The regulatory mechanisms of life span by growth hormone and IGF-I axis

• Project/Area Number: 18390276
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Endocrinology
• Research Institution: Kobe University
• Principal Investigator: CHIHARA Kazuo Kobe University, Graduate School of Medicine, Professor (00107955)
• Co-Investigator(Kenkyū-buntansha): TAKAHASHI Yutaka Kobe University, Hospital, Associate Professor (70301281) ; OKIMURA Yasuhiko Kobe University, School of Medicine, Associate Professor (30204100) ; IIDA Keiji Kobe University, Graduate School of Medicine, Assistant Professor (80324911)
• Project Period (FY): 2006 – 2007
• Project Status: Completed (Fiscal Year 2007)
• Budget Amount: ¥17,110,000 (Direct Cost: ¥15,700,000、Indirect Cost: ¥1,410,000); Fiscal Year 2007: ¥6,110,000 (Direct Cost: ¥4,700,000、Indirect Cost: ¥1,410,000); Fiscal Year 2006: ¥11,000,000 (Direct Cost: ¥11,000,000)
• Keywords: growth hormone (GH) / IGF-I / longevity / aging / oxidative stress / non-alcoholic steatohenatitis (NASH) / 非アルコール性脂肪性肝炎 / ミトコンドリア

Research Abstract

In population aging, such as in Japan, it is important to prolong healthy and productive life span. Growth hormone and IGF-I axis (GH-IGF-I axis) is essentially related to the regulation of life span. We have analyzed how GH-IGF-I axis regulates life span using clinical data, animal models and cellular models. The excess status of GH-IGF-I axis model in human is acromegaly. In acromegaly, shortened life span has been reported, although the mechanisms are unknown. We analyzed the effect of an excess IGF-I in cellular models and found that high concentration of IGF-I induces oxidative stress (reactive oxygen spiecies; ROS) in adipocytes and myocytes. Because it is well known that ROS plays an important role in the aging processes so that it is intriguing that IGF-I stimulates ROS production. It is speculated that ROS produced by IGF-I enhances aging changes in many organs. On the other hand, in a human model of lack in GH-IGF-I axis, adult growth hormone deficiency (AGHD), it has been reported that in AGHD patient, based on its metabolic syndrome-like symptoms including visceral obesity, abnormal lipid profile, reduced muscle and bone mineral density, increased non-alcoholic fatty liver disease (NAFLD)/ non-alcoholic steatohepatitis (NASH), premature atherosclerosis and increased risk in mortality are observed. We found that in a patient with NASH and AGHD, GH treatment drastically ameliorates liver dysfunction and liver histological abnormality concomitant with inflammation and oxidative stress. These results imply an important role of GH-IGF-I axis in the metabolic regulation in adult. Further, we found an independent effect of GH from IGF-I on metabolic regulation. It is suggested that GH has direct action and IGF-I-independent regulatory role in metabolism and life span.

Research Products

• [Journal Article] Involvement of mPOU(Brn-5), a class VI POU protein, in the gene expressi on of Pit-1 as well as PRL. (2008)
  • Author(s): Keizo Toda
  • Journal Title: Molecular and Cellular Endocrinology 280 Pages: 20-29
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Involvement of mPOU(Bm-5),a class VI POU protein,in the gene expression of Pit-1 as well as PRL (2008)
  • Author(s): Keizo, Toda, Daisuke, Yamamoto, Mariko, Fumoto, Nobuko, Ikeshita, Elizabeth, Henny, Herningtyas, Keiji, Iida, Yutaka, Takahashi, Hidesuke, Kaji, Kazuo, Chihara, Yasuhiko, Okimura
  • Journal Title: Molecular and Cellular Endocrinology 280 Pages: 20-29
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Involvement of mPOU(Brn-5), a class VI POU protein, in the gene expression of Pit-1 as well as PRL. (2008)
  • Author(s): Keizo Toda
  • Journal Title: Molecular and Cellular Endocrinology 280 Pages: 20-29
  • Peer Reviewed
• [Journal Article] Neither intravenous nor intracerebroventricular administration of obestation affects the secretion of GH, PRL, TSH and ACTH in rats. (2007)
