Establishment of chemical sensitive animal model concerning modulation of memory-related function induced by inflammatory response

• Project/Area Number: 18390189
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Hygiene
• Research Institution: National Institute for Environmental Studies
• Principal Investigator: FUJIMAKI Hidekazu National Institute for Environmental Studies, 環境リスク研究センター, 室長 (00124355)
• Co-Investigator(Renkei-kenkyūsha): TIN-TIN Win-shwe 独立行政法人国立環境研究所, 環境リスク研究センター, NIESフェロー (00391128)
• Project Period (FY): 2006 – 2008
• Project Status: Completed (Fiscal Year 2008)
• Budget Amount: ¥17,030,000 (Direct Cost: ¥14,600,000、Indirect Cost: ¥2,430,000); Fiscal Year 2008: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000); Fiscal Year 2007: ¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000); Fiscal Year 2006: ¥6,500,000 (Direct Cost: ¥6,500,000)
• Keywords: 化学物質 / 炎症反応 / 記憶分子 / 動物モデル / 神経 / トルエン / 記憶 / サイトカイン / H-2 / 神経伝達物質

Research Abstract

本研究では、これまでに影響の見られない低濃度のトルエン曝露を行い記憶機能分子が影響を受けやすい特性を持った過敏動物の開発を試みた。われわれの研究室でのこれまでの知見でホルムアルデヒドに鋭敏なC3Hマウスを用いての抗原刺激の違いによる検討、免疫系のT細胞が働けないヌードマウスでの反応の変化、組織適合抗原H-2遺伝子のみの異なるコンジェニックマウスでの検討などによりトルエン曝露に対する過敏状態の誘導を検証した結果、C3H系の抗原刺激を受けたマウスがもっとも鋭敏な反応を示すことを突き止めた。

Research Products

• [Journal Article] Strain Difference of Extracellular Amino Acid Neurotransmitter Levels in the Hippocampus of MHC-Congenic Mice in Response to Toluene Exposure (2009)
  • Author(s): Tin-Tin-Win-Shwe, Dai Mitsushima, Shoji Yamamoto, Toshiya Funabashi, Hidekazu Fujimaki
  • Journal Title: Neuroimmunomodulation 16 Pages: 185-190
  • Peer Reviewed
• [Journal Article] Measurement of Toluene Concentrations in the Blood of Fetuses of Pregnant Rats Exposed to Low Concentration Toluene using Headspace Solid Phase Micro Extraction - Gas Chromatograph-Mass Spectrometry (2009)
  • Author(s): Daisuke NAKAJIMA, Shinji TSUKAHARA, Rieko HOJO, Shiho KAGEYAMA, Sumio GOTO, Hiroaki SHIRAISHI, Fujio SHIRAISHI, Hidekazu FUJIMAKI
  • Journal Title: J Health Sci 55 Pages: 50-55
  • Peer Reviewed
• [Journal Article] Establishment of a mouse model to assess brain neurotransmitter level and learning performance simultaneously following toxic chemical exposure: using in vivo microdialysis and schedule-controlled operant behavior. (2009)
  • Author(s): Tin-Tin WIN-SHWE, Rieko HOJO, Dai MITSUSHIMA, Daisuke NAKAJIMA, Shoji YAMAMOTO and Hidekazu FUJIMAKI
  • Journal Title: J UOEH 31 Pages: 1-11
  • NAID: 110007122791
  • Peer Reviewed
• [Journal Article] Modulation of systemic Th1/Th2 immune response in infant mice after prenatal exposure to low-level toluene and TLR2 ligand (2009)
  • Author(s): Yamamoto, S., Win-Shwe, T.T., Yoshida, Y., Kunugita, N., Arashidani, K., Fujimaki, H
  • Journal Title: J. Toxicol. Sci. (in press)
  • Peer Reviewed
• [Journal Article] Strain Difference of Extracellular Amino Acid Neurotransmitter Levels in the Hippocampus of MHC-Congenic Mice in Response to Toluene Exposure (2009)
  • Author(s): Win Shwe T. T.
