Development of specific immunoglobulin against environmental sensitizing chemicals and actual survey on sensitizing status

• Project/Area Number: 18390187
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Hygiene
• Research Institution: University of Occupational and Environmental Health, Japan
• Principal Investigator: KAWAMOTO Toshihiro University of Occupational and Environmental Health, Japan, 医学部, 教授 (60177748)
• Co-Investigator(Kenkyū-buntansha): OYAMA Tsunehiro 産業医科大学, 医学部, 准教授 (00309965) ; ISSE Toyohi 産業医科大学, 医学部, 准教授 (80341494) ; 松野 康二 産業医科大学, 産業医学研究支援施設, 助教授 (40131940)
• Project Period (FY): 2006 – 2009
• Project Status: Completed (Fiscal Year 2009)
• Budget Amount: ¥14,320,000 (Direct Cost: ¥11,800,000、Indirect Cost: ¥2,520,000); Fiscal Year 2009: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000); Fiscal Year 2008: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000); Fiscal Year 2007: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000); Fiscal Year 2006: ¥3,400,000 (Direct Cost: ¥3,400,000)
• Keywords: 環境 / 感作 / 化学物質 / アレルギー / 免疫グロブリン / アルデヒド脱水素酵素 / ノックアウトマウス / 共有結合 / 環境化学物質 / IgE / IgG / 蛋白付加体 / プロテオミクス / 質量分析 / 蛋白質付加体 / SDS-PAGE

Research Abstract

Structural changes of our body proteins caused by the binding of chemical substances are one of the most important mechanisms of allergy onset. When human serum albumin (HSA) was mixed with sensitizing chemical substances, the fluorescence (280nm excitation and 340nm emission) of HSA decreased dose-dependently. The reduction of HSA fluorescence by treatment with chemicals was by the following order ; commonly designated sensitizers> possible sensitizers> non-sensitizers. HSA fluorescence after treatment with test chemicals may be a good predictor for their sensitizing potentials. The antigenicity of chemical-HSA adducts toward sera from sensitized patients was varied according to the condition in which the adducts were formed. An effective method to detect antibody against chemical-HSA adducts were developed. Acetaldehyde inhalation caused more DNA adducts at upper respiratory tracts in Aldh2 knockout mice more than in wild type mice.

Research Products

• [Journal Article] Characteristics of aldehyde dehydrogenase 2 (Aldh2) knockout mice. (2009)
  • Author(s): Yu H-S, Oyama T, Isse T, Kitagawa K, Ogawa M, Pham TTP, Kawamoto T.
  • Journal Title: Toxicology Mechanisms and Methods 19(9) Pages: 535-540
• [Journal Article] Cholinergic alterations following alcohol exposure in the frontal cortex of Aldh2-deficinet mice models. (2009)
  • Author(s): Jamal M, Ameno K, Miki T, Wang W, Kumihashi M, Isse T, Kawamoto T, Kitagawa K, Nakayama K-I, Ijiri I, Kinoshita H
  • Journal Title: Brain Research 1295 Pages: 37-43
  • Peer Reviewed
• [Journal Article] Increased formation of gastric N2-ethylidene-2'-deoxyguanosine DNA adducts in aldehyde dehydrogenase-2 knockout mice treated with ethanol. (2009)
  • Author(s): Nagayoshi H, Matsumoto A, Nishi R, Kawamoto T, Ichiba M, Matsuda T.
  • Journal Title: Mutation Research-Genetic Toxicology and Environmental Mutagenesis. 673 Pages: 74-77
  • Peer Reviewed
• [Journal Article] Application of tryptophan fluorescence to assess sensitizing potentials of chemicals. (2009)
  • Author(s): Pham TTP, Oyama T, Isse T, Kawamoto T
  • Journal Title: Archives of Environmental Contamination and Toxicology. 57 Pages: 427-436
  • Peer Reviewed
• [Journal Article] A new class of organic nitrates : Investigations on bioactivation, tolerance and cross-tolerance phenomena (2009)
  • Author(s): Schuhmacher S, Schulz E, Oelze M, Koenig A, Roegler C, Lange K, Sydow L, Kawamoto T, Wenzel P, Muenzel T, Lehmann J, Daiber A
  • Journal Title: British Journal of Pharmacology 158 Pages: 510-520
  • Peer Reviewed
• [Journal Article] Application of tryptophan fluorescence to assess sensitizing potentials of chemicals (2009)
  • Author(s): Pham TTP, Oyama T, Isse T, Kawamoto T
  • Journal Title: Application of tryptophan fluorescence to assess sensitizing potentials of chemicals 57 Pages: 427-436
  • Peer Reviewed
• [Journal Article] Ethanol metabolism in ALDH2 knockout mice I Blood acetate levels (2009)
  • Author(s): Ameno K, Wang W., Jamal M, Toyohi I, Kawamoto T, Kitagawa K, Nakayama K-I, Ijiri I, Kinoshita H
  • Journal Title: Legal Medicine 11
  • Peer Reviewed
• [Journal Article] Cholinergic alterations following alcohol exposure in the frontal cortex of Aldh2-deficinet mice models (2009)
  • Author(s): Jamal M, Ameno K, Miki T, Wang W, Kumihashi M, Isse T, Kawamoto T, Kitagawa K, Nakayama K-I, Ijiri I, Kinoshita H
  • Journal Title: Brain Research 1295 Pages: 37-43
  • Peer Reviewed
• [Journal Article] Characteristics of aldehyde dehydrogenase 2 (Aldh2) knockout mices (2009)
  • Author(s): Yu H-S, Oyama T, Isse T, Kitagawa K, Ogawa M, Pham TTP, Kawamoto T
  • Journal Title: Toxicology Mechanisms and Methods 19 Pages: 535-540
  • Peer Reviewed
• [Journal Article] ダイオードアレイ検出器高速液体クロマトグラフィーを用いた感作性化学物質による蛋白付加体形成の簡易検査法 (2009)
  • Author(s): 一瀬豊日、Pham TTP、小山倫浩、荻野景規、川本俊弘
  • Journal Title: 日本予防医学会雑誌 4 Pages: 23-28
  • Peer Reviewed
• [Journal Article] 環境省「子どもの健康と環境に関する全国調査(エコチル調査)」 (2009)
  • Author(s): 丹藤昌治、塚本直也、月森清巳、川本俊弘
  • Journal Title: ペリネイタルケア 28 Pages: 66-72
• [Journal Article] Increased formation of gastric N^2-ethylidene-2'-deoxyguanosine DNA adducts in aldehyde dehydrogenase-2 knockout mice treated with ethanol (2009)
  • Author(s): Nagayoshi H, Matsumoto A, Nishi R, Kawamoto T, Ichiba M, Matsuda T
  • Journal Title: Mutation Research-Genetic Toxicology and Environmental Mutagenesis (In press)
  • Peer Reviewed
• [Journal Article] ALDH-2 deficiency increases vascular oxidative stress-Evidence for indirect antioxidative properties. (2008)
  • Author(s): Wenzel P, Muller J, Zurmeyer S, Schumacher S, Schulz E, Oelze M, Pautz A, Kawamoto T, Wojnowski L, Kleinert H, Munzel T.
  • Journal Title: Biochemical and Biophysical Research Communications 367 Pages: 137-143
  • Peer Reviewed
• [Journal Article] Effects of 5-week ethanol feeding on the liver of aldehyde dehydorgenase 2 knockout mice. (2008)
  • Author(s): Matsumoto A, Kawamoto T, Mutoh F, Isse T, Oyama T, Kitagawa K, Nakayama K-I. Ichiba M.
  • Journal Title: Pharmacogenetics and Genomices 18 Pages: 847-852
  • Peer Reviewed
• [Journal Article] ホルムアルデヒドへのアレルギーを主症状としたシックハウス症候群の1例 (2008)
  • Author(s): 小川真規、西中川秀太、横沢冊子、後藤浩之、川本俊弘、圓藤陽子
  • Journal Title: 産業衛生学雑誌 50 Pages: 83-85
  • NAID: 110006783279
  • Peer Reviewed
• [Journal Article] ホルムアルデヒドへのアレルギーを主症状としたシックハウス症候群の1例 (2008)
  • Author(s): 小川真規、西中川秀太、横沢冊子、後藤浩之、川本俊弘、圓藤陽子
  • Journal Title: 産業衛生学雑誌 83-85 Pages: 50-50
  • NAID: 110006783279
  • Peer Reviewed
• [Journal Article] ALDH-2 deficiency increases vascular oxidative stress-Evidence for indirect antioxidative properties (2008)
  • Author(s): Wenzel P
  • Journal Title: Biochemical and Biophysical Research Communications 367 Pages: 137-143
  • Peer Reviewed
• [Journal Article] ホルムアルデヒドへのアレルギーを主症状としたシックハウス症候群の1例 (2008)
  • Author(s): 小川真規, 西中川秀太, 横沢冊子, 後藤浩之, 川本俊弘, 圓藤陽子
  • Journal Title: 産業衛生学雑誌 50 Pages: 83-85
  • NAID: 110006783279
  • Peer Reviewed
• [Journal Article] 特集 : 環境粒子状物質と呼吸器、粒子状物質の成分と健康影響 (2008)
  • Author(s): 川本俊弘, 中館俊夫, 若松伸司, 小山倫浩
  • Journal Title: 呼吸器科 14 Pages: 206-212
• [Journal Article] Increased frequencies of micronucleated reticulocytes and T-cell receptor mutation in Aldh2 knockout mice exposed to aceitaldehyde (2008)
  • Author(s): Kunugita N
  • Journal Title: The Journal of Toxicological Sciences 33 Pages: 31-36
  • Peer Reviewed
• [Journal Article] Effects of lifestyle on urinary 1-hydroxypyrene concentration. (2007)
  • Author(s): Kawamoto T, Yang M, Kim Y-D, Kim H, Oyama T, Isse T, Matsuno K, Katoh T, Uchiyama I
  • Journal Title: Journal of Occupational Health 49(3) Pages: 183-189
  • NAID: 110006278712
  • Peer Reviewed
• [Journal Article] International comparison of criteria for evaluating sensitization of PRTR-designated chemical substances. (2007)
  • Author(s): Murakami T, Oyama T, Isse T, Ogawa M, Sugie T, Kawamoto T
  • Journal Title: Environmental Health and Preventive Medicine 12(2) Pages: 56-65
  • NAID: 110006243383
  • Peer Reviewed
• [Journal Article] Increased formation of hepatic N2-ethylidene-2'-deoxyguanosine DNA adduct in aldehyde dehydrogenase 2 knockout mice treated with ethanol. (2007)
  • Author(s): Matsuda T, Matsumoto A, Uchida M, Kanaly R, Misaki K, Shinya Shibutani S, Kawamoto T, Kitagawa K, Nakayama K-I, Tomokuni K, Ichiba M
  • Journal Title: Carcinogenesis 28(11) Pages: 2363-2366
  • Peer Reviewed
• [Journal Article] Susceptibility to inhalation toxicity of acetaldehyde in Aldh2 knockout mice. (2007)
  • Author(s): Oyama T, Isse T, Ogawa M, Muto M, Uchiyama I, Kawamoto T
  • Journal Title: Frontiers in Bioscience 12 Pages: 1927-1934
  • Peer Reviewed
• [Journal Article] A comparison of covalent binding of ethanol metabolites to DNA according to Aldh2 genotype. (2007)
  • Author(s): Ogawa M, Oyama T, Isse T, Saito K, Tomigahara Y, Endo Y, Kawamoto T
  • Journal Title: Toxicol Lett. 168(2) Pages: 148-154
  • Peer Reviewed
• [Journal Article] 指定感作性物質の国際比較 (2007)
  • Author(s): 村上朋絵、小山倫浩、一瀬豊日、奈良井理恵、金岡麻希、PHAN Thi Thu Phuong、川本俊弘
  • Journal Title: 産業医科大学雑誌 29(3) Pages: 303-388
  • NAID: 110006381797
  • Peer Reviewed
• [Journal Article] Uchiyama I. : Effects of lifestyle on urinary 1-hydroxypyrene concentration (2007)
  • Author(s): Kawamoto T, Yang M, Kim Y-D, Kim H, Oyama T, Isse T, Matsuno K, Katoh T, Uchiyama I
  • Journal Title: Journal of Occupational Health 183-189 Pages: 49-49
  • Peer Reviewed
• [Journal Article] International comparison of criteria for evaluating sensitization of PRTR-designated chemical substances (2007)
  • Author(s): Murakami T, Oyama T, Isse T, Ogawa M, Sugie T, Kawamoto T
  • Journal Title: Environmental Health and Preventive Medicine 56-65 Pages: 12-12
  • NAID: 110006243383
  • Peer Reviewed
• [Journal Article] Susceptibility to inhalation toxicity of acetaldehyde in Aldh2 knockout mice (2007)
  • Author(s): Oyama, T.
