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Study for the viral chemokine-associated pathogenesis in cytomegalovirus infection

Research Project

Project/Area Number 18390293
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field 膠原病・アレルギー・感染症内科学
Research InstitutionTokai University

Principal Investigator

NODA Satoshi  Tokai University, 医学部, 講師 (10297260)

Co-Investigator(Kenkyū-buntansha) SATO Masahito  鹿児島大学, フロンティアサイぇンス研究進センター, 教授 (30287099)
田中 和生  東海大学, 医学部, 准教授 (50236569)
竹腰 正隆  東海大学, 医学部, 講師 (80221373)
Co-Investigator(Renkei-kenkyūsha) SATO Masahito  鹿児島大学, フロンティアサイぇンス研究進センター, 教授 (30287099)
TANAKA Kazuo  昭和大学, 医学部, 教授 (50236569)
TAKEKOSHI Masataka  東海大学, 医学部, 講師 (80221373)
Project Period (FY) 2006 – 2008
Project Status Completed (Fiscal Year 2008)
Budget Amount *help
¥8,800,000 (Direct Cost: ¥7,300,000、Indirect Cost: ¥1,500,000)
Fiscal Year 2008: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2007: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Fiscal Year 2006: ¥2,300,000 (Direct Cost: ¥2,300,000)
Keywords感染症学 / LMP / MCK-2リガンド / Avidity anaysis / バチラス属 / cell-to-cell spread / CXCR4 / CODEHOP / 内因性ヘルペスウイルス / マウスサイトメガロウイルス / ウイルスケモカインホモログ / MCK-2 / Late myeloid progenitor
Research Abstract

1) マウスサイトメガロウイルス(MCMV)由来ケモカインホモログMCK-2は、後期骨髄細胞をその標的細胞として、当該ウイルスの病原性の増大に寄与している知見を得た
2) ヒトヘルペスウイルス潜伏感染/再活性化の動物モデルの構築へむけ、コモンマーモセットにおけるCODEHOP法を用いた内因性ヘルペスウイルスの検出ならびに同定を確立した

Report

(4 results)
  • 2008 Annual Research Report   Final Research Report ( PDF )
  • 2007 Annual Research Report
  • 2006 Annual Research Report
  • Research Products

    (48 results)

All 2009 2008 2007 2006 Other

All Journal Article (31 results) (of which Peer Reviewed: 10 results) Presentation (11 results) Book (6 results)

  • [Journal Article] Role of microbiota in oral tolerance induction and infection.2008

    • Author(s)
      Tanaka, K, Noda, S., Ishikawa, H., Hata, A., Sawamura, S.
    • Journal Title

      Int. J. Prob. Preb. 3

      Pages: 47-52

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] 常在細菌叢によるサイトメガロウイルス特異的CD8+メモリーT細胞の維持 : 生体内における細胞分化ならびに増殖・維持について2008

    • Author(s)
      田中和生, 畑明宏, 野田敏司
    • Journal Title

      臨床免疫・アレルギー科 49

      Pages: 330-336

    • Related Report
      2008 Annual Research Report 2008 Final Research Report
  • [Journal Article] HCMV関連皮膚疾患の診断と治療2008

    • Author(s)
      野田敏司, 田中和生
    • Journal Title

      MB Derma 147 147

      Pages: 71-76

    • Related Report
      2008 Final Research Report
  • [Journal Article] In vivo killing assay.2008

    • Author(s)
      畑明宏, 田中和生, 野田敏司
    • Journal Title

      生物機能研究会会誌 12

      Pages: 19-21

    • Related Report
      2008 Final Research Report
  • [Journal Article] サイトメガロウイルス感染症と検査と治療2008

    • Author(s)
      野田敏司, 畑明宏, 石川裕樹, 前田康行, 志水恵子, 亀谷美恵, 伊東秀記, 田中和生
    • Journal Title

      生物機能研究会会誌 12 12

      Pages: 1-6

    • Related Report
      2008 Final Research Report
  • [Journal Article] Role of microbiota in oral tolerance induction and infection.2008

    • Author(s)
      Tanaka, K, Noda, S, Ishikawa, H, Hata, A, Sawamura, S.
    • Journal Title

      International Journal of Probiotics &Prebiotics 3

      Pages: 47-52

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] HCMV関連皮膚疾患の診断と治療2008

    • Author(s)
      野田敏司, 田中和生
    • Journal Title

      MB Derma 147

      Pages: 71-76

    • Related Report
      2008 Annual Research Report
  • [Journal Article] Role of the indigenous microbiota in maintaining the virus-specific CD8 memory T cells in the lung of mice infected with murine CMV.2007

    • Author(s)
      Tanaka, K, Sawamura, S., Satoh, T., Kobayashi, K., Noda, S.
    • Journal Title

      J. Immunol. 178

      Pages: 5209-5216

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Protection from lethal viral infection by adoptive transfer of CD8 T cells genetically engineered to express viral-specific innate immune receptor.2007

    • Author(s)
      Iizuka, K, Nakajima, K., Iizuka, YM, Takase, K., Kato, S., Noda, S., Tanaka, K., Kanagawa, O.
    • Journal Title

      J. Immunol. 179

      Pages: 1122-1228

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Myeloid cell contribution to cytomegalovirus pathogenesis and latency.2007

    • Author(s)
      Noda, S., Mocarski E. S., Hata, A., Ito, H., