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Development of specific immunoglobulin against environmental sensitizing chemicals and actual survey on sensitizing status

Research Project

Project/Area Number 18390187
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Hygiene
Research InstitutionUniversity of Occupational and Environmental Health, Japan

Principal Investigator

KAWAMOTO Toshihiro  University of Occupational and Environmental Health, Japan, 医学部, 教授 (60177748)

Co-Investigator(Kenkyū-buntansha) OYAMA Tsunehiro  産業医科大学, 医学部, 准教授 (00309965)
ISSE Toyohi  産業医科大学, 医学部, 准教授 (80341494)
松野 康二  産業医科大学, 産業医学研究支援施設, 助教授 (40131940)
Project Period (FY) 2006 – 2009
Project Status Completed (Fiscal Year 2009)
Budget Amount *help
¥14,320,000 (Direct Cost: ¥11,800,000、Indirect Cost: ¥2,520,000)
Fiscal Year 2009: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2008: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2007: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2006: ¥3,400,000 (Direct Cost: ¥3,400,000)
Keywords環境 / 感作 / 化学物質 / アレルギー / 免疫グロブリン / アルデヒド脱水素酵素 / ノックアウトマウス / 共有結合 / 環境化学物質 / IgE / IgG / 蛋白付加体 / プロテオミクス / 質量分析 / 蛋白質付加体 / SDS-PAGE
Research Abstract

Structural changes of our body proteins caused by the binding of chemical substances are one of the most important mechanisms of allergy onset. When human serum albumin (HSA) was mixed with sensitizing chemical substances, the fluorescence (280nm excitation and 340nm emission) of HSA decreased dose-dependently. The reduction of HSA fluorescence by treatment with chemicals was by the following order ; commonly designated sensitizers> possible sensitizers> non-sensitizers. HSA fluorescence after treatment with test chemicals may be a good predictor for their sensitizing potentials. The antigenicity of chemical-HSA adducts toward sera from sensitized patients was varied according to the condition in which the adducts were formed. An effective method to detect antibody against chemical-HSA adducts were developed. Acetaldehyde inhalation caused more DNA adducts at upper respiratory tracts in Aldh2 knockout mice more than in wild type mice.

Report

(6 results)
  • 2009 Annual Research Report   Final Research Report ( PDF )
  • 2008 Annual Research Report   Self-evaluation Report ( PDF )
  • 2007 Annual Research Report
  • 2006 Annual Research Report
  • Research Products

    (83 results)

All 2009 2008 2007 2006 Other

All Journal Article (44 results) (of which Peer Reviewed: 36 results) Presentation (30 results) Book (6 results) Remarks (2 results) Patent(Industrial Property Rights) (1 results)

  • [Journal Article] Characteristics of aldehyde dehydrogenase 2 (Aldh2) knockout mice.2009

    • Author(s)
      Yu H-S, Oyama T, Isse T, Kitagawa K, Ogawa M, Pham TTP, Kawamoto T.
    • Journal Title

      Toxicology Mechanisms and Methods 19(9)

      Pages: 535-540

    • Related Report
      2009 Final Research Report
  • [Journal Article] Cholinergic alterations following alcohol exposure in the frontal cortex of Aldh2-deficinet mice models.2009

    • Author(s)
      Jamal M, Ameno K, Miki T, Wang W, Kumihashi M, Isse T, Kawamoto T, Kitagawa K, Nakayama K-I, Ijiri I, Kinoshita H
    • Journal Title

      Brain Research 1295

      Pages: 37-43

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Increased formation of gastric N2-ethylidene-2'-deoxyguanosine DNA adducts in aldehyde dehydrogenase-2 knockout mice treated with ethanol.2009

    • Author(s)
      Nagayoshi H, Matsumoto A, Nishi R, Kawamoto T, Ichiba M, Matsuda T.
    • Journal Title

      Mutation Research-Genetic Toxicology and Environmental Mutagenesis. 673

      Pages: 74-77

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Application of tryptophan fluorescence to assess sensitizing potentials of chemicals.2009

    • Author(s)
      Pham TTP, Oyama T, Isse T, Kawamoto T
    • Journal Title

      Archives of Environmental Contamination and Toxicology. 57

      Pages: 427-436

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] A new class of organic nitrates : Investigations on bioactivation, tolerance and cross-tolerance phenomena2009

    • Author(s)
      Schuhmacher S, Schulz E, Oelze M, Koenig A, Roegler C, Lange K, Sydow L, Kawamoto T, Wenzel P, Muenzel T, Lehmann J, Daiber A
    • Journal Title

      British Journal of Pharmacology 158

      Pages: 510-520

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Application of tryptophan fluorescence to assess sensitizing potentials of chemicals2009

    • Author(s)
      Pham TTP, Oyama T, Isse T, Kawamoto T
    • Journal Title

      Application of tryptophan fluorescence to assess sensitizing potentials of chemicals 57

      Pages: 427-436

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Ethanol metabolism in ALDH2 knockout mice I Blood acetate levels2009

    • Author(s)
      Ameno K, Wang W., Jamal M, Toyohi I, Kawamoto T, Kitagawa K, Nakayama K-I, Ijiri I, Kinoshita H
    • Journal Title

      Legal Medicine 11

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Cholinergic alterations following alcohol exposure in the frontal cortex of Aldh2-deficinet mice models2009

    • Author(s)
      Jamal M, Ameno K, Miki T, Wang W, Kumihashi M, Isse T, Kawamoto T, Kitagawa K, Nakayama K-I, Ijiri I, Kinoshita H
    • Journal Title

      Brain Research 1295

      Pages: 37-43

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Characteristics of aldehyde dehydrogenase 2 (Aldh2) knockout mices2009

    • Author(s)
      Yu H-S, Oyama T, Isse T, Kitagawa K, Ogawa M, Pham TTP, Kawamoto T
    • Journal Title

      Toxicology Mechanisms and Methods 19

      Pages: 535-540

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] ダイオードアレイ検出器高速液体クロマトグラフィーを用いた感作性化学物質による蛋白付加体形成の簡易検査法2009

    • Author(s)
      一瀬豊日、Pham TTP、小山倫浩、荻野景規、川本俊弘
    • Journal Title

      日本予防医学会雑誌 4

      Pages: 23-28

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 環境省「子どもの健康と環境に関する全国調査(エコチル調査)」2009

    • Author(s)
      丹藤昌治、塚本直也、月森清巳、川本俊弘
    • Journal Title

      ペリネイタルケア 28

      Pages: 66-72

    • Related Report
      2009 Annual Research Report
  • [Journal Article] Increased formation of gastric N^2-ethylidene-2'-deoxyguanosine DNA adducts in aldehyde dehydrogenase-2 knockout mice treated with ethanol2009

    • Author(s)
      Nagayoshi H, Matsumoto A, Nishi R, Kawamoto T, Ichiba M, Matsuda T
    • Journal Title

      Mutation Research-Genetic Toxicology and Environmental Mutagenesis (In press)

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] ALDH-2 deficiency increases vascular oxidative stress-Evidence for indirect antioxidative properties.2008

    • Author(s)
      Wenzel P, Muller J, Zurmeyer S, Schumacher S, Schulz E, Oelze M, Pautz A, Kawamoto T, Wojnowski L, Kleinert H, Munzel T.
    • Journal Title

      Biochemical and Biophysical Research Communications 367

      Pages: 137-143

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Effects of 5-week ethanol feeding on the liver of aldehyde dehydorgenase 2 knockout mice.2008

    • Author(s)
      Matsumoto A, Kawamoto T, Mutoh F, Isse T, Oyama T, Kitagawa K, Nakayama K-I. Ichiba M.
    • Journal Title

      Pharmacogenetics and Genomices 18

      Pages: 847-852

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] ホルムアルデヒドへのアレルギーを主症状としたシックハウス症候群の1例2008

