Biological role of genes at genetic alteration regions for proliferation and differentiation in hem

• Project/Area Number: 18390286
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Hematology
• Research Institution: Aichi Cancer Center Research Institute
• Principal Investigator: SETO Masao Aichi Cancer Center Research Institute, Molecular Medicine, Chief (80154665)
• Project Period (FY): 2006 – 2007
• Project Status: Completed (Fiscal Year 2007)
• Budget Amount: ¥17,540,000 (Direct Cost: ¥15,500,000、Indirect Cost: ¥2,040,000); Fiscal Year 2007: ¥8,840,000 (Direct Cost: ¥6,800,000、Indirect Cost: ¥2,040,000); Fiscal Year 2006: ¥8,700,000 (Direct Cost: ¥8,700,000)
• Keywords: ATLL / T / NK lymphoma / PTCL-U / T細胞リンパ腫 / マントル細胞リンパ腫 / BIM / NK / T白血病・リンパ腫 / 急性前骨髄急性白血病 / アレイCGH / ゲノム異常

Research Abstract

1. Adult T-cell leukemia/lymphoma : Array CGH analysis revealed that genome profiles of acute and lymphoma types are distinct, and suggested that ATLL genetic alterations after HTLV1 infection may play a role for oncogenesis of the two clinmically distinct disease subtypes. Further characterization of genomic regions and identification of responsible genes from these regions are warranted. This will reveal functional significance of these genes in cell profilferation and differentiations.
2. T/NK leukemia/lymphoma : extranodal T/NK and Aggressive NK lymphomas were found to have distinct genetic alteration patterns although clinical manifestations and EBV involvement are similar.
3. Peripheral T-cell lymphoma-unspecified(PTCL-U) : PTCL-U with multiple genomic alterations were found in about half of the cases and the pattern of genomic alterations are similar to that of ATLL lymphoma type. Histology also showed similarity in that they have peomorphic nuclear shape and CCR4 expression.
4. B-cell lymphoma : We have identified BIM gene loss in mantle cell lymphoma(MCL) . BIM gene is known to regulate BCL2 function. We therefore examined significance of apoptotic gene family by expression profiling analysis and suggested that a poor prognosis group in the MCL exist. This needs to further confirmation.

Research Products

• [Journal Article] TNFAIP3 is the target gene of chromosome band 6q23.3-q24.1 loss in cular.Adnexal marginal zone B cell lymphoma. (2008)
  • Author(s): Honma, K.
  • Journal Title: Genes Chrom.Cancer, 47 Pages: 1-8
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Clinical features and prognosis of gastric MALT lymphoma with special reference to responsiveness to H.pylori eradication and API2-MALT1 status. (2008)
  • Author(s): Nakamura, T.
  • Journal Title: Am J Gastroenterol 103 Pages: 62-70
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] TNFAIP3 is the target gene of chromosome band 6q23.3-q24.1 loss in cular. Adnexal marginal zone B cell lymphoma. (2008)
  • Author(s): Honma, K., Tsuzuki, S., Nakagawa, M, Karnan, S., Aizawa, Y., Kim, WS., Kim, YD., Ko, YH., Seto, M.
  • Journal Title: Genes Chrom. Cancer 47 Pages: 39821-39821
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Clinical features and prognosis of gastric MALT lymphoma with special reference to responsiveness to H. pylori eradication and API2-MALT1 status. (2008)
  • Author(s): Nakamura, T., Seto., M, Tajima, M., Kawai, H., Yokoi, T., Yatabe, Y., Nakamura, S.
  • Journal Title: Am J Gastroenterol 103 Pages: 62-70
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] TNFAIP3 is the target gene of chromosome band 6q23.3-q24.1 loss in cular. Adnexal marginal zone B cell lymphoma. (2008)
  • Author(s): Honma, K.
  • Journal Title: Genes Chrom. Cancer, 47 Pages: 1-8
  • Peer Reviewed
• [Journal Article] CD10(-)MUM1(+)follicular lymphoma lacks BCL2 translocation and shows characteristic biological and clinical features. (2007)
  • Author(s): Karube, K.
  • Journal Title: Blood 109 Pages: 3076-3079
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Genetic abnormalities involved in t(12;21)TEL-AML1 acute lymphoblastic leukemia:Analysis by means of array-based comparative genomic hybridization. (2007)
  • Author(s): Tsuzuki, S.
