Establish the chemopreventive strategy using PPAR gamma ligands for colorectal cancer

• Project/Area Number: 18390222
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Gastroenterology
• Research Institution: Yokohama City University
• Principal Investigator: NAKAJIMA Atsushi Yokohama City University, Gastroenterology Division, Assistant professor (30326037)
• Co-Investigator(Kenkyū-buntansha): INAMORI Masahiko Gastroenterology, Gastroenterology Division, Assistant professor (10381477) ; ABE Yasunobu Gastroenterology, Gastroenterology Division, Assistant Professor (10347312)
• Project Period (FY): 2006 – 2007
• Project Status: Completed (Fiscal Year 2007)
• Budget Amount: ¥17,110,000 (Direct Cost: ¥14,800,000、Indirect Cost: ¥2,310,000); Fiscal Year 2007: ¥10,010,000 (Direct Cost: ¥7,700,000、Indirect Cost: ¥2,310,000); Fiscal Year 2006: ¥7,100,000 (Direct Cost: ¥7,100,000)
• Keywords: Chemoprevention / Nuclear receptor / Colorectal Cancer / PPARγ / 大腸癌 / アディポネクチン

Research Abstract

Activating synthetic ligands for PPARY, such as pioglitazone and rosiglitazone, are commonly used to treat patients with diabetes mellitus (DM) in order to improve insulin resistance. Several reports have clearly demonstrated that PPARY ligands, could inhibit colorectal cancer cell growth and induce apoptosis. On the other hands, the insulin resistance or hyper insulinemia are thought to be the one of the major risk factors of colorectal cancer (CRC). If hyper insulinemia, alone or in combination with other features of the insulin resistance syndrome, is associated with increased risk of CRC, activation of PPARY may play a benefited role in colon carcinogenesis. The results of clinical trials for CRC with PPARY ligands have shown modest This implies that aiming at PPARY as a specific anti-tumor target is not likely to be successful, because PPARY ligands are not an active agent for the treatment of advanced or metastatic CRC. Recently, we have demonstrated the substantial suppressive effects of PPARY ligands on colon carcinogenesis in mouse model in the early stage of carcinogenesis, suggesting a potential application as the chemopreventive agents against carcinogenesis. Furthermore, number of aberrant crypt foci, pre cancerous lesion of colorectal, was significantly decreased by PPARY ligand treatment in human study. PPARY ligands are used with safety benefit and may be a clinical application as anti-cancer drug in early stage of CRC. These results suggest that PPARY ligand is a promising candidate as a chemopreventive agent for CRC.

Research Products

• [Journal Article] Peroxisome Proliferator-Activated Receptor γ(PPARy)Suppresses Colonic Epithelial Cell Turnover and Colon Carcinogenesis Through Inhibition of the β-Catenin/T Cell Factor(TCF) Pathway (2008)
  • Author(s): Fujisawa T, Nakajima A, Fujisawa T, Takahashi H, Ikeda I, Tomimoto A, Yonemitsu K, Nakajima N, Kudo C, Wada K, Kubota N, Terauchi Y, Kadowaki T, Nakagama H, RS Blumberg
  • Journal Title: Journal of Pharmacological Sciences 106 Pages: 627-638
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Peroxisome Proliferator-Activated Receptor y(PPAR y) Suppresses Colonic Epithelial Cell Turnover and Colon Carcinogenesis Through Inhibition of the 13-Catenin/T Cell Factor(TCF) Pathway (2008)
  • Author(s): Fujisawa, T., Nakajima, A., Fujisawa, T., Takahashi, H., Ikeda, I., Tomimoto, A., Yonemitsu, K., Nakajima, N., Kudo, C., Wada, K., Kubota, N., Terauchi, Y., Kadowaki T., Nakagama, H., RS., Blumberg
  • Journal Title: Journal of Pharmacological Sciences 106 Pages: 627-638
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Peroxisome Proliferator-Activated Receptor γ(PPARγ)Suppresses Colonic Epithelial Cell Turnover and Colon Carcinogenesis Through Inhibition of the β-Catenin/T Cell Factor(TCF)Pathway (2008)
  • Author(s): Fujisawa T, Nakajima A, Fujisawa T, Takahashi H, Ikeda I, Tomimoto A, Yonemitsu K, Nakajima N, Kudo C, Wada K, Kubota N, Terauchi Y, Kadowaki T, Nakagama H, RS Blumberg
  • Journal Title: Journal of Pharmacological Sciences 106 Pages: 627-638
  • NAID: 10024320097
  • Peer Reviewed
