Development of the biomarker analysis system for evaluating the risk of carcinogenesis related to infection and inflammation

• Project/Area Number: 18390179
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Hygiene
• Research Institution: Suzuka University of Medical Science
• Principal Investigator: KAWANISHI Shosuke Suzuka University of Medical Science, 薬学部, 教授 (10025637)
• Co-Investigator(Kenkyū-buntansha): MURATA Mariko 三重大学, 大学院・医学系研究科, 教授 (10171141) ; OIKAWA Shinji 三重大学, 大学院・医学系研究科, 准教授 (10277006) ; HIRAKU Yusuke 三重大学, 大学院・医学系研究科, 講師 (30324510) ; OHNISHI Shiho 鈴鹿医療科学大学, 薬学部, 助手 (80511914) ; 足立 幸彦 三重大学, 大学院医学系研究科, リサーチアソシエイト (50111026)
• Project Period (FY): 2006 – 2008
• Project Status: Completed (Fiscal Year 2008)
• Budget Amount: ¥17,390,000 (Direct Cost: ¥14,600,000、Indirect Cost: ¥2,790,000); Fiscal Year 2008: ¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000); Fiscal Year 2007: ¥6,500,000 (Direct Cost: ¥5,000,000、Indirect Cost: ¥1,500,000); Fiscal Year 2006: ¥5,300,000 (Direct Cost: ¥5,300,000)
• Keywords: 8-ニトログアニン / 8-oxodG / DNA損傷 / 炎症 / 感染 / 活性窒素種 / バイオマーカー / がん予防 / 発がん / リスク評価

Research Abstract

感染・慢性炎症は極めて重要な発がん因子である。炎症条件下では活性種が生成され、DNAを損傷して発がんに関与する。種々の病因による炎症関連発がんにおいて、発がん好発部位で発がんに先駆けてDNA損傷塩基8-ニトログアニンが生成すること、さらに発がんリスクとなる病因治療により8-ニトログアニンが減少することを明らかにし、発がんリスク評価の新規バイオマーカーに8-ニトログアニンが有効であることを示した。

Research Products

• [Journal Article] Immunohistochemical analysis of 8-nitroguanine, a nitrative DNA lesion, in relation to inflammation-associated carcinogenesis (2009)
  • Author(s): Hiraku Y, Kawanishi S.
  • Journal Title: Methods Mol Biol. 512 Pages: 3-13
  • Peer Reviewed
• [Journal Article] Protective effect of taurine against nitrosative stress in the stomach of rat with water immersion restraint stress (2009)
  • Author(s): Ma N, Sasaki T, Sakata-Haga H, Ohta K, Gao M, Kawanishi S, FukuiY
  • Journal Title: Adv Exp Med Biol. 643 Pages: 273-83
  • Peer Reviewed
• [Journal Article] Damage to cellular and isolated DNAinduced by a metabolite of aspirin (2009)
  • Author(s): Oikawa S, Kobayashi H,Tada-Oikawa S, Isono Y, Kawanishi S
  • Journal Title: Mutat Res. 661(1-2) Pages: 93-100
  • Peer Reviewed
• [Journal Article] Immunohistochemical analysis of 8-nitroguanine, a nitrative DNA lesion, in relation to inflammation-associated carcinogenesis. (2009)
  • Author(s): Hiraku, Y., et al.
  • Journal Title: Methods Mol Biol. 512 Pages: 3-13
  • Peer Reviewed
• [Journal Article] Protective effect of taurine against nitrosative stress in the stomach of rat with water immersion restraint stress. (2009)
  • Author(s): Ma, N., et al.
  • Journal Title: Adv Exp Med Biol. 643 Pages: 273-283
  • Peer Reviewed
• [Journal Article] Mechanism of metal-mediated DNA damage and apoptosis induced by 6-hydroxydopamine in neuroblastoma SH-SY5Y cells (2008)
  • Author(s): Kobayashi H, Oikawa S, Umemura S,Hirosawa I, Kawanishi S
  • Journal Title: Free Radic Res. 42(7) Pages: 651-60
  • Peer Reviewed
• [Journal Article] Oxidative and nitrative stress in Opisthorchis viverrini-infected hamsters : an indirect effect after praziquantel treatment (2008)
  • Author(s): Pinlaor S, Prakobwong S, Hiraku Y,Kaewsamut B, Dechakhamphu S. Boonmars T, Sithithaworn P, Pinlaor P, Ma N, Yongvanit P, Kawanishi S
  • Journal Title: Am J Trop Med Hyg. 78(4) Pages: 564-73
  • Peer Reviewed
• [Journal Article] Urinary 8-oxo-7, 8-dihydro-2'-deoxyguanosine in patients with parasite infection and effect of antiparasitic drug in relation to cholangiocarcinogenesis (2008)
  • Author(s): Thanan R, Murata M, Pinlaor S,Sithithaworn P, Khuntikeo N,Tangkanakul W, Hiraku Y, Oikawa S,Yongvanit P, Kawanishi S.
