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Absolutefracture riskassessmentand interventionthresholdaccording to 10-year follow-up data of a large scale random sample cohort

Research Project

Project/Area Number 18390201
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Public health/Health science
Research InstitutionKinki University

Principal Investigator

IKI Masayuki  Kinki University, 医学部, 教授 (50184388)

Co-Investigator(Kenkyū-buntansha) KOUDA Katsuyasu  近畿大学, 医学部, 准教授 (60273182)
TAMAKI Junko  近畿大学, 医学部, 講師 (90326356)
IKEDA Yukihiro  近畿大学, 医学部, 講師 (20368294)
SATO Yuho  仁愛女子短期大学, 生活科学科, 准教授 (10337115)
MORITA Akemi  独立行政法人国立健康・栄養研究所, 栄養教育プログラム・生活習慣病予防プロジェクト, プロジェクトリーダー (40262638)
Project Period (FY) 2006 – 2008
Project Status Completed (Fiscal Year 2008)
Budget Amount *help
¥16,700,000 (Direct Cost: ¥14,900,000、Indirect Cost: ¥1,800,000)
Fiscal Year 2008: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2007: ¥6,370,000 (Direct Cost: ¥4,900,000、Indirect Cost: ¥1,470,000)
Fiscal Year 2006: ¥8,900,000 (Direct Cost: ¥8,900,000)
Keywords地域保健 / 骨粗鬆症 / 骨折 / 骨密度 / 絶対リスク / リスク評価 / 介入閾値 / 無作為抽出標本 / 縦断研究 / リスク要因
Research Abstract

研究成果の概要:骨粗鬆症性骨折のリスク評価法を確立するため、JPOS Cohort 1515人を満10年追跡した。DXAによるdigital写真で診断した新規椎体骨折のリスクを多重logistic回帰で評価すると、既存椎体骨折、年齢、大腿骨近位部骨密度、閉経、骨折既往・卵巣摘除・高血圧・高脂血症・骨粗鬆症の既往を独立変数としたモデルでROC曲線下面積が0.752となったが、実用化にはもう一段の改善が必要と考えられた。

Report

(4 results)
  • 2008 Annual Research Report   Final Research Report ( PDF )
  • 2007 Annual Research Report
  • 2006 Annual Research Report
  • Research Products

    (22 results)

All 2009 2008 2007 2006

All Journal Article (7 results) (of which Peer Reviewed: 7 results) Presentation (15 results)

  • [Journal Article] Low bone mass is associated with carotid atherosclerosis in postmenopausal women : the Japanese Population-based Osteoporosis (JPOS) Cohort Study2009

    • Author(s)
      Tamaki J, Iki M, Hirano Y, Sato Y, Kajita E, Kagamimori S, Kagawa Y, Yoneshima H
    • Journal Title

      Osteoporos Int 20

      Pages: 53-60

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Low bone mass is associated with carotid atherosclerosis in postmenopausal women : the Japanese Population-based Osteoporosis (JPOS) Cohort study.2009

    • Author(s)
      Tamaki J, et al.
    • Journal Title

      Osteoporosis International 20

      Pages: 53-60

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Use of anthropometnc indicators in screening for undiagnosed vertebral fractures2008

    • Author(s)
      Abe K, Tamaki J, Kadowaki E, Sato Y, Monta A, Komatsu M, Takeuchi S, Kajita E, Iki M
    • Journal Title

      BMC Musculoskeletal Disorders 9(157)

      Pages: 1-10

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Use of Anthropometric Indicators in Screening for Undiagnosed Vertebral Fractures : A Cross-sectional Analysis of the Fukui Osteoporosis Cohort (FOC) Study2008

    • Author(s)
      Abe K, et al.
    • Journal Title

      BMC Musculoskeletal Disorders 9

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Biochemical markers of bone turnover may predict progression to osteoporosis in osteopenic women : the JPOS Cohort Study2007

    • Author(s)
      Iki M, Morita A, Ikeda Y, Sato Y, Akiba T, Matsumoto T, Nishino H, Kagamimori S, Kagawa Y, Yoneshima H
    • Journal Title

      J Bone Miner Metab 25

      Pages: 122-9

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Biochemical markers of bone turnover predict bone loss in perimenopausal women but not in postmenopausal women-the Japanese Population-based Osteoporosis (JPOS) Cohort Study2006

    • Author(s)
      Iki M, Morita A, Ikeda Y, Sato Y, Akiba T, Matsumoto T, Nishino H, Kagamimori S, Kagawa Y, Yoneshima H
    • Journal Title

      Osteoporos Int 17

      Pages: 1086-95

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Intake of fermented soybeans, natto, is associated with reduced bone loss in postmenopausal women : Japanese Population-Based Osteoporosis (JPOS) Study2006

    • Author(s)
      Ikeda Y, Iki M, Morita A, Kajita E, Kagamimori S, Kagawa Y, Yoneshima H
    • Journal Title

      J Nutr 136

      Pages: 1323-8

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Presentation] ビタミンD受容体の遺伝子多型と頸動脈エコーによる動脈硬化性病変の関連の検討-JPOS Studyによる満10年追跡調査2009