  • Journal Title: Cancer Sci. 98 Pages: 698-706
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Genomic profiling of malignant pleural mesothelioma with array-based comparative genomic hybridization shows frequent non-random chromosomal alteration regions including JUN amplification on 1p32.:,2007. (2007)
  • Author(s): Taniguchi, T.
  • Journal Title: Cancer Sci. 98 Pages: 438-446
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Isoform-Specific Potentiation of Stem and Progenitor Cell Engraftment by AML1/RUNX1. (2007)
  • Author(s): Tsuzuki, S.
  • Journal Title: PLoS Med. 4
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Chromosomal imbalances are associated with outcome of Helicobacter pylori eradication in t(11;18)(q21;q21)negative gastric malt lymphomas. (2007)
  • Author(s): Fukuhara, N.
  • Journal Title: Genes Chromosomes and Cancer 46 Pages: 784-790
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Genome-wide array-based comparative genomic hybridization of ocular marginal zone b cell lymphoma:comparison with pulmonary and nodalmarginal zone b cell lymphoma. (2007)
  • Author(s): Kim, W-S.
  • Journal Title: Genes Chromosomes and Cancer 46 Pages: 776-783
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] API2-MALT1 chimeric transcript-positive gastroduodenal MALT lymphoma with subsequent development of adenocarcinoma as a collision tumour over a clinical course of 7 years. (2007)
  • Author(s): Isaka, T.
  • Journal Title: Histopathology, 51 Pages: 119-123
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Synergistic action of the microRNA-17 polycistron and Myc in aggressive cancer development. (2007)
  • Author(s): Tagawa, H.
  • Journal Title: Cancer Sci. 98 Pages: 1482-1490
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Trisomy 3 is a specific genomic aberration of t(14;18)negative follicular lymphoma. (2007)
  • Author(s): Tagawa, H.
  • Journal Title: Leukemia 21 Pages: 2549-2551
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] High-resolution analysis of DNA copy number alterations and gene expression in renal clear cell carcinoma.:,2007. (2007)
  • Author(s): Yoshimoto, T.
  • Journal Title: J Pathol. 213 Pages: 392-401
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Genetic abnormalities involved in t(12 ; 21) TEL-AML1 acute lymphoblastic leukemia : Analysis by means of array-based comparative genomic hybridization. (2007)
  • Author(s): Tsuzuki, S., Karnan, S., Horibe, K., Matsumoto, K., Kato, K., Inukai, T., Goi, K., Sugita, K., Nakazawa, S., Kasugai, Y., Ueda, R., Seto., M.
  • Journal Title: Cancer Sci. 98 Pages: 698-706
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Genomic profiling of malignant pleural mesothelioma with array-based comparative genomic hybridization shows frequent non-random chromosomal alteration regions including JUN amplification on 1p32. (2007)
  • Author(s): Taniguchi, T., Karnan, S, Fukui, T., Yokoyama, T., Tagawa, H., Yokoi, K, Ueda, Y., Mitsudomi, T., Horio, Y, Hida, T., Yatabe, Y., Seto., M., Sekido, Y.
  • Journal Title: Cancer Sci. 98 Pages: 438-46
  • NAID: 10019482069
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Isoform-Specific Potentiation of Stem and Progenitor Cell Engraftment by AML1/RUNX1. (2007)
  • Author(s): Tsuzuki, S., Hong, D., Gupta, E., Matsuo, K., Seto., M., Enver, T.
  • Journal Title: PLoS Med. 4
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Chromosomal imbalances are associated with outcome of Helicobacter pylori eradication in t(11; 18)(q21; q21) negative gastric malt lymphomas. (2007)
  • Author(s): Fukuhara, N., Nakamura, T., Nakagawa, M, Tagawa, H., Takeuchi, I, Yatabe, Y., Morishima, Y, Nakamura, S., Seto., M.
  • Journal Title: Genes Chromosomes and Cancer 46 Pages: 784-790
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Genome-wide array-based comparative genomic hybridization of ocular marginal zone b cell lymphoma : comparison with pulmonary and nodal marginal zone b cell lymphoma. (2007)
  • Author(s): Kim, W-S., Honma, K., Karnan, S., Tagawa, H., Kim, Y-D., Oh, Y-L., Seto, M., Ko, Y-H.
