kiyoshi  名古屋大学, 高等研究院, 特任講師 (20372112)
TOMIDA Shuta  名古屋大学, 大学院・医学系研究科, 助教 (10372111)
後藤 秀実 (後藤 秀美)  名古屋大学, 大学院・医学系研究科, 教授 (10215501)
梛野 正人  名古屋大学, 大学院・医学系研究科, 教授 (20237564)
光冨 徹哉  愛知県がんセンター, 分子腫瘍学部, 研究員 (70209807)
Co-Investigator(Renkei-kenkyūsha) GOTO Hidemi  名古屋大学, 大学院・医学系研究科, 教授 (10215501)
NAGINO Masato  名古屋大学, 大学院・医学系研究科, 教授 (20237564)
MITSUDOMI Tetsuya  愛知県がんセンター, 分子腫瘍学部, 研究 (70209807)
HIDA Toyoaki  愛知がんセンター, 分子腫瘍部, 研究員 (80250249)
YATABE Yasushi  愛知県がんセンター, 分子腫瘍部, 研究員
Project Period (FY) 2006 – 2008
Project Status Completed (Fiscal Year 2008)
Budget Amount *help
¥17,410,000 (Direct Cost: ¥14,800,000、Indirect Cost: ¥2,610,000)
Fiscal Year 2008: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2007: ¥6,370,000 (Direct Cost: ¥4,900,000、Indirect Cost: ¥1,470,000)
Fiscal Year 2006: ¥6,100,000 (Direct Cost: ¥6,100,000)
Keywords臨床検査システム / マイクロRNA / マススペクトロメトリー / プロテオミクス / 網羅的発現解析 / バイオインフォマティクス解析
Research Abstract

本研究はマイクロNAと蛋白の発現プロファイルに着目し、4個のマイクロRNAの発現情報に基づく予後診断モデルの構築に成功するとともに、マイクロRNAと蛋白の両者の発現情報を加味したさらに高精度な予測モデルの構築にも成功した。一方、血液試料を用いた癌の早期発見を目指した膵臓癌のMALDI-MS解析による存在診断については、膵臓癌を7個の蛋白の発現量をもとに感度73%、特異度94%の高精度で検出可能とする診断システムの構築に成功した。

Report

(4 results)
  • 2008 Annual Research Report   Final Research Report ( PDF )
  • 2007 Annual Research Report
  • 2006 Annual Research Report
  • Research Products

    (78 results)

All 2009 2008 2007 2006

All Journal Article (59 results) (of which Peer Reviewed: 36 results) Presentation (16 results) Patent(Industrial Property Rights) (3 results)

  • [Journal Article] Relapse-related molecular signature in lung adenocarcinomas identifies patients with dismal prognosis2009

    • Author(s)
      Tomida, S., Takeuchi, T., Takahashi, T.(8人中8番目), et.al.
    • Journal Title

      J. Clin. Oncol (in press)

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Relationship of deregulated signaling converging onto mTOR with prognosis and classification of lung adenocarcinoma shown by two independent in silico analyses2009

    • Author(s)
      Ebi, H., Tomida, S., Takahashi, T.(9人中9番目), et.al.
    • Journal Title

      Cancer Res (in press)

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Relapse-related molecular signature in lung adenocarcinomas identifies patients with dismal prognosis2009

    • Author(s)
      Tomida s, et al.
    • Journal Title

      Journal of Clinical Oncology (in press)

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Relationship of deregulated signaling converging onto mTOR with prognosis and classification of lung adenocarcinoma shown by two independent in silico analyses2009

    • Author(s)
      Ebi H, et al.
    • Journal Title

      Cancer Research (in press)

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Identification of HIF-1α as a novel target for miR-17-92 microRNA cluster2008

    • Author(s)
      Taguchi, A., Yanagisawa, K., Takahashi, T.(7人中7番目), et.al.
    • Journal Title

      Cancer Res 68

      Pages: 5540-5545

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Roles of ASH1 in DKK1 and E-cadherin repression and neuroendocrine differentiation in lung cancer2008

    • Author(s)
      Osada, H., Tomida, S., Takahashi, T.,(9人中9番目), et.al.
    • Journal Title

      Cancer Res 68

      Pages: 1647-1655

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Detailed characterization of a homozygously deleted region corresponding to a candidate tumor suppressor locus at 21q11-21 in human lung cancer2008

