Role of IL-17 producing T cells in opticospinal multiple sclerosis

• Project/Area Number: 18390261
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Neurology
• Research Institution: Kyushu University
• Principal Investigator: KIRA Jun-ichi Kyushu University, 大学院・医学研究院, 教授 (40183305)
• Co-Investigator(Kenkyū-buntansha): MINOHARA Motozumi 九州大学, 大学病院, 講師 (70398113) ; KAWAMURA Nobutoshi 九州大学, 医学研究院, 学術研究員 (00432930) ; 河野 祐治 九州大学, 大学病院, 講師 (20333479) ; 菊池 仁志 九州大学, 大学病院, 助手 (60322765)
• Project Period (FY): 2006 – 2008
• Project Status: Completed (Fiscal Year 2008)
• Budget Amount: ¥17,880,000 (Direct Cost: ¥15,600,000、Indirect Cost: ¥2,280,000); Fiscal Year 2008: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000); Fiscal Year 2007: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000); Fiscal Year 2006: ¥8,000,000 (Direct Cost: ¥8,000,000)
• Keywords: 多発性硬化症 / 視神経脊髄型 / IL-17 / 自己反応性T細胞 / 抗AQP4抗体 / ELISPOT

Research Abstract

日本人の視神経脊髄型多発性硬化症(OSMS)と再発寛解型neuromyelitis optica(NMO)はその病像が類似点が多い。抗aquaporin-4(AQP4)抗体の有無により日本人MS患者を再分類し、細胞内サイトカイン、並びに髄液中のサイトカイン・ケモカインを測定した結果、抗AQP4抗体陽性患者では脳脊髄液中のCD4陽性T細胞内サイトカインではIL-4産生細胞が上昇し、一方で末梢血では抗体陰性OSMSにおいてIFN-γ^+IL-4^-細胞の比率が高くTh1シフトの傾向を認め、脳脊髄液中では、OSMSではIL-17、IL-8、G-CSFの濃度が上昇している点など、抗AQP4抗体陽性例と、陰性群の中でもOSMSとCMSではそれぞれ異なる炎症性機序が働いていることが示唆された。今後さらに責任自己抗原の違いや拘束分子の相違など検討を進めることで病態を把握し、各病型に特異的な治療法の確立に努めたい。

Research Products

• [Journal Article] Association of the HLA-DRB1 alleles with characteristic MRI features of Asian multiple sclerosis (2009)
  • Author(s): Matsuoka T, Matsushita T, Osoegawa M, Kawano Y, Minohara M, Mihara F, Nishimura Y, Ohyagi Y, Kira J
  • Journal Title: Multiple Sclerosis 14 Pages: 1181-1190
  • Peer Reviewed
• [Journal Article] Increase of CD4^+ TNFα^+ IL-2^-T cells in cerebrospinal fluid of multiple sclerosis patients (2009)
  • Author(s): Shi N, Kawano Y, Matsuoka T, Mei F-J, Ishizu T, Ohyagi Y, Kira J
  • Journal Title: Multiple Sclerosis 15 Pages: 120-123
  • Peer Reviewed
• [Journal Article] Angiotensin-converting anzyme(ACE)and ACE2 levels in the cerebrospinal fluid of patients with multiple sclerosis (2009)
  • Author(s): Kawajiri M, Mogi M, Higaki N, Matsuoka T, Ohyagi Y, Tsukada K, Kahara K, Horiuchi M, Miki T, Kira J
  • Journal Title: Multiple Sclerosis 15 Pages: 262-265
  • Peer Reviewed
• [Journal Article] Temporal changes and geographical differences in multiple sclerosis phenotypes in Japanese : nationwide survey results over 30 years (2009)
  • Author(s): Osoegawa M, Kira J, Fukazawa K, Kikuchi S, Kohriyama T, Sobue G, Yamamura T, Itoyama Y, Saida T, Sakata K, Ochi H, Matsuoka T
  • Journal Title: Multiple Sclerosis(Equal contribution) 15 Pages: 159-173
  • Peer Reviewed
• [Journal Article] Hypercomplementemia at relapse in patients with anti-aquaporin-4 antibody (2009)
  • Author(s): Doi H, Matsushita T, Isobe N, Matsuoka T, Minohara M, Ochi H, Kira J
  • Journal Title: Multiple Sclerosis 15 Pages: 304-310
  • Peer Reviewed
• [Journal Article] Association of the HLADPB1*0501 allele with anti-aquaporin-4 antibody positivity in Japanese patients with idiopathic central nervous system demyelinating disorders (2009)
  • Author(s): Matsushita T, Matsuoka T, Isobe N, Kawamura Y, Minohara M, Shi N, Nishimura Y, Ochi H, Kira J
  • Journal Title: Tissue Antigens 72 Pages: 171-176
  • Peer Reviewed
• [Journal Article] Heterogeneity and continuum of multiple sclerosis phenotypes in Japanese according to the results of the fourth nationwide survey(Equal contribution) (2009)
  • Author(s): Ishizu T, Kira J, Osoegawa M, Fukazawa T, Kikuchi S, Fujihara K, Matsui M, Kohriyama T, Sobue G, Yamamura T, Itoyama Y, Saida T, Sakata K
  • Journal Title: J Neurol Sci 280 Pages: 22-28
  • Peer Reviewed
• [Journal Article] Increase of CD4+ TNFα+ IL-2- T cells in cerebrospinal fluid of multiple sclerosis patients. (2009)
  • Author(s): Shi N, et al
  • Journal Title: Mult Scle 15 Pages: 120-123
  • Peer Reviewed
• [Journal Article] Heterogeneity and continuum of multiple sclerosis phenotypes in Japanese according to the results of the fourth nationwide survey. (2009)
  • Author(s): Ishizu T, et al
  • Journal Title: J Neurol Sci (in press)
  • Peer Reviewed
• [Journal Article] Association of the HLA-DPB1^*0501 allele with anti-aquaporin-4 antibody in Japanese patients with idiopathic central nervous system demyelinating disorders. (2009)
  • Author(s): Matsushita T, et al
