Unraveling liver-derived signals against obesity and diabetes

• Project/Area Number: 18390267
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Metabolomics
• Research Institution: Tohoku University
• Principal Investigator: KATAGIRI Hideki Tohoku University, Tohoku University, School of Medicine, Professor (00344664)
• Co-Investigator(Kenkyū-buntansha): OGIHARA Takehide Tohoku University, School of Medicine, Associate Professor (40361068) ; ISHIGAKI Yasushi Tohoku University, Hosipital, Assistant Professor (50375002) ; YAMADA Tetsuya Tohoku University, Hosipital, Assistant Professor (90400374)
• Project Period (FY): 2006 – 2007
• Project Status: Completed (Fiscal Year 2007)
• Budget Amount: ¥17,390,000 (Direct Cost: ¥15,500,000、Indirect Cost: ¥1,890,000); Fiscal Year 2007: ¥8,190,000 (Direct Cost: ¥6,300,000、Indirect Cost: ¥1,890,000); Fiscal Year 2006: ¥9,200,000 (Direct Cost: ¥9,200,000)
• Keywords: diabetes / metabolic syndrome / obesity

Research Abstract

Metabolism is coordinated and regulated among different organs/tissues throughout the body. This coordinated metabolic regulation is apparently essential for maintaining systemic homeostasis, particularly glucose and energy metabolism. Therefore, communication among organs/tissues is extremely important and perturbation of this control system may lead to the development of metabolic disorders. During this decade, the versatility of adipose tissue as an endocrine organ and as a contributor to disease development has been established. However, a number of recent studies have shown that tissue-specific knockout mice exhibit unexpected phenotypes, suggesting the presence of many as yet unknown forms of cross-talk among organs/tissues.
We have identified several systems consisting of autonomic nerve circuits, i.e. metabolic information highways, which play important roles in conveying inter-organ communication regarding metabolism. This is exemplified by the discovery of involvement of the afferent hepatic vagus in energy expenditure and fat accumulation. We expressed PPAR_γ in the liver, resulting in enhanced lipolysis in fat tissue and increased systemic energy expenditure. Thus, in response to lipid accumulation in the liver, hepatic vagal afferents transmit information regarding excess energy accumulation to the brain, thereby increasing sympathetic outflow to enhance energy expenditure.
Our findings indicate that the brain obtains a variety of metabolic information from peripheral organs/tissues, resulting in cooperative metabolic regulation among tissues/organs throughout the body. Furthermore, these systems appear to contribute to pathological features of the metabolic syndrome under the condition of long-term excess calorie intake. Thus, elucidation of these regulatory systems may facilitate unraveling the mechanisms underlying metabolic homeostasis and those underlying development of the metabolic syndrome.

Research Products

• [Journal Article] Inter-organ metabolic communication involved in energy homeostasis: Potential therapeutic targets for obesity and metabolic syndrome. (2008)
  • Author(s): Yamada T, Oka Y, Katagiri H.
  • Journal Title: Pharmacol Ther 117 Pages: 188-198
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] A novel method for evaluating human carotid artery elasticity: possible detection of early stage atherosclerosis in subjects with type 2 diabetes. (2008)
  • Author(s): Okimoto H, Ishigaki Y, Koiwa Y, Hinikio Y, Ogihara T, Suzuki S, Katagiri H., Ohkubo T, Hasegawa H, Kanai H, Oka Y.
  • Journal Title: Atherosclerosis 196 Pages: 391-397
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] ATF4-Mediated Induction of 4E-BP1 Contributes to Pancreatic β Cell Survival under Endoplasmic Reticulum Stress. (2008)
  • Author(s): Yamaguchi S, Ishihara H, Yamada T, Tamura A, Usui M, Tominaga R, Munakata Y, Satake C, Katagiri H, Tashiro F, Aburatani H, Tsukiyama-Kohara K, Miyazaki J, Sonenberg N, Oka Y.
  • Journal Title: Cell Metabolism 7 Pages: 269-276
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Inter-organ metabolic communication involved in energy homeostasis: Potential therapeutic targets for obesity and metabolic syndrome (2008)
  • Author(s): Yamada T, Oka Y, Katagiri H.