  • Journal Title: Cancer Epidemiol Biomarkers Prev. 17(3) Pages: 518-24
  • Peer Reviewed
• [Journal Article] Comparison of hepatic oxidative DNA damage in patients with chronic hepatitis B and C (2008)
  • Author(s): Fujita N, Sugimoto R, Ma N, TanakaH, Iwasa M, Kobayashi Y, KawanishiS, Watanabe S, Kaito M, Takei Y
  • Journal Title: J Viral Hepat. 15(7) Pages: 498-507
  • Peer Reviewed
• [Journal Article] Reactive nitrogen species-dependent DNA damage in EBV-associated nasopharyngeal carcinoma : the relation to STAT3 activation and EGFR expression (2008)
  • Author(s): Ma N, Kawanishi M, Hiraku Y,Murata M, Huang GW, Huang Y, LuoDZ, Mo WG, Fukui Y, Kawanishi S
  • Journal Title: Int J Cancer. 122(11) Pages: 2517-25
  • Peer Reviewed
• [Journal Article] Hepatic oxidative DNA damage is associated with increased risk for hepatocellular carcinoma in chronic hepatitis C (2008)
  • Author(s): Tanaka H, Fujita N, Sugimoto R,Urawa N, Horiike S, Kobayashi Y,Iwasa M, Ma N, Kawanishi S, Watanabe S, Kaito M, Takei Y.
  • Journal Title: Br J Cancer. 98(3) Pages: 580-6
  • Peer Reviewed
• [Journal Article] Critical role of hydrogen peroxide in the differential susceptibility of Th1 and Th2 cells to tributyltin-induced apoptosis (2008)
  • Author(s): Tada-Oikawa S, Kato T, KuribayashiK, Nishino K, Murata M, KawanishiS
  • Journal Title: Biochem Pharmacol. 75(2) Pages: 552-61
  • Peer Reviewed
• [Journal Article] Mechanism of UVA-dependent DNA damage induced by an antitumor drug dacarbazine in relation to its photogenotoxicity (2008)
  • Author(s): Iwamoto T, Hiraku Y, Okuda M,Kawanishi S
  • Journal Title: Pharm Res. 25(3) Pages: 598-604
  • Peer Reviewed
• [Journal Article] Damage to cellular and isolated DNA induced by a metabolite of aspirin. (2008)
  • Author(s): Oikawa, S., et al.
  • Journal Title: Mutat Res. 661(1-2) Pages: 93-100
  • Peer Reviewed
• [Journal Article] Mechanism of metal-mediated DNA damage and apoptosis induced by 6-hydroxydopamine in neuroblastoma SH-SY5Y cells. (2008)
  • Author(s): Kobayashi, H., et al.
  • Journal Title: Free Radic Res. 42(7) Pages: 651-660
  • Peer Reviewed
• [Journal Article] Urinary 8-oxo-7, 8-dihydro-2'-deoxyguanosine in patients with parasite infection and effect of antiparasitic drug in relation to cholangiocarcinogenesis. (2008)
  • Author(s): Thanan, R., et al.
  • Journal Title: Cancer Epidemiol Biomarkers Prev. 17(3) Pages: 518-524
  • Peer Reviewed
• [Journal Article] Comparison of hepatic oxidative DNA damage in patients with chronic hepatitis B and C. (2008)
  • Author(s): Fujita, N., et al.
  • Journal Title: J Viral Hepat. 15(7) Pages: 498-507
  • Peer Reviewed
• [Journal Article] Reactive nitrogen species-dependent DNA damage in EBV-associated nasopharyngeal carcinoma : the relation to STAT3 activation and EGFR expression. (2008)
  • Author(s): Ma, N., et al.
  • Journal Title: Int J Cancer. 122(11) Pages: 2517-2525
  • Peer Reviewed
• [Journal Article] Reactive nitrogen species-dependent DNA damage in EBV-associated nasopharyngeal carcinoma: the relation to STAT3 activation and EGFR expression (2008)
  • Author(s): Ma, N., et. al.