  • Journal Title: Tissue Antigens 73 Pages: 171-176
  • Peer Reviewed
• [Journal Article] Angiotensin-converting enxyme (ACE) and ACE2 levels in the cerebrospinal fluid of patients with multiple sclerosis. (2009)
  • Author(s): Kawajiri M, et al
  • Journal Title: Mult Scler 15 Pages: 262-265
  • Peer Reviewed
• [Journal Article] Hyrpercomplementemia at relapse in patients with anti-aquaporin-4 antibody. (2009)
  • Author(s): Doi H, et al
  • Journal Title: Mult Scler 15 Pages: 304-310
  • Peer Reviewed
• [Journal Article] Temporal changes and geographical differences in multiple sclerosis phenotypes in Japanese : nationwide survey results over 30 years. (2009)
  • Author(s): Osoegawa M, et al
  • Journal Title: Mult Scler 15 Pages: 157-173
  • Peer Reviewed
• [Journal Article] Neuromyelitis optica and asian phenotype of multiple sclerosis. (2009)
  • Author(s): Kira J
  • Journal Title: Ann N Y Acad Sci 1142 Pages: 58-71
  • Peer Reviewed
• [Journal Article] Frequency of chronic headaches in Japanese patients with multiple sclerosis with special referency to opticospinal and common forms of multiple sclerosis. (2009)
  • Author(s): Doi H, et al
  • Journal Title: Headaache (In press)
  • Peer Reviewed
• [Journal Article] Aquaporin-4 autoimmune syndrome and auti-aquaporin-4 antibody-negative optico spinal multiple sclerosis in Japanese. (2009)
  • Author(s): Matsushita T, et al
  • Journal Title: Mult Scler (In press)
  • Peer Reviewed
• [Journal Article] Multimodality evoked potential study of anti-aquaporin-4 antibody-positive and -negative multiple sclerosis patients. (2009)
  • Author(s): Watanabe, A, et al
  • Journal Title: J Neurol Sci (In press)
  • Peer Reviewed
• [Journal Article] Anterior periventricular linear lesions in optic-spinal multiple sclerosis : a combined neuroimaging and neuropathological study (2008)
  • Author(s): Matsushita T, Matsuoka T, Ishizu T, Kikuchi H, Osoegawa M, Kawano Y, Mihara F, Ohyagi Y, Kira J
  • Journal Title: Multiple Sclerosis 14 Pages: 343-53
  • Peer Reviewed
• [Journal Article] Heterogeneity and continuum of multiple sclerosis in Japanese according to magnetic resonance imaging findings (2008)
  • Author(s): Matsuoka T, Matsushita T, Osoegawa M, Ochi H, Kawano Y, Mihara F, Ohyagi Y, Kira J
  • Journal Title: J Neurol Sci 266 Pages: 115-25
  • Peer Reviewed
• [Journal Article] Distinct CSF cytokine/chemokine profiles in atopic myelitis and other causes of myelitis (2008)
  • Author(s): Tanaka M, Matsushita T, Tateishi T, Ochi H, Kawano Y, Mei F-J, Minohara M, Murai H, Kira J
  • Journal Title: Neurology 71 Pages: 974-981
  • Peer Reviewed
• [Journal Article] Heterogeneity and continuum of multiple sclerosis in Japanese according to magnetic resonance imaging findings. (2008)
  • Author(s): Matsuoka T, et al
  • Journal Title: J Neurol Sci 266 Pages: 115-125
  • Peer Reviewed
• [Journal Article] Anterior periventricular linear lesions in optic-spinal multiple sclerosis : a combined neuroimaging and neuropathological study. (2008)
  • Author(s): Matsushita T, et al
  • Journal Title: Mult Scler 21 Pages: 343-353
  • Peer Reviewed
• [Journal Article] Reduction of angiotensin II in the cerebrospinal fluid of patients with multiple sclerosis. (2008)
  • Author(s): Kawajiri M, et al
  • Journal Title: Mult Scler 14 Pages: 557-560
  • Peer Reviewed
• [Journal Article] Atopic myelitis with focal amyotrophy ; a possible link to Hopkins syndrome. (2008)
  • Author(s): Kira J, et al
  • Journal Title: J Neurol Sci 269 Pages: 143-151
  • Peer Reviewed
• [Journal Article] Association of the HLA-DRB1 alleles with characteristic MRI features of Asian multiple sclerosis. (2008)
  • Author(s): Matsuoka T, et al
  • Journal Title: Mult Scler 14 Pages: 1181-1190
  • Peer Reviewed
• [Journal Article] Distinct CSF cytokine/chemokine profiles in atopic myelitis and other causes of myelitis. (2008)
  • Author(s): Tanaka M, et al
  • Journal Title: Neurology 71 Pages: 974-981
  • Peer Reviewed
• [Journal Article] Intrathecal upregulation of IFN-γ and MIP-Iβ in juvenile muscular atrophy of the distal upper axtremitiy. (2008)
  • Author(s): Tanaka M, et al
  • Journal Title: J Neurol Sci 275 Pages: 74-77
  • Peer Reviewed
• [Journal Article] Anterior periventricular linear lesions in optic-spinal multiple sclerosis: a combined neuroimaging and neuropathological study. (2008)
  • Author(s): Matsushita T, et. al.