  • Journal Title: Pharmacol Ther 117 Pages: 188-198
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] A novel method for evaluating human carotid artery elasticity: possible detection of early stage atherosclerosis in subjects with type 2 diabetes (2008)
  • Author(s): Okimoto H, Ishigaki Y, Koiwa Y, Hinikio Y, Ogihara T, Suzuki S, Katagiri H, Ohkubo T, Hasegawa H, Kanai H, Oka Y.
  • Journal Title: Atherosclerosis 196 Pages: 391-397
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] ATF4-Mediated Induction of 4E-BP1 Contributes to Pancreatic Beta Cell Survival under Endoplasmic Reticulum Stress (2008)
  • Author(s): Yamaguchi S, Ishihara H, Yamada T, Tamura A, Usui M, Tominaga R, Munakata Y, Satake C, Katagiri H, Tashiro F, Aburatani H. Tsukiyama-Kohara K, Miyazaki J, Sonenberg N, Oka Y.
  • Journal Title: Cell Metabolism 7 Pages: 269-276
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Communications between the Brain and Peripheral Tissues/Organs Involved in Energy Homeostasis -Potential Therapeutic Targets for Obesity and Metabolic syndrome- (2008)
  • Author(s): Yamada T, Oka Y, Katagiri H
  • Journal Title: Pharmacol Ther 117 Pages: 188-198
  • Peer Reviewed
• [Journal Article] A novel method for evaluating human carotid artery elasticity: possible detection of early stage atheroscleros is in subjectswith type 2 diabetes (2008)
  • Author(s): Okimoto H, Ishigaki Y, Koiwa Y, Hinikio Y, Ogihara T, Suzuki S, Katagiri H., Ohkubo T, Hasegawa H, Kanai H, Oka Y
  • Journal Title: Atherosclerosis 196 Pages: 188-198
  • Peer Reviewed
• [Journal Article] ATF4-Mediated Induction of 4E-BP1 Contributes to Pancreatic Beta Cell Survival under Endoplasmic Reticulum Stress (2008)
  • Author(s): Yamaguchi S, Ishihara H, Yamada T, Tamura A, Usui M, Tominaga R, Munakata Y, Satake C, Katagiri H, Tashiro F, Aburatani H, Tsukiyama-Kohara K, Miyazaki J, Sonenberg N, Oka Y
  • Journal Title: Cell Metabolism 7 Pages: 269-276
  • Peer Reviewed
• [Journal Article] Involvement of apolipoprotein E in excess fat accumulation and insulin resistance. (2007)
  • Author(s): Cao J., Katagiri H., Ishigaki Y., Yamada T., Ogihara T., Imai J., Uno K., Hasegawa Y., Kanzaki M., Yamamoto TT., Ishibashi S., Oka Y.
  • Journal Title: Diabetes 56 Pages: 24-33
  • NAID: 10027299912
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Efficient and controlled gene expression in mouse pancreatic islets by arterial delivery of tetracycline-inducible adenoviral vectors. (2007)
  • Author(s): Takahashi, R., Ishihara, H., Takahashi, K., Tamura, A., Yamaguchi, S., Yamada, T., Katagiri, H., Oka, Y.
  • Journal Title: J. Mol. Endocrinol 38 Pages: 127-136
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Bone Marrow (BM) Transplantation Promotes Beta Cell Regeneration after Acute Injury throgh BM Cell Mobilization. (2007)
  • Author(s): Hasegawa Y, Ogihara T, Yamada T, Ishigaki Y, Imai J, Uno K, Gao J, Kaneko K, Ishihara H, Sasano H, Nakauchi H, Oka Y, Katagiri H.
  • Journal Title: Endocrinology 148 Pages: 2006-2015
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Avenues of Communication between the Brain and Tissues/Organs Involved in Energy Homeostasis. (2007)
  • Author(s): Yamada T, Katagiri H.
  • Journal Title: Endocrine J 54 Pages: 497-505
  • NAID: 10019809044
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Adiposity and Cardiovascular Disorders: Disturbance of the Regulatory System Consisting of Humoral and Neuronal Signals. (2007)
  • Author(s): Katagiri H, Yamada T, Oka Y.
  • Journal Title: Circulation Research 101 Pages: 27-39
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Caroboxy-terminal modulator protein induces Akt phosphorylation and activation, thereby enhancing antiapoptotic, glycogen synthetic, and glucose uptake pathways. (2007)
  • Author(s): Ono H, Sakoda H, Fujishiro M, Anai M, Kushiyama A, Fukushima Y, Katagiri H, Ogihara T, Oka Y, Kamata H, Horike N, Uchijima Y, Kurihara H, Asano T.