  • Journal Title: Int. J. Cancer 122 Pages: 2517-2525
  • Peer Reviewed
• [Journal Article] Oxidative and nitrative stress in Opisthorchis viverrini-infbcted hamsters: anindirect effect after praziquantel treatment (2008)
  • Author(s): Pinlaor, S., et. al.
  • Journal Title: Am. J. Trop. Med. Hyg. 78 Pages: 564-573
  • Peer Reviewed
• [Journal Article] Critical role of hydrogen peroxide in the differential susceptibility of Th1 and Th2 cells to tributyltin-induced apoptosis (2008)
  • Author(s): Tada-Oikawa, S., et. al.
  • Journal Title: Biochem. Pharmacol. 75 Pages: 552-561
  • Peer Reviewed
• [Journal Article] Hepatic oxidative DNA damage is associated with increased risk for hepatocellular carcinoma in chronic hepatitis C (2008)
  • Author(s): Tanaka, H., et. al.
  • Journal Title: Br. J. Cancer 98 Pages: 580-586
  • Peer Reviewed
• [Journal Article] Urinary 8-oxo-7, 8-dihydro-2'-deoxyguanosine in patients with parasiteinfection and the effect of anti-parasitic drug in relation to cholangiocarcinogenesis (2008)
  • Author(s): Thanan, R., et. al.
  • Journal Title: Cancer Epidemiol. Biomarkers Prev. 17 Pages: 518-524
  • Peer Reviewed
• [Journal Article] 8-Nitroguanine as a potential biomarker for progression of malignant fibrous histiocytoma, a model of inflammation-related cancer (2007)
  • Author(s): Hoki Y, Murata M, Hiraku Y, Ma N,Matsumine A, Uchida A, Kawanishi S
  • Journal Title: Oncol Rep. 18(5) Pages: 1165-9
  • Peer Reviewed
• [Journal Article] H2O2 accelerates cellular senescence by accumulation of acetylated p53 via decrease in the function of SIRT1 by NAD+ depletion (2007)
  • Author(s): Furukawa A, Tada-Oikawa S,Kawanishi S, Oikawa S
  • Journal Title: Cell Physiol Biochem. 20(1-4) Pages: 45-54
  • Peer Reviewed
• [Journal Article] Guanine-specific DNA oxidation photosensitized by the tetraphenylporphyrin phosphorus(V) complex via singlet oxygen generation and electron transfer (2007)
  • Author(s): Hirakawa K, Kawanishi S, Hirano T, Segawa H
  • Journal Title: J Photochem Photobiol B. 87(3) Pages: 209-17
  • Peer Reviewed
• [Journal Article] Nitrative and oxidative DNA damage in cervical intraepithelial neoplasia associated with human papilloma virus infection (2007)
  • Author(s): Hiraku Y, Tabata T, Ma N, Murata M, Ding X, Kawanishi S
  • Journal Title: Cancer Sci. 98(7) Pages: 964-72
  • Peer Reviewed
• [Journal Article] Photosensitized DNA damage induced by NADH : site specificity andmechanism (2007)
  • Author(s): Ito K, Hiraku Y, Kawanishi S
  • Journal Title: Free Radic Res. 41(4) Pages: 461-8
  • Peer Reviewed
• [Journal Article] 9-Nitroanthracene derivative as a precursor of anthraquinone for photodynamic therapy (2007)
  • Author(s): Fukuhara K, Oikawa S, Hakoda N, Sakai Y, Hiraku Y, Shoda T, Saito S,Miyata N, Kawanishi S, Okuda H
  • Journal Title: Bioorg Med Chem. 15(11) Pages: 3869-73
  • Peer Reviewed
• [Journal Article] Hepatic oxidative DNA damage correlates with iron overload in chronic hepatitis C patients (2007)
  • Author(s): Fujita N, Horiike S, Sugimoto R,Tanaka H, Iwasa M, Kobayashi Y,Hasegawa K, Ma N, Kawanishi S, Adachi Y, Kaito M
  • Journal Title: Free Radic Biol Med. 42(3) Pages: 353-62
  • Peer Reviewed
• [Journal Article] Photosensitized DNA damage and its protection via a novel mechanism (2007)
  • Author(s): Hiraku Y, Ito K, Hirakawa K, Kawanishi S
  • Journal Title: Photochem Photobiol. 83(1) Pages: 205-12
  • Peer Reviewed
• [Journal Article] Oxidative and nitrative stress caused by subcutaneous implantation of a foreign body accelerates sarcoma development in Trp53+/- mice (2007)
  • Author(s): Tazawa H, Tatemichi M, Sawa T, Gilibert I, Ma N, Hiraku Y, Donehower LA, Ohgaki H, Kawanishi S, Ohshima H
  • Journal Title: Carcinogenesis. 28(1) Pages: 191-8
  • Peer Reviewed
• [Journal Article] Nitrative and oxidative DNA damage in cervical intraepithelial neoplasia associated with human papilloma virus infection, (2007)
  • Author(s): Hiraku, Y., et. al.