    • Author(s)
      小川真規、西中川秀太、横沢冊子、後藤浩之、川本俊弘、圓藤陽子
    • Journal Title

      産業衛生学雑誌 50

      Pages: 83-85

    • NAID

      110006783279

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] ホルムアルデヒドへのアレルギーを主症状としたシックハウス症候群の1例2008

    • Author(s)
      小川真規、西中川秀太、横沢冊子、後藤浩之、川本俊弘、圓藤陽子
    • Journal Title

      産業衛生学雑誌 83-85

      Pages: 50-50

    • NAID

      110006783279

    • Related Report
      2008 Self-evaluation Report
    • Peer Reviewed
  • [Journal Article] ALDH-2 deficiency increases vascular oxidative stress-Evidence for indirect antioxidative properties2008

    • Author(s)
      Wenzel P
    • Journal Title

      Biochemical and Biophysical Research Communications 367

      Pages: 137-143

    • Related Report
      2008 Annual Research Report 2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] ホルムアルデヒドへのアレルギーを主症状としたシックハウス症候群の1例2008

    • Author(s)
      小川真規, 西中川秀太, 横沢冊子, 後藤浩之, 川本俊弘, 圓藤陽子
    • Journal Title

      産業衛生学雑誌 50

      Pages: 83-85

    • NAID

      110006783279

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 特集 : 環境粒子状物質と呼吸器、粒子状物質の成分と健康影響2008

    • Author(s)
      川本俊弘, 中館俊夫, 若松伸司, 小山倫浩
    • Journal Title

      呼吸器科 14

      Pages: 206-212

    • Related Report
      2008 Annual Research Report
  • [Journal Article] Increased frequencies of micronucleated reticulocytes and T-cell receptor mutation in Aldh2 knockout mice exposed to aceitaldehyde2008

    • Author(s)
      Kunugita N
    • Journal Title

      The Journal of Toxicological Sciences 33

      Pages: 31-36

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Effects of lifestyle on urinary 1-hydroxypyrene concentration.2007

    • Author(s)
      Kawamoto T, Yang M, Kim Y-D, Kim H, Oyama T, Isse T, Matsuno K, Katoh T, Uchiyama I
    • Journal Title

      Journal of Occupational Health 49(3)

      Pages: 183-189

    • NAID

      110006278712

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] International comparison of criteria for evaluating sensitization of PRTR-designated chemical substances.2007

    • Author(s)
      Murakami T, Oyama T, Isse T, Ogawa M, Sugie T, Kawamoto T
    • Journal Title

      Environmental Health and Preventive Medicine 12(2)

      Pages: 56-65

    • NAID

      110006243383

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Increased formation of hepatic N2-ethylidene-2'-deoxyguanosine DNA adduct in aldehyde dehydrogenase 2 knockout mice treated with ethanol.2007

    • Author(s)
      Matsuda T, Matsumoto A, Uchida M, Kanaly R, Misaki K, Shinya Shibutani S, Kawamoto T, Kitagawa K, Nakayama K-I, Tomokuni K, Ichiba M
    • Journal Title

      Carcinogenesis 28(11)

      Pages: 2363-2366

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Susceptibility to inhalation toxicity of acetaldehyde in Aldh2 knockout mice.2007

    • Author(s)
      Oyama T, Isse T, Ogawa M, Muto M, Uchiyama I, Kawamoto T
    • Journal Title

      Frontiers in Bioscience 12

      Pages: 1927-1934

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] A comparison of covalent binding of ethanol metabolites to DNA according to Aldh2 genotype.2007

    • Author(s)
      Ogawa M, Oyama T, Isse T, Saito K, Tomigahara Y, Endo Y, Kawamoto T
    • Journal Title

      Toxicol Lett. 168(2)

      Pages: 148-154

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] 指定感作性物質の国際比較2007

    • Author(s)
      村上朋絵、小山倫浩、一瀬豊日、奈良井理恵、金岡麻希、PHAN Thi Thu Phuong、川本俊弘
    • Journal Title

      産業医科大学雑誌 29(3)

      Pages: 303-388

    • NAID

      110006381797

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Uchiyama I. : Effects of lifestyle on urinary 1-hydroxypyrene concentration2007