  • Journal Title: Frontiers in Bioscience 12 Pages: 1927-1934
  • Peer Reviewed
• [Journal Article] A comparison of covalent binding of ethanol metabolites to DNA according to Aldh2 genotype (2007)
  • Author(s): Ogawa M
  • Journal Title: Toxicology Letters 168 Pages: 148-154
  • Peer Reviewed
• [Journal Article] Effects of lifestyle on urinary l-hydroxypyrene concentration (2007)
  • Author(s): Kawamoto T
  • Journal Title: Journal of Occupational Health 49 Pages: 183-189
  • Peer Reviewed
• [Journal Article] Number of nitrate groups determines reactivity and potency of organic nitrates: a porrf of concept stusy in ALDH-2^<-/-> mice (2007)
  • Author(s): Wenzel P
  • Journal Title: British Journal of Pharmacology 150 Pages: 526-533
  • Peer Reviewed
• [Journal Article] Increased formation of hepatic N^2-ethylidene-2'-deoxyguanosine DNA adduct in aldehyde dehydrogemase 2 knockout mice treated with ethanol (2007)
  • Author(s): Matsuda T
  • Journal Title: Carcinogenesis 28 Pages: 2363-2366
  • Peer Reviewed
• [Journal Article] Increased cytochrome P450 and aryl hydrocarbon receptor in bronchial epithelium of heavy smokers with non-small cell lung carcinoma carries a poor prognosis (2007)
  • Author(s): Oyama T
  • Journal Title: Frontiers in Bioscience 12 Pages: 4497-4503
  • Peer Reviewed
• [Journal Article] Lack of aldehyde dehydrogenase ameliorates oxidative stress induced by single-dose ethanol administration in mouse liver (2007)
  • Author(s): Matsumoto A
  • Journal Title: Alcohol 41 Pages: 57-59
  • Peer Reviewed
• [Journal Article] Activities of antioxidant enzymes induced by ethanol exposure in aldehyde dehydrogenase 2 knockout mice (2007)
  • Author(s): Eom S-Y
  • Journal Title: Journal of Health Science 53 Pages: 378-381
  • Peer Reviewed
• [Journal Article] A pilot study on subacute ethanol treatment of ALPff2 KO mice (2007)
  • Author(s): Oyama T
  • Journal Title: The Journal of Toxicological Sciences 12 Pages: 421-428
  • Peer Reviewed
• [Journal Article] Ethanol-induced oxidative DNA damage and CYP2EI exPression n liver tissue of Aldh2 knockout mice (2007)
  • Author(s): Kim Y-D
  • Journal Title: Journal of Occupational Health 49 Pages: 363-369
  • Peer Reviewed
• [Journal Article] Single-dose ethanol administration downregulates expression of cytochrome p450 2El mRNA in aldehyde dehvdrogenase 2 knockout mice (2007)
  • Author(s): Matsumoto A
  • Journal Title: Alcohol 41 Pages: 587-589
  • Peer Reviewed
• [Journal Article] International comparison of criteria for evaluating sensitization of PRTR-designated chemical substances (2007)
  • Author(s): Murakami T, Oyama T, Isse T, Ogawa M, Sugio T, Kawamoto T
  • Journal Title: Environmental Health and Preventive Medicine 12(2) (in press)
  • NAID: 110006243383
• [Journal Article] Susceptibility to inhalation toxicity of acetaldehyde in Aldh2 knockout mice (2007)
  • Author(s): Oyama T, Isse T, Ogawa M, Muto M, Uchiyama I, Kawamoto T
  • Journal Title: Frontiers in Bioscience 12 Pages: 1927-1934
• [Journal Article] Hemoglobin adducts as a marker of exposure to chemical substances, especially PRTR class I designated chemical substances. (2006)
  • Author(s): Ogawa M, Oyama T, Isse T, Yamaguchi T, Murakami T, Endo Y, Kawamoto T
  • Journal Title: Journal of Occupational Health. 48 Pages: 314-328
  • NAID: 110004821575
• [Journal Article] Urinary 8-Hydoxydeoxyguanosine (8-OHdG) and Plasma Malondialdehyde (MDA) Levels in Aldh2 knock-out mice under acetaldehyde exposure (2006)
  • Author(s): Ogawa M, Isse T, Oyama T, Kunugita N, Yamaguchi T, Kinaga T, Narai R, Kim H, Uchiyama I, Kawamoto T
  • Journal Title: Industrial Health 44 Pages: 179-183
  • NAID: 40007169620
• [Journal Article] Hemoglobin adducts as a marker of exposure to chemical substances, especially PRTR class I designated chemical substances (2006)