  • Journal Title: Am J Physiol Cell Physiol 293
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Possible relevance of HLA-DRB1^*0403 haplotype in insulin autoimmune syndrome induced by α-lipoic acid, used as a dietary supplement. (2007)
  • Author(s): Yamada T, Imai J, Ishigaki Y, Hinokio Y, Oka Y, Katagiri H.
  • Journal Title: Diabetes Care 30
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Involvement of apolipoprotein E in excess fat accumulation and insulin resistance (2007)
  • Author(s): Gao J, Katagiri H, Ishigaki Y, Yamada T, Ogihara T, Imao J, Uno K. Hasegaw Y, Kanzaki M, Yamamoto TT, Ishibashi S, Oka Y.
  • Journal Title: Diabetes 56 Pages: 24-33
  • NAID: 10027299912
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Efficient and controlled gene expression in mouse pancreatic islets by arterial delivery of tetracycline-inducible adenoviral vectors (2007)
  • Author(s): Takahashi, R, Ishihara, H, Takahashi, K, Tamura, A, Yamaguchi, S, Yamada, T, Katagiri, H, Oka, Y.
  • Journal Title: J. Mol. Endocrinol 38 Pages: 127-136
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Bone Marrow (BM) Transplantation Promotes Beta Cell Regeneration after Acute Injury through BM Cell Mobilization (2007)
  • Author(s): Hasegawa Y, Ogihara T, Yamada T, Ishigaki Y, Imai J, Uno K, Gao J, Kaneko K, Ishihara H, Sasano H, Nakauchi H, Oka Y, Katagiri H.
  • Journal Title: Endocrinology 148 Pages: 2006-2015
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Avenues of Communication between the Brain and Tissues/Organs Involved in Energy Homeostasis (2007)
  • Author(s): Yamada T. Katagiri H.
  • Journal Title: Endocrine J 54 Pages: 497-505
  • NAID: 10019809044
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Adiposity and Cardiovascular Disorders: Disturbance of the Regulatory System Consisting of Humoral and Neuronal Signals- (2007)
  • Author(s): Katagiri H, Yamada T, Oka Y.
  • Journal Title: Circulation Research 101 Pages: 27-39
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Caroboxyl-terminal modulator protein (CTMP) induces AKT activation, thereby enhancing anti-apoptotic, glycogen synthetic and glucose uptake pathways (2007)
  • Author(s): Ono H, Sakoda H, Fujishiro M, Anai M, Kushiyama A, Fukushima Y, Katagiri H, Ogihara T, Oka Y, Kamata H, Horike N, Uchijima Y, Kurihara H, Asano T.
  • Journal Title: Am J Physiol Cell Physiol 293
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Possible relevance of HLA-DRB1*0403 haplotype in insulin autoimmune syndrome induced by a-lipoic acid, used as a dietary supplement (2007)
  • Author(s): Yamada T, Imai J, Ishigaki Y, Hinokio Y. Oka Y, Katagiri H.
