Identification of new therapeutic target molecules and development of diagnostic markers for malignant mesothelioma
Project/Area Number |
18390245
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Research Category |
Grant-in-Aid for Scientific Research (B)
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Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Respiratory organ internal medicine
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Research Institution | Aichi Cancer Center Research Institute |
Principal Investigator |
SEKIDO Yoshitaka Aichi Cancer Center Research Institute, 分子腫癌学部, 部長 (00311712)
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Project Period (FY) |
2006 – 2008
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Project Status |
Completed (Fiscal Year 2008)
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Budget Amount *help |
¥18,020,000 (Direct Cost: ¥15,200,000、Indirect Cost: ¥2,820,000)
Fiscal Year 2008: ¥6,110,000 (Direct Cost: ¥4,700,000、Indirect Cost: ¥1,410,000)
Fiscal Year 2007: ¥6,110,000 (Direct Cost: ¥4,700,000、Indirect Cost: ¥1,410,000)
Fiscal Year 2006: ¥5,800,000 (Direct Cost: ¥5,800,000)
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Keywords | 胸膜疾患学 / 中皮腫 / ゲノム / がん遺伝子 / 腫瘍抑制遺伝子 / 染色体異常 / 染色体 |
Research Abstract |
悪性中皮腫の特徴的な遺伝子異常を同定するために網羅的なゲノム解析を行った。従来報告されている異常に加え、複数の新規の染色体・遺伝子異常を明らかにした。JUNやYAP遺伝子は中皮腫における重要ながん遺伝子であること、また染色体16番に新たながん抑制遺伝子が存在する可能性が示唆された。PTEN遺伝子は一部の中皮腫で不活化しており、細胞レベルにおいてがん抑制効果を確認した。本研究成果は悪性中皮腫の新規治療法や診断マーカーの開発への大きな基盤になるものと考えられた。
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Report
(4 results)
Research Products
(42 results)
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[Journal Article] Activation of the PI3K-AKT pathway in human malignant mesothelioma cells2009
Author(s)
Suzuki Y, Murakami H, Kawaguchi K, Taniguchi T, Fujii M, Shinjo K, Kondo Y, Osada H, Shimokata K, Horio Y, Hasegawa Y, Hida T, Sekido Y
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Journal Title
. Mol. Med. Rep. 2
Pages: 181-188
Related Report
Peer Reviewed
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[Journal Article] YAP1 is involved in mesothelioma development and negatively regulated by Merlin through phosphorylation2008
Author(s)
Yokoyama T, Osada H, Murakami H, Tatematsu Y, Taniguchi T, Kondo Y, Yatabe Y, Hasegawa Y, Shimokata K, Horio Y, Hida T, Sekido Y
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Journal Title
Carcinogenesis 29
Pages: 2139-2146
Related Report
Peer Reviewed
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[Journal Article] Lysophosphatidic acid stimulates the proliferation and motility of malignant pleural mesothelioma cells through lysophosphatidic acid receptors, LPA1 and LPA22008
Author(s)
Yamada T, Yano S, Ogino H, Ikuta K, Kakiuchi S, Hanibuchi M, Kanematsu T, Taniguchi T, Sekido Y, Sone S
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Journal Title
Cancer Sci. 99
Pages: 1603-1610
NAID
Related Report
Peer Reviewed
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[Journal Article] Genomic pro filing of malignant pleural mesothelioma with array-based comparative genomic hybridization shows frequent non-random chromosomal alteration regions including JUN amplification on 1p322007
Author(s)
Taniguchi T, Karnan S, Fukui T, Yokoyama T, Tagawa H, Yokoi K, Ueda Y, Mitsudomi T, Horio Y, Hida T, Yatabe Y, Seto M, Sekido Y
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Journal Title
Cancer Sci. 98
Pages: 438-446
Related Report
Peer Reviewed
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[Journal Article] Combined inhibition of MET and EGFR suppresses proliferation of malignant mesothelioma cells
Author(s)
Kawaguchi K, Murakami H, Taniguchi T, Fujii M, Kawata S, Fukui T, Kondo Y, Osada H, Usami N, Yokoi K, Ueda Y, Yatabe Y, Ito M, Horio Y, Hida T, Sekido Y
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Journal Title
Carcinogenesis (in press)
Related Report
Peer Reviewed
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[Presentation] Genomic pro filing of malignant pleural mesothelioma with array-based comparat ive genomic hybridization2007
Author(s)
Taniguchi T, Karnan S, Fukui T, Yokoyama T, Tagawa H, Yokoi K, Ueda Y, Mitsudomi T, Horio Y, Hida T, Yatabe Y, Seto M, Sekido Y
Organizer
12^<th> World Conference on Lung Cancer
Place of Presentation
Seoul, Korea
Year and Date
2007-09-05
Related Report
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[Presentation] Genomic pro filing of malignant pleural mesothelioma with array-based comparat ive genomic hybridization shows frequent nonrandom chromosomal alteration regions including JUN amplification on 1p322007
Author(s)
Taniguchi T, Karnan S, Fukui T, Yokoyama T, Tagawa H, Yokoi K, Ueda Y, Mitsudomi T, Horio Y, Hida T, Yatabe Y, Seto M, Sekido Y
Organizer
AACR
Place of Presentation
Los Angels, USA
Year and Date
2007-04-17
Related Report
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[Presentation] Genome wide analyses for aberrant DNA methylation observed in malignant pleural mesothelioma2007
Author(s)
Goto Y, Kondo Y, Gao D, Toyota M, Suzuki H, Ito M, Yokoyama T, Taniguchi T, Osada H, Murakami H, Tokino T, Imai K, Hasegawa Y, Shimokata K, Sekido Y
Organizer
AACR
Place of Presentation
Los Angels, USA
Year and Date
2007-04-16
Related Report
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[Presentation] Genetic and epigenetic alterations in newly established malignant pleuralmesothelioma cell lines2007
Author(s)
Sekido Y, Murakami H, Kondo Y, Taniguchi T, Yokoyama T, Goto Y, Fukui T, Seto M, Osada H, Hida T
Organizer
7^<th> Joint Conference of the American Association for Cancer Research and the Japanese Cancer Association
Place of Presentation
Waikoloa, USA
Year and Date
2007-01-22
Related Report
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[Presentation] Array CGH法を用いた悪性胸膜中皮腫の網羅的ゲノム解析2006
Author(s)
谷口哲朗, シバスンダラム カルナン, 福井高幸, 横山俊彦, 田川博之, 光冨徹哉, 堀尾芳嗣, 樋田豊明, 谷田部恭, 瀬戸加大, 関戸好孝
Organizer
第65回日本癌学会学術総会
Place of Presentation
横浜
Year and Date
2006-09-29
Related Report
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