  • Journal Title: Cancer Sci. 98 Pages: 964-972
  • Peer Reviewed
• [Journal Article] iNOS-dependent DNA damage in patients with malignant fibrous histiocytoma in relation to prognosis (2007)
  • Author(s): Hoki, Y., et. al.
  • Journal Title: Cancer Sci. 98 Pages: 163-168
  • Peer Reviewed
• [Journal Article] 8-Nitroguanine as a potential biomarker for progression of malignant fibroushistiocytoma, a model of inflammation-related cancer (2007)
  • Author(s): Hoki, Y., et. al.
  • Journal Title: Oncol. Rep. 18 Pages: 1165-1169
  • Peer Reviewed
• [Journal Article] Oxidative and nitrative stress caused by subcutaneous implantation of a foreignbody accelerates sarcoma development in Trp53^<+/->mice (2007)
  • Author(s): Tazawa, H., et. al.
  • Journal Title: Carcinogenesis 28 Pages: 191-198
  • Peer Reviewed
• [Journal Article] H_2O_2 accelerates cellular senescence by accumulation of acetylated p53 viadecrease in the function of SIRTl by NAD+depletion (2007)
  • Author(s): Furukawa, A., et. al.
  • Journal Title: Cell Physiol. Biochem. 20 Pages: 45-54
  • Peer Reviewed
• [Journal Article] Hepatic oxidative DNA damage correlates with iron overload in chronic hepatitis C patients (2007)
  • Author(s): Fujita, N., et. al.
  • Journal Title: Free Radic. Biol. Med. 42 Pages: 353-362
  • Peer Reviewed
• [Journal Article] iNOS-dependent DNA damage in patients with malignant fibrous histiocytoma in relation to prognosis (2007)
  • Author(s): Hoki, Y.
  • Journal Title: Cancer Sci. 98(2) Pages: 163-168
• [Journal Article] Oxidative and nitrative stress caused by subcutaneous implantation of a foreign body accelerates sarcoma development in Trp53^+^/^- mice (2007)
  • Author(s): Tazawa, H.
  • Journal Title: Carcinogenesis 28(1) Pages: 191-198
• [Journal Article] Hepatic oxidative DNA damage correlates with iron overload in chronic hepatitis C patients (2007)
  • Author(s): Fujita, N.
  • Journal Title: Free Radic. Biol. Med. 42(3) Pages: 353-362
• [Journal Article] Proteomic analysis for protein carbonyl as an indicator of oxidative damage in senescence-accelerated mice (2006)
  • Author(s): Nabeshi H, Oikawa S, Inoue S, Nishino K, Kawanishi S
  • Journal Title: Free Radic Res. 40(11) Pages: 1173-81
  • Peer Reviewed
• [Journal Article] Tyrosine-dependent oxidative DNA damage induced by carcinogenic tetranitromethane (2006)
  • Author(s): Murata M, Kurimoto S, Kawanishi S
  • Journal Title: Chem Res Toxicol. 19(10) Pages: 1379-85
  • Peer Reviewed
• [Journal Article] Mechanism of oxidative DNA damage induced by capsaicin, a principal ingredient of hot chili pepper (2006)
  • Author(s): Oikawa S, Nagao E, Sakano K,Kawanishi S
  • Journal Title: Free Radic Res. 40(9) Pages: 966-73
  • Peer Reviewed
• [Journal Article] Mechanism for manganese enhancement of dopamine-induced oxidative DNA damage and neuronal cell death (2006)
  • Author(s): Oikawa S, Hirosawa I, Tada-Oikawa S, Furukawa A, Nishiura K, Kawanishi S
  • Journal Title: Free Radic Biol Med. 41(5) Pages: 748-56
  • Peer Reviewed
• [Journal Article] Oxidative DNA damage induced by hair dye components ortho-phenylenediamines and the enhancement by superoxide dismutase (2006)
  • Author(s): Murata M, Nishimura T, Chen F, Kawanishi S
  • Journal Title: Mutat Res. 607(2) Pages: 184-91
