| Budget Amount *help |
¥17,540,000 (Direct Cost: ¥14,600,000、Indirect Cost: ¥2,940,000)
Fiscal Year 2009: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2008: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2007: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2006: ¥4,800,000 (Direct Cost: ¥4,800,000)
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| Research Abstract |
Secretion of insulin, the glucose-lowering hormone, from pancreatic β-cells is regulated by blood glucose and a gut hormone incretin. These stimuli increase intracellular concentrations of ATP and cAMP, respectively, activating intracellular signals to elicit insulin secretion. In this study, mutual interaction between these two signals was elucidated with special emphasis on an ATP-sensor K_<ATP> channel and a cAMP-sensor Epac2.
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