  • Journal Title: Mult Scler 21
  • Peer Reviewed
• [Journal Article] Heterogeneity and continuum of multiple sclerosis in Japanese according to magnetic resonance imaging findings. (2008)
  • Author(s): Matsuoka T, et. al.
  • Journal Title: J Neurol Sci 266 Pages: 115-125
  • Peer Reviewed
• [Journal Article] Reduction of angiotensin II in the cerebrospinal fluid of patients with multiple sclerosis. (2008)
  • Author(s): Kawajiri M, et. al.
  • Journal Title: Mult Scler (in press)
  • Peer Reviewed
• [Journal Article] Association of the HLA-DRB1 alleles with characteristic MRI features of Asian multiple sclerosis. (2008)
  • Author(s): Matsuoka T, et. al.
  • Journal Title: Mult Scler (in press)
  • Peer Reviewed
• [Journal Article] Atopic myelitis with focal amyotrophy; a possible link to Hopkins syndrome. (2008)
  • Author(s): Kira J, et. al.
  • Journal Title: J Neurol Sci (in press)
  • Peer Reviewed
• [Journal Article] Helicobacter pylori is a potential protective factor against conventional type multiple sclerosis in the Japanese population (2007)
  • Author(s): Li W, Minohara M, Su JJ, Matsuoka T, Osoegawa M, Ishizu T, Kira J
  • Journal Title: J Neuroimmunol 184 Pages: 227-231
  • Peer Reviewed
• [Journal Article] Heterogeneity of aquaporin-4 autoimmunity and spinal cord lesions in multiple sclerosis in Japanese (2007)
  • Author(s): Matsuoka T, Matsushita T, Kawano Y, Osoegawa M, Ochi H, Ishizu T, Minohara M, Kikuchi H, Mihara F, Ohyagi Y, Kira J
  • Journal Title: Brain 130 Pages: 1206-1223
  • Peer Reviewed
• [Journal Article] A distinct subgroup of chronic inflaroroatory demyelinating disease with CNS demyelination and a favorable response to immunotherapy. (2007)
  • Author(s): Pineda AA, et. al.
  • Journal Title: J Neurol Sci 255 Pages: 1-6
  • Peer Reviewed
• [Journal Article] Helicobacter pyoli infection is a potential protective factor against conventional multiple sclerosis in the Japanese population. (2007)
  • Author(s): Li W, et. al.
  • Journal Title: J Neuroimmunol 184 Pages: 277-231
  • Peer Reviewed
• [Journal Article] Heterogeneity of aquaporin-4 autoimmunity and spinal cord lesions in Japanese. (2007)
  • Author(s): Matsuoka T, et. al.
  • Journal Title: Brain 130 Pages: 1206-1223
  • Peer Reviewed
• [Journal Article] Increased IL-13-pxoducing T cells in ALS; positive correlations with disease severity and progression rate. (2007)
  • Author(s): Shi N, et. al.,
  • Journal Title: J Neuroimmunol 182 Pages: 232-235
  • Peer Reviewed
• [Journal Article] A distinct subgroup of chronic inflammatory demyelination disease with CNS demyelination and a favorable response to immunotherapy. (2007)
  • Author(s): Pineda AA et al.
  • Journal Title: J Neurol Sci 255 Pages: 1-6
• [Journal Article] Helicobacter pyoli infection is a potential protective factor aganist conventional multiple sclerosis in the Japanese population. (2007)
  • Author(s): Li W et al.
  • Journal Title: J Neuroimmunol 184 Pages: 277-231
• [Journal Article] Heterogeneity of aquaporin-4 autoimmunity and spinal cord lesions in Japanese. (2007)
  • Author(s): Matsuoka T et al.
