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A prospective cohort study for sleep-disordered breathing and the incidence of hypertension and diabetes

Research Project

Project/Area Number 18390194
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Public health/Health science
Research InstitutionEhime University (2007-2008)
University of Tsukuba (2006)

Principal Investigator

TANIGAWA Takeshi  Ehime University, 大学院・医学系研究科, 教授 (80227214)

Co-Investigator(Kenkyū-buntansha) YAMAGISHI Kazumasa  筑波大学, 大学院・人間総合科学研究科, 講師 (20375504)
SAITOU Isao  愛媛大学, 大学院・医学系研究科, 准教授 (90253781)
SAKURAI Susumu  愛媛大学, 大学院・医学系研究科, 講師 (50375515)
CUI Enzhe  大阪大学, 大学院・医学系研究科, 助教 (40375514)
佐藤 誠  筑波大学, 大学院・人間総合科学研究科, 教授 (50242409)
Co-Investigator(Renkei-kenkyūsha) SATO Makoto  筑波大学, 大学院・人間総合科学研究科, 教授 (50242409)
Research Collaborator MURAKI Isao  大阪大学, 大学院・医学系研究科, 大学院生
Project Period (FY) 2006 – 2008
Project Status Completed (Fiscal Year 2008)
Budget Amount *help
¥17,390,000 (Direct Cost: ¥14,600,000、Indirect Cost: ¥2,790,000)
Fiscal Year 2008: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2007: ¥6,630,000 (Direct Cost: ¥5,100,000、Indirect Cost: ¥1,530,000)
Fiscal Year 2006: ¥5,300,000 (Direct Cost: ¥5,300,000)
Keywords睡眠呼吸障害 / 高血圧 / 糖尿病 / メタボリックシンドローム / コホート研究 / パルスオキシメトリ法 / フローセンサ法 / パルスオキシメータ / フローセンサ
Research Abstract

近年、欧米を中心に睡眠呼吸障害の健康影響が注目されている。しかしながら、日本における睡眠呼吸障害の疫学研究は乏しい。本研究では睡眠呼吸障害の健康、特に高血圧、糖尿病への影響を中心に追跡研究により検討を行った。本研究の結果、日本人においても睡眠呼吸障害は高血圧・糖尿病発症へ寄与することが明らかとなった。ただし、高血圧への影響は塩分摂取や多量飲酒などの既存の危険因子の影響が大きいと考えられた。

Report

(4 results)
  • 2008 Annual Research Report   Final Research Report ( PDF )
  • 2007 Annual Research Report
  • 2006 Annual Research Report
  • Research Products

    (50 results)

All 2009 2008 2007 2006 Other

All Journal Article (25 results) (of which Peer Reviewed: 11 results) Presentation (14 results) Book (7 results) Remarks (4 results)

  • [Journal Article] 睡眠時無呼吸症候群のスクリーニング2009

    • Author(s)
      谷川武、櫻井進
    • Journal Title

      綜合臨床 58

      Pages: 139-140

    • Related Report
      2008 Final Research Report
  • [Journal Article] Association of cardiovascular risk factors with carotid atherosclerosis in middle-aged Japanese men with metabolic syndrome2008

    • Author(s)
      Kirii K, Tanaka S, Yamagishi K, Iso H, Sakurai S, Tanigawa T
    • Journal Title

      Ind Health 46(6)

      Pages: 607-612

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Validation of a single channel airflow monitor for screening of sleep-disordered breathing2008

    • Author(s)
      Nakano H, Tanigawa T, Furukawa T, Ohnishi Y, Uemori H, Senzaki K, Furukawa T, Nishima S
    • Journal Title

      Eur Respir J 32(4)

      Pages: 1060-1067

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Associations of sleep-disordered breathing with excessive daytime sleepiness and blood pressure in Japanese women2008

    • Author(s)
      Cui R, Tanigawa T, Sakurai S, Yamagishi K, Imano H, Ohira T, Kitamura A, Sato S, Shimamoto T, Iso H
    • Journal Title

      Hypertens Res 31(3)

      Pages: 501-506

    • NAID

      10021933878

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] 自覚的な眠気がない睡眠障害に注意2008

    • Author(s)
      谷川武
    • Journal Title

      視点. 公衆衛生 72(9)

      Pages: 684-686

    • Related Report
      2008 Final Research Report
  • [Journal Article] 睡眠時無呼吸症候群の疫学と予後2008

    • Author(s)
      谷川武、斉藤功、櫻井進
    • Journal Title

      Medical Practice. 文光堂(東京) 25(7)