  • Author(s): Daisuke Yamamoto
  • Journal Title: Regulatory Peptides 138 Pages: 141-144
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Growth Hormone Reverses Nonalcoholic Steatohepatitis in a Patient With Adult Growth Hormone Deficiency. (2007)
  • Author(s): Yutaka Takahashi
  • Journal Title: GASTROENTEROLOGY 132 Pages: 938-943
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Hormone Replacement Therapy and Vascular Risk Disorders in Adult Hypop ituitarism. (2007)
  • Author(s): Hidesuke Kaji
  • Journal Title: Endocrine Journal 54(2) Pages: 239-245
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Heterogeneity in responsiveness of perceived quality of life to body composition changes between adult-and childhood-onset Japanese hypopituitary adults with GH deficiency during GH replacement. (2007)
  • Author(s): Hisashi Urushihara
  • Journal Title: European Journal of Endocrinology 156 Pages: 637-645
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] A simple diagnostic test using GH-releasing peptide-2 in adult GH deficiency. (2007)
  • Author(s): Kazuo Chihara
  • Journal Title: European Journal of Endocrinolog 157 Pages: 19-27
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] McCune-Albright Syndrome with Acromegaly and Fibrous Dysplasia Associated with the GNAS Gene Mutation ldentified by Sensitive PNA-clamping Method. (2007)
  • Author(s): Mari Imanaka
  • Journal Title: Internal Medicine 46 Pages: 1577-1583
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] CXCL14 enhances insulin-dependent glucose uptake in adipocytes and is related to high-fat diet-induced obesity. (2007)
  • Author(s): Michiko Takahashi
  • Journal Title: Biochemical and Biophysical Research Communications 364 Pages: 1037-1042
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] 内分泌学 (2007)
  • Author(s): 千原和夫
  • Journal Title: 日本医事新報 4319 Pages: 9-14
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] 総説 内分泌臓器とホルモン (2007)
  • Author(s): 飯田啓二
  • Journal Title: 診断と治療 95(2) Pages: 227-231
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] 日本人成人における血中インスリン様成長因子-I濃度の基準範囲について (2007)
  • Author(s): 島津 章
  • Journal Title: ホルモンと臨床 55(4) Pages: 107-113
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] 1.間脳下垂体系 a.下垂体前葉 (2007)
  • Author(s): 飯田啓二
  • Journal Title: ホルモンと臨床 55増刊号 Pages: 3-9
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] 保存的治療を行った高齢者副甲状腺機能亢進症5例の検討-糖尿病合併との関連- (2007)
  • Author(s): 宮内章光
  • Journal Title: ホルモンと臨床 55増刊号 Pages: 126-130
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] 下垂体前葉機能低下症 (2007)
  • Author(s): 飯田啓二
  • Journal Title: 総合臨床 56増刊号 Pages: 723-737
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] 先端巨大症においてIGF-I/GH比の低下は耐糖能異常と関連する (2007)
  • Author(s): 福岡秀規
  • Journal Title: 日本内分泌学会雑誌 第17回臨床内分泌代謝Update Proceeding 83(Suppl) Pages: 96-98
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] 2A型VHL病の一家系におけるVHL遺伝子解析 (2007)
  • Author(s): 今中真理
  • Journal Title: 日本内分泌学会雑誌 第17回臨床内分泌代謝Update Proceeding 83(Suppl) Pages: 174-177
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] プレクリニカルクッシング症候群を伴った副腎皮質癌の一例 (2007)
  • Author(s): 竹野亮子
  • Journal Title: 日本内分泌学会雑誌 第17回臨床内分泌代謝Update Proceeding 83(Suppl) Pages: 158-160
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Neither intravenous nor intracerebroventricular administration of obestation affects the secretion of GH, PRL, TSH and ACTH in rats (2007)
  • Author(s): Daisuke, Yamamoto, Nobuko, Ikeshita, Rie, Daito, Elizabeth, Henny, Hemingtyas, Keizo, Toda, Kentaro, Takahashi, Keiji, Iida, Yutaka, Takahashi, Hidesuke, Kaji, Kazuo, Chihara, Yasuhiko, Okimura
  • Journal Title: Regulatory Peptides 138 Pages: 141-144
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Growth Hormone Reverses Nonalcoholic Steatohepatitis in a Patient With Adult Growth Hormone Deficiency (2007)