    • Author(s)
      Kawamoto T, Yang M, Kim Y-D, Kim H, Oyama T, Isse T, Matsuno K, Katoh T, Uchiyama I
    • Journal Title

      Journal of Occupational Health 183-189

      Pages: 49-49

    • Related Report
      2008 Self-evaluation Report
    • Peer Reviewed
  • [Journal Article] International comparison of criteria for evaluating sensitization of PRTR-designated chemical substances2007

    • Author(s)
      Murakami T, Oyama T, Isse T, Ogawa M, Sugie T, Kawamoto T
    • Journal Title

      Environmental Health and Preventive Medicine 56-65

      Pages: 12-12

    • NAID

      110006243383

    • Related Report
      2008 Self-evaluation Report
    • Peer Reviewed
  • [Journal Article] Susceptibility to inhalation toxicity of acetaldehyde in Aldh2 knockout mice2007

    • Author(s)
      Oyama, T.
    • Journal Title

      Frontiers in Bioscience 12

      Pages: 1927-1934

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A comparison of covalent binding of ethanol metabolites to DNA according to Aldh2 genotype2007

    • Author(s)
      Ogawa M
    • Journal Title

      Toxicology Letters 168

      Pages: 148-154

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Effects of lifestyle on urinary l-hydroxypyrene concentration2007

    • Author(s)
      Kawamoto T
    • Journal Title

      Journal of Occupational Health 49

      Pages: 183-189

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Number of nitrate groups determines reactivity and potency of organic nitrates: a porrf of concept stusy in ALDH-2^<-/-> mice2007

    • Author(s)
      Wenzel P
    • Journal Title

      British Journal of Pharmacology 150

      Pages: 526-533

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Increased formation of hepatic N^2-ethylidene-2'-deoxyguanosine DNA adduct in aldehyde dehydrogemase 2 knockout mice treated with ethanol2007

    • Author(s)
      Matsuda T
    • Journal Title

      Carcinogenesis 28

      Pages: 2363-2366

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Increased cytochrome P450 and aryl hydrocarbon receptor in bronchial epithelium of heavy smokers with non-small cell lung carcinoma carries a poor prognosis2007

    • Author(s)
      Oyama T
    • Journal Title

      Frontiers in Bioscience 12

      Pages: 4497-4503

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Lack of aldehyde dehydrogenase ameliorates oxidative stress induced by single-dose ethanol administration in mouse liver2007

    • Author(s)
      Matsumoto A
    • Journal Title

      Alcohol 41

      Pages: 57-59

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Activities of antioxidant enzymes induced by ethanol exposure in aldehyde dehydrogenase 2 knockout mice2007

    • Author(s)
      Eom S-Y
    • Journal Title

      Journal of Health Science 53

      Pages: 378-381

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A pilot study on subacute ethanol treatment of ALPff2 KO mice2007

    • Author(s)
      Oyama T
    • Journal Title

      The Journal of Toxicological Sciences 12

      Pages: 421-428

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Ethanol-induced oxidative DNA damage and CYP2EI exPression n liver tissue of Aldh2 knockout mice2007

    • Author(s)
      Kim Y-D
    • Journal Title

      Journal of Occupational Health 49

      Pages: 363-369

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Single-dose ethanol administration downregulates expression of cytochrome p450 2El mRNA in aldehyde dehvdrogenase 2 knockout mice2007

    • Author(s)
      Matsumoto A
    • Journal Title

      Alcohol 41

      Pages: 587-589

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] International comparison of criteria for evaluating sensitization of PRTR-designated chemical substances2007

    • Author(s)
      Murakami T, Oyama T, Isse T, Ogawa M, Sugio T, Kawamoto T
    • Journal Title

      Environmental Health and Preventive Medicine 12(2) (in press)

    • NAID

      110006243383

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Susceptibility to inhalation toxicity of acetaldehyde in Aldh2 knockout mice2007

    • Author(s)
      Oyama T, Isse T, Ogawa M, Muto M, Uchiyama I, Kawamoto T
    • Journal Title