  • Journal Title: Neuroimmunomodulation 16 Pages: 185-190
  • Peer Reviewed
• [Journal Article] Role of CD4+ T cells in the modulation of neurotrophin production in mice exposed to low-level toluene (2008)
  • Author(s): Hidekazu Fujimaki, Tin-Tin-Win-Shwe, Shoji Yamamoto, Daisuke Nakajima and Sumio Goto
  • Journal Title: Immunopharm.Immunotox 31(1) Pages: 146-149
  • Peer Reviewed
• [Journal Article] 揮発性有機化合物および農薬の発達期曝露による中枢神経系への影響についての調査研究 (2008)
  • Author(s): 塚原伸治、石堂正美、黒河佳香、藤巻秀和
  • Journal Title: 大気環境学会誌 43 Pages: 180-190
  • NAID: 110006666086
  • Peer Reviewed
• [Journal Article] オペラント学習法を用いたマウスのVOCガス検知閾値の計測 (2008)
  • Author(s): 北條理恵子、黒河佳香、塚原伸治、中島大介、藤巻秀和
  • Journal Title: におい・かおり環境学会誌 39 Pages: 186-191
  • NAID: 10021104019
  • Peer Reviewed
• [Journal Article] 胎児・小児への影響を考慮したVOC研究の現状と展開 (2008)
  • Author(s): 中島大介、塚原伸治、影山志保、白石不二雄、藤巻秀和
  • Journal Title: 室内環境 11 Pages: 103-109
  • NAID: 130004989128
  • Peer Reviewed
• [Journal Article] 揮発性有機化合物および農薬の発達期曝露による中枢神経系への影響についての調査研究 (2008)
  • Author(s): 塚原伸治
  • Journal Title: 大気環境学会誌 43 Pages: 180-190
  • Peer Reviewed
• [Journal Article] Role of CD4+ T cells in the modulation of neurotrophin production in mice exposed to low-level toluene (2008)
  • Author(s): Fujimaki H.
  • Journal Title: Immunopharm. Immunotox 31 Pages: 146-149
  • Peer Reviewed
• [Journal Article] Increased hippocampal mRNA expression of neuronal synaptic plasticity related genes in mice chronically exposed to toluene at a low-level human occupational-exposure. (2007)
  • Author(s): Sohel Ahmed, Tin-Tin-Win-Shwe, Shoji Yamamoto, Shinji Tsukahara, Naoki Kunugita, Keiichi Arashidani, and Hidekazu Fujimaki
  • Journal Title: Neurotoxicology 28 Pages: 168-174
  • Peer Reviewed
• [Journal Article] Athymic nude mice are insensitive to low-level toluene-induced up-regulation of memory-related gene expressions in the hippocampus. (2007)
  • Author(s): Tin-Tin-Win-Shwe, Shinji Tsukahara, Sohel Ahmed, Atsushi Fukushima, Shoji Yamamoto, Masaki Kakeyama, Daisuke Nakajima, Sumio Goto, Takahiro Kobayashi, Hidekazu Fujimaki
  • Journal Title: Neurotoxicology 28 Pages: 957-964
  • Peer Reviewed
• [Journal Article] Modulation of neurological related allergic reaction in mice exposed to low-level toluene (2007)
  • Author(s): Tin-Tin-Win-Shwe, Shoji Yamamoto, Daisuke Nakajima, Akiko Furuyama, Atsushi Fukushima, Sohel Ahmed, Sumio Goto, Hidekazu Fujimaki
  • Journal Title: Toxicol Appl Pharmacol 222 Pages: 17-24
  • Peer Reviewed
• [Journal Article] Effect of long-term exposure to low-level toluene on airway inflammatory response in mice (2007)
  • Author(s): H.Fujimaki, S.Yamamoto, Tin-Tin-Win-Shwe, R. Hojo, F. Sato, N. Kunugita, K. Arashidani
  • Journal Title: Toxicol Lett 168 Pages: 132-139
  • Peer Reviewed
• [Journal Article] Toluene induces rapid and reverse of hippocampal glutamate and taurine neurotransmitter levels in mice. (2007)
  • Author(s): Tin-Tin-Win-Shwe, D. Mitsushima, D. Nakajima, S. Ahmed, S. Yamamoto, S. Tsukahara, M. Kakeyama, S. Goto, H. Fujimaki
  • Journal Title: Toxicol Lett 168 Pages: 76-82
  • Peer Reviewed
• [Journal Article] Increased hippocampal mRNA expression of neuronal synaptic plasticityrelated genes in mice chronically exposed to toluene at a low-level human occupational-exposure (2007)
  • Author(s): Ahmed Sohel
  • Journal Title: Neurotoxicology 28 Pages: 168-174
  • Peer Reviewed
• [Journal Article] Athymic nude mice are insensitive to low-level toluene-induced up-regdation of memory-related gene expressions in the hippocampus (2007)
  • Author(s): Win Shwe T.T.