  • Journal Title: Diabetes Care 30
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Bone Marrow(BM)Transplantation Promotes Beta Cell Regeneration after Acute Injury through BM Cell Mobilization (2007)
  • Author(s): Hasegawa Y, Ogihara T, Yamada T, Ishigaki Y, Imai J, Uno K, Gao J, Kaneko K, Ishihara H, Sasano H, Nakauchi H, Oka Y, Katagiri H
  • Journal Title: Endocrinology 148 Pages: 2006-2015
  • Peer Reviewed
• [Journal Article] Avenues of Communication between the Brain and Tissues/Organs Involved in Energy Homeostasis. (2007)
  • Author(s): Yamada T, Katagiri H
  • Journal Title: Endocrine J 54 Pages: 497-505
  • NAID: 10019809044
  • Peer Reviewed
• [Journal Article] Adiposity and Cardiovascular Disorders: Disturbance of the Regulatory System Consisting of Humoral and Neuronal Signals- (2007)
  • Author(s): Katagiri H, Yamada T, Oka Y
  • Journal Title: Circulation Research 101 Pages: 27-39
  • Peer Reviewed
• [Journal Article] Caroboxyl-terminal modulator protein(CTMP)induces AKT activation, thereby enhancing anti-apoptotic, glycogen synthetic and glucose uptake pathways (2007)
  • Author(s): Ono H, Sakoda H, Fujishiro M, Anai M, Kushiyama A, Fukushima Y, Katagiri H, Ogihara T, Oka Y, Kamata H, Horike N, Uchijima Y, Kurihara H, Asano T
  • Journal Title: Am J Physiol Cell Physiol 293
  • Peer Reviewed
• [Journal Article] Possible relevance of HLA-DRB1*0403 haplotype in insulin autoimm une syndrome induced by α-lipoic acid, used as a dietary supplement (2007)
  • Author(s): Yamada T, Imai J, Ishigaki Y, Hinokio Y, Oka Y, Katagiri H
  • Journal Title: Diabetes Care 30
  • Peer Reviewed
• [Journal Article] Involvement of apolipoprotein E in excess fat accumulation and insulin resistance. (2007)
  • Author(s): Gao J., Katagiri H., Ishigaki Y., Yamada T., Ogihara T., Imai J., Uno K., Hasegawa Y., Kanzaki M., Yamamoto TT., Ishibashi S., Oka Y
  • Journal Title: Diabetes 56 Pages: 24-33
  • NAID: 10027299912
• [Journal Article] Efficient and controlled gene expression in mouse pancreatic islets by arterial delivery of tetracycline-inducible adenoviral vectors. (2007)
  • Author(s): Takahashi, R., Ishihara, H., Takahashi, K., Tamura, A., Yamaguchi, S., Yamada, T., Katagiri, H., Oka, Y
  • Journal Title: J. Mol. Endocrinol 38 Pages: 127-136
• [Journal Article] Neuronal pathway from the liver modulates energy expenditure and systemic insulin sensitivity. (2006)
  • Author(s): Uno K, Katagiri H, Yamada T, Ishigaki Y, Ogihara T, Imai J, Hasegawa Y, Gao J, Kaneko K, Iwasaki H, Ishihara H, Sasano H, Inukai K, Mizuguchi H, Asano T, Shiota M, Nakazato M, Oka Y.
  • Journal Title: Science 312 Pages: 1656-1659
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Cold Exposure Suppresses Serum Adiponectin Levels through Sympathetic Nerve Activation in Mice. (2006)
  • Author(s): imai, J, Katagiri, H., Yamada, T, Ishigaki, Y, Ogihara, T, Uno, K, Hasegawa, Y, Gao, J, Ishihara, H, Oka, Y.
  • Journal Title: Obesity 14 Pages: 1132-1141
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] WFS1-deficiency increases endoplasmic reticulum stress, impairs cell cycle progression and triggers the apoptotic pathway specifically in pancreatic β-cells. (2006)
  • Author(s): Yamada, T., Ishihara, H., Tamura, A., Takahashi., R, Yamaguchi, S., Takei., D, Tokita, A., Satake, C., Tashiro, F., Katagiri, H., Aburatani, H., Miyazaki, J-I., Oka, Y.
  • Journal Title: Hum Mol Genet. 15 Pages: 1600-1609
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] WFS1 protein modulates the free Ca2+ concentration in the endoplasmic reticulum. (2006)
  • Author(s): Takei, D., Ishihara, H., Yamaguchi, S., Yamada, T., Katagiri, H., Maruyama, Y, Oka, Y.
  • Journal Title: FEBS Lett 580 Pages: 5635-5640
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Neuronal pathway from the liver modulates energy expenditure and systemic insulin sensitivity (2006)
  • Author(s): Uno K, Katagiri H, Yamada T, Ishigaki Y, Ogihara T, Imai J, Hasegawa Y, Gao J, Kaneko K, Iwasaki H, Ishihara H, Sasano H, Inukai K, Mizuguchi H, Asano T, Shiota M, Nakazato M, Oka Y.
  • Journal Title: Science 312 Pages: 1656-1659
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Cold Exposure Suppresses Serum Adiponectin Levels through Sympathetic Nerve Activation in Mice (2006)
  • Author(s): Imai, J, Katagiri, H, Yamada, T, Ishigaki, Y, Ogihara, T, Uno, K Hasegawa, Y, Gao, J, Ishihara, H, Oka, Y.