  • Author(s): Yutaka, Takahashi, Keiji, lida, Kentaro, Takahashi, Shiro, Yoshioka, Hidenori, Fukuoka, Ryoko, Takeno, Mari, Imanaka, Hitoshi, Nishizawa, Michiko, Takahashi, Yasushi, Seo, Yoshitake, Hayashi, Takuma, Kondo, Yasuhiko, Okimura, Hidesuke, Kaji, Riko, Kitazawa, Sohei, Kitazawa, Kazuo, Chihara
  • Journal Title: GASTROENTEROLOGY 132 Pages: 938-943
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Hormone Replacement Therapy and Vascular Risk Disorders in Adult Hypopituitarism (2007)
  • Author(s): Hidesuke, Kaji, Keiji, lida, Yutaka, Takahashi, Yasuhiko, Okimura, Kazuo, Chihara
  • Journal Title: Endocrine Journal 54(2) Pages: 239-245
  • NAID: 10019478618
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Heterogeneity in responsiveness of perceived quality of life to body composition changes between adult-and childhood-onset Japanese hypopituitary adults with GH deficiency during GH replacement (2007)
  • Author(s): Hisashi, Urushihara, Shunichi, Fukuhara, Shigeru, Tai, Satoshi, Morita, Kazuo, Chihara
  • Journal Title: European Journal of Endocrinology 156 Pages: 637-645
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Yuzuru, Kato, for the KP-102 Study Group: A simple diagnostic test using GH-releasing peptide-2 in adult GH deficiency (2007)
  • Author(s): Kazuo, Chihara, Akira, Shimatsu, Naomi, Hizuka, Toshiaki, Tanaka, Yoshiki, Seino
  • Journal Title: European Journal of Endocrinology 157 Pages: 19-27
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] McCune-Albright Syndrome with Acromegaly and Fibrous Dysplasia Associated with the GNAS Gene Mutation Identified by Sensitive PNA-clamping Method (2007)
  • Author(s): Mari, Imanaka, Keiji, lida, Hitoshi, Nishizawa, Hidenori, Fukuoka, Ryoko, Takeno, Kentaro, Takahashi, Hiroshi, Kaji, Yutaka, Takahashi, Yasuhiko, Okimura, Hidesuke, Kaji, Yasuo, Imanishi, kazuo, Chihara
  • Journal Title: Internal Medicine 46 Pages: 1577-1583
  • NAID: 130000076004
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] CXCL14 enhances insulin-dependent glucose uptake in adipocytes and is related to high-fat diet-induced obesity (2007)
  • Author(s): Michiko, Takahashi, Yutaka, Takahashi, Kenichi, Takahashi, Fyodor, N, Zolotaryov, Kyoung, Su, Hong, Keiji, Iida, Yasuhiko, Okimura, Hidesuke, Kaji, Kazuo, Chihara
  • Journal Title: Biochemical and Biophysical Research Communications 364 Pages: 1037-1042
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Hormone Replacement Therapy and Vascular Risk Disorders in Adult Hypopituitarism. (2007)
  • Author(s): Hidesuke Kaji
  • Journal Title: Endocrine Journal 54(2) Pages: 239-245
  • Peer Reviewed
• [Journal Article] A simple diagnostic test using GH-releasing peptide-2 in adult GH deficiency. (2007)
  • Author(s): Kazuo Chihara
  • Journal Title: European Journal of Endocrinology 157 Pages: 19-27
  • Peer Reviewed
• [Journal Article] McCune-Albright Syndrome with Acromegaly and Fibrous Dysplasia Associated with the GNAS Gene Mutation Identified by Sensitive PNA-clamping Method. (2007)
  • Author(s): Mari Imanaka
  • Journal Title: Internal Medicine 46 Pages: 1577-1583
  • Peer Reviewed
• [Journal Article] 下垂体前葉機能低下症 (2007)
  • Author(s): 飯田啓二
  • Journal Title: 総合臨床 56 Pages: 723-737
• [Journal Article] 1.間脳下垂体系 a.下垂体前葉 (2007)
  • Author(s): 飯田啓二
  • Journal Title: ホルモンと臨床 55 Pages: 3-9
• [Journal Article] 保存的治療を行った高齢者副甲状腺機能亢進症5例の検討-糖尿病合併との関連- (2007)
  • Author(s): 宮内章光
  • Journal Title: ホルモンと臨床 55 Pages: 126-130
• [Journal Article] 先端巨大症においてIGF-I/GH比の低下は耐糖能異常と関連する (2007)
  • Author(s): 福岡秀規
  • Journal Title: 日本内分泌学会雑誌 第17回臨床内分泌代謝Updato Proceeding 83 Pages: 96-98
• [Journal Article] 2A型VHL病の一家系におけるVHL遺伝子解析 (2007)
  • Author(s): 今中真理
  • Journal Title: 日本内分泌学会雑誌 第17回臨床内分泌代謝Update Proceeding 83 Pages: 174-177
• [Journal Article] プレクリニカルクッシング症候群を伴った副腎皮質癌の一例 (2007)
  • Author(s): 竹野亮子
  • Journal Title: 日本内分泌学会雑誌 第17回臨床内分泌代謝Update Proceeding 83 Pages: 158-160
• [Journal Article] Growth hormone reverses nonalcoholic steatohepatitis in a patient with adult growth hormone deficiency (2007)
  • Author(s): Takahashi Y et al.