• [Journal Article] PPARgamma inhibitors reduce tubulin protein levels by a PPARgamma,PPARdelta and proteasome-independent mechanism,resulting in cell cycle arrest,apoptosis and reduced metas tasis of colorectal carcinoma cells (2007)
  • Author(s): Schaefer KL, Takahashi H, Morales VM, Harris G, Barton S, Osawa E, Nakajima A, Saubermann LJ
  • Journal Title: Int J Cancer 120(3) Pages: 702-13
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] 5-Aminosalicylic Acid Given in the Remission Stage of Colitis Suppresses Colitis-Associated Cancer in a Mouse Colitis Model (2007)
  • Author(s): Ikeda I, Tomimoto A, Wada K, Fujisawa T, Fujita K, Yonemitsu K, Nozaki Y, Endo H, Takahashi H, Ybneda M, Inamori M, Kubota K, Saito S, Nagashima Y, Nakagama H, Nakajima A
  • Journal Title: Clin Cancer Res 13(21) Pages: 6257-6531
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] PPARと大腸がん (2007)
  • Author(s): 高橋 宏和、中島 淳
  • Journal Title: 医学のあゆみ 220(1) Pages: 81-86
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] PPARgamma inhibitors reduce tubulin protein levels by a PPARgamma, PPARdelta and proteasome-independent mechanism, resulting in cell cycle arrest, apoptosis and reduced metastasis of colorectal carcinoma cells (2007)
  • Author(s): Schaefer, KL., Takahashi, H., Morales, VM., Harris, G., Barton, S., Osawa, E., Nakajima, A., Saubermann, LJ
  • Journal Title: Int J Cancer 120 (3) Pages: 702-13
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] 5-Aminosalicylic Acid Given in the Remission Stage of Colitis Suppresses Colitis-Associated Cancer in a Mouse Colitis Model (2007)
  • Author(s): Ikeda, I., Tomimoto, A., Wada, K., Fujisawa, T., Fujita, K., Yonemitsu, K., Nozaki, Y., Endo, H., Takahashi, H., Yoneda, M., Inamori, M., Kubota, K., Saito, S., Nagashima, Y., Nakagama, H., Nakajima, A
  • Journal Title: Clin Cancer Res 13 (21) Pages: 6257-6531
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] PPARgamma inhibitors reduce tubulin protein levels by a PPARgamma, PPARdelta and proteasome-independent mechanism, resulting in cell cycle arrest, apoptosis and reduced metastasis of colorectal carcinoma cells. (2007)
  • Author(s): Schaefer KL, Takahashi H, Morales VM, Harris G, Barton S, Osawa E, Nakajima A, Saubermann LJ
  • Journal Title: Int J Cancer 120(3) Pages: 702-13
  • Peer Reviewed
• [Journal Article] 5-Aminosalicylic Acid Given in the Remission Stage of Colitis Suppresses Colitis-Associated Cancer in a Mouse Colitis Model. (2007)
  • Author(s): Ikeda I, Tomimoto A, Wada K, Fujisawa T, Fujita K, Yonemitsu K, Nozaki Y, Endo H, Takahashi H, Yoneda M, Inamori M, Kubota K, Saito S, Nagashima Y, Nakagama H, Nakajima A
  • Journal Title: Clin Cancer Res 13(21) Pages: 6257-6531
  • Peer Reviewed
• [Journal Article] PPARと大腸がん (2007)
  • Author(s): 高橋宏和、中島淳
  • Journal Title: 医学のあゆみ 220(1) Pages: 81-86
• [Journal Article] Differntial expression of peroxisome proliferators-activated receptor in histrologically different human gastric cancer tisues (2006)
  • Author(s): Nomura S, Nakajima A, Ishimine S, Matsuishi N, Kadowaki T, aminishi M
  • Journal Title: J Exp Clin Cancer Res 25 Pages: 4438-4438
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] PPARgamma inhibitors reduce tubulin protein levels by a PPARgamma,PPARdelta and proteasome-independent mechanism,resulting in cell cycle arrest,apoptosis and reduced metastasis of colorectal carcinoma cells (2006)
  • Author(s): Schaefer KL, Takahashi H, Morales VM, Harris G, Bartons, Osawa E, Nakajima A, Saubermann LJ
  • Journal Title: Intl J Cancer 120(3) Pages: 702-13
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Inhibition of peroxisome proliferators-activated receptor gamma activity in esophageal carcinoma cells results in a drastic decrease of invasive properties. (2006)
  • Author(s): Hirokazu Takahashi, Kouji Fujita, Toshio Fujisawa, Kyoko Yonemitsu, Ayako Tomimoto, Ikuko Ikeda, Masato Yoneda, Katherine Schaefer, Lawrence J Saubermann, Takeshi Shimamura, Satoru Saitoh, Masashi Tachibana, Koichiro Wada, Hitoshi Nakagama, Atsushi Nakajima
  • Journal Title: Cancer Sci 97(9) Pages: 4906-9
  • NAID: 10018767332
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Leukotriene B4 and lipoxin A4 are regulatory signals for neural stem cell proliferation and differentiation (2006)