  • Journal Title: Genes Chromosomes and Cancer 46 Pages: 776-783
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] API2-MALT1 chimeric transcript-positive gastroduodenal MALT lymphoma with subsequent development of adenocarcinoma as a collision tumour over a clinical course of 7 years. (2007)
  • Author(s): Isaka, T., Nakamura, T., Tajika, M., Kawai, H., Imaoka, H., Okamoto, Y, Aoki, M., Inoue, H., Takahashi, K., Mizuno, N., Sawaki, A., Yamao, K., Seto., M, Yokoi, T., Yatabe, Y., Nakamura, S.
  • Journal Title: Histopathology 51 Pages: 119-123
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Synergistic action of the microRNA-17 polycistron and Myc in aggreasive cancer development. (2007)
  • Author(s): Tagawa, H., Karube, K., Tsuzuki, S., Ohshima, K., Sato, M.
  • Journal Title: Cancer Sci. 98 Pages: 1482-1490
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Trisomy 3 is a specific genomic aberration of t(14 ; 18) negative follicular lymphoma. (2007)
  • Author(s): Tagawa, H., Karube, K., Guo, Y., Takeshita, M., Kikuchi, M., Morishima, Y., Nakamura, S., Ohshima, K., Seto M.
  • Journal Title: Leukemia 21 Pages: 2549-2551
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] High-resolution analysis of DNA copy number alterations and gene expression in renal clear cell carcinoma. (2007)
  • Author(s): Yoshimoto, T., Matsuura, K., Karnan, S., Tagawa, H., Nakada, C., Tanigawa, M., Tsukamoto, Y., Uchida, T., Kashima, K., Akizuki, S., Takeuchi, I., Sato, F., Mimata, H., Seto., M., Moriyama, M.
  • Journal Title: J Pathol. 213 Pages: 392-401
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Genetic abnormalities involved in t(12;21) TEL-AML1 acute lymphoblastic leukemia : Analysis by means of array-based comparative genomic hybridization. (2007)
  • Author(s): Tsuzuki, S
  • Journal Title: Cancer Sci. 98 Pages: 698-706
  • Peer Reviewed
• [Journal Article] Genomic profiling of malignant pleural mesothelioma with array-based comparative genomic hybridization shows frequent non-random chromoso mal alteration regions including JUN amplification on 1p32. :,2007. (2007)
  • Author(s): Taniguchi, T.
  • Journal Title: Cancer Sci. 98 Pages: 438-446
  • Peer Reviewed
• [Journal Article] Chromosomal imbalances are associated with outcome of Helicobacter pylori eradication in t(11;18)(q21;q21) negative gastric malt lymphomas. (2007)
  • Author(s): Fukuhara, N
  • Journal Title: Genes Chromosomes and Cancer 46 Pages: 784-790
  • Peer Reviewed
• [Journal Article] Genome-wide array-based comparative genomic hybridization of ocular marginal zone b cell lymphoma: comparison with pulmonary and nodalmarginal zone b cell lymphoma. (2007)
  • Author(s): Kim, W-S.
  • Journal Title: Genes Chromosomes and Cancer 46 Pages: 776-783
  • Peer Reviewed
• [Journal Article] Trisomy 3 is a specific genomic aberration of t(14;18) negative follicular lymphoma. (2007)
  • Author(s): Tagawa, H.
  • Journal Title: Leukemia 21 Pages: 2549-2551
  • Peer Reviewed
• [Journal Article] High-resolution analysis of DNA copy number alterations and gene expression in renal clear cell carcinoma. :,2007. (2007)
  • Author(s): Yoshimoto, T.
  • Journal Title: J Pathol. 213 Pages: 392-401
  • Peer Reviewed
• [Journal Article] Genomewide array-based comparative genomic hybridization analysis of acute promyelocytic leukemia. (2006)
  • Author(s): Karnan, S.
  • Journal Title: Genes Chrom.Cancer 45 Pages: 420-425
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Identification of subtype-specific genomic alterations in aggressive adult T-cell leukemia/lymphoma. (2006)
  • Author(s): Oshiro, A.
  • Journal Title: Blood 107 Pages: 4500-4507
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Characterization of target genes at the 2p15-16 amplicon in diffuse large B-cell lymphoma. (2006)
  • Author(s): Fukuhara, N.
