| Project/Area Number |
18390202
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Public health/Health science
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| Research Institution | Setsunan University |
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Principal Investigator |
OHTA Souichi Setsunan University, Dept. of Pharmaceutical Sciences, Associated professor (10213729)
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| Co-Investigator(Kenkyū-buntansha) |
AOZASA Osamu Setsunan University, Dept. of Pharmaceutical Sciences, Associated professor (20248066)
NAKAO Teruyuki Setsunan University, Dept. of Pharmaceutical Sciences, Research assistant (20288971)
OCHIAI Tomie Shizuoka Institute of University Univ., Dept. of Nursing, Associated professor (20295554)
SHIMIZU Yoshiko Nagano Nursing University, 看護学部, Professor (80295550)
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| Project Period (FY) |
2006 – 2007
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| Project Status |
Completed (Fiscal Year 2007)
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| Budget Amount *help |
¥7,290,000 (Direct Cost: ¥6,600,000、Indirect Cost: ¥690,000)
Fiscal Year 2007: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Fiscal Year 2006: ¥4,300,000 (Direct Cost: ¥4,300,000)
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| Keywords | Chlorinated / brominated dioxins / Co-PCBs / Conplanar chlorinated / brominated biphenyls / Breast milk contamination / Fish contamination / Food contamination / Global contamination / Non-purpose products / 臭素化難燃剤 / 新規環境汚染物質 |
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| Research Abstract |
In order to clear human exposure by Co-PXBs, it was investigated the Co-PXBs concentration in the breast milk (sampling day; 5 and 30 days) of Japanese multiparae and primiparae. The concentration of Co-PXBs ranged between 0.42 and 1.41 pg TEQ/g lipid, and this observation is our first finding for human exposure by Co-PXBs. With respect the average TEQ level in mother's milk, there is no difference between of multiparae and primiparae, not in the case of CO-PCBs. Interestingly, when the level of Co-PCBs at 5 and 30 days of same woman was compared, that at 5 days-breast milk samples were higher than that at 30days-samples for almost sample analyzed. However, in the case of CO-PXBs, such tendency was not always observed.
Then, the abundant congeners of Co-PXBs were #126A, #126 B and #169, and it was estimated that human exposure by this Co-PXBs #126B is derived from the eating of fish. Then, it was compared the contribution ratio of four kinds of dioxin analogues for total TEQ concentration in mother's milk of Japan. Major analogues were PCDDs/DFs, Co-PCBs and Co-PXBs, and PXDDs/DFs were negligible level, showing unexpected high contribution ratio of Co-PXBs in the breast milk of multiparae. As there are theoretically more few hundreds congeners in the Co-PXBs group, and therefore it needs further detail survey of Co-PXBs contamination
Further study is warranted to evaluate whether Co-PXBs exposures to nursing infants pose a health risk. Additional investigations of Co-PXBss in the daily foods are warranted to better understand the nature and extent of Co-PXBs contamination of Japanese food supply.
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