  • Author(s): Koichiro Wada, Makoto Arita, Atsushi Nakajima, Kazufumi Katayama, Chiho Kudo, Yoshinori Kamisaki, Charles N.Serhan
  • Journal Title: The FASEB Journal 06 Pages: 1785-1792
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Identification of ROBO1 as a novel hepatocellular carcinoma antigen and a potential therapeutic and diagnostic target (2006)
  • Author(s): Ito H, Funahashi S, Yamauchi N, Shibahara J, Midorikawa Y, Kawai S, Kinoshita Y, Watanave A, Hippo Y, Ohtomo T. Jwanari H, Nakajima A, Makuuchi M, Fukayama M, Hirata Y, Hamakubo T, Kodama T, Tsuchiya M, Aburatani H
  • Journal Title: Clin Cancer Res 12(11Pt1) Pages: 3257-64
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Blastocystis hominis infection in patient with regular dialysis (2006)
  • Author(s): Hayashi M, Inamori M, Goto K, Akiyama T, Fujita K, Ikeda I, Fujisawa T, Takahashi H, Yoneda M, Hara K, Abe Y, Kirikoshi H, Kubota K, Saito S, Ueno N, Nakajima A, Hamada Y, fukutomi H, Satsuta H
  • Journal Title: J Gastroenterol 41(6) Pages: 605-6
  • NAID: 10018170757
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Peroxisome Proliferator-activated Receptor γ-mediated Regulation of Neural Stem Cell Proliferation and Differentiation (2006)
  • Author(s): Koichiro Wada, Atsushi Nakajima, Katayama Kazufumi, Chiho Kudo, Atsuhito Shibuya, Naoto Kubota, Yasuo Terauchi, Masashi tachibana, Hiroyuki Miyoshi, Yoshinori Kamisaki, Tadanori Mayumi, Takashi Kadowaki, Richard S.Blumberg
  • Journal Title: Journal of Biological Chemistry 18 Pages: 12673-81
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Pleural Effusions following Endoscopic Injection Sclerotherapy forCirrhotic Patients with Exophageal Varices (2006)
  • Author(s): Hideyuki Kayama, Masahiko Inamori, Jun-ichi Togawa, Takeshi Shimamura, Yoko Tokita, Tadashi Umezawa, Takashi Sakaguchi, Makoto Naitoh, ajimeNagase, Atsushi Nakajima, Toshifumi Saito, Shizuo Tominaga, Norio Ueno, Katsuaki Tanaka, Hisahiko Sekihara
  • Journal Title: Hepato-Gastroenterology 53 Pages: 376-380
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] mRNA Expression of InducibleNitric Oxide Synthase, Endothelial Nitric Oxide Synthase and Vascular Endothelial growth Gactor in Exophageal Mucosa Biopsy Specimens from Patients with Reflux Exophagitis (2006)
  • Author(s): Masahiko Inamori, Takeshi Shimamura, Hajime Nagase, Yasunobu Abe, Tadashi Umezawa, Atsushi akajima, Toshifumi Saito, Norio Ueno, Katsuaki Tanaka, Hisahiko Sekihara, Jun-ichi Togawa, Hiroki Kaifu, Hideo Tsuboi, Hideyuki Kayama, Shizuo tominaga
  • Journal Title: Hepato-Gastroenterology 53 Pages: 361-365
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Predominant T helper type 2-inflammatory responses promote murine colon cancers (2006)
  • Author(s): Osawa E, Nakajima A, Fujisawa T, Kawamura YI, Toyama-Sorimachi N, Nakagama H, Dohi-T
  • Journal Title: Int J.Cancer 118(9) Pages: 2232-6
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Relationship between the serum concentrations of C-reactive protein and parameters of adiposity and insulin resistance in patients with type2 diabetes mellitus (2006)
  • Author(s): Iwasaki T, Nakajima A, Yoneda M, Terauchi Y
  • Journal Title: Endocr J 53(3) Pages: 345-56
  • NAID: 10018178010
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Gastrointestinal:rectal polyp associated with schistosomiasis (2006)
  • Author(s): Abe Y, Inamori M, Fujita K, Fujisawa T, Fujisawa N, Yoneda M, Takahashi H, Ikeda T, Hara K, Akiyama T, Kawamura H, Kato A, Kirikoshi H, Kobayashi N, Kubota K, Saito S, Sasaki T, Inayama Y, Ueno N, Nakajima A
  • Journal Title: J Gastroenterol Hepatol 21(7) Pages: 1216-1216
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Gastrointestinal:Gastrointestinal metastases from malignant melanoma (2006)
  • Author(s): Inamori M, Ueno N, Fujita K, Fujisawa N, Yoneda M, Takahashi H, Ikeda T, Kawamura H, Abe Y, Kato A, Kirikoshi H, Kobayashi N, Shimamura T, Kubota K, Saito S, Sakaguchi T, Yamanaka S, Inayama Y, Nakajima A
  • Journal Title: J Gastroenterol Hepatol 21 Pages: 327-327