    • Author(s)
      玉置淳子, 他
    • Organizer
      第19回日本疫学会学術総会
    • Place of Presentation
      金沢市
    • Year and Date
      2009-01-24
    • Related Report
      2008 Final Research Report
  • [Presentation] ビタミンD受容体の遺伝子多型と頚動脈エコーによる動脈硬化性病変の関連の検討-JPOS Study による満10年追跡調査2009

    • Author(s)
      玉置淳子, 他
    • Organizer
      第19回日本疫学会学術総会
    • Place of Presentation
      石川県金沢市
    • Year and Date
      2009-01-24
    • Related Report
      2008 Annual Research Report
  • [Presentation] 若年女性、特に低体重女性の喫煙は低骨量に関連する-JPOS Cohort2008

    • Author(s)
      玉置淳子, 他
    • Organizer
      第67回日本公衆衛生学会総会
    • Place of Presentation
      福岡市
    • Year and Date
      2008-11-06
    • Related Report
      2008 Final Research Report
  • [Presentation] 低握力は椎体骨折のリスクを高める-JPOS Cohort Study2008

    • Author(s)
      門脇英子, 他
    • Organizer
      第67回日本公衆衛生学会総会
    • Place of Presentation
      福岡市
    • Year and Date
      2008-11-06
    • Related Report
      2008 Final Research Report
  • [Presentation] 若年女性、特に低体重女性の喫煙は低骨量に関連する-JPOS Cohort Study2008

    • Author(s)
      玉置淳子, 他
    • Organizer
      第67回日本公衆衛生学会総会
    • Place of Presentation
      福岡県福岡市
    • Year and Date
      2008-11-06
    • Related Report
      2008 Annual Research Report
  • [Presentation] 低握力は椎体骨折のリスクを高める-JPOS Cohort Study2008

    • Author(s)
      門脇英子, 他
    • Organizer
      第67回日本公衆衛生学会総会
    • Place of Presentation
      福岡県福岡市
    • Year and Date
      2008-11-06
    • Related Report
      2008 Annual Research Report
  • [Presentation] Ten-year Change in Bone Mineral Density in a Representative Sample of Japanese Women -JPOS Cohort Study-2008

    • Author(s)
      Iki M, et al.
    • Organizer
      0th Annual Meeting of American Society of Bone and Mineral Research
    • Place of Presentation
      Montreal, Canada
    • Year and Date
      2008-06-30
    • Related Report
      2008 Final Research Report
  • [Presentation] Effects of parity on bone mineral density in premenopausal women : JPOS Cohort Study2008

    • Author(s)
      Tamaki J, et al.
    • Organizer
      30th Annual Meeting of American Society of Bone and Mineral Research
    • Place of Presentation
      Montreal, Canada
    • Year and Date
      2008-06-30
    • Related Report
      2008 Final Research Report
  • [Presentation] Ten-year Change in Bone Mineral Density in a Representative Sample of Japanese Women - JPOS Cohort study -2008

    • Author(s)
      Iki M, et al.
    • Organizer
      30th Annual Meeting of American Society of Bone and Mineral Research
    • Place of Presentation
      Montreal, Canada
    • Year and Date
      2008-06-30
    • Related Report
      2008 Annual Research Report
  • [Presentation] Effects of parity on bone mineral density in premenopausal women : JPOS Cohort study2008

    • Author(s)
      Tmaki J, et al.
    • Organizer
      30th Annual Meeting of American Society of Bone and Mineral Research
    • Place of Presentation
      Montreal, Canada
    • Year and Date
      2008-06-30
    • Related Report
      2008 Annual Research Report
  • [Presentation] 日本人女性の無作為抽出コホ-ト10年追跡研究で見た骨密度への年齢効果とコホ-ト効果-JPOS Cohort Study-2007

    • Author(s)
      伊木雅之, 他
    • Organizer
      第66回日本公衆衛生学会
    • Place of Presentation
      松山市
    • Year and Date
      2007-10-25
    • Related Report
      2008 Final Research Report
  • [Presentation] 日本人女性の無作為抽出コホート10年追跡研究で見た骨密度への年齢効果とコホート効果-JPOS Cohort Study-2007

    • Author(s)
      伊木 雅之
    • Organizer
      第66回日本公衆衛生学会
    • Place of Presentation
      愛媛県松山市
    • Year and Date
      2007-10-25
    • Related Report
      2007 Annual Research Report
  • [Presentation] 若年女性での適正体重の獲得は最大骨量を高めるか-JPOS Cohort Study-2007

    • Author(s)
      玉置淳子, 他
    • Organizer
      第66回日本公衆衛生学会
    • Place of Presentation
      松山市
    • Year and Date
      2007-10-24
    • Related Report
      2008 Final Research Report
  • [Presentation] 若年女性での適正体重の獲得は最大骨量を高めるか-JPOS Cohort Study-2007

    • Author(s)
      玉置 淳子
    • Organizer
      第66回日本公衆衛生学会
    • Place of Presentation
      愛媛県松山市
    • Year and Date
      2007-10-24
    • Related Report
      2007 Annual Research Report
  • [Presentation] 骨粗鬆症と頸動脈エコーによる動脈硬化性病変の関連の検討-JPOS Studyによる満10年追跡調査2007

    • Author(s)
      玉置淳子, 他
    • Organizer
      第17回日本疫学会
    • Place of Presentation
      広島市
    • Year and Date
      2007-01-26
    • Related Report
      2008 Final Research Report

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Published: 2006-04-01   Modified: 2016-04-21  

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