  • Journal Title: Neurotoxicology 28 Pages: 957-964
  • Peer Reviewed
• [Journal Article] Modulation of neurological related allergic reaction in mice exposed to lowlevel toluene (2007)
  • Author(s): Win Shwe T.T.
  • Journal Title: Toxicol. Appl. Pharmacol 222 Pages: 17-24
  • Peer Reviewed
• [Journal Article] Effects of low-level formaldehyde exposure on synaptic plasticity related gene expression in the hippocalnpus of immunized mice (2007)
  • Author(s): Ahmed Sohel
  • Journal Title: J. Neuroimmunol. 186 Pages: 104-111
  • Peer Reviewed
• [Journal Article] Toluene induces rapid and reverse of hippocampal glutamate and taurine neurotransmitter levels in mice. (2007)
  • Author(s): Tin-Tin-Win-Shwe et al.
  • Journal Title: Toxicology Letters 168 Pages: 75-82
• [Journal Article] Effect of long-term exposure to low-level toluene on airway inflammatory response in mice. (2007)
  • Author(s): H.Fujimaki et al.
  • Journal Title: Toxicology Letters 168 Pages: 132-139
• [Journal Article] Effects of Subchronic Exposure to Low Concentration of Toluene on the Hypothalamo-Pituitary-Adrenal Gland Axis of Female Mice (2006)
  • Author(s): Dwi Kesuma Sari, Sachi Kuwahara, Yasuhiro Tsukamoto, Hajime Hori, Naoki Kunugita, Keiichi Arashidani, Hidekazu Fujimaki, Fumihiko Sasaki
  • Journal Title: J. Jpn. Soc. Atmos. Environ. 41 Pages: 38-43
  • NAID: 110004852002
  • Peer Reviewed
• [Journal Article] Determination of Toluene in Brain of Freely Moving Mice using Solid-Phase Microextraction Method (2006)
  • Author(s): Daisuke Nakajima, Tin Tin Win Shwe, Masaki Kakeyama, Hidekazu Fujimaki, Sumio Goto
  • Journal Title: Neurotoxicology 27 Pages: 615-618
  • Peer Reviewed
• [Journal Article] シックハウス症候群の発症-中枢神経と揮発性化学物質 (2006)
  • Author(s): 藤巻秀和、市川眞澄、佐々木文彦、嵐谷奎一
  • Journal Title: 臨床免疫とアレルギー(科学評論社) 46 Pages: 182-187
• [Journal Article] シックハウス症候群の発症-中枢神経と揮発性科学物質。 (2006)
  • Author(s): 藤巻秀和
  • Journal Title: 臨床免疫・アレルギー科 46 Pages: 182-187
• [Journal Article] Effects of maternal toluene exposure on levels of sex steroids in prenatal offspring of rats: A study of the developmental toxicity of toluene on sexual differentiation of the brain
  • Author(s): Shinji Tsukahara, Disuke Nakajima, Rieko Hojo, Shiho Kageyama, Yoshiko Kuroda, Hidekazu Fujimaki
  • Journal Title: Toxicol. Lett (in press)
  • Peer Reviewed
• [Journal Article] Alteration of Th1/Th2 immunity in infant mice after prenatal and postnatal exposure to low-level toluene and peptidoglycan
  • Author(s): Shoji Yamamoto, Tin-Tin-Win-Shwe, Yasuhiro Yoshida, Naoki Kunugita, Keiichi Arashidani, Hidekazu Fujimaki
  • Journal Title: Inhalation Toxicology (in press)
  • Peer Reviewed
• [Journal Article] Effects of maternal toluene exposure on levels of sex steroids in prenatal offspring of rats : A study of the developmental toxicity of toluene on sexual differentiation of the brain
  • Author(s): Tsukahara S.
  • Journal Title: Toxicol Letter (印刷中)
  • Peer Reviewed
• [Presentation] Stimulating signaling pathway leading to CREB-mediated target gene transcription related to learning and memory in hippocampus of toluene-exposed mice. (2009)
  • Author(s): Fujimaki H., Tin-Tin Win-Shwe, Yamamoto S., Kunugita N., Arashidani K.