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Evaluation of postprandial 3 h pH monitoring for gastroesophageal reflux disease:is there a possibility of streamlining the 24 h test (2006)
  • Author(s): Inamori M, Akiyama T, Akimoto K, Takahashi H, Abe Y, Nakajima A
  • Journal Title: J Gastroenterol Hepatol 21(11) Pages: 1751-2
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Undifferentiated spindle-cell carcinoma of the gallbladder:an immunohistochemical study (2006)
  • Author(s): Kubota K, Kakuta Y, Kawamuras, Abe Y, Inamori M, Kawamura H, Kirikoshi H, Kobayashi N, Saito S, Nakajima A
  • Journal Title: J Hepatobiliary Pncreat Surg 13(5) Pages: 468-71
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] SHP1 Phosphatase-Dependent T Cell Inhibition by CEACAMl Adhesion Molocule Isoforms (2006)
  • Author(s): Nagaishi T, Pao L, Lin SH, Iijima H, Kaser A Qiao SW, Chen Z, Glickman J, Najjar SM, Nakajima A, Neel BG, Blumberg RS
  • Journal Title: Immunity 209(Pt22) Pages: 4574-9
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Role of CEACAMI as a regulator of T cells (2006)
  • Author(s): Nagaishi T, Iijima H, Nakajima A, Chen D, Blumberg RS
  • Journal Title: Ann N Y Acad Sci Aug Pages: 1072-75
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Differential expression of peroxisome proliferators-activated receptor in histrologically different human gastric cancer tissues. (2006)
  • Author(s): Nomura, S., Nakajima, A., Ishimine, S., Matsuishi, N., Kadowaki, T., Kaminishi, M
  • Journal Title: J Exp Clin Cancer Res 25 Pages: 4438-4438
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] PPARgamma inhibitors reduce tubulin protein levels by a PPARgamma, PPARdelta and proteasome-independent mechanism, resulting in cell cycle arrest. apoptosis and reduced metastasis of colorectal carcinoma cells (2006)
  • Author(s): Schaefer, KL., Takahashi, H., Morales, VM., Harris, G., Barton, s., Osawa, E., Nakajima, A., Saubermann, LJ
  • Journal Title: Intl J Cancer 120(3) Pages: 702-13
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Inhibition of peroxisome proliferators-activated receptor gamma activity in esophageal carcinoma cells results in a drastic decrease of invasive properties (2006)
  • Author(s): Hirokazu, Takahashi, Kouji, Fujita, Toshio, Fujisawa, Kyoko, Yonemitsu, Ayako, Tomimoto, Ikuko, Ikeda, Masato, Yoneda, Katherine, Schaefer, Lawrence, J Saubermann, Takeshi, Shimamura, Satoru, Saitoh, Masashi, Tachibana, Koichiro, Wada, Hitoshi, Nakagama, Atsushi, Nakajima
  • Journal Title: Cancer Sci 97 (9) Pages: 4906-9
  • NAID: 10018767332
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Leukotriene B4 and lipoxin A4 are regulatory signals for neural stem cell proliferation and differentiation (2006)
  • Author(s): Koichiro, Wada, Makoto, Arita, Atsushi, Nakajima, Kazufumi, Katayama, Chiho, Kudo, Yoshinori, Kamisaki, Charles, N., Serhan
  • Journal Title: The FASEB Journal 06 Pages: 1785-1792
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Identification of ROBO1 as a novel hepatocellular carcinoma antigen and a potential therapeutic and diagnostic target (2006)
  • Author(s): Ito, H., Funahashi, S., Yamauchi, N., Shibahara, J., Midorikawa, Y., Kawai, S., Kinoshita, Y., Watanave, A., Hippo, Y., Ohtomo, T., Iwanari, H., Nakajima, A., Makuuchi, M., Fukayama, M., Hirata, Y., Hamakubo, T., Kodama, T., Tsuchiya, M., Aburatani, H
  • Journal Title: Clin Cancer Res 12(11 Pt 1) Pages: 3257-64
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Blastocvstis hominis infection in natient with regular dialysis (2006)
  • Author(s): Hayashi, M., Inamori, M., Goto, K., Akiyama, T., Fujita, K., Ikeda, I., Fujisawa, T., Takahashi, H., Yoneda, M., Hara, K., Abe, Y., Kirikoshi, H., Kubota, K., Saito, S., Ueno, N., Nakajima, A., Hamada, Y., fukutomi, H., Satsuta, H
  • Journal Title: J Gastroenterol 41(6) Pages: 605-6
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Peroxisome Proliferator-activated Receptor r-mediated Regulation of Neural Stem Cell Proliferation and Differentiation (2006)
  • Author(s): Koichiro, Wada, Atsushi, Nakajima, Katayama, Kazufumi, Chiho, Kudo, Atsuhito, Shibuya, Naoto, Kubota, Yasuo, Terauchi, Masashi, tachibana, Hiroyuki, Miyoshi, Yoshinori, Kamisaki, Tadanori, Mayumi, Takashi, Kadowaki, Richard, S. Blumberg