  • Journal Title: Obesity 14 Pages: 1132-1141
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] WFS1-deficiency increases endoplasmic reticulum stress, impairs cell cycle progression and triggers the apoptotic pathway specifically in pancreatic β-cells (2006)
  • Author(s): Yamada, T.Ishihara, H. Tamura, A. Takahashi. R, Yamaguchi, S. Takei. D, Tokita, A. Satake, C, Tashiro, R, Katagiri, H., Aburatani, H., Miyazaki, J-I., Oka, Y.
  • Journal Title: Hum Mol Genet 15 Pages: 1600-1609
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] WFS1 protein modulates the free Ca2+ concentration in the endoplasmic reticulum (2006)
  • Author(s): Takei, D, Ishihara, H, Yamaguchi, S, Yamada, T, Katagiri, H, Maruyama, Y, Oka, Y.
  • Journal Title: FEBS Lett 580 Pages: 5635-5640
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Neuronal pathway from the liver modulates energy expenditure and systemic insulin sensitivity. (2006)
  • Author(s): Uno K, Katagiri H, Yamada T, Ishigaki Y, Ogihara T, Imai J, Hasegawa Y, Gao J, Kaneko K, Iwasaki H, Ishihara H, Sasano H, Inukai K, Mizuguchi H, Asano T, Shiota M, Nakazato M, Oka Y
  • Journal Title: Science 312 Pages: 1656-1659
• [Journal Article] Activation of sympathetic nervous system suppresses serum adiponectin levels in mice. (2006)
  • Author(s): Imai, J, Katagiri, H., Yamada, T, Ishigaki, Y, Ogihara, T, Uno, K, Hasegawa, Y, Gao, J, Ishihara, H, Oka, Y
  • Journal Title: Obesity 14 Pages: 1132-1141
• [Journal Article] WFS1-deficiency enhances endoplasmic reticulum stress, triggers apoptotic pathway and impairs cell cycle progression specifically in pancreatic β-cells. (2006)
  • Author(s): Yamada, T., Ishihara, H., Tamura, A., Takahashi., R, Yamaguchi, S., Takei., D, Tokita, A., Satake, C., Tashiro, F., Katagiri, H., Aburatani, H., Miyazaki, J-I., Oka, Y.
  • Journal Title: Hum Mol Genet. 15 Pages: 1600-1609
• [Journal Article] WFS1 protein modulates the free Ca2+ concentration in the endoplasmic reticulum. (2006)
  • Author(s): Takei, D., Ishihara, H., Yamaguchi, S., Yamada, T., Katagiri, H., Maruyama, Y., Oka Y
  • Journal Title: FEBS Lett 580 Pages: 5635-5640
• [Presentation] エネルギー代謝維持機構を標的とした治療開発 (2008)
  • Author(s): 片桐秀樹
  • Organizer: 第42回糖尿病学の進歩
  • Place of Presentation: 高松
  • Year and Date: 2008-02-16
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Development of Therapeutic Strategies Targeting at Energy Homeostasis (2008)
  • Author(s): Katagiri H
  • Organizer: Advances in Diabetology 42nd Annual Post Graduate Course
  • Place of Presentation: Takamatsu, Japan
  • Year and Date: 2008-02-16
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] エネルギー代謝維持機構を標的とした治療開発 (2008)
  • Author(s): 片桐秀樹
  • Organizer: 第42回糠尿病学の進歩
  • Place of Presentation: 高松
  • Year and Date: 2008-02-16
• [Presentation] 肝からの神経シグナルによる臓器間代謝情報ネットワーク (2008)
  • Author(s): 片桐秀樹
  • Organizer: 第22回日本糖尿病・肥満動物学会
  • Place of Presentation: 東京
  • Year and Date: 2008-02-08
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Metabolic Information Network among Organs via Neuronal Signals Originating in the Liver (2008)
  • Author(s): Katagiri H
  • Organizer: 22th Japan Society of Experimental Diabetes and Obesity
  • Place of Presentation: Tokyo, Japan
  • Year and Date: 2008-02-08
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] 自律神経系による臓器間代謝情報ネットワーク機構 (2007)
  • Author(s): 片桐秀樹
  • Organizer: BMB2007(第30回日本分子生物学会年会第80回日本生化学会 合同大会)
  • Place of Presentation: 東京
  • Year and Date: 2007-12-12
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Inter-organ Communication via Autonomic Nervous System Involved in Coordinated Metabolic Regulation (2007)
  • Author(s): Katagiri H
  • Organizer: The 30th Annual Meeting of the Molecular Biology Society of Japan The 80th Annual Meeting of the Japanese Biochemical Society