  • Author(s): Ogawa M, Oyama T, Isse T, Yamaguchi T, Murakami T, Endo Y, Kawamoto T
  • Journal Title: Journal of Occupational Health 48(5) Pages: 314-328
  • NAID: 110004821575
• [Presentation] DNA adducts in liver and lung of Aldh2 knockout mice treated with acetaldehyde inhalation (2009)
  • Author(s): Oyama T, Thi-Thu-Phuong Pham TTP, Yu H-S, Tanaka M, Nagayoshi H, Matsuda T, Kawamoto T
  • Organizer: The 12^<th> International Symposium of Society for the Aldh2 Knockout Mouse Research
  • Place of Presentation: 産業医科大学(Kitakyushu, Japan)
  • Year and Date: 2009-10-05
• [Presentation] Application of tryptophan fluorescence to assess sensitizing potentials of chemicals (Special Lecture) (2009)
  • Author(s): Pham TTP, Oyama T, Isse T, Kawamoto T
  • Organizer: The 12^<th> International Symposium of Society for the Aldh2 Knockout Mouse Research
  • Place of Presentation: 産業医科大学(Kitakyushu, Japan)
  • Year and Date: 2009-10-05
• [Presentation] Characteristics of aldehyde dehydrogenase 2 (Aldh2) knockout mice (Special Lecture) (2009)
  • Author(s): Yu H-S, Oyama T, Isse T, Kitakawa K, Ogawa M, Pham TTP, Kawamoto T
  • Organizer: The 12^<th> International Symposium of Society for the Aldh2 Knockout Mouse Research
  • Place of Presentation: 産業医科大学(Kitakyushu, Japan)
  • Year and Date: 2009-10-05
• [Presentation] Application of tryptophan fluorescence to assess sensitizing potentials of chemicals (2009)
  • Author(s): Pham TTP, Oyama T, Isse T, Kawamoto T
  • Organizer: 48th Annual Meeting of Society of Toxicology.
  • Place of Presentation: Baltimore, MA. USA.
• [Presentation] Nation -wide birth cohort study on children's health and the environment in Japan (2009)
  • Author(s): Kawamoto T, Hasegawa M, Tsukamoto N, Kayama F, Nitta H, Murata K, Kishi, Satoh H
  • Organizer: 3^<rd> WHO International Conference on Children's Health and the Environment
  • Place of Presentation: Busan Exhibition and Convention Center (Korea)
• [Presentation] ALDH2 genotype is critical for DNA adducts formation in mice treated with alcohol and acetaldehyde (2009)
  • Author(s): Matsuda T, Nagayoshi H, Oka M, Yukawa Y, K Hori K, T Kawamoto T, Muto M, T Oyama T
  • Organizer: 10th International Conference on Environmental Mutagens (ICEM), 39th Annual Meeting of the European Environmental Mutagen Society (EEMS) and 18th Annual Meeting of the Italian Environmental Mutagen Society (SIMA)
  • Place of Presentation: Firenze International Conference Center (Italy)
• [Presentation] Historical changes of setting EQSs (environmental quality standards) for ambient air in Japan (Symposium) (2009)
  • Author(s): Kawamoto T
  • Organizer: 2009 Taiwan-Japan Environmental Medicine Workshop. Kaoshiung Medical University
  • Place of Presentation: 高雄医科大学(Taiwan)
• [Presentation] 子どもの健康と環境に関する全国調査(エコチル調査)について.フォーラムII「化学物質の健康リスク評価の最前線」 (2009)
  • Author(s): 川本俊弘
  • Organizer: フォーラム2009衛生薬学・環境トキシコロジー-安心・安全、健やかな環境、そして福寿へ-
  • Place of Presentation: 沖縄コンベンションセンター(宜野湾市)
• [Presentation] Application of tryptophan fluorescence to assess sensitizing potentials of chemicals (2009)
  • Author(s): Pham TTP, Oyama T, Isse T, Kawamoto T
  • Organizer: 48^<th> Annual Meeting of Society of Toxicology
  • Place of Presentation: Baltimore (USA)
• [Presentation] Health risk assessment and management of hazardous air pollutants in Japan (2008)
  • Author(s): Kawamoto T
  • Organizer: The 30^<th> International Sympsium on Environmental Issues. -Fosterage of environmental industry and management of toxic pollutants-
  • Place of Presentation: Kyungsan (Korea)
  • Year and Date: 2008-06-03
• [Presentation] Aneletrophoretic study on covalent bidings of sensitizing chemical substances to albumin. (2008)
  • Author(s): Kawamoto T, Oyama T, Isse T, Pham TTP
  • Organizer: 47th Annual Meeting of Society of Toxicology. Seattle
  • Place of Presentation: WA. USA.