      Frontiers in Bioscience 12

      Pages: 1927-1934

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Hemoglobin adducts as a marker of exposure to chemical substances, especially PRTR class I designated chemical substances.2006

    • Author(s)
      Ogawa M, Oyama T, Isse T, Yamaguchi T, Murakami T, Endo Y, Kawamoto T
    • Journal Title

      Journal of Occupational Health. 48

      Pages: 314-328

    • NAID

      110004821575

    • Related Report
      2009 Final Research Report
  • [Journal Article] Urinary 8-Hydoxydeoxyguanosine (8-OHdG) and Plasma Malondialdehyde (MDA) Levels in Aldh2 knock-out mice under acetaldehyde exposure2006

    • Author(s)
      Ogawa M, Isse T, Oyama T, Kunugita N, Yamaguchi T, Kinaga T, Narai R, Kim H, Uchiyama I, Kawamoto T
    • Journal Title

      Industrial Health 44

      Pages: 179-183

    • NAID

      40007169620

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Hemoglobin adducts as a marker of exposure to chemical substances, especially PRTR class I designated chemical substances2006

    • Author(s)
      Ogawa M, Oyama T, Isse T, Yamaguchi T, Murakami T, Endo Y, Kawamoto T
    • Journal Title

      Journal of Occupational Health 48(5)

      Pages: 314-328

    • NAID

      110004821575

    • Related Report
      2006 Annual Research Report
  • [Presentation] DNA adducts in liver and lung of Aldh2 knockout mice treated with acetaldehyde inhalation2009

    • Author(s)
      Oyama T, Thi-Thu-Phuong Pham TTP, Yu H-S, Tanaka M, Nagayoshi H, Matsuda T, Kawamoto T
    • Organizer
      The 12^<th> International Symposium of Society for the Aldh2 Knockout Mouse Research
    • Place of Presentation
      産業医科大学(Kitakyushu, Japan)
    • Year and Date
      2009-10-05
    • Related Report
      2009 Annual Research Report
  • [Presentation] Application of tryptophan fluorescence to assess sensitizing potentials of chemicals (Special Lecture)2009

    • Author(s)
      Pham TTP, Oyama T, Isse T, Kawamoto T
    • Organizer
      The 12^<th> International Symposium of Society for the Aldh2 Knockout Mouse Research
    • Place of Presentation
      産業医科大学(Kitakyushu, Japan)
    • Year and Date
      2009-10-05
    • Related Report
      2009 Annual Research Report
  • [Presentation] Characteristics of aldehyde dehydrogenase 2 (Aldh2) knockout mice (Special Lecture)2009

    • Author(s)
      Yu H-S, Oyama T, Isse T, Kitakawa K, Ogawa M, Pham TTP, Kawamoto T
    • Organizer
      The 12^<th> International Symposium of Society for the Aldh2 Knockout Mouse Research
    • Place of Presentation
      産業医科大学(Kitakyushu, Japan)
    • Year and Date
      2009-10-05
    • Related Report
      2009 Annual Research Report
  • [Presentation] Application of tryptophan fluorescence to assess sensitizing potentials of chemicals2009

    • Author(s)
      Pham TTP, Oyama T, Isse T, Kawamoto T
    • Organizer
      48th Annual Meeting of Society of Toxicology.
    • Place of Presentation
      Baltimore, MA. USA.
    • Related Report
      2009 Final Research Report
  • [Presentation] Nation -wide birth cohort study on children's health and the environment in Japan2009

    • Author(s)
      Kawamoto T, Hasegawa M, Tsukamoto N, Kayama F, Nitta H, Murata K, Kishi, Satoh H
    • Organizer
      3^<rd> WHO International Conference on Children's Health and the Environment
    • Place of Presentation
      Busan Exhibition and Convention Center (Korea)
    • Related Report
      2009 Annual Research Report
  • [Presentation] ALDH2 genotype is critical for DNA adducts formation in mice treated with alcohol and acetaldehyde2009