  • Journal Title: Brain (In press)
• [Journal Article] Upregulation of vascular growth factors in multiple sclerosis : correlation with MRI findings (2006)
  • Author(s): Su J-J, Osoegawa M, Minohara M, Tanaka M, Ishizu T, Mihara F, Taniwaki T, Kira J
  • Journal Title: J Neurol Sci 243 Pages: 21-30
  • Peer Reviewed
• [Journal Article] Long-term favorable response to interferon beta-1b is linked to cytokine deviation toward the Th2 and Tc2 sides in Japanese patients with multiple sclerosis (2006)
  • Author(s): Mei F-J, Osoegawa M, Ochi H, Minohara M, Shi N, Murai H, Ishizu T, Taniwaki T, Kira J
  • Journal Title: J Neurol Sci 246 Pages: 71-77
  • Peer Reviewed
• [Journal Article] Upregulation of myeloperoxidase in patients with opticospinal multiple sclerosis : positive correlation with disease severity (2006)
  • Author(s): Minohara M, Matsuoka T, Li W, Osoegawa M, Ishizu T, Ohyagi Y, Kira J
  • Journal Title: J Neuroimmunol 178 Pages: 156-160
  • Peer Reviewed
• [Journal Article] The selective Rho-kinase inhibitor Fasudil is protective and therapeutic in experimental allergic encephalomyelitis (2006)
  • Author(s): Sun X, Minohara M, Kikuchi S, Ishizu T, Tanaka M, Piao H, Osoegawa M, Ohyagi Y, Shimokawa H, Kira J
  • Journal Title: J Neuroimmunol 180 Pages: 126-134
  • Peer Reviewed
• [Journal Article] Upregulation of vascular grouth factors in multiple sclerosis : correlation with MRI findings. (2006)
  • Author(s): Su JJ et al.
  • Journal Title: J Neurol Sci 243 Pages: 21-30
• [Journal Article] Long-term favorable response to interferon beta-1b is linked to cytokine deviation toward the Th2 sides in Japanese patients with multiple sclerosis. (2006)
  • Author(s): Mei FJ et al.
  • Journal Title: J Neurol Sci 246 Pages: 71-77
• [Journal Article] CSF cytokine and chemokine profiles in acute disseminated encephalomyelitis. (2006)
  • Author(s): Ishizu T et al.
  • Journal Title: J Neuroimmunol 175 Pages: 52-58
• [Journal Article] Upregulation of myeloperoxidase in patients with opticospinal multiple sclerosis : positive correlation with disease severity. (2006)
  • Author(s): Minohara M et al.
  • Journal Title: J Neuroimmunol 178 Pages: 156-160
• [Journal Article] The selective Rho-kinase inhibitor Fasudil is protective and therapeutic in experimental allergic encephalomuelitis. (2006)
  • Author(s): Sun X et al.
  • Journal Title: J Neuroimmunol 180 Pages: 126-134
• [Journal Article] Aquaporin-4 autoimmune syndrome and anti-aquaporin-4 antibody-negative optico spinal multiple sclerosis in Japanese
  • Author(s): Matsushita T, Isobe N, Matsuoka T, Shi N, Kawano Y, Wu X-M, Yoshiura T, Nakao Y, Ishizu T, Kira J
  • Journal Title: Multiple Sclerosis (in press)
  • Peer Reviewed
• [Presentation] 末梢免疫担当細胞におけるbrain-derivedneurotrophic factor (BDNF)産生能と多発性硬化症(MS)病態との関連 (2009)
  • Author(s): 吉村怜, ら
  • Organizer: 第21回日本神経免疫学会学術集会
  • Place of Presentation: 大阪
  • Year and Date: 2009-03-12
• [Presentation] 多発性硬化症および抗アクアポリン4抗体陽性症例における補体系の検討 (2009)
  • Author(s): 土井光, ら
  • Organizer: 第21回日本神経免疫学会学術集会
  • Place of Presentation: 大阪
  • Year and Date: 2009-03-12
• [Presentation] 抗aquaporin-4(AQP4)抗体陽性例における細胞内・脳脊髄液中サイトカインの特徴 (2009)
  • Author(s): 松下拓也, ら
  • Organizer: 第21回日本神経免疫学会学術集会
  • Place of Presentation: 大阪
  • Year and Date: 2009-03-12
• [Presentation] Multiple Sclerosis in Asians : Temporal Changes, Geographical Differences, and Immunological Features of Japanese MS Patients (2008)
  • Author(s): Kira J
  • Organizer: 第9回中国神経免疫学会
  • Place of Presentation: 南昌、中国
  • Year and Date: 2008-10-31
• [Presentation] CSF and peripheral blood cytokine production profiles and HLA class II alleles in patients with antibody to aquaporin-4 (2008)
  • Author(s): Kira et.al.
  • Organizer: 133rd Annual Meeting of the American Neurological Association
  • Place of Presentation: Salt Lake City, USA
  • Year and Date: 2008-09-21
• [Presentation] Distinct cerebrospinal fluid cytokine/chemokine profiles in opticospinal multiple sclerosis, atopic myelitis and other causes of myelitis (2008)
  • Author(s): Kira J et.al.
  • Organizer: WORLD CONGRESS ON TREATMENT AND RESEARCH IN MULTIPLE SCLEROSIS
  • Place of Presentation: Montreal, Canada
  • Year and Date: 2008-09-17
• [Presentation] Anti-AQP4 autoimmuity and idiopathic demyelinating diseases in Asians (2008)
  • Author(s): Kira J
  • Organizer: Korean Study Group for Multiple Sclerosis and Other Demyelinating Diseases
  • Place of Presentation: Seoul, Korea
  • Year and Date: 2008-08-30
• [Presentation] Research update from Kyushu University, Japan (2008)
  • Author(s): Kira J
  • Organizer: MS Forum Consensus Group Meeting
  • Place of Presentation: Bangkok, Thailand
  • Year and Date: 2008-06-21
• [Presentation] Introduction of New Treatment Guidelines from Japan (2008)
  • Author(s): Kira J
  • Organizer: MS Forum Consensus Group Meeting
  • Place of Presentation: Bangkok, Thailand
  • Year and Date: 2008-06-21
• [Presentation] Japanese opticospinal form of MS-the real story (2008)
  • Author(s): Kira J.