  • Journal Title: Gastroenterology (In press)
• [Journal Article] Hormone Replacement Therapy and Vascular Risk Disorders in Adult Hypopituitarism. (2007)
  • Author(s): Kaji H et al.
  • Journal Title: Endocr J (In press)
• [Journal Article] Gene expression profile in the heart of spontaneous dwarf rat: In vivo effects of growth hormone. (2006)
  • Author(s): Shiro Yositioka
  • Journal Title: Biochemical and Biophysical Research Communications 341 Pages: 88-93
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] The Threshold of Bone Mineral Density for Vertebral Fracture in Female Patients with Glucocorticoid-induced Osteoporosis. (2006)
  • Author(s): Hiroshi Kaji
  • Journal Title: Endocrine Journal 53(1) Pages: 27-34
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Body composition and vertebral fracture risk in female patients treated with glucocorticoid. (2006)
  • Author(s): H. Kaji
  • Journal Title: Osteoporos Int1 7 Pages: 627-633
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] A Novel Mutation in the von Hippel-Lindau Tumor Suppressor Gene Identi fied in a Japanese Family with Pheochromocytoma and Hepatic Hemangioma. (2006)
  • Author(s): Kentaro Takahashi
  • Journal Title: Internal Medicine 45 Pages: 265-269
  • NAID: 130000076543
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Efficacy and safety of growth hormone (GII) in the treatment of adult Japanese patients with GH deficiency: A randomised, placebo-controlled study. (2006)
  • Author(s): K. Chihara
  • Journal Title: Growth Hormone & IGF Research 16 Pages: 132-142
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] A case of primary hyperparathyroidism with marked changes in bone mine ral density and geometry after parathyroidectomy. (2006)
  • Author(s): Hiroshi Kaji
  • Journal Title: J Bone Miner Metab 24 Pages: 349-352
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Parathyroid Hormone Increases β-Catenin Levels through Smad3 in Mouse Osteoblastic Cells. (2006)
  • Author(s): Takako Tobimatsu
  • Journal Title: Endocrinology 147(5) Pages: 2583-2590
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] The Usefulness of Bone Metabolic Indices for the Prediction of Changes in Bone Mineral Density after Parathyroidectomy in Patients with Primary Hyperparathyroidism. (2006)
  • Author(s): H. Kaji
  • Journal Title: Hormone and Metabolic Research 38 Pages: 411-416
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Effect of growth hormone treatment on trunk fat accumulation in adult GH-deficient Japanese patients: a randomised, placebo-controlled trial. (2006)
  • Author(s): Kazuo Chihara
  • Journal Title: CURRENT MEDICAL RESEARCH AND OPINION 22(10) Pages: 1973-1979
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Validation of the Japanese version of the Quality of Life-Assessment of Growth Hormone Deficiency in Adults (QoL-AGHDA). (2006)
  • Author(s): Yoshimi Suzukamo
  • Journal Title: Growth Hormone & IGF Research 16 Pages: 340-347
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Smad3 Differently Affects Osteoblast Differentiation Depending upon its Differentiation Stage. (2006)
  • Author(s): N. Kaji
  • Journal Title: Hormone and Metabolic Research 38 Pages: 740-745
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] The N131S Mutation in the von Hippel-Lindau Gene in a Japanese Family with Pheochromocytoma and Hemangioblastomas. (2006)
  • Author(s): Mari Imanaka
  • Journal Title: Endocrine Journal 53(6) Pages: 819-827
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Low-dose Growth Hormone Treatment (0.175mg/kg/week) for Short Stature in Patients with Turner Syndrome: Data from KIGS Japan. (2006)
  • Author(s): Yoshiya Ito
  • Journal Title: Endocrine Journal 53(5) Pages: 699-703
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Growth Hormone (GH) Effects on Central Fat Accumulation in Adult Japanese GH Deficient Patients: 6-month fixed-dose Effects Persist during Second 6-month Individualized-dose Phase. (2006)