  • Journal Title: Journal of Biological Chemistry 18 Pages: 12673-81
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Pleural Effusions following Endoscopic Injection Sclerotherapy for Cirrhotic Patients with Exonhageal Varices (2006)
  • Author(s): Hideyuki, Kayama, Masahiko, Inamori, Jun-ichi, Togawa, Takeshi, Shimamura, Yoko, Tokita, Tadashi, Umezawa, Takashi, Sakaguchi, Makoto, Naitoh, ajime, Nagase, Atsushi, Nakajima, Toshifumi, Saito, Shizuo, Tominaga, Norio, Ueno, Katsuaki, Tanaka, Hisahiko, Sekihara
  • Journal Title: Hepato-Gastroenterology 53 Pages: 376-380
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Predominant T helper type 2-inflammatory responses promote murine colon cancers (2006)
  • Author(s): Osawa, E., Nakajima, A., Fujisawa, T., Kawamura, YI., Toyama-Sorimachi, N., Nakagama, H., Dohi-T
  • Journal Title: Int J. Cancer 118(9) Pages: 2232-6
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Relationship between the serum concentrations of C-reactive protein and parameters of adiposity and insulin resistance in patients with type2 diabetes mellitus (2006)
  • Author(s): Iwasaki, T., Nakajima, A., Yoneda, M., Terauchi, Y
  • Journal Title: Endocr J 53(3) Pages: 345-56
  • NAID: 10018178010
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Gastrointestinal:rectal polyp associated with schistosomiasis (2006)
  • Author(s): Abe, Y., Inamori, M., Fujita, K., Fujisawa, T., Fujisawa, N., Yoneda, M., Takahashi, H., Ikeda, T., Hara, K., Akiyama, T., Kawamura, H., Kato, A., Kirikoshi, H., Kobayashi, N., Kubota, K., Saito, S., Sasaki, T., Inayama, Y., Ueno, N., Nakajima, A
  • Journal Title: J Gastroenterol Hepatol 21(7) Pages: 1216-1216
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Gastrointestinal :Gastrointestinal metastases from malignant melanoma (2006)
  • Author(s): Inamori, M., Ueno, N., Fujita, K., Fujisawa, N., Yoneda, M., Takahashi, H., Ikeda, T., Kawamura, H., Abe, Y., Kate, A., Kirikoshi, H., Kobayashi, N., Shimamura, T., Kubota, K, Saito, S., Sakaguchi, T., Yamanaka, S., Inayama, Y., Nakajima, A
  • Journal Title: J Gastroenterol Hepatol 21 Pages: 327-327
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Evaluation of postprandial 3 h pH monitoring for gastroesophageal reflux disease:is there a possibility of streamlining the 24 h test? (2006)
  • Author(s): Inamori, M., Akiyama, T., Akimoto, K., Takahashi, H., Abe, Y., Nakajima, A
  • Journal Title: J Gastroenterol Hepatol 21(11) Pages: 1751-2
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Undifferentiated spindle-cell carcinoma of the gallbladder:an immunohistochemical study (2006)
  • Author(s): Kubota, K., Kakuta, Y., Kawamura, s., Abe, Y., Inamori, M., Kawamura, H., Kirikoshi, H., Kobayashi, N., Saito, S., Nakajima, A
  • Journal Title: J Hepatobiliary Pncreat Surg 13(5) Pages: 468-71
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] SHP1 Phosphatase-Dependent T Cell Inhibition by CEACAM1 Adhesion Molocule Isoforms (2006)
  • Author(s): Nagaishi, T., Pao, L., Lin, SH., Iijima, H., Kaser, A., Qiao, SW., Chen, Z., Glickman, J., Najjar, SM., Nakajima, A., Neel, BG., Blumberg, RS
  • Journal Title: Immunity 209(Pt22) Pages: 4574-9
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Role of CEACAM1 as a regulator of T cells (2006)
  • Author(s): Nagaishi, T., Iijima, H., Nakajima, A., Chen, D., Blumberg, RS
  • Journal Title: Ann N Y Acad Sci.Aug Pages: 1072-75
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Differntial expression of peroxisome proliferators-activated receptor in histrologically different human gastric cancer tisues. (2006)
  • Author(s): Nomura S, Nakajima A, Ishimine S, Matsuishi N, Kadowaki T, Kaminishi M
  • Journal Title: J Exp Clin Cancer Res. 25 Pages: 4438-4438
• [Journal Article] PPARgamma inhibitors reduce tubulin protein levels by a PPARgamma, PPARdelta and proteasome-independent mechanism, resulting in cell cycle arrest, apoptosis and reduced metastasis of colorectal carcinoma cells. (2006)
  • Author(s): Schaefer KL, Takahashi H, Morales VM, Harris G, Barton s, Osawa E, Nakajima A, Saubermann LJ.
