| Project/Area Number |
18390186
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Hygiene
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| Research Institution | Kawasaki Medical School |
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Principal Investigator |
OTSUKI Takemi Kawasaki Medical School, SCHOOL OF MEDICINE, DEPARTMENT OF HYGINE, PROFESSOR (40160551)
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| Co-Investigator(Kenkyū-buntansha) |
NISHIMURA Yasumitsu Kawasaki Medical School, SCHOOL OF MEDICINE, DEPARIMENT OF HYGINE, ASSISTANT PROFESSOR (90360271)
MAEDA Megumi Kawasaki Medical School, SCHOOL OF MEDICINE, DEPARTMENT OF HYGINE, RESEARCH FELLOW (20434988)
MURAKAMI Shuko Kawasaki Medical School, SCHOOL OF MEDICINE, DEPARTMENT OF HYGINE, RESEARCH FELLOW (50454848)
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| Project Period (FY) |
2006 – 2007
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| Project Status |
Completed (Fiscal Year 2007)
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| Budget Amount *help |
¥16,830,000 (Direct Cost: ¥14,700,000、Indirect Cost: ¥2,130,000)
Fiscal Year 2007: ¥9,230,000 (Direct Cost: ¥7,100,000、Indirect Cost: ¥2,130,000)
Fiscal Year 2006: ¥7,600,000 (Direct Cost: ¥7,600,000)
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| Keywords | ASBESTOS / T CELL / TGF-BETA / IL-10 / REGULATORYT CELL / CXCR3 / MALIGNANT MESOTHELIOMA / CANCER PREVENTION / アポトーシス / Bcl-2 / 石綿肺 / T細胞受容体 |
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| Research Abstract |
IT IS COMMON KNOWLEDGE THAT ASBESTOS EXPOSURE CAUSES ASBESTOS-RELATED DISEASES SUCH AS ASBESTOSIS, LUNG CANCER AND MALIGNANT MESOTHELIOMA (MM) NOT ONLY IN PEOPLE WHO HAVE HANDLED ASBESTOS IN THE WORK ENVIRONMENT, BUT ALSO IN RESIDENTS LIVING NEAR FACTORIES THAT HANDLE ASBESTOS. THESE FACTS HAVE BEEN AN ENORMOUS MEDICAL AND SOCIAL PROBLEM IN JAPAN SINCE THE SUMMER OF 2005. WE FOCUSED ON THE IMMUNOLOGICAL EFFECTS OF ASBESTOS AND SILICA ON THE HUMAN IMMUNE SYSTEM IN THIS BRIEF REVIEW, WE PRESENT IMMUNOLOGICAL CHANGES IN PATIENTS WITH MM AND OUTLINE THEIR EXPERIMENTAL DETECTION. FOR EXAMPLE, THERE IS OVER-EXPRESSION OF BCL-2 IN CD4+ PERIPHERAL T CELLS, HIGH PLASMA CONCENTRATIONS OF INI'ERLEUKIN (L)-l0 AND TRANSFORMING GROWTH FACTOR (TGF)-β AND MULTIPLE OVER ON OF T CELL RECEPTOR (TCR)-Vβ IN PERIPHERAL CD3+ T CELLS FOUND IN MM PATIENTS. WE ALSO DETAIL AN EXPERIMENTAL LONGTERM EXPOSURE T-CELL MODEL. ANALYSIS OF THE IMMUNOLOGICAL EFFECTS OF ASBESTOS MAY HELP OUR UNDERSTANDING OF THE BIOLOGICAL EFFECTS OF ASBESTOS. RECENT ADVANCES IN IMMUNOMOLECULAR STUDIES HAVE LED TO DETAILED ANALYSES OF THE IMMUNOLOGICAL EFFECTS OF ASBESTOS. ASBESTOS AFFECTS IMMUNOCOMPETENT CELLS AND THESE EFFECTS MAY RE ASSOCIATED WITH THE PATHOPHYSIOLOGICAL DEVELOPMENT OF COMPLICATIONS IN ASBESTOS-EXPOSED PATIENTS SUCH AS MALIGNANT TUMORS. IN ADDITION, IMMUNOLOGICAL ANALYSES MAY LEAD TO THE DISCOVERY OF NEW CLINICAL TOOLS FOR THE MODIFICATION OF PATHOPHYSIOLOGICAL ASPECTS OF DISEASES, SUCH AS THE REGULATION OF TUMOR IMMUNITY USING CELL-MEDLATED THERAPIES, VARIOUS CYTOKINES AND MOLECULE-TARGETING THERAPIES. AS THE INCIDENCE OF ASBESTOS-RELATED MALIGNANCIES INCREASES AGAINST THE GROWING CONCERN IN JAPAN SINCE THE SUMMER OF 2005 FOR MEDICAL AND SOCIAL PROBLEMS CREATED BY SUCH MALIGNANCIES, EFFORTS SHOULD RE FOCUSED ON DEVELOPING A CURE FOR THESE DISEASES IN ORDER TO ELIMINATE THE NATIONWIDE ANXIETY CONCERNING THESE MALIGNANCIES.
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