  • Peer Reviewed
• [Journal Article] Oxidative and nitrative DNA damage as biomarker for carcinogenesis with special reference to inflammation (2006)
  • Author(s): Kawanishi S, Hiraku Y
  • Journal Title: Antioxid Redox Signal. 8(5-6) Pages: 1047-58
  • Peer Reviewed
• [Journal Article] Mechanism of DNA damage and apoptosis induced by tetrahydropapaveroline, a metabolite of dopamine (2006)
  • Author(s): Kobayashi H, Oikawa S, Kawanishi S
  • Journal Title: Neurochem Res. 31(4) Pages: 523-32
  • Peer Reviewed
• [Journal Article] Oxidative and nitrative DNA damage in animals and patients with inflammatory diseases in relation to inflammation-related carcinogenesis (2006)
  • Author(s): Kawanishi S, Hiraku Y, Pinlaor S, MaN
  • Journal Title: Biol Chem. 387(4) Pages: 365-72
  • Peer Reviewed
• [Journal Article] Endocrine disruptors that deplete glutathione levels in APC promote Th2 polarization in mice leading to the exacerbation of airway inflammation (2006)
  • Author(s): Kato T, Tada-Oikawa S, Takahashi K, Saito K, Wang L, Nishio A, Hakamada-Taguchi R, Kawanishi S, Kuribayashi K
  • Journal Title: Eur J Immunol. 36(5) Pages: 1199-209
  • Peer Reviewed
• [Journal Article] iNOS-dependent DNA damage via NF-kappaB expression in hamsters infected with Opisthorchis viverrini and its suppression by the antihelminthic drug praziquantel (2006)
  • Author(s): Pinlaor S, Hiraku Y, Yongvanit P, Tada-Oikawa S, Ma N, Pinlaor P, Sithithaworn P, Sripa B, Murata M, Oikawa S, Kawanishi S
  • Journal Title: Int J Cancer. 119(5) Pages: 1067-72
  • Peer Reviewed
• [Journal Article] Carcinogenic 3-nitrobenzanthrone induces oxidative damage to isolated and cellular DNA (2006)
  • Author(s): Murata M, Tezuka T, Ohnishi S, Takamura-Enya T, Hisamatsu Y, Kawanishi S
  • Journal Title: Free Radic Biol Med. 40(7) Pages: 1242-9
  • Peer Reviewed
• [Journal Article] Mechanism of DNA damage induced by bromate differs from general types of oxidative stress (2006)
  • Author(s): Kawanishi S, Murata M
  • Journal Title: Toxicology. 221(2-3) Pages: 172-8
  • Peer Reviewed
• [Journal Article] 特集「胸膜中皮腫の診断と治療」金属化合物およびアスベストによる酸化・ニトロ化DNA損傷 (2006)
  • Author(s): 平工雄介
  • Journal Title: THE LUNG perspectives 14 Pages: 316-321
• [Journal Article] Oxidative and nitrative DNA damage as biomarker for carcinogenesis with special reference to inflammation (2006)
  • Author(s): Kawanishi, S.
  • Journal Title: Antioxid. Redox Signal. 8(5-6) Pages: 1047-1058
• [Journal Article] Oxidative and nitrative DNA damage in animals and patients with inflammatory diseases in relation to inflammation-related carcinogenesis (2006)
  • Author(s): Kawanishi, S.
  • Journal Title: Biol. Chem. 387(4) Pages: 365-372
• [Journal Article] iNOS-dependent DNA damage via NF-KB expression in hamsters infected with Opisthorchis viverrini and its suppression by the antihelminthic drug praziquantel (2006)
  • Author(s): Pinlaor, S.
  • Journal Title: Int. J. Cancer 119(5) Pages: 1067-1072
• [Journal Article] Critical roles for polymerase S in cellular tolerance to nitric oxide-induced DNA damage (2006)
  • Author(s): Wu, X
  • Journal Title: Cancer Res. 66(2) Pages: 748-752
• [Journal Article] 8-Nitroguanine formation in oral leukoplakia, a premalignant lesion (2006)
  • Author(s): Ma, N.