  • Journal Title: Intl J Cancer. 120(3) Pages: 702-13
• [Journal Article] Inhibition of peroxisome proliferators-activated receptor gamma activity in esophageal carcinoma cells results in a drastic decrease of invasive properties. (2006)
  • Author(s): Hirokazu Takahashi, Kouji Fujita, Toshio Fujisawa, Kyoko Yonemitsu, Ayako Tomimoto, Ikuko Ikeda, Masato Yoneda, Katherine Schaefer, Lawrence J Saubermann, Takeshi Shimamura, Satoru Saitoh, Masashi Tachibana, Koichiro Wada, Hitoshi Nakagama, Atsushi Nakajima
  • Journal Title: Cancer Sci. 97(9) Pages: 4906-9
  • NAID: 10018767332
• [Journal Article] Leukotriene B4 and lipoxin A4 are regulatory signals for neural stem cell proliferation and differentiation (2006)
  • Author(s): Koichiro Wada, Makoto Arita, Atsushi Nakajima, Kazufumi Katayama, Chiho Kudo, Yoshinori Kamisaki, Charles N. Serhan
  • Journal Title: The FASEB Journal 06 Pages: 1785-1792
• [Journal Article] Identification of ROBO1 as a novel hepatocellular carcinoma antigen and a potential therapeutic and diagnostic target. (2006)
  • Author(s): Ito H, Funahashi S, Yamauchi N, Shibahara J, Midorikawa Y, Kawai S, Kinoshita Y, Watanave A, Hippo Y, Ohtomo T, Iwanari H, Nakajima A, Makuuchi M, Fukayama M, Hirata Y, Hamakubo T, Kodama T, Tsuchiya M, Aburatani H.
  • Journal Title: Clin Cancer Res. 12(11 Pt 1) Pages: 3257-64
• [Journal Article] Blastocystis hominis infection in patient with regular dialysis. (2006)
  • Author(s): Hayashi M, Inamori M, Goto k, Akiyama T, Fujita K, Ikeda I, Fujisawa T, Takahashi H, Yoneda M, Hara K, Abe Y, Kirikoshi H, Kubota K, Saito S, Ueno N, Nakajima A, Hamada Y, fukutomi H, Satsuta H.
  • Journal Title: J Gastroenterol. 41(6) Pages: 605-6
  • NAID: 10018170757
• [Journal Article] Peroxisome Proliferator-activated Receptor y-mediated Regulation of Neural Stem Cell Proliferation and Differentiation. (2006)
  • Author(s): Koichiro Wada, Atsushi Nakajima, Katayama Kazufumi, Chiho Kudo, Atsuhiro Shibuya, Naoto Kubota, Yasuo, Terauchi, Masashi tachibana, Hiroyuki Miyoshi, Yoshinori Kamisaki, Tadanori Mayumi, Takashi Kadowaki, Richard S. Blumberg.
  • Journal Title: Journal of Biological Chemistry 18 Pages: 12673-81
• [Journal Article] Pleural Effusions following Endoscopic Injection Sclerotherapy for Cirrhotic Patients with Exophageal Varices (2006)
  • Author(s): Hideyuki Kayama, Masahiko Inamori, Jun-Ichi Togawa, Takeshi Shimamura, Yoko Tokita, Tadashi Umezawa, Takashi Sakaguchi, Makoto Naitoh, ajime Nagase, Atsushi Nakajima, Toshifumi Saito, Shizuo Tominaga, Norio Ueno, Katsuaki Tanaka, Hisahiko Sekihara
  • Journal Title: Hepato-Gastroenterology 53 Pages: 376-380
• [Journal Article] mRNA Expression of Inducible Nitric Oxide Synthase, Endothelial Nitric Oxide Synthase and Vascular Endothelial growth Gactor in Exophageal Mucosa Biopsy Specimens from Patients with Reflux Exophagitis (2006)
  • Author(s): Masahiko Inamori, Takeshi Shimamura, Hajime Nagase, Yasunobu Abe, Tadashi Umezawa, Atsushi akajima, Toshifumi Saito, Norio Ueno, Katsuaki Tanaka, Hisahiko Sekihara, Jun-ichi Togawa, Hiroki Kaifu, Hideo Tsuboi, Hideyuki Kayama, Shizuo tominaga.
