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Establishment of epigenetic epidemiology

Research Project

Project/Area Number 18390178
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Hygiene
Research InstitutionTokyo Medical and Dental University

Principal Investigator

YUASA Yasuhito  Tokyo Medical and Dental University, Department of Molecular Oncology, Professor (80111558)

Co-Investigator(Kenkyū-buntansha) AKIYAMA Yoshimitsu  Tokyo Medical and Dental University, Department of Molecular Oncology, lecturer (80262187)
Project Period (FY) 2006 – 2007
Project Status Completed (Fiscal Year 2007)
Budget Amount *help
¥16,720,000 (Direct Cost: ¥14,800,000、Indirect Cost: ¥1,920,000)
Fiscal Year 2007: ¥8,320,000 (Direct Cost: ¥6,400,000、Indirect Cost: ¥1,920,000)
Fiscal Year 2006: ¥8,400,000 (Direct Cost: ¥8,400,000)
Keywordsgastric cancer / DNA Methylation / life style / smoking / CDX2 / BMP-2 / biomarker / risk evaluation / エビジェネティクス / メチル化 / 血球DNA / 緑茶 / カルシウムチャンネル
Research Abstract

(1) Epigenetic gene silencing through DNA methylation is one of the important steps in the mechanism underlying tumorigenesis, including of the stomach. Past lifestyle factors of cancer patients, such as intake of vegetables, are very important to affect gastric carcinogenesis. However, the relationship between DNA methylation and past dietary habits in cancer patients remains largely unknown. We analyzed the methylation states of the CDX2, BMP-2, p16. CACNA2D3, GATA-5, and estrogen receptor genes in 106 primary gastric cancers by methylation-specific PCR, and compared them with the past lifestyle of the patients. Methylation of CDX2 and BMP-2 was correlated with the decreased intake of green tea. Methylation of CACNA2D3 was inversely correlated with the physical activity. Thus, the past lifestyle could be important factors determining the methylation states of genes and the resultant aberrant expression of genes involved in carcinogenesis.
(2) SOX transcription factors play critical ro … More les in cell fate determination, differentiation and proliferation. We previously reported that the SOX2 protein is expressed in normal gastric mucosae but down-regulated in some human gastric carcinomas. To clarify the roles of SOX2 in gastric carcinogenesis, we carried out functional characterization of SOX2 in gastric epithelial cell lines. Exogenous expression of SOX2 suppressed cell proliferation in gastric epithelial cells. Flow cytometry analysis revealed that SOX2-overexpressing cells exhibited cell cycle arrest and apoptosis. SOX2 hypermethylation signals were observed in some cultured and primary gastric cancers with no or weak SOX2 expression. Among the 52 patients with advanced gastric cancers, those with cancers showing SOX2 methylation had a significantly shorter survival time than those without this methylation. Hence, SOX2 plays important roles in growth inhibition through cell cycle arrest and apoptosis in gastric epithelial cells, and the loss of SOX2 expression may be related to gastric carcinogenesis and poor prognosis. Less

Report

(3 results)
  • 2007 Annual Research Report   Final Research Report Summary
  • 2006 Annual Research Report
  • Research Products

    (77 results)

All 2008 2007 2006 Other

All Journal Article (38 results) (of which Peer Reviewed: 15 results) Presentation (38 results) Book (1 results)

  • [Journal Article] SOX2 is frequently down-regulated in gastric cancers and inhibits cell growth through cell cycle arrest and apoptosis.2008

    • Author(s)
      Otsubo T, et. al.
    • Journal Title

      Brit. J. Cancer 98

      Pages: 824-831

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Annual Research Report 2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] IQGAP2 inactivation through aberrant promoter methylation and promotion of invasion in gastric cancer cells.2008

    • Author(s)
      Jin S-H, et. al.
    • Journal Title

      Int. J. Cancer 122

      Pages: 1040-1046

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Annual Research Report 2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Differentiation in vitro of Runx3-/-p53-/- gastric epithelial cells into intestinal type cells.2008

    • Author(s)
      Fukamachi H, et. al.
    • Journal Title

      Cancer Sci. 99

      Pages: 671-676

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] SOX2 is frequently down-regulated in gastric cancers and inhibits cell growth through cell cycle arrest and apoptosis2008

    • Author(s)
      Otsubo T, et. al.
    • Journal Title

      Brit. J. Cancer 98

      Pages: 824-831

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] IQGAP2 inactivation through aberrant promoter methylation and promotion of invasion in gastric cancer cells2008