  • Author(s): Kazuo Chihara
  • Journal Title: Endocrine Journal 53(6) Pages: 853-858
  • NAID: 10020612773
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Serum Soluble Factors Induce the Proliferation, Alkaline Phosphatase Activity and Transforming Growth Factor-β Signal in Osteoblastic Cells in the Patzent with Hepatitis C-associated Osteosclerosis. (2006)
  • Author(s): H. Kaji
  • Journal Title: Endocrinology & Diabetes 114 Pages: 599-604
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] 学会長を訪ねて(第79回日本内分泌学会学術総会会長) (2006)
  • Author(s): 千原和夫
  • Journal Title: 薬の知識 57(1) Pages: 16-17
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] GH産生巨大下垂体腺腫によるPreclinical Acromegalyの一例 (2006)
  • Author(s): 福岡秀規
  • Journal Title: 日本内分泌学会雑誌 第16回日本間脳下垂体腫傷学会proceeding 82(Suppl) Pages: 69-71
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] 28年の経過中に脳幹浸潤、脊髄播種をきたした浸潤性プロラクチノーマの1例 (2006)
  • Author(s): 高橋健太郎
  • Journal Title: 日本内分泌学会雑誌 第16回日本間脳下垂体腫傷学会proceeding 82(Suppl) Pages: 75-78
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] 下垂体腫瘍の診断と治療 (2006)
  • Author(s): 置村康彦
  • Journal Title: 脳神経外科 34(11) Pages: 1083-1092
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] 成人成長ホルモン分泌不全症(AGHD) (2006)
  • Author(s): 置村康彦
  • Journal Title: 日本医事新報 4297 Pages: 57-62
  • NAID: 40007387327
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] 成長ホルモン/IGF-Iとカルシウム骨代謝 (2006)
  • Author(s): 梶博史
  • Journal Title: 内分泌・糖尿病科 23(Suppl.3) Pages: 95-99
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] グルココルチコイド服用女性における体組成の椎体骨折発症への影響:閉経前後における検討 (2006)
  • Author(s): 梶博史
  • Journal Title: 日本内分泌学会雑誌 82(Suppl) Pages: 67-69
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] 機能性下垂体腫瘍 座談会 下垂体腫瘍を見逃さないために (2006)
  • Author(s): 有田和徳
  • Journal Title: 最新医学・別冊 新しい診断と治療のABC 43 Pages: 196-207
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] 多腺性腫瘍 von Hippel-Lindau病 (2006)
  • Author(s): 高橋健太郎
  • Journal Title: 別冊日本臨床 新領域別症候群シリーズ 3 Pages: 351-354
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] 副腎 両側副腎腫大を伴うプレクリニカルクッシング症候群の1例 (2006)
  • Author(s): 今中真理
  • Journal Title: ホルモンと臨床 54 Pages: 150-155
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Published by Bio Scientifica LTD (2006)
  • Author(s): Edited, by, K, Ho, K, Chihara
  • Journal Title: Molecular Pathogenesis and Therapy of Pituitary Disease, HypoCCS Series Volume 9, 211
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Gene expression profile in the heart of spontaneous dwarf rat: In vivo effects of growth hormone (2006)
  • Author(s): JOURNAL, Shiro, Yoshioka, Yutaka, Takahashi, Yasuhiko, Okimura, Kentaro, Takahashi, Genzo, Iguchi, Keiji, Iida, Hidesuke, Kaji, Kazuo, Chihara
  • Journal Title: Biochemical and Biophysical Research Communications 341 Pages: 88-93
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] The Threshold of Bone Mineral Density for Vertebral Fracture in Female Patients with Glucocorticoid-induced Osteoporosis (2006)
  • Author(s): iroshi, Kaji, Mika, Yamauchi, Kazuo, Chihara, Toshitsugu, Sugimoto
  • Journal Title: Endocrine Journal 53(1) Pages: 27-34
  • NAID: 10020545780
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Body composition and vertebral fracture risk in female patients treated with glucocorticoid (2006)
  • Author(s): H, Kaj, T, Tob, imatsu, J, Naito, M.- F, Iu, M, Yamauchi, T, Sugimoto, K, Chihara
  • Journal Title: Osteoporos Int 17 Pages: 627-633
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] A Novel Mutation in the von Hippel-Lindau Tumor Suppressor Gene Identified in a Japanese Family with Pheochromocytoma and Hepatic Hemangioma (2006)
  • Author(s): Kentaro, Takahashi, Keiji, Iida, Yasuhiko, Okimura, Yutaka, Takahashi, Junko, Naito, Shin-ichiro, Nishikawa, Seizo, Kadowaki, Genzo, Iguchi, Hidesuke, Kaji, Kazuo, Chihara
  • Journal Title: Internal Medicine 45 Pages: 265-269
  • NAID: 130000076543
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Efficacy and safety of growth hormone (GH) in the treatment of adult Japanese patients with GH deficiency:A randomised,placebo-controlled study (2006)