  • Journal Title: Nitric Oxide 14(2) Pages: 137-143
• [Journal Article] Role of oxidative DNA damage in dietary carcinogenesis (2006)
  • Author(s): Hiraku, Y
  • Journal Title: Genes Environ. 28(4): Pages: 127-140
  • NAID: 110005717023
• [Journal Article] Radical production and DNA damage induced by carcinogenic 4-hydrazinobenzoic acid, an ingredient of mushroom Agaricus bisporus, (2006)
  • Author(s): Oikawa, S
  • Journal Title: Free Radic. Res. 40(1): Pages: 31-39
• [Journal Article] Mechanism for manganese enhancement of dopamine-induced oxidative DNA damage and neuronal cell death (2006)
  • Author(s): Oikawa, S
  • Journal Title: Free Radic. Biol. Med. 41(5) Pages: 748-756
• [Journal Article] Mechanism of oxidative DNA damage induced by capsaicin, a principal ingredient of hot chili pepper (2006)
  • Author(s): Oikawa, S
  • Journal Title: Free Radic. Res. 40(9) Pages: 966-973
• [Journal Article] Proteomic analysis for protein carbonyl as an indicator of oxidative damage in senescence-accelerated mice (2006)
  • Author(s): Nabeshi, H.
  • Journal Title: Free Radic. Res. 40(11) Pages: 1173-1181
• [Journal Article] Carcinogenic 3-nitrobenzanthrone induces oxidative damage to isolated and cellular DNA (2006)
  • Author(s): Murata, M.
  • Journal Title: Free Radic. Biol. Med. 40(7) Pages: 1242-1249
• [Journal Article] Oxidative DNA damage induced by hair dye components ortho-phenylenediamines and the enhancement by superoxide dismutase (2006)
  • Author(s): Murata, M.
  • Journal Title: Mutat. Res. 607(2) Pages: 184-191
• [Journal Article] Tyrosine-dependent oxidative DNA damage induced by carcinogenic tetranitromethane (2006)
  • Author(s): Murata, M.
  • Journal Title: Chem. Res. Toxicol. 19(10) Pages: 1379-1385
• [Journal Article] Mechanism of DNA damage and apoptosis induced by tetrahydropapaveroline, a metabolite of dopamine (2006)
  • Author(s): Kobayashi, H.
  • Journal Title: Neurochem. Res. 31(4) Pages: 523-532
• [Journal Article] Mechanism of DNA damage induced by bromate differs from general types of oxidative stress (2006)
  • Author(s): Kawanishi, S.
  • Journal Title: Toxicology 221(2-3) Pages: 172-178
• [Journal Article] Endocrine disruptors that deplete glutathione levels in APC promote Th2 polarization in mice leading to the exacerbation of airway inflammation (2006)
  • Author(s): Kato, T.
  • Journal Title: Eur. J. Immunol. 36(5) Pages: 1199-1209
• [Journal Article] Pravastatin increases survival and suppresses an increase in myocardial matrix metalloproteinase activity in a rat model of heart failure (2006)
  • Author(s): Ichihara, S.
  • Journal Title: Cardiovasc. Res. 69(3) Pages: 726-735
• [Journal Article] Guanine-specific DNA damage photosensitized by the dihydroxo-(tetraphenylporphyrinato) antimony(V) complex (2006)
  • Author(s): Hirakawa, K.
  • Journal Title: J. Photochem. Photobiol. B. 82(1) Pages: 37-44
• [Journal Article] Nitrative and oxidative DNA damage in cervical intraepithelial neoplasia associated with human papilloma cirus infection
  • Author(s): Hiraku, Y.
  • Journal Title: Cancer Sci. (印刷中)
• [Journal Article] Photosensitized DNA damage and its protection via a novel mechanism
  • Author(s): Hiraku, Y.
  • Journal Title: Photochem. Photobiol. (印刷中)
• [Journal Article] Photosensitized DNA damage induced by NADH : site specificity and mechanism
  • Author(s): Ito, K.