    • Author(s)
      Matsuda T, Nagayoshi H, Oka M, Yukawa Y, K Hori K, T Kawamoto T, Muto M, T Oyama T
    • Organizer
      10th International Conference on Environmental Mutagens (ICEM), 39th Annual Meeting of the European Environmental Mutagen Society (EEMS) and 18th Annual Meeting of the Italian Environmental Mutagen Society (SIMA)
    • Place of Presentation
      Firenze International Conference Center (Italy)
    • Related Report
      2009 Annual Research Report
  • [Presentation] Historical changes of setting EQSs (environmental quality standards) for ambient air in Japan (Symposium)2009

    • Author(s)
      Kawamoto T
    • Organizer
      2009 Taiwan-Japan Environmental Medicine Workshop. Kaoshiung Medical University
    • Place of Presentation
      高雄医科大学(Taiwan)
    • Related Report
      2009 Annual Research Report
  • [Presentation] 子どもの健康と環境に関する全国調査(エコチル調査)について.フォーラムII「化学物質の健康リスク評価の最前線」2009

    • Author(s)
      川本俊弘
    • Organizer
      フォーラム2009衛生薬学・環境トキシコロジー-安心・安全、健やかな環境、そして福寿へ-
    • Place of Presentation
      沖縄コンベンションセンター(宜野湾市)
    • Related Report
      2009 Annual Research Report
  • [Presentation] Application of tryptophan fluorescence to assess sensitizing potentials of chemicals2009

    • Author(s)
      Pham TTP, Oyama T, Isse T, Kawamoto T
    • Organizer
      48^<th> Annual Meeting of Society of Toxicology
    • Place of Presentation
      Baltimore (USA)
    • Related Report
      2008 Annual Research Report
  • [Presentation] Health risk assessment and management of hazardous air pollutants in Japan2008

    • Author(s)
      Kawamoto T
    • Organizer
      The 30^<th> International Sympsium on Environmental Issues. -Fosterage of environmental industry and management of toxic pollutants-
    • Place of Presentation
      Kyungsan (Korea)
    • Year and Date
      2008-06-03
    • Related Report
      2008 Annual Research Report
  • [Presentation] Aneletrophoretic study on covalent bidings of sensitizing chemical substances to albumin.2008

    • Author(s)
      Kawamoto T, Oyama T, Isse T, Pham TTP
    • Organizer
      47th Annual Meeting of Society of Toxicology. Seattle
    • Place of Presentation
      WA. USA.
    • Related Report
      2009 Final Research Report
  • [Presentation] Covalent bindings of environmental sensitizing chemicals to human serum albumin.2008

    • Author(s)
      Kawamoto T, Pham TTP, Isse T, Oyama T, Matsuno K
    • Organizer
      The 2nd East Asia Conference of the International Society for Environmental Epidemiology.
    • Place of Presentation
      Lotte Hotel Jeju, Korea
    • Related Report
      2009 Final Research Report
  • [Presentation] An electrophoretic study on covalent bindings of sensitizing chemical substances to albumin2008

    • Author(s)
      Kawamoto T, Oyama T, Isse T, Pham TTP
    • Organizer
      47^<th> Annual Meeting of Society of Toxicology. Seattle Annual Meeting of Society of Toxicology. Seattle
    • Place of Presentation
      Seattle, USA, Mar
    • Related Report
      2008 Self-evaluation Report
  • [Presentation] Covalent bindings of environiental sensitizing chemicals to human serum albumin2008

    • Author(s)
      Kawaioto T, Pham TTP, Isse T, Oyama T, Matsuno K
    • Organizer
      The 2nd East Asia Conference of the International Society for Environmental Epidemiology
    • Place of Presentation
      Jeju (Korea)
    • Related Report
      2008 Annual Research Report
  • [Presentation] Action Plan of Japan National Children's study2008

    • Author(s)
      Kawamoto T
    • Organizer
      International Symposium on the Environmental Risk of Chemicals-For Children Who Will Play Active Roles in Tomorrow's Society-
    • Place of Presentation
      Tokyo
    • Related Report
      2008 Annual Research Report
  • [Presentation] SuscePtibility differences of the Koren Pears(pyrus pyrifolia var.)induced alcohol detoxification in Aldh2 knockout mice2008