  • Author(s): K, Chihara, Y, Kato, H, Kohno, K, Takano, T, Tanaka, A, Teramoto, A, Shimatsu
  • Journal Title: Growth Hormone & IGF Research 16 Pages: 132-142
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] A case of primary hyperparathyroidism with marked changes in bone mineral density and geometry after parathyroidectomy (2006)
  • Author(s): Hiroshi, Kaji, Mei-Fway, lu, Junko, Naito, Toshitsugu, Sugimoto, Kazuo, Chihara
  • Journal Title: J Bone Miner Metab 24 Pages: 349-352
  • NAID: 10018193735
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] The Usefulness of Bone Metabolic Indices for the Prediction of Changes in Bone Mineral Density after Parathyroidectomy in Patients with Primary Hyperparathyroidism (2006)
  • Author(s): H, Kaji, R, Nomura, M, Yamauchi, K, Chihara, T, Sugirnoto
  • Journal Title: Hormone and Metabolic Research 38 Pages: 411-416
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Effect of growth hormone treatment on trunk fat accumulation in adult GHJapanese patients: a randomised,placebo-controlled trial deficient (2006)
  • Author(s): Kazuo, Chihara, Yuzuru, Kato, Kazue, Takano, Akira, Shimatsu, Hitoshi, Kohno, Toshiaki, Tanaka, Minoru, Irie
  • Journal Title: CURRENT MEDICAL RESEARCH AND OPINION Vol. 22, No. 10 Pages: 1973-1979
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Validation of the Japanese version of the Quality of LifeAssessment of Growth Hormone Deficiency in Adults (QoL-AGHDA) (2006)
  • Author(s): Yoshimi, Suzukamo, Hiroyuki, Noguchi, Natsuko, Takahashi, Akira, Shimatsu, Kazuo, Chihara, Joseph, Green, Shunichi, Fukuhara
  • Journal Title: Growth Hormone&IGF Research 16 Pages: 340-347
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Smad3 Differently Affects Osteoblast Differentiation Depending upon its Differentiation Stage (2006)
  • Author(s): H, Kaji, J, Naito, H, Sowa, T, Sugimoto, K, Chihara
  • Journal Title: Hormone and Metabolic Research 38 Pages: 740-745
  • NAID: 120001384673
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] The N131S Mutation in the von Hippel-Lindau Gene in a Japanese Family with Pheochromocytoma and Hemangioblastomas (2006)
  • Author(s): Mari, Imanaka, Keiji, Iida, Kentaro, Takahashi, Kazuo, Tsuji, Hitoshi, Nishizawa, Hidenori, Fukuoka, Ryoko, Takeno, Yutaka, Takahashi, Yasuhiko, Okimura, Hidesuke, Kaji, Kazuo, Chihara
  • Journal Title: Endocrine Journal 53(6) Pages: 819-827
  • NAID: 10020612693
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] KIGS(Pfizer International Growth Study)Japan Scientific Committee: Low-dose Growth Hormone Treatment(0.175mg/kg/week)for Short Stature in Patients with Turner Syndrome:Data from KIGS Japan (2006)
  • Author(s): Yoshiya, Ito, Kenji, Fujieda, Toshiaki, Tanaka, Kazue, Takano, Kazuo, Chihara, Yoshiki, Seino, Minoru, Irie
  • Journal Title: Endocrine Journal 53(5) Pages: 699-703
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Growth Hormone(GH)Effects on Central Fat Accumulation in Adult Japanese GH Deficient Patients:6-month Fixed-dose Effects Persist during Second 6-month Individualized-dose Phase (2006)
  • Author(s): Kazuo, Chihara, Akira, Shimatsu, Yuzuru, Kato, Hitoshi, Kohno, Toshiaki, Tanaka, Kazue, Takano, Minoru, Irie
  • Journal Title: Endocrine Journal 53(6) Pages: 853-858
  • NAID: 10020612773
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Serum Soluble Factors Induce the Proliferation,Alkaline Phosphatase Activity and Transforming Growth Factor-β Signal in Osteoblastic Cells in the Patient with Hepatitis C-associated Osteosclerosis (2006)
  • Author(s): H, Kaji, J, Naito, H, Sowa, T, Sugimoto, K, Chihara
  • Journal Title: Endocrinology & Diabetes 114 Pages: 599-604
  • NAID: 120001384674
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Neither intravenous nor intracerebroventricular administration of obestatin affects the secretion of GH, PRL, TSH and ACTH in rats (2006)
  • Author(s): Yamamoto D et al.