    • Author(s)
      Jin S-H, et. al.
    • Journal Title

      Int. J. Cancer 122

      Pages: 1040-1046

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Differentiation in vitro of Runr3-/-p53-/-gastric epithelial cells into intestinal type cells2008

    • Author(s)
      Fukamachi H, et. al.
    • Journal Title

      Cancer Sci 99

      Pages: 671-676

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Differentiation in vitro of Runx3-/-p53-/-gastric epithelial cells into intestinal type cells.2008

    • Author(s)
      Fukamachi H, et. al.
    • Journal Title

      Cancer Sci. 99

      Pages: 671-676

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Human Gsα mutant causes pseudohypoparathyroidism type Ia/neonatal diarrhea, a potential cell-specific role of the palmitoylation cycle.2007

    • Author(s)
      Makita N, et. al.
    • Journal Title

      Proc. Natl. Acad. Sci. U.S.A. 104

      Pages: 17424-17429

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Annual Research Report 2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Transcription factor SOX2 up-regulates stomach-specific pepsinogen A gene expression.2007

    • Author(s)
      Tani Y, et. al.
    • Journal Title

      J. Cancer Res. Clin. Oncology 133

      Pages: 263-269

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Annual Research Report 2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Dual blockade of the Hedgehog and ERK1/2 pathways coordinately decreases proliferation and survival of cholangiocarcinoma cells.2007

    • Author(s)
      Jinawath A, et. al.
    • Journal Title

      J. Cancer Res. Clin. Oncology 133

      Pages: 271-278

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Annual Research Report 2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Lysophosphatidic acid protection against apoptosis in the human pre-B cell line Nalm-6.2007

    • Author(s)
      Satoh, et. al.
    • Journal Title

      Eur. J. Hemat. 78

      Pages: 510-517

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] 質疑応答公衆衛生学がん発症と性差2007

    • Author(s)
      湯浅保仁
    • Journal Title

      日本医事新報 4326

      Pages: 92-93

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Human Gsa mutant causes pseudohypoparathyroidism type Ia/neonatal diarrhea, a potential cell-specific role of the palmitoylation cycle2007

    • Author(s)
      Makita N, et. al.
    • Journal Title

      Proc. Natl. Acad. Sci. U. S. A. 104

      Pages: 17424-17429

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Transcription factor SOX2 up-regulates stomach-specific pepsinogen A gene expression2007

    • Author(s)
      Tani Y, et. al.
    • Journal Title

      J. Cancer Res. Clin. Oncology 133

      Pages: 263-269

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Dual blockade of the Hedgehog and ERK1/2 pathways coordinately decreases proliferation and survival of cholangiocarcinoma cells2007

    • Author(s)
      Jinawath A, et. al.
    • Journal Title

      J. Cancer Res. Clin. Oncology 133

      Pages: 271-278

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Lysophosphatidic acid protection against apoptosis in the human pre-B cell line Nalm-62007

    • Author(s)
      Satoh, et. al.
    • Journal Title

      Eur. J. Hemat 78

      Pages: 510-517

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Lysophosphatidic acid protection against apoptosis in the humanpre-B cell line Nalm-6.2007

    • Author(s)
      Satoh, et. al.
    • Journal Title

      Eur. J. Hemat. 78

      Pages: 510-517

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 質疑応答 公衆衛生学 がん発症と性差2007

    • Author(s)
      湯浅保仁
    • Journal Title

      日本医事新報 4326

      Pages: 92-93

    • Related Report
      2007 Annual Research Report
  • [Journal Article] Dual blockaed of the Hedgehog and ERK1/2 pathways coordinately decreases proliferation and survival of cholangiocarcinoma cells.2007

    • Author(s)
      Jinawath A, et al.
    • Journal Title

      J. Cancer Res. Clin. Oncology 133

      Pages: 271-278

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Transcription factor SOX2 up-regulates stomach-specific pepsinogen A gene expression.2007

    • Author(s)
      Tani Y, et al.
    • Journal Title

      J. Cancer Res. Clin. Oncology 133

      Pages: 263-269

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Lysophosphatidic acid protection against apoptosis in the human pre-B cell line Nalm-6.2007

    • Author(s)
      Satoh, et al.
    • Journal Title

      Eur. J. Hemat. in press

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Frequent epigenetic silencing of the bone morphogenetic protein 2 gene by methylation in gastric carcinomas.2006