    • Author(s)
      Yang M
    • Organizer
      47th Annual Meeting of Society of Toxicology
    • Place of Presentation
      Seattle
    • Related Report
      2007 Annual Research Report
  • [Presentation] 低濃度アセトアルデヒド経気道曝露によるマウスにおける生体影響評価2007

    • Author(s)
      欅田 尚樹
    • Organizer
      第25回産業医科大学学会
    • Place of Presentation
      北九州
    • Year and Date
      2007-10-05
    • Related Report
      2007 Annual Research Report
  • [Presentation] ノックアウトマウスを用いた遺伝子多型研究~産業衛生学からの発展~2007

    • Author(s)
      川本俊弘
    • Organizer
      第80回日本産業衛生学会
    • Place of Presentation
      大阪(学会賞受賞講演)
    • Year and Date
      2007-04-27
    • Related Report
      2009 Final Research Report
  • [Presentation] ノックアウトとマウスを用いた遺伝子多型研究〜産業衛生学からの発展[学会賞受賞講演]2007

    • Author(s)
      川本 俊弘
    • Organizer
      第80回日本産業衛生学会
    • Place of Presentation
      大阪
    • Year and Date
      2007-04-27
    • Related Report
      2007 Annual Research Report
  • [Presentation] Covalent bindings of environmental chemicals and albumin: An analysis by electrophoresis.2007

    • Author(s)
      Kawamoto T, Yamaguchi T, Pham TTP, Isse T, Oyama T, Matsuno K
    • Organizer
      XI International Congress of Toxicology. Montreal
    • Place of Presentation
      Canada.
    • Related Report
      2009 Final Research Report
  • [Presentation] Numher of nitrate group determines reactive and potency of organic nitrate:a proof of concept study in ALDH2-/-mice2007

    • Author(s)
      Wenzel P
    • Organizer
      Ateriosclerosis, Thrombosis and Vascular Biology Annual Congerence 2007 (American Heart Association)
    • Place of Presentation
      Chicago
    • Related Report
      2007 Annual Research Report
  • [Presentation] アルデヒド脱水素酵素2ノックアウトの呼吸器系組織におけるアルデヒド感受性2007

    • Author(s)
      小山 倫浩
    • Organizer
      第80回日本産業衛生学会
    • Place of Presentation
      大阪
    • Related Report
      2007 Annual Research Report
  • [Presentation] 遺伝子多型による毒性の差を検出する簡易濃度固定急性吸入毒性試験;アルデヒド脱水素酵素2ノックアウトマウス(Aldh2-/-)を用いた検討2007

    • Author(s)
      一瀬 豊日
    • Organizer
      第34回日本トキシコロジー学会
    • Place of Presentation
      東京
    • Related Report
      2007 Annual Research Report
  • [Presentation] Covalent bindings of environmental chemicals and albumin:An analysis by electrophoresis2007

    • Author(s)
      Kawamoto T
    • Organizer
      XI International Congress of Toxicology
    • Place of Presentation
      Montreal
    • Related Report
      2007 Annual Research Report
  • [Presentation] Effect of ethylene glycol monoethyl ether on sperm in Aldh2 Knockout mice2007

    • Author(s)
      Wang RS
    • Organizer
      XI International Congress of Toxicology
    • Place of Presentation
      Montreal
    • Related Report
      2007 Annual Research Report
  • [Presentation] Aldh2 transgenic knockout mice dislike alcohol drinking and receive severer acetaldehyde toxicity2007

    • Author(s)
      Isse T
    • Organizer
      11th Congress of the European Society for Biomedical Research on Alcoholism
    • Place of Presentation
      Berlin
    • Related Report
      2007 Annual Research Report
  • [Presentation] Electrophoresis of human serum albumin treated with environmental chemicals2007