  • Journal Title: Cancer Sci. 97 Pages: 499-504
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Expression profiling analysis of the CD5(+)diffuse large B-cell lymphoma subgroup:Development of a CD5 signature. (2006)
  • Author(s): Suguro, M.
  • Journal Title: Cancer Sci. 97 Pages: 868-874
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Genomewide array-based comparative genomic hybridization analysis of acute promyelocytic leukemia. (2006)
  • Author(s): Karnan, S., Tsuzuki, S., Kiyoi, H., Tagawa, H., Ueda, R., Seto, M., Naoe, T.
  • Journal Title: Genes Chrom. Cancer 45 Pages: 420-425
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Identification of subtype-specific genomic alterations in aggressive adult T-cell leukemia/lymphoma. (2006)
  • Author(s): Oshiro, A., Tagawa, H., Ohshima, K, Karube, K, Uike, N., Tashiro, Y., Utsunomiya, A., Masuda, M., Takasu, N., Nakanura, S., Morishima, Y., Seto, M.
  • Journal Title: Blood 107 Pages: 4500-4507
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Characterization of target genes at the 2p15-16 amplicon in diffuse large B-cell lymphoma. (2006)
  • Author(s): Fukuhara, N, Tagawa, H., Kameoka, Y., Kasugai, Y., Karnan, S., Kameoka, J., Sasaki, T., Morishima, Y., Nakamura, S, Seto., M.
  • Journal Title: Cancer Sci. 97 Pages: 499-504
  • NAID: 10018176261
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Expression profiling analysis of the CD5(+) diffuse large B-cell lymphoma subgroup : Development of a CDS signature. (2006)
  • Author(s): Suguro, M., Tagawa, H., Kagami, Y., Okamoto, M., Ohshima, K., Shiku, H., Morishima, Y., Nakamura, S., Seto, M.
  • Journal Title: Cancer Sci. 97 Pages: 868-874
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] CD10(-) MUM1(+) follicular lymphoma lacks BCL2 translocation and shows characteristic biological and clinical features. (2006)
  • Author(s): Karube, K., Guo, Y., Suzumiya, J., Sugita, Y., Nomura, Y., Yamamoto, K., Shimizu, K., Yoshida, S., Komatani, H., Takeshita, M., Kikuchi, M., Nakamura, N., Takasu, O., Arakawa, F., Tagawa, H., Seto, M., Ohshima, K.
  • Journal Title: Blood 109 Pages: 3076-3079
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Genomewide array-based comparative genomic hybridization analysis of acute promyelocytic leukemia. (2006)
  • Author(s): Karnan, S.
  • Journal Title: Genes Chrom. Cancer 45 Pages: 420-425
• [Journal Article] Characterization of target genes at 2p15-16 amplicon in diffuse large B cell lymphoma. (2006)
  • Author(s): Fukuhara, N.
  • Journal Title: Cancer Science 97 Pages: 499-504
• [Journal Article] Expression profiling analysis of the CD5(+) diffuse large B-cell lymphoma subgroup : Development of a CD5 signature. (2006)
  • Author(s): Suguro, M.
  • Journal Title: Cancer Sci. 97 Pages: 868-874
• [Journal Article] Molecular pathogenesis of MALT lymphoma : two signaling pathways underlying the antiapoptotic effect of API2-MALT1 fusion protein. (2006)
  • Author(s): Nakagawa, M.
  • Journal Title: Leukemia 20 Pages: 929-936
• [Journal Article] CD10(-)MUM1(+) follicular lymphoma lacks BCL2 translocation and shows characteristic biological and clinical features. (2006)
  • Author(s): Karube, K.
  • Journal Title: Blood (in press)
• [Presentation] Ocular adnexal marginal zone B cell lymphoma has characteristic deletion of TNFAIP3,suppressor of NF-〓B.(B6) (2008)
  • Author(s): Honma, K.
  • Organizer: KeyStone Symposia NF-kappaB
  • Place of Presentation: (米国)[ポスター(示説)]
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Ocular adnexal marginal zone B cell lymphoma has characteristic deletion of TNFAIP3, suppressor of NF-〓B.(B6) (2008)
  • Author(s): Honma, K.