    • Author(s)
      Yamada, H., Yanagisawa, K., Takahashi, T.(8人中8番目), et.al.
    • Journal Title

      Genes, Chromosomes, Cancer 47

      Pages: 810-818

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Epidermal growth factor receptor gene amplification is acquired in association with tumor progression of EGFR-mutated lung cancer2008

    • Author(s)
      Yatabe, Y., Takahashi, T., and Mitsudomi, T.
    • Journal Title

      Cancer Res 68

      Pages: 2106-2111

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] let-7 regulates Dicer expression and constitutes a negative feedback loop2008

    • Author(s)
      Tokumaru, S., Suzuki, M., Yamada, H., Nagino, N. and Takahashi, T.
    • Journal Title

      Carcinogenesis 29

      Pages: 2073-2077

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] mRNA expression of RRM1, ERCC1 and ERCC2 is not associated with chemosensitivity to cisplatin, carboplatin and gemcitabine in human lung cancer cell lines2008

    • Author(s)
      Shimizu, J., Horio, Y., Takahashi, T.(9人中7番目), et.al.
    • Journal Title

      Respirology 13

      Pages: 510-517

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Identification of HIF-1α as a novel target for miR-17-92 microRNA cluster2008

    • Author(s)
      Taguchi A, et al.
    • Journal Title

      Cancer Research 68

      Pages: 1647-1655

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Roles of ASH1 in DKK1 and E-cadherin repression and neuroendocrine differentiation in lung cancer2008

    • Author(s)
      Osada H, et al.
    • Journal Title

      Cancer Research 68

      Pages: 1647-1655

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Epidermal growth factor receptor gene amplification is acquired in association with tumor progression of EGFR-mutated lung cancer2008

    • Author(s)
      Yatabe Y, et al.
    • Journal Title

      Cancer Research 68

      Pages: 2106-2111

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] let-7 regulates Dicer expression and constitutes a negative feedback loop2008

    • Author(s)
      Tokumaru S, et al.
    • Journal Title

      Carcinogenesis 29

      Pages: 2073-2077

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Detailed characterization of a homozygously deleted region corresponding to a candidate tumor suppressor locus at 21qll-21 in human lung cancer2008

    • Author(s)
      Yamada H, et al.
    • Journal Title

      Genes, Chromosomes, Cancer 47

      Pages: 810-818

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] mRNA expression of RRM1, ERCC1 and ERCC2 is not associated with chemosensitivity to cisplatin, carboplatin and gemcitabine in human lung cancer cell lines2008

    • Author(s)
      Shimizu J, et al.
    • Journal Title

      Respirology 13

      Pages: 510-517

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Roles of ASHI in DKKI and E-cadherin repression and neuroendocrine differentiation in lung cancer.2008

    • Author(s)
      Osada H, et. al.
    • Journal Title

      Cancer Res. (in press)

    • Related Report
      2007 Annual Research Report
  • [Journal Article] A 25-signal proteomic signature and outcome for patients with resected non-small-cell lung cancer2007

    • Author(s)
      Yanagisawa, K., Tomida, S., Takahashi, T.(6人中6番目), et.al.
    • Journal Title

      J. Natl. Cancer Inst 99

      Pages: 858-867

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Lineage-specific dependency of lung adenocarcinomas on the lung development regulator TTF-12007

    • Author(s)
      Tanaka, H., Yanagisawa, K., Takahashi, T.(15人中15番目), et.al.
    • Journal Title

      Cancer Res 67

      Pages: 6007-6011

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Novel NBS1 heterozygous germline mutation causing MRE11-binding domain loss predisposes to common types of cancer2007

    • Author(s)
      Ebi, H., Matsuo, K., Takahashi, T.(8人中8番目), et.al.
    • Journal Title

      Cancer Res 67

      Pages: 11158-65

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] CLCP1 interacts with semaphorin 4B and regulates motility of lung cancer cells2007

    • Author(s)
      Nagai, H., Sugito, N., Takahashi, T.(10人中9番目), et.al.
    • Journal Title

      Oncogene 26

      Pages: 4025-4031

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Apoptosis induction by antisense oligonucleotides against miR-17-5p and miR-20a in lung cancers overexpressing miR-17-922007

    • Author(s)
      Matsubara, H., Takeuchi, T., Takahashi, T.(12人中12番目), et.al.
    • Journal Title