  • Place of Presentation: Prague, Czech Republic
  • Year and Date: 2009-03-14
• [Presentation] ライブイメージングと細胞の形態変化の定量的解析による新規神経毒性試験法の開発 (2008)
  • Author(s): 藤巻秀和
  • Organizer: 第31回日本分子生物学会年会
  • Place of Presentation: 神戸
  • Year and Date: 2008-12-09
• [Presentation] 発達期のトルエン曝露によるテストステロン分泌および脳内のアポトーシス細胞死への影響 (2008)
  • Author(s): 塚原伸治、黒田淑子、中島大介、影山志保、藤巻秀和
  • Organizer: 平成20年度室内環境学会総会
  • Place of Presentation: 東京
  • Year and Date: 2008-12-01
• [Presentation] Effects of exposure to toluene on steroidogenesis in testes and sromatization of testosterone in brain of male rats furing fetal life (2008)
  • Author(s): Tsukahara S, Nakajima D, Kuroda Y, Kageyama S, Hojo R & Fujimaki H
  • Organizer: 45th Congress of the European Societies of Toxicology
  • Place of Presentation: Rhodes, Greece
  • Year and Date: 2008-10-06
• [Presentation] Effects of exposure to toluene on steroidogenesis in testes and sromatization of testosterone in brain of male rats furing fetal life (2008)
  • Author(s): Fujimaki H.
  • Organizer: 45th Congress of the European Societies of Toxicology
  • Place of Presentation: Rhodes
  • Year and Date: 2008-10-06
• [Presentation] 低濃度トルエン曝露によるアレルギー性炎症反応の修飾作用 (2008)
  • Author(s): 藤巻秀和
  • Organizer: 第58回日本アレルギ-学会秋季学術大会 同講演要旨集P.(1490)
  • Place of Presentation: 東京
  • Year and Date: 2008-09-28
• [Presentation] 低濃度トルエン曝露によるアレルギー性炎症反応の修飾作用 (2008)
  • Author(s): 藤巻秀和
  • Organizer: 第58回日本アレルギ-学会秋季学術大会
  • Place of Presentation: 東京
  • Year and Date: 2008-09-28
• [Presentation] 脳の性分化に関与する発達期の性ステロイドホルモン分泌および性的二型核のアポトーシスに及ぼすトルエン曝露の影響 (2008)
  • Author(s): 塚原伸治、中島大介、黒田淑子、影山志保、藤巻秀和
  • Organizer: 第49回大気環境学会年会
  • Place of Presentation: 金沢
  • Year and Date: 2008-09-17
• [Presentation] マウス系統差で探る低濃度有機化合物に対する感受性要因-神経成長因子- (2008)
  • Author(s): 藤巻秀和、Tin-Tin-Win-Shwe、山元昭二、塚原伸治、欅田尚樹1)、嵐谷奎一1) (1)産業医科大学・産業保健学部)
  • Organizer: 第49回大気環境学会年会 同講演要旨集P.(524)
  • Place of Presentation: 金沢
  • Year and Date: 2008-09-17
• [Presentation] マウス系統差で探る低濃度有機化合物に対する感受性要因-神経成長因子- (2008)
  • Author(s): 藤巻秀和
  • Organizer: 第49回大気環境学会年会
  • Place of Presentation: 金沢
  • Year and Date: 2008-09-17
• [Presentation] マウス乳児期におけるトルエン曝露とBCG刺激がTh1/Th2バランスの発達に及ぼす影響 (2008)
  • Author(s): 山元昭二, Tin-Tin-Win-Shwe, 藤巻秀和
  • Organizer: 第15回日本免疫毒性学会学術大会 同講演要旨集, 50
  • Place of Presentation: 東京
  • Year and Date: 2008-09-11
• [Presentation] マウス乳児期におけるトルエン曝露とBCG刺激がTh1/Th2バランスの発達に及ぼす影響 (2008)
  • Author(s): 藤巻秀和
  • Organizer: 第15回日本免疫毒性学会学術大会
  • Place of Presentation: 東京
  • Year and Date: 2008-09-11
• [Presentation] Modulation of T cell development by biological and chemical agents neonatal mice. (2008)
  • Author(s): Fujimaki H., Tin-Tin-Win-Shwe, Yamamoto S.