  • Journal Title: Regulatory peptides 138(2-3) Pages: 141-144
• [Journal Article] The N131S Mutation in the von Hippel-Lindau Gene in a Japanese Family with Pheochromocytoma and Hemangioblastomas (2006)
  • Author(s): Imanaka M
  • Journal Title: Endocr J 53(6) Pages: 819-827
• [Journal Article] A novel mutation in the von Hippel-Lindau tumor suppressor gene identified in a Japanese family with pheochromocytoma and hepatic hemangioma (2006)
  • Author(s): Takahashi K et al.
  • Journal Title: Intern Med 45(5) Pages: 265-269
  • NAID: 130000076543
• [Journal Article] Gene expression profile in the heart of spontaneous dwarf rat : In vivo effects of growth hormone (2006)
  • Author(s): Yoshioka S et al.
  • Journal Title: Biochem Biophys Res Commun 341(1) Pages: 88-93
• [Journal Article] Trophoblast stem cells rescue SOCS3 deficient placenta (2006)
  • Author(s): Takahashi Y et al.
  • Journal Title: Journal of Biochemistry 281(17) Pages: 11444-11445
• [Journal Article] Parathyroid Hormone Increases β -Catenin Levels through Smad3 in Mouse Osteoblastic Cells
  • Author(s): Takako, Tobimatsu, Hiroshi, Kaji, Hideaki, Sowa, Junko, Naito, Lucie, Canaff, Geoffrey, N, Hendy, Toshitsugu, Sugimoto, Kazuo, Chihara
  • Journal Title: Endocrinology 147(5) Pages: 2583-2590
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] 成人成長ホルモン分泌不全症の臨床 (2007)
  • Author(s): 千原和夫
  • Organizer: 第37回日本内科学会近畿支部生涯教育講演会
  • Place of Presentation: 京都
  • Year and Date: 2007-12-01
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] 成長ホルモン受容体拮抗剤により著明に耐糖能が改善した先端巨大症の一例 (2007)
  • Author(s): 高橋 裕
  • Organizer: 第44回日本糖尿病学会近畿地方会
  • Place of Presentation: 大阪
  • Year and Date: 2007-11-03
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] IGF-Iは脂肪細胞において活性酸素種(ROS)の産生促進を介し、インスリン依存性糖取り込みを抑制する (2007)
  • Author(s): 福岡秀規
  • Organizer: 第80回日本内分泌学会学術総会
  • Place of Presentation: 東京
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] 成長ホルモンは、Fox01の遺伝子発現、活性を調節し脂肪細胞におけるインスリンシグナルに拮抗する (2007)
  • Author(s): 福岡秀規
  • Organizer: 第34回日本神経内分泌学会
  • Place of Presentation: 群馬
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] IGF-I stimulates reactive oxygen species (ROS) production, thereby affecting insulin sensitivity in adipocytes. (2007)
  • Author(s): H. Fukuoka
  • Organizer: The 89th Annual Meeting of the Endocrine Society
  • Place of Presentation: Toronto, Canada
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] IGF-I stimulates reactive oxygen species (ROS) production, thereby affecting insulin sensitivity in adipocytes (2007)
  • Author(s): H, Fukuoka, Y, Takahashi, K, Iida, H, Nishizawa, M, Imanaka, R, Takeno, G, Iguchi, K, Takahashi, M, Takahashi, Y, Okimura, H, Kaji, K, Chihara
  • Organizer: The 89th Annual Meeting of the Endocrine Society
  • Place of Presentation: Toronto, Canada
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] IGF-I stimulates reactive oxygen species(ROS)production, thereby affecting insulin sensitivity in adipocytes (2007)
  • Author(s): H. Fukuoka
  • Organizer: The 89th Annual Meeting of the Endocrine Society
  • Place of Presentation: Canada, Toronto
• [Presentation] インスリン抵抗性、非アルコール性脂肪性肝炎を合併した成人成長ホルモン分泌不全症 (2006)
  • Author(s): 高橋 裕
  • Organizer: 第43回日本糖尿病学会近畿地方会
  • Place of Presentation: 京都
  • Year and Date: 2006-11-18
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] cDNA マイクロアレイを用いた骨格筋、骨における成長ホルモン標的遺伝子の解析 (2006)
  • Author(s): 吉岡嗣朗
  • Organizer: 第79回日本内分泌学会学術総会
  • Place of Presentation: 神戸
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] インスリン感受性および分泌を調節する新規ケモカインの同定と解析 (2006)
  • Author(s): 高橋 裕
  • Organizer: 第79回日本内分泌学会学術総会
  • Place of Presentation: 神戸
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] 成長ホルモンによって誘導されるケモカインCXCL14は3T3L1脂肪細胞におけるインスリン依存性の糖取り込みを促進する (2006)
  • Author(s): 高橋路子
  • Organizer: 第79回日本内分泌学会学術総会
  • Place of Presentation: 神戸
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] 成長ホルモンは、脂肪、肝細胞においてFOXO1の蛋白量、インスリンによるリン酸化を調節する (2006)
  • Author(s): 福岡秀規
  • Organizer: 第79回日本内分泌学会学術総会
  • Place of Presentation: 神戸
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Growth hormone regulates FOXO1 in adipocyte. (2006)
  • Author(s): Hidenori Fukuoka
  • Organizer: 88th Annual Meeting of the Endocrine Society
  • Place of Presentation: Boston, U.S.A.