  • Journal Title: Free Radic. Res. (印刷中)
• [Presentation] 環境汚染物質2-nitrotolueneによる発がん機構の検討 (2008)
  • Author(s): 渡邊千草
  • Organizer: 日本環境変異原学会第37回大会
  • Place of Presentation: 宜野湾市
  • Year and Date: 2008-12-04
• [Presentation] ビスフェノールAによる発がん機構の解明 (2008)
  • Author(s): 小端久美
  • Organizer: 日本環境変異原学会第37回大会
  • Place of Presentation: 宜野湾市
  • Year and Date: 2008-12-04
• [Presentation] メチレンブルーによる金属依存性DNA損傷 : 発がん性との関連 (2008)
  • Author(s): 平工雄介
  • Organizer: 日本環境変異原学会第37回大会
  • Place of Presentation: 宜野湾市
  • Year and Date: 2008-12-04
• [Presentation] 乳癌治療薬タモキシフェン代謝物による酸化的DNA損傷 ; 発がん性との関連 (2008)
  • Author(s): 村田真理子
  • Organizer: 第67回日本癌学会学術総会
  • Place of Presentation: 名古屋市
  • Year and Date: 2008-10-28
• [Presentation] EBウイルス感染による上咽頭癌患者におけるニトロ化DNA損傷塩基8-ニトログアニンの生成 (2008)
  • Author(s): 平工雄介
  • Organizer: 第67回日本癌学会学術総会
  • Place of Presentation: 名古屋市
  • Year and Date: 2008-10-28
• [Presentation] The role of oxidative nitrative in inflammation-related carcinogenesis. (2008)
  • Author(s): Kawanishi, S.
  • Organizer: The 5th International Conference on the Biology, Chemistry and Therapeutic Applications of Nitric Oxide.
  • Place of Presentation: Bregenz
  • Year and Date: 2008-08-25
• [Presentation] Nitrative and oxidative DNA damage via chronic inflammation by liver fluke infection ; in relation to cholangiocarcinoma development. (2008)
  • Author(s): Murata, M.
  • Organizer: The 5th International Conference on the Biology, Chemistry and Therapeutic Applications of Nitric Oxide.
  • Place of Presentation: Bregenz
  • Year and Date: 2008-08-25
• [Presentation] Formation of 8-nitroguanine, a nitrative DNA lesion, in patients infected with oncogenic viruses, HPV and EBV. (2008)
  • Author(s): Hiraku, Y.
  • Organizer: The 5th International Conference on the Biology, Chemistry and Therapeutic Applications of Nitric Oxide.
  • Place of Presentation: Bregenz
  • Year and Date: 2008-08-25
• [Presentation] The role of oxidative nitrative in inflammation-related carcinogenesis (2008)
  • Author(s): S. Kawanishi
  • Organizer: The 5th International Conference on the Biology, Chemistry and Therapeutic Applications of Nitric Oxide
  • Place of Presentation: Bregenz
• [Presentation] シンポジウム「分子予防・環境医学への新たな挑戦」感染・炎症関連発がんにおけるニトロ化DNA損傷塩基8-ニトログアニンの役割 (2008)
  • Author(s): 平工 雄介
  • Organizer: 第78回日本衛生学会総会
  • Place of Presentation: 熊本県熊本市
• [Presentation] タイ肝吸虫感染者および胆管癌患者における酸化ストレスマーカー8-oxo-7, 8-dihydro-2'-deoxyguanosineの有用性の検討 (2008)
  • Author(s): 村田 真理子
  • Organizer: 第78回日本衛生学会総会
  • Place of Presentation: 熊本県熊本市
• [Presentation] アスベスト気管内投与マウスの肺組織におけるDNA損傷塩基8-ニトログアニンの生成 (2007)
  • Author(s): 平工 雄介
  • Organizer: 平成19年度日本産業衛生学会東海地方会
  • Place of Presentation: 愛知県名古屋市
  • Year and Date: 2007-11-17
• [Presentation] アスベスト気管内投与マウスの肺組織におけるニトロ化DNA損傷 (2007)
  • Author(s): 平工 雄介
  • Organizer: 第7回分子予防環境医学研究会
  • Place of Presentation: 福岡県北九州市
  • Year and Date: 2007-10-27
• [Presentation] アスベスト曝露マウス肺におけるDNA損傷塩基8-ニトログアニンの生成 (2007)
  • Author(s): 平工 雄介
  • Organizer: 第80回日本産業衛生学会
  • Place of Presentation: 大阪府大阪市
  • Year and Date: 2007-04-27
• [Presentation] Formation of 8-nitroguanine, a nitrative DNA lesion, in the lung of mice exposed to asbestos (2007)