  • Organizer: KeyStone Symposia NF-kappaB
  • Place of Presentation: (米国)[ポスター(示説)]
• [Presentation] 胃MALTリンパ腫のH.pylori 除菌反応とゲノム異常. (2007)
  • Author(s): 福原 規子
  • Organizer: 第47回日本網内系学会総会
  • Place of Presentation: (淡路)[ポスター]
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] 胃MALTリンパ腫の病態とゲノム異常. (2007)
  • Author(s): 中村 常哉
  • Organizer: 第13回日本ヘリコバクター学会総会
  • Place of Presentation: (滋賀)[シンポジウム]
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Functional analysis of the t(12;21)-associated TEL-AML1 fusion gene. (2007)
  • Author(s): Tsuzuki, S.
  • Organizer: 第66回日本癌学会学術総会
  • Place of Presentation: (横浜)[ポスター(示説)]
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Comparison of PTCL-U and lymphoma-type ATLL in terms of genomic imbalance by using array CGH analysis. (2007)
  • Author(s): 中川 雅夫
  • Organizer: 第66回日本癌学会学術総会
  • Place of Presentation: (横浜)[口演]
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Analysis of advanced gastric carcinoma with array-based comparative genomic hybridization. (2007)
  • Author(s): Uchida, T.,
  • Organizer: 第66回日本癌学会学術総会
  • Place of Presentation: (横浜)[ポスター(示説)]
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] High-resolution analysis of DNA copy number alterations and the geneexpression in renal clear cell carcinoma. (2007)
  • Author(s): Matsuura, K.
  • Organizer: 第66回日本癌学会学術総会
  • Place of Presentation: (横浜)[ポスター(示説)]
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Karnan S.,Tagawa,H.,Masao Seto:Ocular adnexal marginal zone B cell lymphoma showed distinct genomic profile. (2007)
  • Author(s): Honma, K.
  • Organizer: 第66回日本癌学会学術総会
  • Place of Presentation: (横浜)[ポスター(示説)]
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Activating mutations and copy number gains of Notch2 in diffuse large B-cell lymphoma. (2007)
  • Author(s): Lee, S-Y.
  • Organizer: 第66回日本癌学会学術総会
  • Place of Presentation: (横浜)[ワークショップ]
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] 濾胞性リンパ腫の臨床病態・分子病態. (2007)
  • Author(s): 加留部 謙之輔
  • Organizer: 第69回日本血液学会総会・第49回日本臨床血液学会総会
  • Place of Presentation: (横浜)[シンポジウム]
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] HUVECおよびlL-2依存性ATL腫瘍細胞株の樹立.Growth of ATLL cells by HUVEC and IL-2. (2007)
  • Author(s): 鏡味 良豊
  • Organizer: 第69回日本血液学会総会・第49回日本臨床血液学会総会
  • Place of Presentation: (横浜)[シンポジウム]
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] アレイCGH解析によるPTCL-U再分類の可能性. (2007)
  • Author(s): 中川 雅夫
  • Organizer: 第69回日本血液学会総会・第49回日本臨床血液学会総会
  • Place of Presentation: (横浜)[ポスター]
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Array CGH analysis for PTCL-U revealed a distinct subgroup with pathological and clinical relevance. (2007)
  • Author(s): Nakagawa, M.
  • Organizer: 第49回米国血液学会総会
  • Place of Presentation: (米国)[誌上発表]
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Ocular adnexal marginal zone B cell lymphoma has characteristic deletion at chromosome band 6q23.3-24.1 whose target is TNFAIP3. (2007)
  • Author(s): Honma, K.
  • Organizer: 第49回米国血液学会総会
  • Place of Presentation: (米国)[ポスター(示説)]
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Array CGH analysis of peripheral T-cell lymphoma-unspecified revealed common genomic alterations with adult T-cell leukemia/lymphoma. (2007)
  • Author(s): Nakagawa M., Nakagawa-Oshiro A., Tagawa H., Karnan, S., Tsuzuki S, Ohshima, K., Nakamura, S., Seto, M.
  • Organizer: An AACR special conference in cancer research ; oncogenomis 2007
  • Place of Presentation: USA
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Functional analysis of the t(12 ; 21)-associated TEL-AML1fusion gene. (2007)
  • Author(s): Tsuzuki, S., Seto, M.
  • Organizer: 66th Annual Meeting of the Japanese Cancer Association
  • Place of Presentation: Yokohama
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Analysis of advanced gastric carcinoma with array-based comparative genomic hybridization. (2007)
  • Author(s): Uchida, T., Karnan, S., Tsukamoto, Y., Noguchi, T., Tagawa H., Hijiya, N., Matsuura, K., Seto, M., Moriyama, M.