    • Author(s)
      Pham TTP
    • Organizer
      4th Joint Meeting of the Society for Free Radical Research(SFRR)Australasia and Japan
    • Place of Presentation
      Kyoto
    • Related Report
      2007 Annual Research Report
  • [Presentation] An electrophoretic study on covalent bindings of sensitizing chemical substances to albumin2007

    • Author(s)
      Kawamoto T
    • Organizer
      47th Annual Meeting of Society of Toxicology
    • Place of Presentation
      Seattle
    • Related Report
      2007 Annual Research Report
  • [Presentation] Chemical substances which each country evaluates to produce sensitization.2006

    • Author(s)
      Murakami T, Oyama T, Isse T, Narai R, Kinaga T, Ogawa M, Yamaguchi T, Kawamoto T
    • Organizer
      The 45th Annual Meeting of Society of Toxicology.
    • Place of Presentation
      San Diego, California, USA
    • Related Report
      2009 Final Research Report
  • [Presentation] Hemoglobin adduct as exposure markers of chemical substances.2006

    • Author(s)
      Ogawa M, Oyama T, Isse T, Murakami T, Yamaguchi T, Kinaga T, Kawamoto T
    • Organizer
      The 45th Annual Meeting of Society of Toxicology.
    • Place of Presentation
      San Diego, California, USA
    • Related Report
      2009 Final Research Report
  • [Book] Biological Monitoring-National-wide practice and future directions-. In: Cato MA editor. Environmental Research Trends.2007

    • Author(s)
      Kawamoto T, Wada O
    • Publisher
      Nova Science Publishers; Inc.
    • Related Report
      2009 Final Research Report
  • [Book] Progress in Environmental Research.(Irma C. Willis editor., Chapter 10. Biological Monitoring:-Nation-wide practice and future directions-.)2007

    • Author(s)
      Kawamoto T, Wada O
    • Publisher
      Nova Science Publishers; Inc.
    • Related Report
      2009 Final Research Report
  • [Book] Chapter 10. Biological Monitoring : ~Nation-wide practice and future directions~2007

    • Author(s)
      Kawamoto T, Wada O
    • Publisher
      Irma C. Willis editor. Progress in Environmental Research. Nova Science Publishers
    • Related Report
      2008 Self-evaluation Report
  • [Book] Environmental Research Trends2007

    • Author(s)
      Kawamoto T
    • Publisher
      Nova Science Publications
    • Related Report
      2007 Annual Research Report
  • [Book] Biological Monitoring ~Nation-wide practice and future directions~2007

    • Author(s)
      Kawamoto T, Wada O
    • Publisher
      Cato MA editor. Environmental Research Trends. Nova Science Publishers; Inc. (in press)
    • Related Report
      2006 Annual Research Report
  • [Book] Enzymology and Molecular Biology of Carbonyl Metabolism-12.(Weiner, H., Plapp, B., Lindahl, R., Maser, E. (Eds), Actalodehyde elimination changes in transgenic mice lacking aldehyde dehydrogenase 2 activity.)2006

    • Author(s)
      Isse T, Oyama T, Matsuno K, Kitagawa K, Ogawa M, Kinaga T, Suzuki-Narai R, Yamaguchi T, Uchiyama I, Kawamoto T
    • Publisher
      Purdue University Press
    • Related Report
      2009 Final Research Report
  • [Remarks] ホームページ

    • URL

      http://www.uoeh-u.ac.jp/kouza/eiseigak/intro_j.

    • Related Report
      2009 Final Research Report
  • [Remarks]

    • URL

      http://www.uoeh-u.ac.jp/kouza/eiseigak/intro_j.html

    • Related Report
      2008 Self-evaluation Report
  • [Patent(Industrial Property Rights)] 化学物質のアレルギー誘発能の簡便・迅速定量方法2008

    • Inventor(s)
      川本俊弘
    • Industrial Property Rights Holder
      川本俊弘
    • Industrial Property Number
      2008-120130
    • Filing Date
      2008-05-02
    • Acquisition Date
      2008-05-02
    • Related Report
      2009 Final Research Report 2008 Annual Research Report 2008 Self-evaluation Report

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Published: 2006-04-01   Modified: 2016-04-21  

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