  • Organizer: International Neuro-Opthalmology Society
  • Place of Presentation: California, USA
  • Year and Date: 2008-06-07
• [Presentation] Neuromyelitis optica (2008)
  • Author(s): Kira J.
  • Organizer: MULTIPLE SCLEROSIS : COMPREHENSIVE APPROACHES TO COMPLEXCHALLENGES 22ND CMSC ANNUAL MEETING
  • Place of Presentation: Denver, USA
  • Year and Date: 2008-05-28
• [Presentation] 多発性硬化症における神経系レニン・アンジオテンシン系に関する研究 (2008)
  • Author(s): 川尻真和ら
  • Organizer: 第49回日本神経学会総会
  • Place of Presentation: 横浜
  • Year and Date: 2008-05-17
• [Presentation] 日本人MS患者におけるIFNβ製剤の使用実態に関する全国調査 (2008)
  • Author(s): 越智博文ら
  • Organizer: 第49回日本神経学会総会
  • Place of Presentation: 横浜
  • Year and Date: 2008-05-17
• [Presentation] 抗CLDND1抗体陽性多発性硬化症の臨床像 (2008)
  • Author(s): 三野原元澄ら
  • Organizer: 第49回日本神経学会総会
  • Place of Presentation: 横浜
  • Year and Date: 2008-05-16
• [Presentation] 多発性硬化症におけるBrain derived neurotrophic factor(BDNF)の役割 (2008)
  • Author(s): 吉村怜ら
  • Organizer: 第49回日本神経学会総会
  • Place of Presentation: 横浜
  • Year and Date: 2008-05-16
• [Presentation] CD4+TNFα+IL-2-T細胞のMS髄液中での増加 (2008)
  • Author(s): 史楠ら
  • Organizer: 第49回日本神経学会総会
  • Place of Presentation: 横浜
  • Year and Date: 2008-05-16
• [Presentation] FACSによる抗native AQP4抗体の高感度検出法の開発 (2008)
  • Author(s): 河野祐治, ら
  • Organizer: 第49回日本神経学会総
  • Place of Presentation: 横浜
  • Year and Date: 2008-05-15
• [Presentation] 抗aquaporin-4(AQP4)抗体価とMRI所見・サイトカインバランス・HLAとの相関 (2008)
  • Author(s): 松下拓也, ら
  • Organizer: 第49回日本神経学会総会
  • Place of Presentation: 横浜
  • Year and Date: 2008-05-15
• [Presentation] CD4^+TNFα+IL2^-T細胞のMS髄液中での増加 (2008)
  • Author(s): 史楠, ら
  • Organizer: 第49回日本神経学会総会
  • Place of Presentation: 横浜
  • Year and Date: 2008-05-15
• [Presentation] 日本人多発性硬化症(MS)患者における抗AQP4抗体(AQP4)と誘発電位(EP)の関連 (2008)
  • Author(s): 渡邉暁博ら
  • Organizer: 第49回日本神経学会総会
  • Place of Presentation: 横浜
  • Year and Date: 2008-05-15
• [Presentation] FACSによる抗native AQP4抗体の高感度検出法の開発 (2008)
  • Author(s): 河野祐治ら
  • Organizer: 第49回日本神経学会総会
  • Place of Presentation: 横浜
  • Year and Date: 2008-05-15
• [Presentation] 抗体価と臨床像からみた抗aquaporin-4(AQP4)抗体の意義 (2008)
  • Author(s): 松岡健ら
  • Organizer: 第49回日本神経学会総会
  • Place of Presentation: 横浜
  • Year and Date: 2008-05-15
• [Presentation] 多発性硬化症(MS)病態へのbrain derived neurotrophic factor (BDNF)の関与 (2008)
  • Author(s): 吉村怜ら
  • Organizer: 第20回日本神経免疫学会学術集会
  • Place of Presentation: 新潟
  • Year and Date: 2008-04-18
• [Presentation] 日本人多発性硬化症患者におけるIFNβ製剤の使用実態に関する全国調査 (2008)
  • Author(s): 越智博文ら
  • Organizer: 第20回日本神経免疫学会学術集会
  • Place of Presentation: 新潟
  • Year and Date: 2008-04-18
• [Presentation] MS髄液におけるCD4+TNでFa+IL-2-T細胞サブセット異常 (2008)
  • Author(s): 史楠ら
  • Organizer: 第20回日本神経免疫学会学術集会
  • Place of Presentation: 新潟
  • Year and Date: 2008-04-18
• [Presentation] アクアポリン4と多発性硬化症 : AQP4自己免疫症候群とseronegative OSMS (2008)
  • Author(s): 吉良潤一
  • Organizer: 第20回日本神経免疫学会学術集会
  • Place of Presentation: 新潟
  • Year and Date: 2008-04-17
• [Presentation] 抗aquaporin-4(AQP4)抗体価による多発性硬化症の免疫学的・遺伝学的背景の差異 (2008)
  • Author(s): 河野祐治, ら
  • Organizer: 第20回日本神経免疫学会学術集会
  • Place of Presentation: 新潟
  • Year and Date: 2008-04-17
• [Presentation] 多発性硬化症におけるconformationalにAQP1を認識する抗体の検索 (2008)