  • Organizer: 66th Annual Meeting of the Japanese Cancer Association
  • Place of Presentation: Yokohama
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] 胃MALTリンパ腫のH.pylori除菌反応とゲノム異常. (2007)
  • Author(s): 福原 規子
  • Organizer: 第47回日本網内系学会総会
  • Place of Presentation: (淡路)[ポスター]
• [Presentation] High-resolution analysis of DNA copy number alterations and the gene expression in renal clear cell carcinoma. (2007)
  • Author(s): Matsuura, K
  • Organizer: 第66回日本癌学会学術総会
  • Place of Presentation: (横浜)[ポスター(示説)]
• [Presentation] Karnan S., Tagawa, H., Masao Seto: Ocular adnexal marginal zone B cell lymphoma showed distinct genomic profile. (2007)
  • Author(s): Honma, K.
  • Organizer: 第66回日本癌学会学術総会
  • Place of Presentation: (横浜)[ポスター(示説)]
• [Presentation] HUVECおよびIL-2依存性ATL腫瘍細胞株の樹立.Growth of ATLL cells by HUVEC and IL-2. (2007)
  • Author(s): 鏡味 良豊
  • Organizer: 第69回日本血液学会総会・第49回日本臨床血液学会総会
  • Place of Presentation: (横浜)[シンポジウム]
• [Presentation] Genome-wide array-based comparative genomic hybridization of ocular marginal zone B-cell lymphoma:Comparison with pulmonary and nodal marginal zone B-cell lymphoma. (2006)
  • Author(s): Kim, W.
  • Organizer: 第9回日韓リンパ腫会議,
  • Place of Presentation: (韓国)[Oral Presentation]
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Genomic alterations in aggressive adult T-cell leukemia/lymphoma and PTCL-U. (2006)
  • Author(s): Oshiro, A.
  • Organizer: 第9回日韓リンパ腫会議
  • Place of Presentation: (韓国)[Oral Presentation]
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] 高密度、高解像度のゲノム解析法(Array CGH法)を用いた悪性リンパ腫のゲノム異常解析. (2006)
  • Author(s): 瀬戸 加大
  • Organizer: 第65回日本癌学会学術総会
  • Place of Presentation: (横浜)[シンポジウム]
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] 造血幹/前駆細胞におけるRunx1アイソフォームの役割. (2006)
  • Author(s): 都築 忍
  • Organizer: 第65回日本癌学会学術総会
  • Place of Presentation: (横浜)[ポスター]
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] 悪性胸膜中皮腫における染色体11q22増幅領域の解析. (2006)
  • Author(s): 横山 俊彦
  • Organizer: 第65回日本癌学会学術総会
  • Place of Presentation: (横浜)[ポスター]
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Array-based comparative genomic hybridization(array-CGH)法を用いた胃癌における網羅的な染色体構造異常の解析. (2006)
  • Author(s): 内田 智久
  • Organizer: 第65回日本癌学会学術総会
  • Place of Presentation: (横浜)[ポスター]
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] 成人T細胞白血病/リンパ腫のarray CGHによるゲノム異常解析とオリゴDNAマイクロアレイを用いた遺伝子発現解析の比較. (2006)
  • Author(s): 中川 綾
  • Organizer: 第65回日本癌学会学術総会
  • Place of Presentation: (横浜)[ポスター]
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] 濾胞性リンパ腫のゲノムコピー数異常および遺伝子異常-BCL2転座陽性群と陰性群との比較. (2006)
  • Author(s): 田川 博之
  • Organizer: 第65回日本癌学会学術総会
  • Place of Presentation: (横浜)[ポスター]
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] 胃MALTリンパ腫のアレイCGH解析. (2006)
  • Author(s): 福原 規子
  • Organizer: 第65回日本癌学会学術総会
  • Place of Presentation: (横浜)[ポスター]
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] アレイCGHを用いた腎細胞癌ゲノム異常の網羅的遺伝子解析. (2006)
  • Author(s): 吉本 多一郎
  • Organizer: 第65回日本癌学会学術総会
  • Place of Presentation: (横浜)[一般口演]
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Array CGH法を用いた悪性胸膜中皮腫の網羅的ゲノム解析. (2006)
  • Author(s): 谷口 哲郎
  • Organizer: 第65回日本癌学会学術総会
  • Place of Presentation: (横浜)[ポスター]
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] リンパ節内支持細胞によるリンパ系腫瘍細胞の増殖. (2006)
  • Author(s): 鏡味 良豊
  • Organizer: 第68回日本血液学会総会・第48回日本臨床血液学会総会
  • Place of Presentation: (福岡)[ポスター]
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] びまん性大細胞型B細胞型非ホジキンリンパ腫におけるNotch2遺伝子の変異. (2006)
  • Author(s): 李 碩瑛
  • Organizer: 第68回日本血液学会総会・第48回日本臨床血液学会総会
  • Place of Presentation: (福岡)[一般口演]
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] 成人T細胞白血病/リンパ腫のオリゴDNAマイクロアレイを用いた遺伝子発現解析.2006, (2006)
  • Author(s): 中川 綾
  • Organizer: 第68回日本血液学会総会・第48回日本臨床血液学会総会,
  • Place of Presentation: (福岡)[ポスター]
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] The synergistic action of the microRNA-17 cluster with c-MYC in Aggressive cancer development. (2006)
  • Author(s): Tagawa, H.