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] New insights of chemokine in metabolism (2006)
  • Author(s): Yutaka Takahashi
  • Organizer: GPCR国際シンポジウム
  • Place of Presentation: 箱根
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] A metabolic syndrome model for adult growth hormone (GH) deficiency in GH-deficient spontaneous dwarf rat. (2006)
  • Author(s): Y. Takahashi
  • Organizer: The third international congress of the GRS and the IGF society
  • Place of Presentation: 神戸
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Growth hormone regulates FOX01 in adipocyte (2006)
  • Author(s): H, Fukuoka, Y, Takahashi, J, Nakae, H, Nishizawa, M, Imanaka, R, Takeno, K, Takahashi, K, Iida, Y, Okimura, H, Kaji, K, Chihara
  • Organizer: 88th Annual Meeting of the Endocrine Society
  • Place of Presentation: Boston, U.S.A
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] New insights of chemokine in metabolism (2006)
  • Author(s): Yutaka, Takahashi, Kazuo, Chihara
  • Organizer: International GPCR Symposium
  • Place of Presentation: Kanagawa, Japan
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] A metabolic syndrome model for adult growth hormone (GH) deficiency in GH-deficient spontaneous dwarf rat (2006)
  • Author(s): Y, Takahashi, S, Yoshioka, R, Kitazawa, T, Takahashi, H, Fukuoka, M, Takahashi, H, DNishizawa, S, Kitazawa, Y, Yanagisawa, M, Ito, R, Homma, J, Imai, S, Watanabe, K, Iida, G, Iguchi, H, Kaji, Y, Okimura, K, Chihara
  • Organizer: The third international congress of the GRS and the IGF society
  • Place of Presentation: Kobe, Japan
  • Description: 「研究成果報告書概要(欧文)」より
• [Book] NEW 薬理学 (2007)
  • Author(s): 千原和夫
  • Total Pages: 642
  • Publisher: (株)南光堂
  • Description: 「研究成果報告書概要(和文)」より
• [Book] 内分泌代謝 専門医ガイドブック (2007)
  • Author(s): 千原和夫
  • Total Pages: 322
  • Publisher: (株)診断と治療社
  • Description: 「研究成果報告書概要(和文)」より
• [Book] 今日の診断基準 (2007)
  • Author(s): 千原和夫
  • Total Pages: 979
  • Publisher: (株)南江堂
  • Description: 「研究成果報告書概要(和文)」より
• [Book] 「NEW 薬理学」改訂第5版 (2007)
  • Author(s): 千原和夫
  • Publisher: 南光堂
• [Book] Molecular Pathogenesis and Therapy of Pituitary Disease, HypoCCs Series Volume9 (2006)
  • Author(s): Edited by K Ho and K Chihara
  • Total Pages: 211
  • Publisher: Bio Scientifica LTD
  • Description: 「研究成果報告書概要(和文)」より
• [Book] インフォームドコンセントのための図説シリーズ 先端巨大症 (2006)
  • Author(s): 千原和夫(編集)
  • Total Pages: 51
  • Publisher: (株)医薬ジャーナル社
  • Description: 「研究成果報告書概要(和文)」より
• [Book] 成人成長ホルモン分泌不全症の臨床 (2006)
  • Author(s): 千原和夫
  • Total Pages: 189
  • Publisher: (株)メディカルレビュー社
  • Description: 「研究成果報告書概要(和文)」より
• [Book] 新しい診断と治療のABC43/内分泌3 機能性下垂体腫瘍 (2006)
  • Author(s): 千原和夫(編集・監修・執筆)
  • Total Pages: 211
  • Publisher: (株)最新医学社
  • Description: 「研究成果報告書概要(和文)」より