      Pages: 1120-1128

    • Related Report
      2008 Final Research Report
  • [Journal Article] Association of cardiovascular risk factors with carotid atherosclerosis in middle-aged Japanese men with metabolic syndrome2008

    • Author(s)
      Kirii K, Tanaka S, Yamagishi K, Iso H, Sakurai S, Tanigawa T
    • Journal Title

      Ind Health 46

      Pages: 607-612

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Associations of Sleep-Disordered Breathing with Excessive Daytime Sleepiness and Blood Pressure in Japanese Women2008

    • Author(s)
      Cui R, Tanigawa T, Sakurai S, Yamagishi K, Imano H, Ohira T, Kitamura A, Sato S, Shimamoto T, Iso H.
    • Journal Title

      Hypertension research 31

      Pages: 501-506

    • NAID

      10021933878

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Alcohol consumption before sleep associates the severity of sleep-disordered breathing among professional Japanese truckdrivers2007

    • Author(s)
      Sakurai S, Cui R, Tanigawa T, Yamagishi K, Iso H
    • Journal Title

      Alcohol Clin Exp Res 31(12)

      Pages: 2053-2058

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Automatic detection of sleep-disordered breathing from a single-channel airflow record2007

    • Author(s)
      Nakano H, Tanigawa T, Furukawa T, Nishima S
    • Journal Title

      29(4)

      Pages: 728-736

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Alcohol consumption before sleep associates the severity of sleep disordered breathing among professional Japanese truckdrivas2007

    • Author(s)
      Sakurai S, Cui R, Tanigawa T, Yamagishi K, Iso H.
    • Journal Title

      Alcchol Clin Exp Res 31

      Pages: 2053-2058

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Automatic detection of sleep-disordered breathing from a single-channel airflow record.2007

    • Author(s)
      Nakano H, Tanigawa T, Furukawa T, Nishima S.
    • Journal Title

      Eur Respir J 29

      Pages: 728-736

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Arterial oxygen desaturation during sleep and atrial fibrillation2006

    • Author(s)
      Tanigawa T, Yamagishi K, Sakurai S, Muraki I, Noda H, Shimamoto T, Iso H
    • Journal Title

      Heart 92

      Pages: 1854-1855

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Relationships between sleep-disordered breathing and blood pressure and excessive daytime sleepiness among truck drivers2006

    • Author(s)
      Cui R, Tanigawa T, Sakurai S, Yamagishi K, Iso H
    • Journal Title

      Hypertens Res 29

      Pages: 605-610

    • NAID

      10018335489

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Sleep-disordered breathing and blood pressure levels among shift and day workers2006

    • Author(s)
      Tanigawa T, Muraki I, Umesawa M, Tachibana N, Noda H, Takahashi M, Mutou K, Kage Y, Smith L, Iso H
    • Journal Title

      Am J Hypertens 19

      Pages: 346-351

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] SASスクリーニングのグランドデザイン2006

    • Author(s)
      谷川武、櫻井進、山岸良匡
    • Journal Title

      Progress in Medicine 26

      Pages: 2625-2632

    • Related Report
      2008 Final Research Report
  • [Journal Article] 睡眠時無呼吸症候群の疫学2006

    • Author(s)
      谷川武、村木功、櫻井進、山岸良匡
    • Journal Title

      治療学 40

      Pages: 9-16

    • Related Report
      2008 Final Research Report
  • [Journal Article] Arterial oxygen desaturation during sleep and atrial fibrillation.2006

    • Author(s)
      Tanigawa T et al.
    • Journal Title

      Heart 92

      Pages: 1854-1855

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Relationships between sleep-disordered breathing and blood pressure and excessive daytime sleepiness among truck drivers.2006

    • Author(s)
      Cui R, Tanigawa T, et al.
    • Journal Title

      Hypertens Res 29

      Pages: 605-610

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Sleep-disordered breathing and blood pressure levels among shift and day workers2006

    • Author(s)
      Tanigawa T et al.
    • Journal Title

      Am J Hypertens 19

      Pages: 346-351

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Relation between sleep-disordered breathing and high-sensitivity C-reactive protein in apanese men2006

    • Author(s)
      Yao M, Tanigawa T et al.
    • Journal Title

      Sleep 29

      Pages: 661-665

    • Related Report
      2006 Annual Research Report
  • [Journal Article] 7)睡眠時呼吸障害検査機器2006

    • Author(s)
      片寄泰子, 安田京, 櫻井進, 谷川武, 佐藤誠
    • Journal Title

      Medical Technology 34

      Pages: 1700-1703

    • Related Report
      2006 Annual Research Report
  • [Journal Article] 睡眠時無呼吸症候群(SAS)再考-プライマリケアで何ができるか-VI.SASスクリーニングの実際 2.職域検診におけるSASスクリーニングの取り組み2006