      Oncogene 26

      Pages: 6099-6105

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Identification of a metastasis signature and the DLX4 homeobox protein as a regulator of metastasis by combined transcriptome approach2007

    • Author(s)
      Tomida, S., Yanagisawa, K., Takahashi, T.(7人中7番目), et.al.
    • Journal Title

      Oncogene 26

      Pages: 4600-4608

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Non-genomic β estrogen receptors enhance β1 adrenergic signaling induced by the nicotine-derived carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone in human small airway epithelial cells2007

    • Author(s)
      Majidi, M., Al-Wadei, H. A., Takahashi, T. and Schuller H. M.
    • Journal Title

      Cancer Res 67

      Pages: 6863-6871

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] hDREF regulates cell proliferation and expression of ribosomalprotein genes2007

    • Author(s)
      Yamashita, D., Sano, Y., Takahashi, T.(9人中6番目), et.al.
    • Journal Title

      Mol Cell Biol 27

      Pages: 2003-2013

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Expression profiling of genes regulated by TGF-beta : Differential regulation in normal and tumour cells2007

    • Author(s)
      Ranganathan, P., Agrawal, A., Takahashi, T.(7人中6番目), et.al.
    • Journal Title

      BMC Genomics 8

      Pages: 98-98

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Aryl radical involvement in amiodarone-induced pulmonary toxicity : Investigation of cytoprotection by spin trapping nitorones2007

    • Author(s)
      Nicolescu, A.C., Comeau, J.L., Takahashi, T.(8人中5番目), et.al.
    • Journal Title

      Toxicol. Appl. Pharmacol 220

      Pages: 60-71

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] ESDN is a marker of vascular remodeling and regulator of cell proliferation in graft arteriosclerosis2007

    • Author(s)
      Sadeghi, M. M., Esmailzadeh, L., Takahashi, T.(13人中10番目), et.al.
    • Journal Title

      Am. J. Transplant 7

      Pages: 2098-2105

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Disproportionate representation of KRAS gene mutation in atypical adenomatous hyperplasia, but even distribution of EGFR gene mutation from preinvasive to invasive adenocarcinomas2007

    • Author(s)
      Sakamoto, H., Shimizu, J., Takahashi, T.(7人中5番目), et.al.
    • Journal Title

      J Pathol 212

      Pages: 287-94

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] LKB1 gene mutations in Japanese lung cancer patients2007

    • Author(s)
      Onozato, R., Kosaka, T., Takahashi, T.(7人中5番目), et.al.
    • Journal Title

      Cancer Sci 98

      Pages: 1747-1751

    • NAID

      10020119091

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] MicroRNAs in Biological Processes and Carcinogenesis2007

    • Author(s)
      Osada, H. and Takahashi, T.
    • Journal Title

      Carcinogenesis 28

      Pages: 2-12

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Identification of a metastasis signature and the DLX4 homeobox protein as a regulator of metastasis by combined transcriptome approach.2007

    • Author(s)
      Tomida S, et. al.
    • Journal Title

      Oncogene 26

      Pages: 466-4608

    • Related Report
      2007 Annual Research Report
  • [Journal Article] CLCP1 interacts with semaphorin 4B and regulates motility of lung cancer cells2007

    • Author(s)
      Nagai H, et. al.
    • Journal Title

      Oncogene 26

      Pages: 4025-4031

    • Related Report
      2007 Annual Research Report
  • [Journal Article] Apoptosis induction by antisense oligonucleotides against miR-17-5p and miR-20a in lung cancers overexpressing miR-17-92.2007

    • Author(s)
      Matsubara H, et. al.
    • Journal Title

      Oncogene 26

      Pages: 6099-6105

    • Related Report
      2007 Annual Research Report
  • [Journal Article] A25-signal proteomic signature and outcome for patients with resected non-small-cell lung cancer.2007

    • Author(s)
      Yanagisawa K, et. al.
    • Journal Title

      J. Natl. Cancer Inst. 99

      Pages: 858-867

    • Related Report
      2007 Annual Research Report
  • [Journal Article] Lineage-specific dependency of lung adenocarcinomas on the lung development regulator TTF-1.2007

    • Author(s)
      Tanaka H, et. al.
    • Journal Title

      Cancer Res. 67

      Pages: 6007-6011

    • Related Report
      2007 Annual Research Report
  • [Journal Article] Novel NBSl heterozygous germline mutation causing MRE11-binding domain loss predisposes to common types of cancer.2007