    • Author(s)
      Wen X-Z, et. al.
    • Journal Title

      Oncogene 25

      Pages: 2666-2673

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Involvement of GATA-4/-5 transcription factors in ovarian carcinogenesis.2006

    • Author(s)
      Wakana K, et. al.
    • Journal Title

      Cancer Letters 241

      Pages: 281-288

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Hath1up-regulates gastric mucin genes in gastric cells.2006

    • Author(s)
      SekineaA, et al.
    • Journal Title

      SekineA, et al. 344

      Pages: 166-1171

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Expression of phosphorylated ERK1/2 and homeodomain protein CDX2 in cholangiocarcinoma.2006

    • Author(s)
      Jinawath A, et. al.
    • Journal Title

      J. Cancer Res. Clin. Oncology 132

      Pages: 805-810

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Inhibition of DNA binding of Sox2 by the SUMO conjugation.2006

    • Author(s)
      Tsuruzoe S, et. al.
    • Journal Title

      Biochem. Biophys. Res. Commun. 351

      Pages: 920-926

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Frequent epigenetic silencing of the bone morphogenetic protein 2 gene by methylation in gastric carcinomas2006

    • Author(s)
      Wen X-Z, et. al.
    • Journal Title

      Oncogene 25

      Pages: 2666-2673

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Involvement of GATA-4/-5 transcription factors in ovarian carcinogenesis2006

    • Author(s)
      Wakana K, et. al.
    • Journal Title

      Cancer Letters 241

      Pages: 281-288

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Hath1 up-regulates gastric mucin genes in gastric cells2006

    • Author(s)
      Sekine A, et. al.
    • Journal Title

      Biochem. Biophys. Res. Commun 344

      Pages: 1166-1171

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Expression of phosphorylated ERK1/2 and homeodomain protein CDX2 in cholangiocarcinoma2006

    • Author(s)
      Jinawath A, et. al.
    • Journal Title

      J. Cancer Res. Clin. Oncology 132

      Pages: 805-810

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Inhibition of DNA binding of Sox2 by the SUMO conjugation2006

    • Author(s)
      Tsuruzoe S, et. al.
    • Journal Title

      Biochem. Biophys. Res. Commun 351

      Pages: 920-926

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Frequent epigenetic silencing of the bone morphogenetic protein 2 gene by methylation in gastric carcinomas.2006

    • Author(s)
      Wen X-Z, et al.
    • Journal Title

      Oncogene 25

      Pages: 2666-2673

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Involvement of GATA-4/-5 transcription factors in ovarian carcinogenesis.2006

    • Author(s)
      Wakana K, et al.
    • Journal Title

      Cancer Letters 241

      Pages: 281-288

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Hathl up-regulates gastric mucin genes in gastric cells.2006

    • Author(s)
      Sekine A, et al.
    • Journal Title

      Biochem. Biophys. Res. Commun. 344

      Pages: 1166-1171

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Expression of phosphorylated ERK1/2 and homeodomain protein CDX2 in cholangiocarcinoma.2006

    • Author(s)
      Jinawath A, et al.
    • Journal Title

      J. Cancer Res. Clin. Oncology 132

      Pages: 805-810

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Inhibition of DNA binding of Sox2 by the SUMO conjugation.2006

    • Author(s)
      Tsuruzoe S, et al.
    • Journal Title

      Biochem. Biophys. Res. Commun. 351

      Pages: 920-926

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Methylation of the calcium channel-related gene, CACNA2D3, is frequent and a poor prognostic factor in gastric cancer.

    • Author(s)
      Wanajo A, et. al.
    • Journal Title

      Gastroenterology (in press)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Methylation of the calcium channel-related gene, CACNA2D3, is frequent and a poor prognostic factor in gastric cancer

    • Author(s)
      Wanajo A, et. al.
    • Journal Title

      Gastroenterology (in press)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Hypermethylation of GATA4 and GATA5 transcription factor genes in gastric cancer.2007

    • Author(s)
      Akiyama Y, Yuasa Y
    • Organizer
      The 12th Korea-Japan Cancer Research Workshop
    • Place of Presentation
      札幌
    • Year and Date
      2007-12-22
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Annual Research Report 2007 Final Research Report Summary
  • [Presentation] Hypermethylation of GATA4 and GATA5 transcription factor genes in gastric cancer2007

    • Author(s)
      Akiyyama Y, Yuasa Y
    • Organizer
      The 12th Korea-Japan Cancer Research Workshop
    • Place of Presentation
      Sapporo, Japan
    • Year and Date
      2007-12-22
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Relationship between DNA methylation and epidemiological factors in gastric cancer patients2007

