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Study on the mechanism of LAM cell proliferation and disease progression in lymphangioleiomyomatosis

Research Project

Project/Area Number 18390243
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Respiratory organ internal medicine
Research InstitutionJuntendo University

Principal Investigator

SEYAMA Kuniaki  Juntendo University, 医学部, 准教授 (10226681)

Co-Investigator(Kenkyū-buntansha) KUMASAKA Toshio  順天堂大学, 医学部, 准教授 (00286709)
KODAMA Yuzo  順天堂大学, 医学部, 助教 (30384069)
Project Period (FY) 2006 – 2008
Project Status Completed (Fiscal Year 2008)
Budget Amount *help
¥15,030,000 (Direct Cost: ¥12,600,000、Indirect Cost: ¥2,430,000)
Fiscal Year 2008: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2007: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2006: ¥4,500,000 (Direct Cost: ¥4,500,000)
Keywordsリンパ脈管筋腫症 / がん抑制遺伝子 / TSC遺伝子 / リンパ管新生 / 結節性硬化症 / 自然気胸 / 嚢胞性肺疾患 / リンパ行性転移 / 癌抑制遺伝子
Research Abstract

肺リンパ脈管筋腫症(LAM)の病因であるLAM細胞の増殖や転移機構の解明をめざし、LAM細胞クラスター(LCC)や組織よりLAM細胞を分離培養し、その細胞生物学的特性を検討した。また、LAM細胞を高度免疫不全マウスに移植し、治療や病態解明に役立つLAMモデルマウス作成を試みた。LAM細胞の多様性、培養中の性質変化、マウス内で生着の困難さなど、今後のLAM研究の発展への課題が明らかとなった。

Report

(4 results)
  • 2008 Annual Research Report   Final Research Report ( PDF )
  • 2007 Annual Research Report
  • 2006 Annual Research Report

Research Products

(28 results)

All 2009 2008 2007 2006 Other

All Journal Article (16 results) (of which Peer Reviewed: 12 results) Presentation (8 results) Book (1 results) Remarks (3 results)

  • [Journal Article] Matrix metalloproteinases in blood from patients with LAM2009

    • Author(s)
      Odajima N, Betsuyaku T, Nasuhara Y, Inoue H, Seyama K, Nishimura M
    • Journal Title

      Respir Med 103

      Pages: 124-129

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Matrix metalloproteinases in blood from patients with LAM.2009

    • Author(s)
      Odajima N, et al.
    • Journal Title

      Respir Med. 103

      Pages: 124-129

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Sirolimus amelioration of clinical symptoms of recurrent lymphangioleiomyomatosis after living-donor lobar lung transplantation2008

    • Author(s)
      Sugimoto R, Nakao A, Yamane M, Toyooka S, Okazaki M, Aoe M, Seyama K, Date H, Oto T, Sano Y
    • Journal Title

      J Heart Lung Transplant 27

      Pages: 921-924

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Peritoneovenous shunting for intractable chylous ascites complicated with lymphangioleiomyoma-tosis2008

    • Author(s)
      Makino Y, Shimanuki Y, Fujiwara N, Morio Y, Sato K, Yoshimoto J, Gunji Y, Suzuki T, Sasaki S, Iwase A, Kawasaki S, Takahashi K, Seyama K
    • Journal Title

      Intern Med 47

      Pages: 281-285

    • NAID

      130000079736

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Sirolimus amelioration of clinical symptoms of recurrent lymphangiolei omyomatosis after living-donor lobar lung transplantation.2008

    • Author(s)
      Sugimoto R, et al.
    • Journal Title

      J Heart Lung Transplant. 27

      Pages: 921-924

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Peritoneovenous shunting for intractable chylous ascites complicated with lymphanioleiomvomatosis2008

    • Author(s)
      Makino Y, et. al.
    • Journal Title

      Intern Med 47

      Pages: 281-285

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Lymphangioleiomyomatosis diagnosed by immunocytochemical and genetic analysis of lymphangioleiomyoma-tosis cell clusters found in chylous pleural effusion2007

    • Author(s)
      Hirama M, Atsuta R, Mitani K, Kumasaka T, Gunji Y, Sasaki S, Iwase A, TakahashiK, Seyama K
    • Journal Title

      Intern Med 46

      Pages: 1593-1596

    • NAID

      130000076007

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Respiratory Failure Research Group of the Japanese Ministry of Health, Labor, and Welfare2007

    • Author(s)
      Hayashida M, Seyama K, Inoue Y, Fujimoto K, Kubo K
    • Journal Title

      The epidemiology of lymphangioleiomyomatosisin Japan : a nationwide cross-sectionalstudy of presenting features andprognostic factors 12

      Pages: 523-530

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] The epidemiology of lymphangioleiomyomatosis in Japan:anationwide cross-sectioval study of presenting features and prognostic factors2007

    • Author(s)
      Hayashida M, et. al.
    • Journal Title

      Respirology 12

      Pages: 523-530

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Lymphangioleiomyomatosis diagnosed by immunocytochemical and genetic analysis of lymphangioleiomyomatosis cell clusters found in chvlous pleural effusion2007

    • Author(s)
      Hirama M, et. al.
    • Journal Title

      Intern Med 46

      Pages: 1593-1596

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] LAMは腫瘍か?2007

    • Author(s)
      瀬山邦明, 熊坂利夫ら
    • Journal Title

      呼吸 26

      Pages: 23-30

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Vascular endothelial growth factor-D is increased in serum of patients with lymphangioleiomyomatosis2006