  • Author(s): 河村信利, ら
  • Organizer: 第20回日本神経免疫学会学術集会
  • Place of Presentation: 新潟
  • Year and Date: 2008-04-17
• [Presentation] 脊髄炎症性疾患のサイトカイン・ケモカインプロフィール (2008)
  • Author(s): 田中正人, ら
  • Organizer: 第20回日本神経免疫学会学術集会
  • Place of Presentation: 新潟
  • Year and Date: 2008-04-17
• [Presentation] 抗AQP4抗体価からみた日本人多発性硬化症患者の病像・画像所見の特徴 (2008)
  • Author(s): 松岡健ら
  • Organizer: 第20回日本神経免疫学会学術集会
  • Place of Presentation: 新潟
  • Year and Date: 2008-04-17
• [Presentation] 抗aquaporin-4 (AQP4)抗体価による多発性硬化症の免疫学的・遺伝学的背景の差異 (2008)
  • Author(s): 河野祐治ら
  • Organizer: 第20回日本神経免疫学会学術集会
  • Place of Presentation: 新潟
  • Year and Date: 2008-04-17
• [Presentation] FACSを用いた高感度抗AQP4抗体検出法の開発 (2008)
  • Author(s): 河野祐治ら
  • Organizer: 第20回日本神経免疫学会学術集会
  • Place of Presentation: 新潟
  • Year and Date: 2008-04-17
• [Presentation] 抗CLDND1抗体陽性多発性硬化症を抗AQP4抗体との関連 (2008)
  • Author(s): 三野原元澄ら
  • Organizer: 第20回日本神経免疫学会学術集会
  • Place of Presentation: 新潟
  • Year and Date: 2008-04-17
• [Presentation] 抗AQP4抗体からみた日本人MS患者における誘発電位異常の特徴 (2008)
  • Author(s): 渡邉暁博ら
  • Organizer: 第20回日本神経免疫学会学術集会
  • Place of Presentation: 新潟
  • Year and Date: 2008-04-17
• [Presentation] 多発性硬化症におけるヘリコバクターピロリ感染の影響 (2008)
  • Author(s): 三野原元澄ら
  • Organizer: 第21回日本神経免疫学会学術集会
  • Place of Presentation: 大阪
  • Year and Date: 2008-03-13
• [Presentation] 末梢免疫担当細胞におけるbrain-derived neurotrophic factor(BDNF)産生能と多発性硬化症(MS)病態との関連 (2008)
  • Author(s): 吉村怜ら
  • Organizer: 第21回日本神経免疫学会学術集会
  • Place of Presentation: 大阪
  • Year and Date: 2008-03-12
• [Presentation] 多発性硬化症および抗アクアポリン4抗体陽性症例における補体系の検討 (2008)
  • Author(s): 土井光ら
  • Organizer: 第21回日本神経免疫学会学術集会
  • Place of Presentation: 大阪
  • Year and Date: 2008-03-12
• [Presentation] 抗aquaporin-4(AQP4)抗体陽性例における細胞内・脳脊髄液中サイトカインの特徴 (2008)
  • Author(s): 松下拓也ら
  • Organizer: 第21回日本神経免疫学会学術集会
  • Place of Presentation: 大阪
  • Year and Date: 2008-03-12
• [Presentation] 日本人多発性硬化症剖検症例の特徴 : アストロサイトにおけるAQP4発現に注目して (2008)
  • Author(s): 松岡健ら
  • Organizer: 第21回日本神経免疫学会学術集会
  • Place of Presentation: 大阪
  • Year and Date: 2008-03-12
• [Presentation] FACSを用いた高感度抗AQP4抗体の検出 : サブクラス解析を含めて (2008)
  • Author(s): 磯部紀子ら
  • Organizer: 第21回日本神経免疫学会学術集会
  • Place of Presentation: 大阪
  • Year and Date: 2008-03-12
• [Presentation] Neuromyelitis Optica (2008)
  • Author(s): Kira J
  • Organizer: MULTIPLE SCLEROSIS : COMPREHENSIVE APPROACHES TO COMPLEXCHALLENGES 22ND CMSC ANNUAL MEETING
  • Place of Presentation: Denver, USA
• [Presentation] CSF and Peripheral Blood Cytokine Production Profiles and HLA Class II Alleles in Patients with Antibody to Aquaporin-4 (2008)
  • Author(s): Kira J, et al
  • Organizer: 133rd Annual Meeting of the American Neurological Association
  • Place of Presentation: Salt Lake City, USA
• [Presentation] Distinct cerebrospinal fluid cytokine/chemokine profiles in opticospinal multiple sclerosis, atopicmyelitis and other causes of myelitis (2008)
  • Author(s): Kira J, et al
  • Organizer: WORLD CONGRESS ON TREATMENT AND RESEARCH IN MULTIPLE SCLEROSIS
  • Place of Presentation: Montreal, Canada
• [Presentation] Multiple Sclerosis in Japan : Nationwide Surveys Over 30 yuars (2008)
  • Author(s): Kira J
  • Organizer: PACTRIMS for Treatment and Research in Multiple Sclerosis