    • Author(s)
      湯浅保仁, 他
    • Organizer
      第66回日本癌学会総会
    • Place of Presentation
      横浜
    • Year and Date
      2007-10-05
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Annual Research Report 2007 Final Research Report Summary
  • [Presentation] Expression analysis of microRNA in gastric cancer2007

    • Author(s)
      和田りえ、秋山好光、深町博史、湯浅保仁
    • Organizer
      第66回日本癌学会総会
    • Place of Presentation
      横浜
    • Year and Date
      2007-10-05
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Annual Research Report 2007 Final Research Report Summary
  • [Presentation] Relationship between DNA methylation and epidemiological factors in gastric cancer patients2007

    • Author(s)
      Yuasa Y, et. al.
    • Organizer
      66th Annual Meeting of the Japanese Cancer Association
    • Place of Presentation
      Yokohama, Japan
    • Year and Date
      2007-10-05
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Expression analysis of micro RNA in gastric cancer2007

    • Author(s)
      Wada R, et. al.
    • Organizer
      66th Annual Meeting of the Japanese Cancer Association
    • Place of Presentation
      Yokohama. Japan
    • Year and Date
      2007-10-05
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Frequent methylation of GATA4 and GATA5 transcription factor genes in gastric cancer2007

    • Author(s)
      秋山好光、長崎弘美、河本絢子、湯浅保仁
    • Organizer
      第66回日本癌学会総会
    • Place of Presentation
      横浜
    • Year and Date
      2007-10-04
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Epigenetic silencing of SOX2 by DNA methylation in gastric cancers2007

    • Author(s)
      大坪武史、秋山好光、湯浅保仁
    • Organizer
      第66回日本癌学会総会
    • Place of Presentation
      横浜
    • Year and Date
      2007-10-04
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Annual Research Report 2007 Final Research Report Summary
  • [Presentation] Frequent methylation of GATA4 and GATA5 transcription factor genes in gastric cancer2007

    • Author(s)
      Akiyama Y, et. al.
    • Organizer
      66th Annual Meeting of the Japanese Cancer Association
    • Place of Presentation
      Yokohama, Japan
    • Year and Date
      2007-10-04
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Epigenetic silencing of SOX2 by DNA methylation in gastric cancers2007

    • Author(s)
      Otsubo T, et. al.
    • Organizer
      66th Annual Meeting of the Japanese Cancer Association
    • Place of Presentation
      Yokohama, Japan
    • Year and Date
      2007-10-04
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Frequent methylation of GATA4 and GATA5 transcription. factor genes in gastric cancer2007

    • Author(s)
      秋山好光、長崎弘美、河本絢子、湯浅保仁
    • Organizer
      第66回日本癌学会総会
    • Place of Presentation
      横浜
    • Year and Date
      2007-10-04
    • Related Report
      2007 Annual Research Report
  • [Presentation] Identification of stem-like cells form p53-/- gastro-intestinal epithelial cell lines by FACS2007

    • Author(s)
      深町博史、湯浅保仁
    • Organizer
      第66回日本癌学会総会
    • Place of Presentation
      横浜
    • Year and Date
      2007-10-03
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Identification of stein-like cells from p53-/-gastro-intestinal epithelial cell lines by FACS2007

    • Author(s)
      Fukamachi H, et. al.
    • Organizer
      66th Annual Meeting of the Japanese Cancer Association
    • Place of Presentation
      Yokohama, Japan
    • Year and Date
      2007-10-03
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Identification of stem-like cells from p53-/- gastro-intestinal epithelial cell lines by FACS2007

    • Author(s)
      深町博史、湯浅保仁
    • Organizer
      第66回日本癌学会総会
    • Place of Presentation
      横浜
    • Year and Date
      2007-10-03
    • Related Report
      2007 Annual Research Report
  • [Presentation] p53-/-消化管上皮細胞株内の幹様細胞の同定とその性質2007

    • Author(s)
      深町博史、湯浅保仁
    • Organizer
      日本動物学会第78回大会
    • Place of Presentation
      弘前
    • Year and Date
      2007-09-20
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Annual Research Report 2007 Final Research Report Summary
  • [Presentation] Differentiation of Runx3-/-p53-/- gastric epithelial cells into intestinal type cells in vitro2007