• [Presentation] Covalent bindings of environmental sensitizing chemicals to human serum albumin. (2008)
  • Author(s): Kawamoto T, Pham TTP, Isse T, Oyama T, Matsuno K
  • Organizer: The 2nd East Asia Conference of the International Society for Environmental Epidemiology.
  • Place of Presentation: Lotte Hotel Jeju, Korea
• [Presentation] An electrophoretic study on covalent bindings of sensitizing chemical substances to albumin (2008)
  • Author(s): Kawamoto T, Oyama T, Isse T, Pham TTP
  • Organizer: 47^<th> Annual Meeting of Society of Toxicology. Seattle Annual Meeting of Society of Toxicology. Seattle
  • Place of Presentation: Seattle, USA, Mar
• [Presentation] Covalent bindings of environiental sensitizing chemicals to human serum albumin (2008)
  • Author(s): Kawaioto T, Pham TTP, Isse T, Oyama T, Matsuno K
  • Organizer: The 2nd East Asia Conference of the International Society for Environmental Epidemiology
  • Place of Presentation: Jeju (Korea)
• [Presentation] Action Plan of Japan National Children's study (2008)
  • Author(s): Kawamoto T
  • Organizer: International Symposium on the Environmental Risk of Chemicals-For Children Who Will Play Active Roles in Tomorrow's Society-
  • Place of Presentation: Tokyo
• [Presentation] SuscePtibility differences of the Koren Pears(pyrus pyrifolia var.)induced alcohol detoxification in Aldh2 knockout mice (2008)
  • Author(s): Yang M
  • Organizer: 47th Annual Meeting of Society of Toxicology
  • Place of Presentation: Seattle
• [Presentation] 低濃度アセトアルデヒド経気道曝露によるマウスにおける生体影響評価 (2007)
  • Author(s): 欅田 尚樹
  • Organizer: 第25回産業医科大学学会
  • Place of Presentation: 北九州
  • Year and Date: 2007-10-05
• [Presentation] ノックアウトマウスを用いた遺伝子多型研究～産業衛生学からの発展～ (2007)
  • Author(s): 川本俊弘
  • Organizer: 第80回日本産業衛生学会
  • Place of Presentation: 大阪(学会賞受賞講演)
  • Year and Date: 2007-04-27
• [Presentation] ノックアウトとマウスを用いた遺伝子多型研究〜産業衛生学からの発展[学会賞受賞講演] (2007)
  • Author(s): 川本 俊弘
  • Organizer: 第80回日本産業衛生学会
  • Place of Presentation: 大阪
  • Year and Date: 2007-04-27
• [Presentation] Covalent bindings of environmental chemicals and albumin: An analysis by electrophoresis. (2007)
  • Author(s): Kawamoto T, Yamaguchi T, Pham TTP, Isse T, Oyama T, Matsuno K
  • Organizer: XI International Congress of Toxicology. Montreal
  • Place of Presentation: Canada.