  • Place of Presentation: Tokyo, Japan
  • Year and Date: 2007-12-12
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] 自律神経系による臓器間代謝情報ネットワーク機構 (2007)
  • Author(s): 片桐秀樹
  • Organizer: BMB2007(第30回日本分子生物学会年会 第80回日本生化学会 合同大会)
  • Place of Presentation: 東京
  • Year and Date: 2007-12-12
• [Presentation] 自律神経を介した臓器(組織)間代謝情報ネットワーク (2007)
  • Author(s): 片桐秀樹
  • Organizer: 第28回日本肥満学会
  • Place of Presentation: 東京
  • Year and Date: 2007-10-20
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Inter-organ Network Regarding Metabolic Regulation via Autonomic Nervous System (2007)
  • Author(s): Katagiri H
  • Organizer: 28th Annual Meeting of Japan Society for the Study of Obesity
  • Place of Presentation: Tokyo, Japan
  • Year and Date: 2007-10-20
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Metabolic Information Highway〜メタボリックシンドローム研究の新展開〜 (2007)
  • Author(s): 片桐秀樹
  • Organizer: 第62回日本体力医学会大会
  • Place of Presentation: 秋田
  • Year and Date: 2007-09-15
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Metabolic Information Highway-New Paradigm for Metabolic Syndrome Research- (2007)
  • Author(s): Katagiri H
  • Organizer: 62th the Japanese Society of Physical Fitness and Sports Medicine
  • Place of Presentation: Akita,Japan
  • Year and Date: 2007-09-15
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] 臓器間連関によるインスリン抵抗性改善機構 (2007)
  • Author(s): 片桐秀樹
  • Organizer: 第80回日本内分泌学会学術総会
  • Place of Presentation: 東京
  • Year and Date: 2007-06-15
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Inter-organ Communication System Alleviates Insulin Resistance (2007)
  • Author(s): Katagiri H
  • Organizer: The 80th Annual Meeting of the Japan Endocrine Society
  • Place of Presentation: Tokyo, Japan
  • Year and Date: 2007-06-15
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] 自律神経系を介した臓器間ネットワークによる糖・エネルギー代謝の協調的調節機構 (2007)
  • Author(s): 片桐秀樹
  • Organizer: 第50回日本糖尿病学会
  • Place of Presentation: 仙台
  • Year and Date: 2007-05-24
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Inter-organ Communication via Autonomic Nervous System is Involved in Coordinated Regulation of Glucose and Energy Metabolism (2007)
  • Author(s): Katagiri H
  • Organizer: 50th Annual Meeting of the Japan Diabetes Society
  • Place of Presentation: Sendai, Japan
  • Year and Date: 2007-05-24
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] 生体内での膵β細胞再生を目指した治療法開発 (2007)
  • Author(s): 片桐秀樹
  • Organizer: 第46回日本生体医工学会
  • Place of Presentation: 仙台
  • Year and Date: 2007-04-25
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] In Vivo Regeneration of Pancreatic Beta Cells (2007)
  • Author(s): Katagiri H
  • Organizer: The 46th Annual Conference of Japanese for Medical and Biological Engineering
  • Place of Presentation: Sendai, Japan
  • Year and Date: 2007-04-25
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] 臓器間情報ネットワークによる糖・エネルギー代謝の協調的調節 (2007)
  • Author(s): 片桐秀樹
  • Organizer: 第21回日本糖尿病動物研究会年次学術集会
  • Place of Presentation: 盛岡
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Autonomic nerve circuits modulate energy and glucose metabolism (2007)
  • Author(s): Yamada T., Katagiri H.
  • Organizer: Okazaki Symposium 2007 on Obesity and Diabetes
  • Place of Presentation: Okazaki, Japan
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Activation of Hepatic ERK Pathway Promotes Pancreatic Bet a Cell Proliferation (2007)
  • Author(s): Imai J., Katagiri H., Suzuki T., Oka Y.
  • Organizer: American Diabetes Association, 67th Scientific Sessions
  • Place of Presentation: Chicago, IL, USA
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Inter-organ communication via autonomic nerve circuits modulates systemic energy and glucose metabolism (2007)
  • Author(s): Katagiri H.