    • Author(s)
      Ebi H, et. al.
    • Journal Title

      Cancer Res. 67

      Pages: 11158-11165

    • Related Report
      2007 Annual Research Report
  • [Journal Article] Non-genomic estrogen receptors enhance 1 adrenergic signaling induced by the nicotine-derived carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone in human small airway epithelial cells.2007

    • Author(s)
      Majidi M, et. al.
    • Journal Title

      Carcinogenesis 67

      Pages: 6863-6871

    • Related Report
      2007 Annual Research Report
  • [Journal Article] Disproportionate representation of KRAS gene mutation in atypical adenomatous hyperplasia, but even distribution of EGFR gene mutation from preinvasive to invasive adenocarcinomas.2007

    • Author(s)
      Sakamoto H, et. al.
    • Journal Title

      J. Pathol. 212

      Pages: 287-294

    • Related Report
      2007 Annual Research Report
  • [Journal Article] Identification of a metastasis signature and the DLX4 homeobox protein as a regulator of metastasis by combined transcriptome approach.2007

    • Author(s)
      Onozato R, et. al.
    • Journal Title

      Cancer Sci. 98

      Pages: 1747-1751

    • Related Report
      2007 Annual Research Report
  • [Journal Article] Aryl radical involvement in amiodarone-induced pulmonary toxicity:Investigation of cytoprotection by spin trapping nitorones.2007

    • Author(s)
      Nicolescu AC, et. al.
    • Journal Title

      Toxicol. Appl. Pharmacol. 220

      Pages: 60-71

    • Related Report
      2007 Annual Research Report
  • [Journal Article] hDREF regulates cell proliferation and expression of ribosomal protein genes.2007

    • Author(s)
      Yamashita D, et. al.
    • Journal Title

      Mol. Cell. Biol. 27

      Pages: 2003-2013

    • Related Report
      2007 Annual Research Report
  • [Journal Article] hDREF regulates cell proliferation and expression of ribosomal protein genes.2007

    • Author(s)
      Yamashita D et al.
    • Journal Title

      Molecular and Cellular Biology 27

      Pages: 2003-2013

    • Related Report
      2006 Annual Research Report
  • [Journal Article] MicroRNAs in Biological Processes and Carcinogenesis.2007

    • Author(s)
      Osada H et al.
    • Journal Title

      Carcinogenesis 28

      Pages: 2-12

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Apoptosis induction by antisense oligonucleotides against miR-17-5p and miR-20a in lung cancers overexpressing miR-17-92.2007

    • Author(s)
      Matsubara H et al.
    • Journal Title

      Oncogene (in press)

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Identification of a metastasis signature and the DLX4 homeobox protein as a regulator of metastasis by combined transcriptome approach.2007

    • Author(s)
      Tomida S et al.
    • Journal Title

      Oncogene (in press)

    • Related Report
      2006 Annual Research Report
  • [Journal Article] CLCP1 interacts with semaphorin 4B and regulates motility of lung cancer cells.2007

    • Author(s)
      Nagai H et al.
    • Journal Title

      Oncogene (in press)

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Expression profile-defined classification of lung adenocarcinoma shows close relationship with underlying major genetic changes and clinicopathologic behaviors2006

    • Author(s)
      Takeuchi, T., Tomida, S., Takahashi, T.(8人中8番目), et.al.
    • Journal Title

      J. Clin. Oncol 24

      Pages: 1679-1688

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Altered regulation of c-jun and its involvement in anchorage-independent growth of human lung cancers2006

    • Author(s)
      Maeno, K., Masuda, A., Takahashi, T.(8人中8番目), et.al.
    • Journal Title

      Oncogene 25

      Pages: 271-277

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] A rapid, sensitive assay to detect EGFR mutation in small biopsy specimens from lung cancer2006

    • Author(s)
      Yatabe, Y., Hida, T., Takahashi, T.(6人中5番目), et.al.
    • Journal Title

      J Mol Diagn 8

      Pages: 335-341

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Caffeine stimulates the proliferation of human lung adenocarcinoma cells and small airway epithelial cells via activation of PKA, CREB and ERK1/22006

    • Author(s)
      Al-Wadei, H.A., Takahashi, T., and Schuller, H.M.
    • Journal Title

      Oncol Rep 15

      Pages: 431-435

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Fundamental study of small interfering RNAs for ganglioside GD3 synthase gene as a therapeutic target of lung cancers2006