    • Author(s)
      Seyama K, Kumasaka T, Souma S, Sato T, Kurihara M, Mitani K, Tominaga S, Fukuchi Y
    • Journal Title

      Lymphat Res Biol 4

      Pages: 143-52

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] LAMと遺伝子多型2006

    • Author(s)
      佐藤輝彦, 三谷恵子
    • Journal Title

      呼吸と循環 54

      Pages: 827-832

    • Related Report
      2006 Annual Research Report
  • [Journal Article] リンパ脈管筋腫症-TSC遺伝子解析からLAMの進展機序への展開-2006

    • Author(s)
      瀬山邦明, 熊坂利夫
    • Journal Title

      二本内科学会雑誌 95

      Pages: 1048-1057

    • NAID

      10018198718

    • Related Report
      2006 Annual Research Report
  • [Journal Article] 肺リンパ脈管筋腫症の病理と病態2006

    • Author(s)
      熊坂利夫, 瀬山邦明ら
    • Journal Title

      病理と臨床 24

      Pages: 939-948

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Cytological, immunocytochemical, and ultrastructural characterization of LAM cell clusters in chylous effusion of patients with lymphangioleiomyomatosis

    • Author(s)
      Mitani K, Kumasaka T, Takemura H, Hayashi T, Gunji Y, Kunogi M, Akiyoshi T, Takahashi K, Suda K, Seyama K
    • Journal Title

      Acta Cytologica (in press)

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Presentation] Lymphangiogenesis in lymphangioleiomyomatosis -Lymphangiogenesis and GnRH therapy-9:25-9:50a. m.2008

    • Author(s)
      Seyama K
    • Organizer
      LAM Foundation 2008 International Research Conference
    • Place of Presentation
      Cincinnati, USA
    • Year and Date
      2008-04-05
    • Related Report
      2008 Annual Research Report
  • [Presentation] Lymphangiogenesis in lymphangioleiomyomatosis-Lymphangiogenesis and GnRH therapy-2008

    • Author(s)
      Seyama K
    • Organizer
      LAM Foundation 2008 International Research Conference
    • Place of Presentation
      in Cincinnati USA
    • Related Report
      2008 Final Research Report
  • [Presentation] Genetic and Molecular Mechanism of Diffuse Lung Diseases 2. Lymphangioleiomyomatosis2007

    • Author(s)
      Seyama K
    • Organizer
      The 4th international meeting of WASOG
    • Place of Presentation
      Tokyo
    • Year and Date
      2007-10-20
    • Related Report
      2008 Final Research Report
  • [Presentation] Effect of long term administration of gonadotropin-releasing hormone an alogues on chylous effusion in patients with lymphangioleiomyomatosis2007

    • Author(s)
      Seyama K
    • Organizer
      The LAM foundation/NHLBI International Research Conference
    • Place of Presentation
      Cincinnati,USA
    • Year and Date
      2007-04-21
    • Related Report
      2007 Annual Research Report
  • [Presentation] Effect of long term administration of gonadotropin-releasing hormone analogueson chylous effusion in patients with lymphangioleiomyomatosis2007

    • Author(s)
      Seyama K, Sato T, Gunji Y, Kumasaka T, Mitani K, Akiyoshi T, Tobino K, Hayashi T
    • Organizer
      LAM Foundation2007 International Research Conference
    • Place of Presentation
      in Cincinnati USA.
    • Year and Date
      2007-04-20
    • Related Report
      2008 Final Research Report
  • [Presentation] Cytological, immunocytochemical, and ultrastructual characterization of LAM cell clusters in chylous effusion in patients with lymphangioleiomyomatosis2007

    • Author(s)
      Mitani K, Kumasaka T, Takemura H, Hayashi T, Hosokawa Y, Suda K, Gunji Y, Akiyoshi T, Seyama K
    • Organizer
      LAM Foundation 2007 International Research Conference
    • Place of Presentation
      in Cincinnati USA
    • Year and Date
      2007-04-20
    • Related Report
      2008 Final Research Report
  • [Presentation] Loss of heterozygosity of the TSC genes and overexpression of mTOR-related proteins in multifocalmicronodular pneumocyte hyperplasia of the lung2007

    • Author(s)
      Hayashi H, Kumasaka T, Mitani K, Gunji Y, Suda K, Seyama K
    • Organizer
      LAM Foundation 2007 International Research Conference
    • Place of Presentation
      in Cincinnati USA
    • Year and Date
      2007-04-20
    • Related Report
      2008 Final Research Report
  • [Presentation] LAM and Lymphangiogenesis2007

    • Author(s)
      Seyama K
    • Organizer
      Global LAM summit
    • Place of Presentation
      in Stockholm
    • Year and Date
      2007-02-25
    • Related Report
      2008 Final Research Report
  • [Book] Stacker SD and Achen MG

    • Author(s)
      Seyama K, Kumasaka T, Sato T, and Mitani K
    • Publisher
      Chapter 8. Lymphangioleiomyomatosis. In : Cancer and lymphatic metastasis
    • Related Report
      2008 Final Research Report
  • [Remarks] 気胸・肺のう胞スタディグループ

    • Related Report
      2008 Final Research Report
  • [Remarks]

    • URL

      http://kikyoustudy.wordpress.com

    • Related Report
      2008 Final Research Report
  • [Remarks] 気胸・肺のう胞スタディグループホームページ:

    • URL

      http://kikyoustudy.wordpress.com

    • Related Report
      2008 Annual Research Report

URL: 

Published: 2006-03-31   Modified: 2016-04-21  

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