  • Journal Title: Hepato-Gastroenterology 53 Pages: 361-365
• [Journal Article] Predominant T helper type 2-inflammatory responses promote murine colon cancers (2006)
  • Author(s): Osawa E, Nakajima A, Fujisawa T, Kawamura YI, Toyama-Sorimachi N, Nakagama H, Dohi-T.
  • Journal Title: Int J. Cancer. 118(9) Pages: 2232-6
• [Journal Article] Relationship between the serum concentrations of C-reactive protein and parameters of adiposity and insulin resistance in patients with type2 diabetes mellitus (2006)
  • Author(s): Iwasaki T, Nakajima A, Yoneda M, Terauchi Y.
  • Journal Title: Endocr J. 53(3) Pages: 345-56
  • NAID: 10018178010
• [Journal Article] Gastrointestinal : rectal polyp associated with schistosomiasis. (2006)
  • Author(s): Abe Y, Inamori M, Fujita K, Fujisawa T, Fujisawa N, Yoneda M, Takahashi H, Ikeda T, Hara K, Akiyama T, Kawamura H, Kato A, Kirikoshi H, Kobayashi N, Kubota K, Saito S, Sasaki T, Inayama Y, Ueno N, Nakajima A.
  • Journal Title: J Gastroenterol Hepatol. 21(7) Pages: 1216-1216
• [Journal Article] Gastrointestinal : Gastrointestinal metastases from malignant melanoma. (2006)
  • Author(s): Inamori M, Ueno N, Fujita K, Fujisawa N, Yoneda M, Takahashi H, Ikeda T, Kawamura H, Abe Y, Kato A, Kirikoshi H, Kobayashi N, Shimamura T, Kubota K, Saito S, Sakaguchi T, Yamanaka S, Inayama Y, Nakajima A.
  • Journal Title: J Gastroenterol Hepatol. 21 Pages: 327-327
• [Journal Article] Evaluation of postprandial 3 h pH monitoring for gastroesophageal reflux disease-is there a possibility of streamlining the 24h test? (2006)
  • Author(s): Inamori M, Akiyama T, Akimoto K, Takahashi H, Abe Y, Nakajima A
  • Journal Title: J Gastroenterol Hepatol. 21(11) Pages: 1751-2
• [Journal Article] Undifferentiated spindle-cell carcinoma of the gallbladder : an immunohistochemical study. (2006)
  • Author(s): Kubota K, Kakuta Y, Kawamura s, Abe Y, Inamori M, Kawamura H, Kirikoshi H, Kobayashi N, Saito S, Nakajima A.
  • Journal Title: J Hepatobiliary Pncreat Surg. 13(5) Pages: 468-71
  • NAID: 10018765285
• [Journal Article] SHP1 Phosphatase-Dependent T Cell Inhibition by CEACAM1 Adhesion Molocule Isoforms. (2006)
  • Author(s): Nagaishi T, Pao L, Lin SH, Iijima H, Kaser A Qiao SW, Chen Z, Glickman J, Najjar SM, Nakajima A, Neel BG, Blumberg RS
  • Journal Title: Immunity. 209(Pt22) Pages: 4574-9
• [Journal Article] Role of CEACAM1 as a regulator of T cells. (2006)
  • Author(s): Nagaishi T, Iijima H, Nakajima A, Chen D, Blumberg RS.