  • Organizer: The 25th JES Summer Seminar on Endocrinology & Metabolism
  • Place of Presentation: Awaji, Japan
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Activation of Hepatic ERK Pathway Promotes Pancreatic Bet a Cell Proliferation (2007)
  • Author(s): Imai J., Katagiri H., Oka Y
  • Organizer: Office of Life Sciences/National University of Singapore-Tohoku University/Centre of Excellence Joint Symposium
  • Place of Presentation: Kent Ridge Crescent, Singapore
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Neuronal pathway from the liver modulates energy expenditure and systemic insulin sensitivity (2007)
  • Author(s): Yamada T., Katagiri H., Uno K., Oka Y.
  • Organizer: Congress of the International Society for Autonomic Neuroscience
  • Place of Presentation: Kyoto, Japan
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Involved in Coordinated Regulation of Glucose and Energy Metabolism via Inter-organ Communication (2007)
  • Author(s): Katagiri H
  • Organizer: 21th Japan Society of Experimental Diabetes and Obesity
  • Place of Presentation: Morioka, Japan
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Activation of Hepatic ERK Pathway Promotes Pancreatic Beta Cell Proliferation (2007)
  • Author(s): Imai J., Katagiri H., Suzuki T., Oka Y
  • Organizer: American Diabetes Association 67th Scientific Sessions
  • Place of Presentation: Chicago, IL, USA
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Activation of Hepatic ERK Pathway Promotes Pancreatic Beta Cell Proliferation (2007)
  • Author(s): Imai J., Katagiri H., Oka Y
  • Organizer: Office of Life Sciences/National University of Singapore-Tbhoku University/Centre of Excellence Joint Symposium
  • Place of Presentation: Singapore
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Activation of Hepatic ERK Pathway Promotes Pancreatic Beta Cell Proliferation (2007)
  • Author(s): Imai J., Katagiri H., Suzuki T., Oka Y.
  • Organizer: American Diabetes Association, 67th Scien tific Sessions
  • Place of Presentation: Chicago, IL, USA
• [Presentation] Activation of Hepatic ERK Pathway Promotes Pancreatic Beta Cell Proliferation (2007)
  • Author(s): Imai J., Katagiri H., Oka Y.
  • Organizer: Office of Life Sciences/Nationa1 University of Singapore-Tohoku University/Centre of Excellence Joint Symposium
  • Place of Presentation: Singapore
• [Presentation] Novel Inter-Organ Communication Involved in Glucose and Enersy Homeostasis (2006)
  • Author(s): Katagiri H.
  • Organizer: The 11^<th> Adiposcience Symposium
  • Place of Presentation: Osaka, Japan
  • Year and Date: 2006-08-19
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Novel Inter-Organ Communication Involved in Glucose and Energy Homeostasis (2006)
  • Author(s): Katagiri H
  • Organizer: The 11^<th> Adiposcience Symposium
  • Place of Presentation: Osaka, Japan
  • Year and Date: 2006-08-19
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] 肝におけるインスリン産生細胞の創生と骨髄細胞動員による膵β細胞の再生 (2006)
  • Author(s): 片桐秀樹、荻原健英、今井淳太、長谷川豊、岡芳知
  • Organizer: 第49回日本糖尿病学会年次学術総会
  • Place of Presentation: 東京
  • Year and Date: 2006-05-26
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Generation of Insulin-Producing Cells in the Liver and Regeneration of Pancreatic Beta Cells by Mobilization of Bone Marrow Cells. (2006)
  • Author(s): Katagiri H., Ogihara T., Imai J., Hasegawa Y., Oka Y
  • Organizer: 49^<th> Annual Meeting of the Japan Diabetes Society
  • Place of Presentation: Tokyo, Japan
  • Year and Date: 2006-05-26
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] 自律神経系を介した協調的エネルギー代謝調節機構 (2006)
  • Author(s): 片桐秀樹
  • Organizer: 第27回日本肥満学会
  • Place of Presentation: 神戸
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Neuronal Pathway from the Liver Modulates Energy Expenditure and Systemic Insulin Sensitivity (2006)
  • Author(s): Katagiri H., Uno K., Yamada T., Oka Y
  • Organizer: American Diabetes Association, 66th Scientific Sessions
  • Place of Presentation: Washington, DC, USA