    • Author(s)
      Ko, K., Furukawa, K., Takahashi, T., et.al.(8人中3番目)
    • Journal Title

      Oncogene 25

      Pages: 6924-6935

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Growth regulation via insulin-like growth factor binding protein-4 and -2 in association with mutant K-ras in lung epithelia2006

    • Author(s)
      Sato, H., Yazawa, T., Takahashi, T.(13人中11番目), et.al.
    • Journal Title

      Am J Pathol 169

      Pages: 1550-1566

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Expression profile-defined classification of lung adenocarcinoma shows close relationship with underlying major genetic changes and clinicopathologic behaviors.2006

    • Author(s)
      Takeuchi T et al.
    • Journal Title

      Journal of Clinical Oncology 24

      Pages: 155-160

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Altered regulation of c-jun and its involvement in anchorage-independent growth of human lung cancers.2006

    • Author(s)
      Maeno K et al.
    • Journal Title

      Oncogene 25

      Pages: 271-277

    • Related Report
      2006 Annual Research Report
  • [Journal Article] A rapid, sensitive assay to detect EGFR mutation in small biopsy specimens from lung cancer.2006

    • Author(s)
      Yatabe Y et al.
    • Journal Title

      Journal of Molecular Diagnosis 8

      Pages: 335-341

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Growth regulation via insulin-like growth factor binding protein-4 and -2 in association with mutant K-ras in lung epithelia.2006

    • Author(s)
      Sato H et al.
    • Journal Title

      American Journal of Pathology 169

      Pages: 1550-1556

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Fundamental study of small interfering RNAs for gaglioside GD3 synthase gene as a therapeutic target of lung cancers.2006

    • Author(s)
      Ko K et al.
    • Journal Title

      Oncogene 25

      Pages: 6924-6935

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Growth stimulation of human pulmonary adenocarcinoma cells and small airway epithelial cells by beta-carotene via activation of cAMP, PKA, CREB and ERK1/2.2006

    • Author(s)
      Al-Wadei HA et al.
    • Journal Title

      International Journal of Cancer 118

      Pages: 1370-1380

    • Related Report
      2006 Annual Research Report
  • [Presentation] ヒト肺癌の多様性の理解を目指して(シンポジウム)2008

    • Author(s)
      高橋隆
    • Organizer
      第31回日本分子生物学会年会、第81回日本生化学会大会合同大会
    • Place of Presentation
      名古屋
    • Year and Date
      2008-12-11
    • Related Report
      2008 Final Research Report
  • [Presentation] ゲノム情報の読出しに反映された肺腺癌の分子病態の多様性(シンポジウム)2008

    • Author(s)
      高橋隆
    • Organizer
      第49回日本肺癌学会総会
    • Place of Presentation
      名古屋
    • Year and Date
      2008-10-30
    • Related Report
      2008 Final Research Report
  • [Presentation] ヒト肺癌の病態とマイクロRNAの異常(シンポジウム)2008

    • Author(s)
      高橋隆
    • Organizer
      第68回日本癌学会学術総会
    • Place of Presentation
      名古屋
    • Year and Date
      2008-10-30
    • Related Report
      2008 Final Research Report
  • [Presentation] ヒト肺癌の病態とマイクロRNAの異常(シンポジウム)2008

    • Author(s)
      高橋隆
    • Organizer
      第67回日本癌学会学術総会
    • Place of Presentation
      名古屋
    • Year and Date
      2008-10-30
    • Related Report
      2008 Annual Research Report
  • [Presentation] ヒト癌の分子病態の多様性 : 網羅的発現解析による描出と応用(教育講演)2008

    • Author(s)
      高橋隆
    • Organizer
      第19回日本消化器癌発生学会総会
    • Place of Presentation
      別府
    • Year and Date
      2008-08-28
    • Related Report
      2008 Final Research Report
  • [Presentation] "Omics views" of lung cancers(シンポジウム)2008

    • Author(s)
      Takahashi T
    • Organizer
      The 2^<nd> Asian Pacific conference on perspectives in lung cancer
    • Place of Presentation
      Sapporo, Japan
    • Year and Date
      2008-08-02
    • Related Report
      2008 Final Research Report
  • [Presentation] Improved integrative "omics" view and an unresolved question in lung cancer pathogenesis(ワークショップ)2008