  • Author(s): Yusuke Hiraku
  • Organizer: 1st Asian Conference on Environmental Mutagens & 36th Annual Meeting of The Japanese Environmental Mutagen Society
  • Place of Presentation: 福岡県北九州市
• [Presentation] Cellular and isolated DNA damage induced by a metabolite of aspirin as a risk factor for pancreatic cancer (2007)
  • Author(s): Hatasu Kobayashi
  • Organizer: 1st Asian Conference on Environmental Mutagens & 36th Annual Meeting of The Japanese Environmental Mutagen Society
  • Place of Presentation: 福岡県北九州市
• [Presentation] Formation of 8-nitroguanine and 8-oxo-7, 8-dihydro-2'-deoxyguanosine bynitric oxide(NO)and superoxide(O_2^-) (2007)
  • Author(s): Shiko Takeuchi
  • Organizer: 1st Asian Conference on Environmental Mutagens & 36th Annual Meeting of The Japanese Environmental Mutagen Society
  • Place of Presentation: 福岡県北九州市
• [Presentation] Manganese enhances oxidative damage to cellular and isolated DNA induced by a coffee polyphenol, chlorogenic acid (2007)
  • Author(s): Mariko Murata
  • Organizer: European Meeting 2007 of the Society for Free Radical Research
  • Place of Presentation: Portugal
• [Presentation] Iron and copper mediated DNA damage and apoptosis induced by 6-hydroxydopamine (2007)
  • Author(s): Hatasu Kobayashi
  • Organizer: European Meeting 2007 of the Society for Free Radical Research
  • Place of Presentation: Portugal
• [Presentation] Nitrative DNA damage in the lung of asbestos-exposed mice(アスベスト曝露マウス肺におけるニトロ化DNA損傷) (2007)
  • Author(s): 平工 雄介
  • Organizer: 第66回日本癌学会総会
  • Place of Presentation: 神奈川県横浜市
• [Presentation] プロテオーム解析によるタイ肝吸虫関連胆管癌におけるcytokeratin 19の検出 (2007)
  • Author(s): 村田 真理子
  • Organizer: 第66回日本癌学会総会
  • Place of Presentation: 神奈川県横浜市
• [Presentation] 過酸化水素によるSIRT1の機能低下を介したアセチル化p53の蓄積による細胞老化促進機構 (2007)
  • Author(s): 古川 絢子
  • Organizer: 日本基礎老化学会第30回大会
  • Place of Presentation: 北海道札幌市
• [Presentation] アミトロールによる発がん機構の解明 (2007)
  • Author(s): 及川 伸二
  • Organizer: 第29回日本フリーラジカル学会学術集会
  • Place of Presentation: 愛知県名古屋市
• [Presentation] LPSによるニトロ化DNA損傷の分子機構:感染・炎症関連発がんとの関連 (2007)
  • Author(s): 平工 雄介
  • Organizer: 第7回日本NO学会学術集会
  • Place of Presentation: 滋賀県大津市
• [Presentation] NOとO_2^-による8-nitroguanineおよび8-oxodG生成の定量と塩基配列特異性の解析 (2007)
  • Author(s): 竹内 士紘
  • Organizer: 第7回日本NO学会学術集会
  • Place of Presentation: 滋賀県大津市
• [Presentation] 8-Nitroguanine as a biomarker for inflammation-related carcinogenesis (2006)
  • Author(s): Yusuke Hiraku
  • Organizer: The 36th Annual Meeting of the Environmental Mutagen Society
  • Place of Presentation: Prague, Czech
• [Book] 食品機能性の科学「第6節フラボノイドの酸化促進効果」(第7章フラボノイドの生理活性) (2008)
  • Author(s): 村田真理子, 及川(多田)佐枝子, 川西正祐
  • Publisher: 産業技術サービスセンター
• [Book] 「第6節フラボノイドの酸化促進効果」(第7章フラボノイドの生理活性). 食品機能性の科学 (2008)
  • Author(s): 村田真理子
  • Publisher: 産業技術サービスセンター
• [Book] 活性酸素・窒素種とDNA損傷 (2007)
  • Author(s): 平工雄介、川西正祐
  • Publisher: 化学同人
• [Book] 化学フロンティア18ゲノム化学(齋藤烈、杉山弘、中谷和彦 編) (2007)
  • Author(s): 平工雄介、川西正祐
  • Publisher: 化学同人
• [Book] 化学フロンティア18 ゲノム化学(齋藤烈 他 編、化学同人) (2007)
  • Author(s): 平工雄介
  • Total Pages: 215
  • Publisher: 活性酸素・窒素種とDNA損傷