  • Place of Presentation: Kuala Lumpur, Malaysia
• [Presentation] Opticospinal Multiple Sclerosis in Japanese (2008)
  • Author(s): Kira J
  • Organizer: PACTRIMS for Treatment and Research in Multiple Sclerosis
  • Place of Presentation: Kuala Lumpur, Malaysia
• [Presentation] Hypercomplementemia at Relapse in Patients with Anti-Aquaporin-4 Antibody (2008)
  • Author(s): Doi H, et al
  • Organizer: PACTRIMS for Treatment and Research in Multiple Sclerosis
  • Place of Presentation: Kuala Lumpur, Malaysia
• [Presentation] CSF and peripheral blood cytokine production profiles and HLA class II alleles in patients with antibody to aquaporin-4 (2008)
  • Author(s): Kira J, et al
  • Organizer: PACTRIMS for Treatment and Research in Multiple Sclerosis
  • Place of Presentation: Kuala Lumpur, Malaysia
• [Presentation] アトピー性脊髄炎の髄液サイトカインプロフィールからみた免疫機構 (2007)
  • Author(s): 吉良 潤一, 他
  • Organizer: 日本神経学会
  • Place of Presentation: 名古屋
  • Year and Date: 2007-05-18
• [Presentation] 日本人多発性硬化症におけるMRI所見とHLAクラスII遺伝子多型との相関 (2007)
  • Author(s): 三野原 元澄, 他
  • Organizer: 日本神経学会
  • Place of Presentation: 名古屋
  • Year and Date: 2007-05-18
• [Presentation] 2004年MS全国調査結果報告代3報-MS病像の緯度と出生年代による違いについての検討- (2007)
  • Author(s): 小副 川学, 他
  • Organizer: 日本神経学会
  • Place of Presentation: 名古屋
  • Year and Date: 2007-05-18
• [Presentation] 日本人多発性硬化症における抗aquaporin-4 抗体陽生率と陽性例と陰性例との臨床像の比較 (2007)
  • Author(s): 松下 拓也, 他
  • Organizer: 日本神経学会
  • Place of Presentation: 名古屋
  • Year and Date: 2007-05-17
• [Presentation] 臨床型と抗aquaporin-4 (AQP4)抗体からみた日本人多発性硬化症の長大な脊椎病巣の解析 (2007)
  • Author(s): 松岡 健, 他
  • Organizer: 日本神経学会
  • Place of Presentation: 名古屋
  • Year and Date: 2007-05-17
• [Presentation] 日本人多発性硬化症におけるMRI所見とHLAクラスII遺伝子多型との相関 (2007)
  • Author(s): 三野原元澄, ら
  • Organizer: 第48回日本神経学会総会
  • Place of Presentation: 名古屋
  • Year and Date: 2007-05-16
• [Presentation] 自験多発性硬化症患者連続113例における抗AQP4抗体陽性群と陰性群との差異 (2007)
  • Author(s): 松岡 健, 他
  • Organizer: 日本神経免疫学会
  • Place of Presentation: 金沢
  • Year and Date: 2007-04-12
• [Presentation] 日本人多発性硬化症における抗CLDND1抗体の意義 (2007)
  • Author(s): 三野原 元澄, 他
  • Organizer: 日本神経免疫学会
  • Place of Presentation: 金沢
  • Year and Date: 2007-04-12
• [Presentation] 日本人多発性興亜証(MS)臨床像・MRI所見の出生年代と緯度による変化:全国疫学調査結果から (2007)
  • Author(s): 小副 川学, 他
  • Organizer: 日本神経免疫学会
  • Place of Presentation: 金沢
  • Year and Date: 2007-04-12
• [Presentation] 自験多発性硬化症患者の画像所見とHLAとの関連:連続121例の解析結果 (2007)
  • Author(s): 松岡 健, 他
  • Organizer: 日本神経免疫学会
  • Place of Presentation: 金沢
  • Year and Date: 2007-04-12
• [Presentation] Heterogeneity and HLA-association of aquaporin-4 autoinlmunity in optic-spinal multiple sclerosis in Japanese. (2007)
  • Author(s): Matsuoka T, et. al.
  • Organizer: ECTRIMS
  • Place of Presentation: Prague, Czech Republic
• [Presentation] Serum autoantibodies to claudin domain containing 1 protein in Japanese patients with multiple sclerosis. (2007)
  • Author(s): Minohara M, et. al.
  • Organizer: ECTRIMS
  • Place of Presentation: Prague, Czech Republic
• [Presentation] Temporal and geographical changes of multiple sclerosis phenotype in Japanese: nationwide survey results over 30 years. (2007)
  • Author(s): Osoegawa M, et. al.