  • Organizer: 7th annual European Life Scientist Organization meeting 同講演要旨集P.(126)
  • Place of Presentation: フランス Nice
  • Year and Date: 2008-09-01
• [Presentation] Modulation of T cell development by biological and chemical agents neonatal mice (2008)
  • Author(s): Fujimaki H.
  • Organizer: 7th annual European Life Scientist Organization meeting
  • Place of Presentation: Nice
  • Year and Date: 2008-09-01
• [Presentation] 周産期トルエン曝露による胎仔ラットの脳内エストラジオール含量および出生仔ラットのSDN-POAのアポトーシスへの影響 (2008)
  • Author(s): 塚原伸治、中島大介、黒田淑子、影山志保、藤巻秀和
  • Organizer: 第31回日本神経科学大会
  • Place of Presentation: 東京
  • Year and Date: 2008-07-09
• [Presentation] 低濃度トルエン曝露が発達期のマウス免疫系に及ぼす影響 (2008)
  • Author(s): 山元昭二, 藤巻秀和
  • Organizer: 第35回日本トキシコロジー学会学術年会-こどもシンポジウム5- J. Toxicol. Sci., Vol 33:S30
  • Place of Presentation: 東京
  • Year and Date: 2008-06-28
• [Presentation] 低濃度トルエン曝露が発達期のマウス免疫系に及ぼす影響 (2008)
  • Author(s): 藤巻秀和
  • Organizer: 第35回日本トキシコロジー学会学術年会-こどもシンポジウム5-
  • Place of Presentation: 東京
  • Year and Date: 2008-06-28
• [Presentation] 化学物質に対する感受性要因の解明 (2008)
  • Author(s): 藤巻秀和
  • Organizer: 第35回日本トキシコロジー学会学術年会 同講演要旨集P.(S47)(招待講演)
  • Place of Presentation: 東京
  • Year and Date: 2008-06-27
• [Presentation] 化学物質に対する感受性要因の解明 (2008)
  • Author(s): 藤巻秀和
  • Organizer: 第35回日本トキシコロジー学会学術年会
  • Place of Presentation: 東京
  • Year and Date: 2008-06-27
• [Presentation] Expression of transcription factor genes for T-cell differentiation in the spleen of C3H/HeN and BALB/c mice by the inhalation of low-level toluene (2007)
  • Author(s): Fukushima A., Win Shwe T.T., Yamamoto S., Kunugita N., Yoshida Y., Arashidani K., Fujimaki,H.
  • Organizer: World Allergy Congress 2007
  • Place of Presentation: Bangkok
  • Year and Date: 2007-12-04
• [Presentation] Effect of prenatal and postnatal exposure to low-level toluene and peptidoglycan on systemic Th1/Th2 immunity in infant mice (2007)
  • Author(s): Yamamoto S., Fukushima A., Win Shwe T.T., Hojo R., Yoshida Y., Kunugita N., Arashidani K., Fujimaki H.
  • Organizer: World Allergy Congress 2007
  • Place of Presentation: Bangkok
  • Year and Date: 2007-12-04
• [Presentation] Expression of transcription factor genes for T-cell differentiation in the spleen of C3H/HeN and BALB/c mice by the inhalation of low-level toluene (2007)
  • Author(s): Hidekazu Fujimaki
  • Organizer: World Allergy Congress 2007
  • Place of Presentation: バンコク
  • Year and Date: 2007-12-04
• [Presentation] Effect of prenatal and postnatal exposure to low-level toluene and peptidoglycan on systemic Th1/Th2 immunity in infant mice (2007)
  • Author(s): Hidekazu Fujhnaki
  • Organizer: World Allergy Congress 2007
  • Place of Presentation: バンコク