• [Presentation] Numher of nitrate group determines reactive and potency of organic nitrate:a proof of concept study in ALDH2-/-mice (2007)
  • Author(s): Wenzel P
  • Organizer: Ateriosclerosis, Thrombosis and Vascular Biology Annual Congerence 2007 (American Heart Association)
  • Place of Presentation: Chicago
• [Presentation] アルデヒド脱水素酵素2ノックアウトの呼吸器系組織におけるアルデヒド感受性 (2007)
  • Author(s): 小山 倫浩
  • Organizer: 第80回日本産業衛生学会
  • Place of Presentation: 大阪
• [Presentation] 遺伝子多型による毒性の差を検出する簡易濃度固定急性吸入毒性試験;アルデヒド脱水素酵素2ノックアウトマウス(Aldh2-/-)を用いた検討 (2007)
  • Author(s): 一瀬 豊日
  • Organizer: 第34回日本トキシコロジー学会
  • Place of Presentation: 東京
• [Presentation] Covalent bindings of environmental chemicals and albumin:An analysis by electrophoresis (2007)
  • Author(s): Kawamoto T
  • Organizer: XI International Congress of Toxicology
  • Place of Presentation: Montreal
• [Presentation] Effect of ethylene glycol monoethyl ether on sperm in Aldh2 Knockout mice (2007)
  • Author(s): Wang RS
  • Organizer: XI International Congress of Toxicology
  • Place of Presentation: Montreal
• [Presentation] Aldh2 transgenic knockout mice dislike alcohol drinking and receive severer acetaldehyde toxicity (2007)
  • Author(s): Isse T
  • Organizer: 11th Congress of the European Society for Biomedical Research on Alcoholism
  • Place of Presentation: Berlin
• [Presentation] Electrophoresis of human serum albumin treated with environmental chemicals (2007)
  • Author(s): Pham TTP
  • Organizer: 4th Joint Meeting of the Society for Free Radical Research(SFRR)Australasia and Japan
  • Place of Presentation: Kyoto
• [Presentation] An electrophoretic study on covalent bindings of sensitizing chemical substances to albumin (2007)
  • Author(s): Kawamoto T
  • Organizer: 47th Annual Meeting of Society of Toxicology
  • Place of Presentation: Seattle
• [Presentation] Chemical substances which each country evaluates to produce sensitization. (2006)
  • Author(s): Murakami T, Oyama T, Isse T, Narai R, Kinaga T, Ogawa M, Yamaguchi T, Kawamoto T
  • Organizer: The 45th Annual Meeting of Society of Toxicology.
  • Place of Presentation: San Diego, California, USA
• [Presentation] Hemoglobin adduct as exposure markers of chemical substances. (2006)
  • Author(s): Ogawa M, Oyama T, Isse T, Murakami T, Yamaguchi T, Kinaga T, Kawamoto T
  • Organizer: The 45th Annual Meeting of Society of Toxicology.
  • Place of Presentation: San Diego, California, USA
• [Book] Biological Monitoring-National-wide practice and future directions-. In: Cato MA editor. Environmental Research Trends. (2007)
  • Author(s): Kawamoto T, Wada O
  • Publisher: Nova Science Publishers; Inc.
• [Book] Progress in Environmental Research.(Irma C. Willis editor., Chapter 10. Biological Monitoring:-Nation-wide practice and future directions-.) (2007)
  • Author(s): Kawamoto T, Wada O
  • Publisher: Nova Science Publishers; Inc.
• [Book] Chapter 10. Biological Monitoring : ~Nation-wide practice and future directions~ (2007)
  • Author(s): Kawamoto T, Wada O
  • Publisher: Irma C. Willis editor. Progress in Environmental Research. Nova Science Publishers
• [Book] Environmental Research Trends (2007)
  • Author(s): Kawamoto T
  • Publisher: Nova Science Publications
• [Book] Biological Monitoring ~Nation-wide practice and future directions~ (2007)
  • Author(s): Kawamoto T, Wada O
  • Publisher: Cato MA editor. Environmental Research Trends. Nova Science Publishers; Inc. (in press)
• [Book] Enzymology and Molecular Biology of Carbonyl Metabolism-12.(Weiner, H., Plapp, B., Lindahl, R., Maser, E. (Eds), Actalodehyde elimination changes in transgenic mice lacking aldehyde dehydrogenase 2 activity.) (2006)
  • Author(s): Isse T, Oyama T, Matsuno K, Kitagawa K, Ogawa M, Kinaga T, Suzuki-Narai R, Yamaguchi T, Uchiyama I, Kawamoto T
  • Publisher: Purdue University Press
• [Remarks] ホームページ
  • URL: http://www.uoeh-u.ac.jp/kouza/eiseigak/intro_j.
• [Remarks]
  • URL: http://www.uoeh-u.ac.jp/kouza/eiseigak/intro_j.html
• [Patent(Industrial Property Rights)] 化学物質のアレルギー誘発能の簡便・迅速定量方法 (2008)
  • Inventor(s): 川本俊弘
  • Industrial Property Rights Holder: 川本俊弘
  • Industrial Property Number: 2008-120130
  • Filing Date: 2008-05-02
  • Acquisition Date: 2008-05-02