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Signals from Intra-Abdominal Fat Modulate Insulin and Leptin Sensitivity through Different Mechanisms: Neuronal Involvement in Food Intake Regulation (2006)
  • Author(s): Yamada T., Katagiri H., Ishigaki Y., Oka Y
  • Organizer: American Diabetes Association, 66th Scientific Sessions
  • Place of Presentation: Washington, DC, USA
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Apolipoprotein E Involvement in Excess Fat Accumulation and Insulin Resistance (2006)
  • Author(s): Gao J., Katagiri H., Ishigaki Y., Oka Y
  • Organizer: American Diabetes Association, 66th Scientific Sessions
  • Place of Presentation: Washington, DC, USA
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Bone Marrow-derived Cell Recruitment Is Involved in Regeneration after Pancreatic Beta Cell Injury (2006)
  • Author(s): Ogihara T., Katagiri H., Hasegawa Y. Oka Y
  • Organizer: 20th IUBMB International Congress of Biochemistry and Molecular Biology
  • Place of Presentation: Kyoto, Japan
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Neuronal Pathway from the Liver Modulates Energy Expendi tureand Systemic Insulin Sensitivity (2006)
  • Author(s): Uno K., Katagiri H., Yamada T., Oka Y
  • Organizer: Tohoku University 21st century COE program The 3rd International Symposium
  • Place of Presentation: Sendai, Japan
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Bone Marrow Transplantation Promotes β Cell Regeneration after Acute Injury through Bone Marrow Cell Mobilization (2006)
  • Author(s): Hasegawa Y., Katagiri H., Ogihara T., Saito T., Oka Y
  • Organizer: Tohoku University 21st century COE program The 3rd International Symposium
  • Place of Presentation: Sendai, Japan
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Coordinated Metabolic Regulation via Autonomic Nervous System (2006)
  • Author(s): Katagiri H
  • Organizer: 27th Annual Meeting of Japan Society for the Study of Obesity
  • Place of Presentation: Kobe, Japan
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Neuronal Pathway from the Liver Modulates Energy Expenditure and Systemic Insulin Sensitivity (2006)
  • Author(s): Katagiri H., Uno K, Yamada T, Oka Y
  • Organizer: American Diabetes Association 66th Scientific Sessions
  • Place of Presentation: Washington, DC, USA
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Signals from Intra-Abdominal Fat Modulate Insulin and Leptin Sensitivity through Different Mechanisms: Neuronal Involvement in Food intake Regulation (2006)
  • Author(s): Yamada T., Katagiri H., Ishigaki Y., Oka Y
  • Organizer: American Diabetes Association 66th Scientific Sessions
  • Place of Presentation: Washington, DC, USA
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Apolipoprotein E Involvement in Excess Fat Accumulation and Insulin Resistance (2006)
  • Author(s): Gao J., Katagiri H., Ishigaki Y., Oka Y
  • Organizer: American Diabetes Association 66th Scientific Sessions
  • Place of Presentation: Washington, DC, USA
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Neuronal Pathway from the Liver Modulates Energy Expenditure and Systemic Insulin Sensitivity (2006)
  • Author(s): Uno K, Katagiri H., Yamada T., Oka Y
  • Organizer: Tbhoku University 21st century COE program The 3rd International Symposium
  • Place of Presentation: Sendai, Japan
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Bone Marrow Transplantation Promotes 6 Cell Regeneration after Acute Injury through Bone Marrow Cell Mobilization (2006)
  • Author(s): Hasegawa Y., Katagiri H., Ogihara T., Saito T., Oka Y
  • Organizer: Tbhoku University 21st century COE program The 3rd International Symposium
  • Place of Presentation: Sendai, Japan
  • Description: 「研究成果報告書概要(欧文)」より
• [Patent(Industrial Property Rights)] 肥満・糖尿病治療薬Angptl1 (2007)
  • Inventor(s): 片桐 秀樹 岡 芳知 山田 哲也 宇野 健司
  • Industrial Property Rights Holder: 国立大学法人東北大学
  • Filing Date: 2007-05-21
  • Description: 「研究成果報告書概要(和文)」より
  • Overseas
• [Patent(Industrial Property Rights)] 肥満・糖尿病治療薬Angptl1 (2007)
  • Inventor(s): 片桐 秀樹 岡 芳知 山田 哲也 宇野 健司
  • Industrial Property Rights Holder: 国立大学法人東北大学
  • Filing Date: 2007-05-21
  • Overseas