  • Year and Date: 2007-12-04
• [Presentation] 感受性要因に注目した化学物質の健康影響評価 (2007)
  • Author(s): 藤巻秀和
  • Organizer: 第51回全国環境衛生大会(招待講演)
  • Place of Presentation: 札幌
  • Year and Date: 2007-10-18
• [Presentation] 感受性要因に注目した化学物質の健康影響評価 (2007)
  • Author(s): 藤巻 秀和
  • Organizer: 第51回全国環境衛生大会
  • Place of Presentation: 札幌
  • Year and Date: 2007-10-18
• [Presentation] マウス胎生期および新生児期における低濃度トルエン曝露とペプチドグリカン刺激が全身性のTh1/Th2免疫バランスに及ぼす影響 (2007)
  • Author(s): 山元昭二,福島篤,Shwe T.T., 北條理恵子,藤巻秀和
  • Organizer: 第14回日本免疫毒性学会学術大会
  • Place of Presentation: 神戸
  • Year and Date: 2007-09-21
• [Presentation] トルエン曝露によるマウス海馬における記憶関連遺伝子発現増強へのT細胞の役割 (2007)
  • Author(s): Shwe T.T., 山元昭二,藤巻秀和
  • Organizer: 第14回日本免疫毒性学会学術大会
  • Place of Presentation: 神戸
  • Year and Date: 2007-09-20
• [Presentation] マウスにおける揮発性化学物質の嗅覚検知閾値 (2007)
  • Author(s): 黒河佳香,北條理恵子,中島大介,藤巻秀和
  • Organizer: 第30回日本神経科学大会
  • Place of Presentation: 横浜
  • Year and Date: 2007-09-10
• [Presentation] マウス海馬における記憶形成機構に及ぼす低濃度トルエン曝露の影響 (2007)
  • Author(s): 福島篤,Shwe T.T., 欅田尚樹,山元昭二,嵐谷奎一,藤巻秀和
  • Organizer: 第48回大気環境学会年会
  • Place of Presentation: 岡山
  • Year and Date: 2007-09-06
• [Presentation] 妊娠ラットにおけるトルエン吸入曝露による仔獣のオペラント学習行動への影響 (2007)
  • Author(s): 北條理恵子,塚原伸治,中島大介,黒河佳香,後藤純雄,藤巻秀和
  • Organizer: 第48回大気環境学会年会
  • Place of Presentation: 岡山
  • Year and Date: 2007-09-06
• [Presentation] VOCの健康影響研究の現状 (2007)
  • Author(s): 藤巻秀和
  • Organizer: 第48回大気環境学会年会
  • Place of Presentation: 岡山
  • Year and Date: 2007-09-05
• [Presentation] マウスに対する低濃度トルエン経気道曝露による免疫系への影響 (2007)
  • Author(s): 欅田尚樹,真鍋龍治,吉田安宏,山元昭二,藤巻秀和,嵐谷奎一
  • Organizer: 第48回大気環境学会年会
  • Place of Presentation: 岡山
  • Year and Date: 2007-09-05
• [Presentation] Analysis of toluene-induced extracellular amino acid neurotransmitter levels in the hippocampus using in vivo microdialysis in a freely moving mouse model (2007)
  • Author(s): Win Shwe T.T., Mitsushima D., Nakajima D., Fukushima A., Yamamoto S., Tsukahara S., Kakeyama M., Goto S, Fujimaki H.
  • Organizer: XI International Congress of Toxicology
  • Place of Presentation: Montreal
  • Year and Date: 2007-07-16
• [Presentation] Immunomodulatory role of low level toluene exposure in mice (2007)
  • Author(s): Fujimaki H., Yamamoto S., Win Shwe T.T., Fukushima A., Nakajima D., Goto S.
  • Organizer: XI International Congress of Toxicology
  • Place of Presentation: Montreal
  • Year and Date: 2007-07-16
• [Presentation] Neuronal synaptic plasticity related gene expressions in the hippocampus and olfactory bulb of mice chronically exposed to low level toluene (2007)
  • Author(s): Fukushima A., Win Shwe T.T., Ahmed S., Yamamoto S., Tsukahara S., Kunugita N., Arashidani K., Fujimaki H.
