Study for the viral chemokine-associated pathogenesis in cytomegalovirus infection
Project/Area Number |
18390293
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Research Category |
Grant-in-Aid for Scientific Research (B)
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Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
膠原病・アレルギー・感染症内科学
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Research Institution | Tokai University |
Principal Investigator |
NODA Satoshi Tokai University, 医学部, 講師 (10297260)
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Co-Investigator(Kenkyū-buntansha) |
SATO Masahito 鹿児島大学, フロンティアサイぇンス研究進センター, 教授 (30287099)
田中 和生 東海大学, 医学部, 准教授 (50236569)
竹腰 正隆 東海大学, 医学部, 講師 (80221373)
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Co-Investigator(Renkei-kenkyūsha) |
SATO Masahito 鹿児島大学, フロンティアサイぇンス研究進センター, 教授 (30287099)
TANAKA Kazuo 昭和大学, 医学部, 教授 (50236569)
TAKEKOSHI Masataka 東海大学, 医学部, 講師 (80221373)
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Project Period (FY) |
2006 – 2008
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Project Status |
Completed (Fiscal Year 2008)
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Budget Amount *help |
¥8,800,000 (Direct Cost: ¥7,300,000、Indirect Cost: ¥1,500,000)
Fiscal Year 2008: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2007: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Fiscal Year 2006: ¥2,300,000 (Direct Cost: ¥2,300,000)
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Keywords | 感染症学 / LMP / MCK-2リガンド / Avidity anaysis / バチラス属 / cell-to-cell spread / CXCR4 / CODEHOP / 内因性ヘルペスウイルス / マウスサイトメガロウイルス / ウイルスケモカインホモログ / MCK-2 / Late myeloid progenitor |
Research Abstract |
1) マウスサイトメガロウイルス(MCMV)由来ケモカインホモログMCK-2は、後期骨髄細胞をその標的細胞として、当該ウイルスの病原性の増大に寄与している知見を得た 2) ヒトヘルペスウイルス潜伏感染/再活性化の動物モデルの構築へむけ、コモンマーモセットにおけるCODEHOP法を用いた内因性ヘルペスウイルスの検出ならびに同定を確立した
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Report
(4 results)
Research Products
(48 results)
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[Journal Article] Protection from lethal viral infection by adoptive transfer of CD8 T cells genetically engineered to express viral-specific innate immune receptor.2007
Author(s)
Iizuka, K, Nakajima, K., Iizuka, YM, Takase, K., Kato, S., Noda, S., Tanaka, K., Kanagawa, O.
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Journal Title
J. Immunol. 179
Pages: 1122-1228
Related Report
Peer Reviewed
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[Journal Article] Protection from lethal viral infection by adoptive transfer of CD8 T cells genetically engineered to express viral-specific innate immune receptor2007
Author(s)
Iizuka, K, Nakajima, K, Iizuka, YM, Takase, K, Kato, S, Noda, S, Tanaka, K, Kanagawa, O
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Journal Title
J.Immunol. 179
Pages: 1122-1228
Related Report
Peer Reviewed
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[Journal Article] One-step generation of recombineering constructs by asymmet ric-end ligation and negative selection2007
Author(s)
Ohtsuka, M, Mizutani, A, Kikuti, YY, Kulski, JK, Sato, M, Kimura, M, Tanaka, M, Inoko, H
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Journal Title
Anal.Biochem 360
Pages: 306-308
Related Report
Peer Reviewed
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[Journal Article] Cytomegalovirus MCK-2 controls mobilization and recruitment of myeloid progenitor cells to facilitate dissemination2006
Author(s)
Noda, S, Aguirre, SA, BitMansour, A., Brown, JM, Sparer, TE, Huang, J, Mocarski, ES.
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Journal Title
Related Report
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[Journal Article] Construction of mouse 129/Ola BAC library for targeting experiments using E14 embryonic stem cells.2006
Author(s)
Ohtsuka, M, Ishi, K, Kikuti, YY, Warita, T, Suzuki, D, Sato, M, Kimura, M, Inoko, H.
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Journal Title
Genes and genetic Systems 81
Pages: 143-146
NAID
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[Journal Article] Treatment of Natto, a fermented soybean preparation, to prevent excessive plasma vitamin K concentrations in patients taking Warfarin.2006
Author(s)
Homma, K., Wakana, N., Suzuki, Y., Nukui, M., Daimatsu, T., Tanaka, E., Tanaka, K., Koga, Y., Nakajima, Y., Nakazawa, H.
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Journal Title
J. Nutr. Sci. Vitamiol. 52
Pages: 297-301
NAID
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[Journal Article] Production of Fab fragment corresponding to surface protein antigen of Streptococcus mutans serotype c-derived peptide by Escherichia coli and cultured tobacco cells.2006
Author(s)
Yano, A., Takekoshi, M., Morita, E., Imai, S., Nisizawa, T., Hanada, N.
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Journal Title
J. Biosci. Bicengineer. 101
Pages: 251-256
NAID
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[Presentation] NKT cell deficient mice increases sysceptibility to influenza virus infection.2008
Author(s)
Ishikawa, H, Kutsukake, E, Fukuyi, T, Hata, A, Noda, S, Tanaka, K., Masthumoto, T.
Organizer
The 38^<th> Annual Meeting of the Japanese Society for Immunology
Place of Presentation
Kyoto
Related Report
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[Presentation] NKT cell deficient mice increases sysceptibility to influenza virus infection.2008
Author(s)
Ishikawa. H, Kutsukake, E, Fukui, T, Hata, A, Noda, S, Tanaka, K., Matsumoto, T
Organizer
第38回日本免疫学会
Place of Presentation
京都
Related Report
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[Presentation] Protection of mice from lethal viral infection by CD8 T-cells expressing virus-specific innate immune receptor2006
Author(s)
Kato, T., Nakajima, C., Iizuka-Matsubayashi, Y., Takase, M., Noda, S., Tanaka, K., Kanagawa, O., Iizuka, K.
Organizer
第36回日本免疫学会
Place of Presentation
大阪
Related Report
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[Book] Myeloid cell recruitment and function in pathogenesis and latency. In : Reddehase, M.J., ed. Cytomegaloviruses : Molecular Biology and Immunology.(64)2006
Author(s)
Mocarski, E.S., G. Hahn, K.L. White, J.Xu, B. Slobedman, L. Hertel, S.A. Aguirre, S. Noda.
Publisher
Hethersettorfolk, Udom : Caister Academic Press
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[Book] Cytomegaloviruses : Molecular Biology and Immunology : Myeloid cell recruitment and function in pathogenesis and latency.2006
Author(s)
Mocarski, E.S., G.Hahn, K.L.White, J.Xu, B.Slobedman, L.Hertel, S.A.Aguirre, S.Noda.
Publisher
Caister Academic Press, Hethersett, Norfolk, United Kingdom
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