    • Author(s)
      津田徹, 谷川武
    • Journal Title

      Progress in Medicine 26

      Pages: 2683-2686

    • Related Report
      2006 Annual Research Report
  • [Journal Article] 睡眠時無呼吸症候群(SAS)再考-プライマリケアで何ができるか-IV.SASスクリーニングのグランドデザイン2006

    • Author(s)
      谷川武, 櫻井進, 山岸良匡
    • Journal Title

      Progress in Medicine 26

      Pages: 2625-2632

    • Related Report
      2006 Annual Research Report
  • [Journal Article] 就労と睡眠時無呼吸症候群2006

    • Author(s)
      津田徹, 新島邦行, 指原俊介, 森本泰夫, 谷川武, 成井浩司
    • Journal Title

      精神科治療学 21

      Pages: 727-733

    • Related Report
      2006 Annual Research Report
  • [Presentation] Non-Sleepy Sleep Apnea(NOSSA) : An Important Public Health Burden. Invited speaker2009

    • Author(s)
      Tanigawa T, Nakano H, Sakurai S
    • Organizer
      9th World Congress on Sleep Apnea
    • Place of Presentation
      Seoul, Korea
    • Year and Date
      2009-03-26
    • Related Report
      2008 Final Research Report
  • [Presentation] Relationships of alcohol consumption and arterial oxygen desaturation during sleep among professional Japanese truck drivers2009

    • Author(s)
      Sakurai S, Cui R, Mori H, Saito I, Yamagishi K Iso H, Tanigawa T
    • Organizer
      9th World Congress on Sleep Apnea
    • Place of Presentation
      Seoul, Korea
    • Year and Date
      2009-03-26
    • Related Report
      2008 Final Research Report
  • [Presentation] Non-Sleepy Sleep Apnea (NOSSA) : An Important Public Health Burden. Invited Speaker2009

    • Author(s)
      Tanigawa T, Nakano H, Sakurai S
    • Organizer
      9^<th> World Congress on Sleep Apnea
    • Place of Presentation
      Seoul, Korea
    • Year and Date
      2009-03-26
    • Related Report
      2008 Annual Research Report
  • [Presentation] Relationship of alcohol consumption and arterial oxygen desaturation during sleep among professional Japanese truck drivers2009

    • Author(s)
      Sakurai S, Cui Renzhe, Mori H, Saito I, Yamagishi K, Iso H, Tanigawa T
    • Organizer
      9th World Congress on Sleep Apnea
    • Place of Presentation
      Seoul, Korea
    • Year and Date
      2009-03-26
    • Related Report
      2008 Annual Research Report
  • [Presentation] High prevalence of moderate to severe sleep disordered breathing without daytime hypersomnolence in Japanese male truck drivers2008

    • Author(s)
      Tanigawa T, Nakano H, Sakurai S
    • Organizer
      The 22th Annual Meeting of the Associated Professional Sleep Societies
    • Place of Presentation
      Baltimore, MD
    • Year and Date
      2008-06-11
    • Related Report
      2008 Final Research Report
  • [Presentation] High prevalence of moderate to severe sleep disordered breathing without daytime hypersomnolence in Japanese male truck drivers.2008

    • Author(s)
      Tanigawa T, Nakano H, Sakurai S
    • Organizer
      The 22th Annual Meeting of the Associated Professional Sleep Societies
    • Place of Presentation
      Baltimore, MD, USA
    • Year and Date
      2008-06-11
    • Related Report
      2008 Annual Research Report
  • [Presentation] Screening for sleep-disordered breathing in community and in workplace2008

    • Author(s)
      Tanigawa T, Sakurai S, Nakano H, Iso H
    • Organizer
      5th Sleep Respiratory Forum in Otaru
    • Place of Presentation
      Japan
    • Year and Date
      2008-02-28
    • Related Report
      2008 Final Research Report
  • [Presentation] 職業運転者における睡眠呼吸障害スクリーニングに関する検討2007

    • Author(s)
      谷川 武、桜井 進、中野 博
    • Organizer
      日本睡眠学会第32回定期学術集会
    • Place of Presentation
      東京
    • Year and Date
      2007-11-09
    • Related Report
      2007 Annual Research Report
  • [Presentation] 飲酒量と睡眠呼吸障害の重症度との関連2007

    • Author(s)
      谷川 武、桜井 進、山岸 良匡
    • Organizer
      第17回日本産業衛生学会・産業医産業看護全国協議会
    • Place of Presentation
      東京
    • Year and Date
      2007-11-03
    • Related Report
      2007 Annual Research Report
  • [Presentation] 地域・職域における睡眠時無呼吸症候群スクリーニングの重要性2007