  • Organizer: XI International Congress of Toxicology
  • Place of Presentation: Montreal
  • Year and Date: 2007-07-16
• [Presentation] Analysis of toluene-induced extracellular amino acid neurotransmitter levels in the hippocampus using in vivo microdialysis in a freely moving mouse model (2007)
  • Author(s): Hidekazu Fujimaki
  • Organizer: XI International Congress of Toxicology
  • Place of Presentation: モントリオール
  • Year and Date: 2007-07-16
• [Presentation] Immunomodulatory role of low level toluene exposure in mice (2007)
  • Author(s): Hidekazu Fujimaki
  • Organizer: XI International Congress of Toxicology
  • Place of Presentation: モントリオール
  • Year and Date: 2007-07-16
• [Presentation] Neuronal synaptic plasticity related gene expressions in the hippocampus and olfactory bulb of mice chronically exposed to low level toluene (2007)
  • Author(s): Hidekazu Fujimaki
  • Organizer: XI International Congress of Toxicology
  • Place of Presentation: モントリオール
  • Year and Date: 2007-07-16
• [Presentation] 実験動物で探る低濃度有機化合物の影響機構 (2007)
  • Author(s): 藤巻秀和
  • Organizer: 第16回日本臨床環境医学会総会(招待講演)
  • Place of Presentation: 東京
  • Year and Date: 2007-07-08
• [Presentation] 実験動物で探る低濃度有機化合物の影響機構 (2007)
  • Author(s): 藤巻 秀和
  • Organizer: 第16回日本臨床環境医学会総会
  • Place of Presentation: 東京
  • Year and Date: 2007-07-08
• [Presentation] オペラント学習法を用いたマウスのにおい検知閾値の計測 (2007)
  • Author(s): 北條理恵子,黒河佳香,塚原伸治,中島大介,藤巻秀和
  • Organizer: 第20回におい・かおり環境学会
  • Place of Presentation: 東京
  • Year and Date: 2007-06-07
• [Presentation] Modulation of pro-inflammatory and neural activity-related gene expression in the olfactory bulb of mice by nasal inhalation of low-level toluene (2006)
  • Author(s): S. Ahmed, H. Fujimaki, T.T.W. Shwe, S. Yamamoto, S. Tsukahara, Y. Kurokawa, D. Nakajima, S. Goto
  • Organizer: 8th International Conference of Neuroimmunology
  • Place of Presentation: Nagoya
  • Year and Date: 2006-10-19
• [Presentation] Role of T cells in toluene-induced memory-related gene expressions in mouse hippocampus (2006)
  • Author(s): T.T.W. Shwe, S. Ahmed, S. Yamamoto, M. Kakeyama, D. Nakajima, S. Goto, H. Fujimaki
  • Organizer: 8th International Conference of Neuroimmunology
  • Place of Presentation: Nagoya
  • Year and Date: 2006-10-16
• [Presentation] オペラント条件づけによるマウスのVOC臭気検出試験系の確立 (2006)
  • Author(s): 北條理恵子、掛山正心、黒河佳香、中島大介、塚原伸治、後藤純雄、藤巻秀和
  • Organizer: 第47回大気環境学会
  • Place of Presentation: 東京
  • Year and Date: 2006-09-21
• [Presentation] マイクロダイアリシス法による有害化学物質曝露マウスにおける神経伝達物質の評価 (2006)
  • Author(s): Tin-Tin-Win-Shwe、福島篤、美津島大、中島大介、Ahmed Sohel、山元昭二、塚原伸治、掛山正心、後藤純雄、藤巻秀和
  • Organizer: 第47回大気環境学会
  • Place of Presentation: 東京
  • Year and Date: 2006-09-20
• [Presentation] T cell-mediated neuroprotective response in toxic chemical induced memory-related gene expressions in a mouse hippocampus (2006)
  • Author(s): T.T.W. Shwe, S. Ahmed, S. Tsukahara, S. Yamamoto, M. Kakeyama, D. Nakajima, S. Goto, T. Kobayashi, H. Fujimaki
  • Organizer: 23rd International Neurotoxicology Conference
  • Place of Presentation: Little Rock
  • Year and Date: 2006-09-19
• [Presentation] Role of CD4 T cells in allergic inflammatory responses in mice exposed to low-level toluene (2006)
  • Author(s): H. Fujimaki, S. Yamamoto, T.T.W. Shwe, S. Ahmed, D. Nakajima, S. Goto
  • Organizer: 1st Joint Meeting of European National Societies of Immunology
  • Place of Presentation: Paris
  • Year and Date: 2006-09-07
• [Presentation] Modulated memory-related gene expression in olfactory bulb of low-level toluene-exposed mice (2006)
  • Author(s): H. Fujimaki, T.T.W. Shwe, S. Yamamoto, D. Nakajima, S. Ahemd, S. Goto
  • Organizer: 5th Forum of Europian Neuroscience.
  • Place of Presentation: Vienna
  • Year and Date: 2006-07-09
• [Book] 生体防御医学事典 (2007)
  • Author(s): 藤巻 秀和
  • Publisher: 朝倉書店