    • Author(s)
      Fukamachi H, Tanaka I, Ito K, Ito Y, Yuasa Y
    • Organizer
      Int. RUNX Meeting
    • Place of Presentation
      Singapore
    • Year and Date
      2007-08-20
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Differentiation of Runx3-/-p53-/- gastric epithelial cells into intestinal type cells in vitro2007

    • Author(s)
      Fukamachi H, Tanaka I, Ito K, Ito Y, Yuasa Y
    • Organizer
      Iut. RUNX Meeting
    • Place of Presentation
      Singapore
    • Year and Date
      2007-08-20
    • Related Report
      2007 Annual Research Report
  • [Presentation] GATA4 and GATA5 transcription factor genes were frequently silenced by methylation in gastric cancer2007

    • Author(s)
      Akiyama Y, Nagasaki H, Kawamoto A, Yuasa Y
    • Organizer
      The 8th Korea-Japan Joint Symposium on Cancer and Ageing Research
    • Place of Presentation
      岐阜
    • Year and Date
      2007-08-11
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Runx3-1- gastric epithelial cells differentiate into intestional type cells in vitro2007

    • Author(s)
      Fukamachi H, Tanaka I, Ito K, Ito Y, Yuasa Y
    • Organizer
      The 8th Korea-Japan Joint Symposium on Cancer and Ageing Research
    • Place of Presentation
      岐阜
    • Year and Date
      2007-08-11
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Sox2, epigentically silenced in gastric cancers, inhibits growth through cell cycle arrest and apoptosis2007

    • Author(s)
      Otsubo T, Akiyama Y, Yanagihara K, Yuasa Y
    • Organizer
      The 8th Korea-Japan Joint Symposium on Cancer and Ageing Research
    • Place of Presentation
      岐阜
    • Year and Date
      2007-08-11
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] IQGAP2 inactivation through aberrant promoter methylation and promotion of invasion in gastric cancer cells2007

    • Author(s)
      Jin S-H, Akiyama Y, Fukamachi H, Yanagihara K, Akashi T, Yuasa Y
    • Organizer
      The 8th Korea-Japan Joint Symposium on Cancer and Ageing Research
    • Place of Presentation
      岐阜
    • Year and Date
      2007-08-11
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Annual Research Report 2007 Final Research Report Summary
  • [Presentation] GATA4 and GATA5 transcription factor genes were frequently silenced by methylation in gastric cancer2007

    • Author(s)
      Akiyama Y, et. al.
    • Organizer
      The 8th Korea-Japan Joint Symposium on Cancer and Ageing Research
    • Place of Presentation
      Gifu, Japan
    • Year and Date
      2007-08-11
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Runx3-/-gastric epithelial cells differentiate into intestinal type cells in vitro2007

    • Author(s)
      Fukamachi H, et. al.
    • Organizer
      The 8th Korea-Japan Joint Symposium on Cancer and Ageing Research
    • Place of Presentation
      Gifu, Japan
    • Year and Date
      2007-08-11
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Sox2, epigenetically silenced in gastric cancers, inhibits growth through cell cycle arrest and apoptosis2007

    • Author(s)
      Otsubo T, et. al.
    • Organizer
      The 8th Korea-Japan Joint Symposium on Cancer and Ageing Research
    • Place of Presentation
      Gifu, Japan
    • Year and Date
      2007-08-11
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] IQGAP2 inactivation through aberrant promoter methylation and promotion of invasion in gastric cancer cells2007

    • Author(s)
      Jin S-H, et. al.
    • Organizer
      The 8th Korea-Japan Joint Symposium on Cancer and Ageing Research
    • Place of Presentation
      Gifu, Japan
    • Year and Date
      2007-08-11
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Differentiation of Runr3-/p53-/-gastric epithelial cells into intestinal typecells in vitro2007

    • Author(s)
      Fukamachi H, et. al.
    • Organizer
      The 8th Korea-Japan Joint Symposium on Cancer and Ageing Research
    • Place of Presentation
      Gifu, Japan
    • Year and Date
      2007-08-11
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] GATA4 and transcription factor genes were frequently silenced by methylation in gastric cancer2007

    • Author(s)
      Akiyama Y, Nagasaki H, Kawamoto A, Yuasa Y
    • Organizer
      The 8th Korea-Japan Joint Symposium on Cancer and Ageing Research
    • Place of Presentation
      岐阜
    • Year and Date
      2007-08-11
    • Related Report
      2007 Annual Research Report
  • [Presentation] Runx3-/- gastric epithelial cells differentiate into intestinal type cells in vitro2007