  • Organizer: 第48回米国血液学会総会
  • Place of Presentation: (米国)[ポスター]
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Array CGH analysis for PTCL-U revealed two genetically distinct subgroups. (2006)
  • Author(s): Nakagawa, M.
  • Organizer: 第48回米国血液学会総会
  • Place of Presentation: (米国)[ポスター]
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Genomic imbalances are associated with outcome of helicobacter pylorieradication in t(11;18)(q21;q21)-negative gastric MALT lymphomas. (2006)
  • Author(s): Fukuhara, N.
  • Organizer: 第48回米国血液学会総会,
  • Place of Presentation: (米国)[ポスター]
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Genomic alterations in aggressive adult T-cell leukemia/lymphoma and PTCL-U. (2006)
  • Author(s): Oshiro, A., Tagawa, H., Nakagawa M., Oshima, K., Utsunomiya A., Nakamura, S., Morishima, Y., Seto, M.
  • Organizer: The 9th Korean-Japanese Lymphoreticular Workshop
  • Place of Presentation: South Korea
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] The synergistic action of the microRNA-17 cluster with c-MYC in Aggressive cancer development. (2006)
  • Author(s): Tagawa, H., Karube, K., Tsuzuki, S., Ohshima, K., Seto M.
  • Organizer: 48th American society of hematology Annual meeting and enposition
  • Place of Presentation: USA
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Array CGH analysis for PTCL-U revealed two genetically distinct subgroups. (2006)
  • Author(s): Nakagawa, M., Oshiro, A., Tagawa, H., Karnan S., Tsuzuki, S., Ohshima, K., Nakamura, S., Seto, M.
  • Organizer: 48th American society of hematology Annual meeting and enposition
  • Place of Presentation: USA
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Genomic imbalances are associated with outcome of helicobacter pylori eradication in t(11; 18)(q21; q21) -negative gastric MALT lymphomas. (2006)
  • Author(s): Fukuhara, N., Tagawa, H., Nakamura, T., Inagaki, H., Morishima, Y., Nakamura, S., Seto M.
  • Organizer: 48th American society of hematology Annual meeting and enposition
  • Place of Presentation: USA
  • Description: 「研究成果報告書概要(欧文)」より
• [Remarks] 「研究成果報告書概要(和文)」より
  • URL: http://read.jst.go.jp/
• [Remarks] 研究開発支援総合ディレクトリ(ReaD)
  • URL: http://read.jst.go.jp/
• [Patent(Industrial Property Rights)] びまん性大細胞方型B細胞リンパ腫の病型の診断方法及び予後診断の方法 (2006)
  • Inventor(s): 瀬戸 加大 他3名
  • Industrial Property Rights Holder: 愛知県, 日本ガイシ
  • Filing Date: 2006-04-19
• [Patent(Industrial Property Rights)] 生物体のタイプを判別するためのマーカーの選択方法及び選択されたマーカーの利用 (2006)
  • Inventor(s): 瀬戸 加大 他4名
  • Industrial Property Rights Holder: 愛知県, 日本ガイシ, 三重大学
  • Filing Date: 2006-08-25