    • Author(s)
      谷川 武
    • Organizer
      第66回日本公衆衛生学会総会 ランチョンセミナー
    • Place of Presentation
      愛媛
    • Year and Date
      2007-10-25
    • Related Report
      2007 Annual Research Report
  • [Presentation] 健康リスクと事故リスクの軽減を目的とした睡眠からのアプローチ-産業保健医療職の役割とは2007

    • Author(s)
      谷川 武
    • Organizer
      第80回日本産業衛生学会総会 教育講演
    • Place of Presentation
      大阪
    • Year and Date
      2007-04-29
    • Related Report
      2007 Annual Research Report
  • [Presentation] 睡眠時無呼吸症候群スクリーニングのポイント2007

    • Author(s)
      谷川 武
    • Organizer
      第80回日本産業衛生学会総会 ランチョンセミナ
    • Place of Presentation
      大阪
    • Year and Date
      2007-04-28
    • Related Report
      2007 Annual Research Report
  • [Presentation] Alcohol consumption before sleep associates the severity of sleep-disordered breathing among professional Japanese truck drivers2007

    • Author(s)
      Sakurai S, Cui R, Tanigawa T, Yamagishi K, Iso H
    • Organizer
      5^<th> Tsukuba International symposium of Sleep Medicine
    • Place of Presentation
      Tsukuba, Japan
    • Year and Date
      2007-03-16
    • Related Report
      2008 Final Research Report
  • [Presentation] Sleep-disordered breathing and blood pressure levels among shift and day workers2006

    • Author(s)
      Tanigawa T, Sakurai S, Iso H
    • Organizer
      8th World Congress on Sleep Apnea
    • Place of Presentation
      Montreal, Canada
    • Year and Date
      2006-09-29
    • Related Report
      2008 Final Research Report
  • [Book] 睡眠時無呼吸症候群スクリーニング. 睡眠学2009

    • Author(s)
      谷川武、櫻井進
    • Publisher
      朝倉書店
    • Related Report
      2008 Final Research Report
  • [Book] 睡眠学(睡眠時無呼吸症候群スクリーニング)2009

    • Author(s)
      谷川武, 櫻井進
    • Total Pages
      3
    • Publisher
      朝倉書店
    • Related Report
      2008 Annual Research Report
  • [Book] 職域における睡眠時無呼吸症候群(SAS)スクリーニングの重要性. 睡眠障害の基礎知識2008

    • Author(s)
      谷川武、櫻井進
    • Publisher
      日本労務研究会
    • Related Report
      2008 Final Research Report
  • [Book] 睡眠障害の基礎知職(職域における睡眠時無呼吸症候群(SAS)スクリーニングの重要性)2008

    • Author(s)
      谷川武, 櫻井進
    • Total Pages
      21
    • Publisher
      日本労務研究会
    • Related Report
      2008 Annual Research Report
  • [Book] 睡眠障害の基礎知識(職域における睡眠時無呼吸症候群(SAS)スクリーニングの重要性)2008

    • Author(s)
      谷川 武、桜井 進
    • Publisher
      日本労務研究会(東京)
    • Related Report
      2007 Annual Research Report
  • [Book] 健康2007秋(睡眠時無呼吸症候群とは)2007

    • Author(s)
      谷川 武
    • Publisher
      主婦の友社(東京)
    • Related Report
      2007 Annual Research Report
  • [Book] 動脈硬化予防(特集:脳卒中の病型と危険因子 脳卒中発症危険因子としての喫煙)2007

    • Author(s)
      山岸 良匡、谷川 武、磯博 康
    • Publisher
      メジカルレビュー社(東京)
    • Related Report
      2007 Annual Research Report
  • [Remarks] 国土交通省自動車交通局

    • URL

      http://www.mlit.go.jp/kisha/kisha07/09/090601/01.pdf

    • Related Report
      2008 Final Research Report
  • [Remarks]

    • URL

      http://www.pbhel.med.osaka-u.ac.jp/home.htm

    • Related Report
      2008 Annual Research Report
  • [Remarks]

    • URL

      http://www.md.tsukuba.ac.jp/community-med/publicmd/public_health_medicine/achievement.html

    • Related Report
      2008 Annual Research Report
  • [Remarks] 国土交通省自動車交通局

    • URL

      http://www.mlit.go.jp/kisha/kisha07/09/090601/01.pdf

    • Related Report
      2007 Annual Research Report

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Published: 2006-04-01   Modified: 2016-04-21  

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