    • Author(s)
      Fukamachi H, Tanaka I, Ito K, Ito Y, Yuasa Y
    • Organizer
      The 8th Korea-Japan Joint Symposium on Cancer and Ageing Research
    • Place of Presentation
      岐阜
    • Year and Date
      2007-08-11
    • Related Report
      2007 Annual Research Report
  • [Presentation] Sox2, epigenetically silenced in gastric cancers, inhibits growth through cell cycle arrest and apoptosis2007

    • Author(s)
      Otsubo T, Akiyama Y, Yanagihara K, Yuasa Y
    • Organizer
      The 8th Korea-Japan Joint Svmnosium on Cancer and Ageing Research
    • Place of Presentation
      岐阜
    • Year and Date
      2007-08-11
    • Related Report
      2007 Annual Research Report
  • [Presentation] 胃がんにおけるメチル化異常とエピジェネティクス疫学2007

    • Author(s)
      湯浅保仁, 他
    • Organizer
      第14回日本がん予防学会・第8回日本がん分子疫学研究会・第30回日本がん疫学研究会合同大会
    • Place of Presentation
      東京
    • Year and Date
      2007-07-13
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Annual Research Report 2007 Final Research Report Summary
  • [Presentation] 胃がんにおける転写関連遺伝子GATA4/5のメチル化の解析2007

    • Author(s)
      秋山好光、長崎弘美、河本絢子、湯浅保仁
    • Organizer
      第14回日本がん予防学会・第8回日本がん分子疫学研究会・第30回日本がん疫学研究会合同大会
    • Place of Presentation
      東京
    • Year and Date
      2007-07-13
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Annual Research Report 2007 Final Research Report Summary
  • [Presentation] 胃がんにおけるメチル化異常と疫学的因子との関連2007

    • Author(s)
      湯浅保仁, 他
    • Organizer
      第1回日本エピジェネティクス研究会年会
    • Place of Presentation
      大阪
    • Year and Date
      2007-06-15
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Annual Research Report 2007 Final Research Report Summary
  • [Presentation] 転写固子GATA-5の遺伝子プロモーター領域の解析.2007

    • Author(s)
      秋山好光、大脇秀一、湯浅保仁
    • Organizer
      第1回日本エピジェネティクス研究会年会
    • Place of Presentation
      大阪
    • Year and Date
      2007-06-15
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 転写因子GATA-5の遺伝子プロモーター領域の解析2007

    • Author(s)
      秋山好光、大脇秀一、湯浅保仁
    • Organizer
      第1回日本エピジェネティクス研究会年会
    • Place of Presentation
      大阪
    • Year and Date
      2007-06-15
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Annual Research Report 2007 Final Research Report Summary
  • [Presentation] Sox2 inhibits growth of gastric epithelial cell lines through cell cycle arrest and apoptosis2007

    • Author(s)
      Otsubo T, Akiyama Y, Yuasa Y.
    • Organizer
      AACR (American Association for Cancer research) 97th Annual Meeting
    • Place of Presentation
      Los Angeles, 米国
    • Year and Date
      2007-04-15
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Sox2 inhibits growth of gastric epithelial cell lines through cell cycle arrest and apoptosis2007

    • Author(s)
      Otsubo T, et. al.
    • Organizer
      AACR(American Association for Cancer research) 97th Annual Meeting
    • Place of Presentation
      Los Angeles. CA
    • Year and Date
      2007-04-15
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 胃がんにおけるメチル化異常とエピジェネティック疫学2007

    • Author(s)
      湯浅保仁
    • Organizer
      平成18年度文部科学省がん特定研究合同シンポジウム
    • Place of Presentation
      東京
    • Year and Date
      2007-02-23
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Sox2 inhibits growth of gastric epithelial cell lines through cell cycle arrest and apoptosis2007

    • Author(s)
      Otsubo T, Akiyama Y, Yuasa Y.
    • Organizer
      AACR (American Association for Cancer research) 97th Annual Meeting
    • Place of Presentation
      Los Angeles,米国
    • Related Report
      2007 Annual Research Report
  • [Book] DNAメチル化と発がん-エピジェネティック疫学 がん研究のいま(4) がんの疫学2006

    • Author(s)
      湯浅保仁(分担執筆)
    • Total Pages
      10
    • Publisher
      東京大学出版会
    • Related Report
      2006 Annual Research Report

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Published: 2006-04-01   Modified: 2016-04-21  

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