An intervention study for the arteriosclerosis prevention considering NOS genetic polymorphism in the occupational area group
| Project/Area Number |
18390180
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Hygiene
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| Research Institution | Tottori University |
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Principal Investigator |
KISHIMOTO Takuji (TAKUJI Kishimoto) Tottori University, 医学部, 教授 (00116394)
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| Co-Investigator(Kenkyū-buntansha) |
OSAKI Yoneatsu 鳥取大学, 医学部, 准教授 (10325003)
OKAMOTO Mikizo 鳥取大学, 医学部, 講師 (40032205)
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| Project Period (FY) |
2006 – 2009
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| Project Status |
Completed (Fiscal Year 2009)
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| Budget Amount *help |
¥16,990,000 (Direct Cost: ¥14,200,000、Indirect Cost: ¥2,790,000)
Fiscal Year 2009: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2008: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2007: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2006: ¥4,900,000 (Direct Cost: ¥4,900,000)
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| Keywords | 遺伝子 / 衛生 / 社会医学 / 循環器 / 高血圧 / 糖尿病 / 循環器・高血圧 / 糠尿病 |
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| Research Abstract |
Tendencies to brachial-ankle pulse wave velocity (baPWV) improvement were analyzed in subjects with a slight arteriosclerosis judged by baPWV in reporting group (weak intervention) and intervention group (strong intervention). In the reporting group, the significant improvement was not shown in both -786C allele carriers and non--786C allele carriers of the NOS T-786C genetic polymorphism. However, in the intervention group, a tendency to significant improvement was found in non--786C allele carriers. The effect by the intervention was suggested to be low in -786C allele carriers.
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Report
(6 results)
Research Products
(20 results)