    • Author(s)
      Takahashi T
    • Organizer
      1^<st> European Lung Cancer Conference
    • Place of Presentation
      Geneva, Switzerland
    • Year and Date
      2008-04-25
    • Related Report
      2008 Final Research Report
  • [Presentation] Improved integrative“omics"view and an unresolved question in lung cancer pathogenesis (ワークショップ)2008

    • Author(s)
      Takahashi T
    • Organizer
      1^<st> European Lung Cancer Conference
    • Place of Presentation
      Geneva, Switzerland
    • Year and Date
      2008-04-25
    • Related Report
      2008 Annual Research Report
  • [Presentation] Omics views" of lung cancers (シンポジウム)2008

    • Author(s)
      Takahashi T
    • Organizer
      The 2^<nd> Asian Pacific conference on perspectives in lung cancer
    • Place of Presentation
      Sapporo, Japan
    • Related Report
      2008 Annual Research Report
  • [Presentation] 肺癌分子病態の基礎的理解のアップデートとこれから(教育講演)2007

    • Author(s)
      高橋隆
    • Organizer
      第48回日本肺癌学会総会
    • Place of Presentation
      名古屋
    • Year and Date
      2007-11-08
    • Related Report
      2008 Final Research Report
  • [Presentation] microRNA alterations in the molecular pathogenesis of lung cancers.(シンポジウム)2007

    • Author(s)
      高橋隆
    • Place of Presentation
      横浜
    • Year and Date
      2007-10-04
    • Related Report
      2008 Final Research Report
  • [Presentation] microRNA alterations in the pathogenesis of lung cancer(シンポジウム)2007

    • Author(s)
      Takahashi, T
    • Organizer
      33rd Annual Meeting of the Korean Cancer Association
    • Place of Presentation
      Seoul, Korea
    • Year and Date
      2007-06-14
    • Related Report
      2008 Final Research Report
  • [Presentation] MicroRNAs in Biological Processes and Carcinogenesis(Meet-the-Professorセッション)2007

    • Author(s)
      Takahashi, T
    • Organizer
      33rd Annual Meeting of the Korean Cancer Association
    • Place of Presentation
      Seoul, Korea
    • Year and Date
      2007-06-14
    • Related Report
      2008 Final Research Report
  • [Presentation] 肺腺癌の発生とterminal respiratory unit(TRU)(シンポジウム)2007

    • Author(s)
      高橋隆
    • Organizer
      第47回日本呼吸器学会総会
    • Year and Date
      2007-05-12
    • Related Report
      2008 Final Research Report
  • [Presentation] ヒト肺癌におけるマイクロRNAの発現異常とその役割(シンポジウム)2007

    • Author(s)
      高橋隆
    • Organizer
      第95回日本病理学会総会
    • Year and Date
      2007-05-01
    • Related Report
      2008 Final Research Report
  • [Presentation] Transcriptome and proteome analyses toward better understandings of lung cancer biology and realization of tailor-made medicine(シンポジウム)2006

    • Author(s)
      Takahashi, T
    • Organizer
      Asia-Pacific Congress on Lung Cancer
    • Place of Presentation
      Taipei, Taiwan
    • Year and Date
      2006-12-03
    • Related Report
      2008 Final Research Report
  • [Patent(Industrial Property Rights)] 質量分析法を利用した複数癌腫の血液検出のための方法および生物マーカー2008

    • Inventor(s)
      高橋隆、柳澤聖、冨田秀太、他4名
    • Industrial Property Rights Holder
      国立大学法人名古屋大学、他2者
    • Industrial Property Number
      2008-235216
    • Filing Date
      2008-09-12
    • Related Report
      2008 Final Research Report
  • [Patent(Industrial Property Rights)] 質量分析法を利用した複数癌腫の血液検出のための方法および生物マーカー2008

    • Inventor(s)
      高橋隆, 柳澤聖, 冨田秀太, 他4名
    • Industrial Property Rights Holder
      国立大学法人名古屋大学, 他2者
    • Industrial Property Number
      2008-235216
    • Filing Date
      2008-09-12
    • Related Report
      2008 Annual Research Report
  • [Patent(Industrial Property Rights)] 癌の新規治療用組成物2006

    • Inventor(s)
      高橋隆, 柳澤聖, 他1名
    • Industrial Property Rights Holder
      名古屋大学, 愛知県
    • Filing Date
      2006-04-27
    • Related Report
      2006 Annual Research Report

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Published: 2006-04-01   Modified: 2016-04-21  

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