Study on the mechanism of LAM cell proliferation and disease progression in lymphangioleiomyomatosis
| Project/Area Number |
18390243
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Respiratory organ internal medicine
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| Research Institution | Juntendo University |
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Principal Investigator |
SEYAMA Kuniaki Juntendo University, 医学部, 准教授 (10226681)
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| Co-Investigator(Kenkyū-buntansha) |
KUMASAKA Toshio 順天堂大学, 医学部, 准教授 (00286709)
KODAMA Yuzo 順天堂大学, 医学部, 助教 (30384069)
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| Project Period (FY) |
2006 – 2008
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| Project Status |
Completed (Fiscal Year 2008)
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| Budget Amount *help |
¥15,030,000 (Direct Cost: ¥12,600,000、Indirect Cost: ¥2,430,000)
Fiscal Year 2008: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2007: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2006: ¥4,500,000 (Direct Cost: ¥4,500,000)
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| Keywords | リンパ脈管筋腫症 / がん抑制遺伝子 / TSC遺伝子 / リンパ管新生 / 結節性硬化症 / 自然気胸 / 嚢胞性肺疾患 / リンパ行性転移 / 癌抑制遺伝子 |
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| Research Abstract |
肺リンパ脈管筋腫症(LAM)の病因であるLAM細胞の増殖や転移機構の解明をめざし、LAM細胞クラスター(LCC)や組織よりLAM細胞を分離培養し、その細胞生物学的特性を検討した。また、LAM細胞を高度免疫不全マウスに移植し、治療や病態解明に役立つLAMモデルマウス作成を試みた。LAM細胞の多様性、培養中の性質変化、マウス内で生着の困難さなど、今後のLAM研究の発展への課題が明らかとなった。
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Report
(4 results)
Research Products
(28 results)
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[Journal Article] Peritoneovenous shunting for intractable chylous ascites complicated with lymphangioleiomyoma-tosis2008
Author(s)
Makino Y, Shimanuki Y, Fujiwara N, Morio Y, Sato K, Yoshimoto J, Gunji Y, Suzuki T, Sasaki S, Iwase A, Kawasaki S, Takahashi K, Seyama K
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Journal Title
Intern Med 47
Pages: 281-285
NAID
Related Report
Peer Reviewed
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[Journal Article] Cytological, immunocytochemical, and ultrastructural characterization of LAM cell clusters in chylous effusion of patients with lymphangioleiomyomatosis
Author(s)
Mitani K, Kumasaka T, Takemura H, Hayashi T, Gunji Y, Kunogi M, Akiyoshi T, Takahashi K, Suda K, Seyama K
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Journal Title
Acta Cytologica (in press)
Related Report
Peer Reviewed
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[Presentation] Cytological, immunocytochemical, and ultrastructual characterization of LAM cell clusters in chylous effusion in patients with lymphangioleiomyomatosis2007
Author(s)
Mitani K, Kumasaka T, Takemura H, Hayashi T, Hosokawa Y, Suda K, Gunji Y, Akiyoshi T, Seyama K
Organizer
LAM Foundation 2007 International Research Conference
Place of Presentation
in Cincinnati USA
Year and Date
2007-04-20
Related Report
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[Book] Stacker SD and Achen MG
Author(s)
Seyama K, Kumasaka T, Sato T, and Mitani K
Publisher
Chapter 8. Lymphangioleiomyomatosis. In : Cancer and lymphatic metastasis
Related Report
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