  • Organizer: ECTRIMS
  • Place of Presentation: Prague, Czech Republic
• [Presentation] 日本人多発性硬化症の疫学と動向-視神経脊髄型多発性硬化症を中心として- (2006)
  • Author(s): 吉良潤一
  • Organizer: 第47回日本神経学会総会
  • Place of Presentation: 東京
  • Year and Date: 2006-05-11
• [Presentation] 神経免疫疾患のエフェクターアーム (2006)
  • Author(s): 吉良潤一
  • Organizer: 第18回日本神経免疫学会学術集会
  • Place of Presentation: 名古屋
  • Year and Date: 2006-03-02
• [Presentation] 日本人多発性硬化症の自験130例脳・脊髄MRIの特徴と欧米例との差異 (2006)
  • Author(s): 松岡健, ら
  • Organizer: 第18回日本神経免疫学会学術集会
  • Place of Presentation: 名古屋
  • Year and Date: 2006-03-02
• [Presentation] 日本人多発性硬化症における血清myeloperoxidase値の上昇 (2006)
  • Author(s): 三野原元澄, ら
  • Organizer: 第18回日本神経免疫学会学術集会
  • Place of Presentation: 名古屋
  • Year and Date: 2006-03-02
• [Book] 脱髄性疾患.最新神経内科学(荒木淑朗(編)) (2008)
  • Author(s): 吉良潤一
  • Publisher: 金芳堂
• [Book] わが国における多発性硬化症の臨床像・診断・治療の変遷.多発性硬化症の診断と治療(吉良潤一(編)) (2008)
  • Author(s): 吉良潤一
  • Publisher: 新興医学出版
• [Book] 多発性硬化症の治療の進め方.急性憎悪期の治療の進め方.副腎皮質ステロイド薬.多発性硬化症の診断と治療(吉良潤一(編)) (2008)
  • Author(s): 吉良潤一
  • Publisher: 新興医学出版
• [Book] New専門医を目指すCASE METHOD APPROACH (2008)
  • Author(s): 松岡健, 吉良潤一
  • Publisher: 日本医事新報社
• [Book] 最新神経内科学 (2008)
  • Author(s): 吉良潤一
  • Publisher: 金芳堂
• [Book] 多発性硬化症の診断と治療 (2008)
  • Author(s): 吉良潤一
  • Publisher: 新興医学出版
• [Book] 多発性硬化症の診断と治療 (2008)
  • Author(s): 松岡健, 吉良潤一
  • Publisher: 新興医学出版
• [Book] 神経難病のすべて 多発性硬化症 (2008)
  • Author(s): 越智 博文, 他
  • Publisher: 新興医学出版
• [Book] 多発性硬化症よくわかる病態生理.第8巻「神経疾患」(松尾理(編)) (2007)
  • Author(s): 吉良潤一
  • Publisher: 日本医事新報社
• [Book] 今日の診断基準 多発性硬化症 (2007)
  • Author(s): 吉良 潤一
  • Publisher: 南江堂
• [Book] 最新自律神経学 多発性硬化症 (2007)
  • Author(s): 吉良 潤一
  • Publisher: 新興医学出版
• [Book] EBM 神経疾患の治療 2007-2008 多発性硬化症の最新治療法は (2007)
  • Author(s): 松下 拓也, 他
  • Publisher: 中外医学
• [Book] よくわかる病態生理 第8巻 「神経疾患」 多発性硬化症 (2007)
  • Author(s): 吉良 潤一
  • Publisher: 日本医事新報社
• [Book] Etiology of multiple sclerosis. WFN Seminars in Clinical Neurology. Edited by Oger J (2006)
  • Author(s): Kira J
  • Publisher: Al-Aragi A. Demos Medical Pub. Inc. (New York)
• [Book] 多発性硬化症神経疾患最新の治療2006-2008(小林祥泰、水澤英洋(編)) (2006)
  • Author(s): 三野原元澄、吉良潤一
  • Publisher: 南江堂
• [Book] Aquaporin 4 autoimmunity in multiple sclerosis in Japanese. Ed. by Tabira T, Yamamura T, Kira J. Current Topics in Neuroimmunology (2006)
  • Author(s): Kira J, Matsushita T, Matsuoka T
  • Publisher: Medimond
• [Book] WFN Seminars in Clinical Neurology. Etiology of multiple sclerosis. (2006)
  • Author(s): Kira J
  • Publisher: Demos Medical Pub. Inc. (New York)
• [Book] 神経疾患最新の治療2006-2008、多発性硬化症 (2006)
  • Author(s): 三野原元澄 他
  • Publisher: 南江堂
• [Book] EBMに基づく脳神経疾患の基本治療、多発性硬化症 (2006)
  • Author(s): 村井弘之 他
  • Publisher: メジカルビュー
• [Book] EBM 神経疾患の治療 2007-2008、多発性硬化症の最新治療法は (2006)
  • Author(s): 松下拓也 他
  • Publisher: 中外医学
• [Book] International Neurology. A clinical approach.
  • Author(s): Kira J, et. al.
  • Publisher: Blackwell
• [Book] 多発性硬化症の診断と治療 我が国における多発性硬化症の臨床像・診断・治療の変遷
  • Author(s): 吉良 潤一
  • Publisher: 新興医学出版社
• [Book] 多発性硬化症の診断と治療 多発性硬化症の病型診断
  • Author(s): 松岡 健, 他
  • Publisher: 新興医学出版
• [Remarks]
  • URL: http://www.med.kyushu-u.ac.jp/neuro/
• [Remarks]
  • URL: http://www.med.kyushu-u.ac.jp/neuro/
• [Remarks]
  • URL: http://www.med.kyushu-u.ac.jp/neuro/