  • Journal Title: Ann NY Acad Sci. Aug Pages: 1072-75
• [Journal Article] mRNA Expression of Inducible Nitric Oxide Synthase, Endothelial Nitric Oxide Synthase and Vascular Endothelial growth Gactor in Exophageal Mucosa Biopsy Specimens from Patients with Reflux Exophagitis
  • Author(s): Masahiko, Inamori, Takeshi, Shimamura, Hajime, Nagase, Yasunobu, Abe, Tadashi, Umezawa, Atsushi, akajima, Toshifumi, Saito, Norio, Ueno, Katsuaki, Tanaka, Hisahiko, Sekihara, Jun-ichi, Togawa, Hiroki, Kaifu, Hideo, Tsuboi, Hideyuki, Kayama, Shizuo, tominaga
  • Journal Title: Hepat-Gastroenterology53 Pages: 361-365
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Adiponectin prevents colorectal carcinogenesis through suppressing mTOR signaling pathway stimulated by high fat diet (2007)
  • Author(s): Fujisawa T, Tomimoto A, Takahashi H, Yonemitsu K, Nakajima A
  • Organizer: AACR Annual Meeting 2007
  • Place of Presentation: Los Angels
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Visceral fat obesity increase dysplastic aberrant cript foci (2007)
  • Author(s): Takahashi H, Fujisawa T, Yonemitsu K, Tomimoto A, Endo H, Nakajima A
  • Organizer: AACR Annual Meeting 2007
  • Place of Presentation: Los Angels
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Adipocytokines and dysplastic aberrant crypt foci (2007)
  • Author(s): Takahashi H, Yoneda K, Iida H.Tomimoto A, Endo H, Inamori M, Abe Y, Nakajima A
  • Organizer: AACR Annual Meeting 2007
  • Place of Presentation: Philadelphia
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Visceral fat obesity increase dvsnlastic aberrant crint foci (2007)
  • Author(s): Takahashi, H., Fujisawa, T., Yonemitsu, K., Tomimoto, A., Endo, H., Nakajima, A
  • Organizer: AACR Annual Meeting 2007
  • Place of Presentation: Los Angels
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Adiponectin prevents colorectal carcinogenesis through suppressing mTOR signaling pathway stimulated by high fat diet. (2007)
  • Author(s): Fujisawa T, Tomimoto A, Takahashi H, Yonemitsu K, Nakajima A
  • Organizer: AACR Annual Meeting 2007
  • Place of Presentation: Los Angels
• [Presentation] Adipocytokines and dysplastic aberrant crypt foci. (2007)
  • Author(s): Takahashi H, Yoneda K, Iida H. Tomimoto A, Endo H, Inamori M, Abe Y, Nakajima A
  • Organizer: AACR Annual Meeting 2007
  • Place of Presentation: Philadelphia
• [Patent(Industrial Property Rights)] 脂肪性肝疾患の診断方法、診断装置、診断プログラム、診断薬及び脂肪性肝疾患用治療薬のスクリーニング方法 (2007)
  • Inventor(s): 中島 淳、米田 正人、藤田 浩司、中江 大、高村 岳樹、高橋 正一、畑中 豊
  • Industrial Property Rights Holder: 公立大学法人横浜市立大学
  • Filing Date: 2007-08-31
  • Description: 「研究成果報告書概要(和文)」より
  • Overseas
• [Patent(Industrial Property Rights)] 血液中一酸化窒素代謝物量測定による内臓脂肪量非侵襲的測定法 (2007)
  • Inventor(s): 中島 淳, 米田 正人, 藤田 浩司, 斉藤 聡, 桐越 博之
  • Industrial Property Rights Holder: 公立大学法人横浜市立大学
  • Industrial Property Number: 2007-107257
  • Filing Date: 2007-04-16
  • Description: 「研究成果報告書概要(和文)」より
• [Patent(Industrial Property Rights)] 脂肪肝炎の診断及び/又は治療における肝臓へのコリン集積値の有用性 (2007)
  • Inventor(s): 中島 淳, 米田 正人, 藤田 浩司, 斉藤 聡, 桐越 博之, 井上 登美夫, 雫石 一也
  • Industrial Property Rights Holder: 公立大学法人横浜市立大学
  • Industrial Property Number: 2007-042095
  • Filing Date: 2007-02-22
  • Description: 「研究成果報告書概要(和文)」より
• [Patent(Industrial Property Rights)] 公開不可 (2007)
  • Inventor(s): 公開不可
  • Industrial Property Rights Holder: 公開不可
  • Filing Date: 2007-10-12
  • Description: 「研究成果報告書概要(和文)」より
• [Patent(Industrial Property Rights)] 公開不可 (2007)
  • Inventor(s): 公開不可
  • Industrial Property Rights Holder: 公開不可
  • Filing Date: 2007-07-11
  • Description: 「研究成果報告書概要(和文)」より
• [Patent(Industrial Property Rights)] 脂肪肝炎の診断及び/又は治療における血清コリン値の有用性 (2006)
  • Inventor(s): 中島 淳、米田 正人、藤田 浩司、中江 大、高村 岳樹、高橋 正一、畑中 豊
  • Industrial Property Rights Holder: 公立大学法人横浜市立大学
  • Industrial Property Number: 2006-299978
  • Filing Date: 2006-11-06
  • Description: 「研究成果報告書概要(和文)」より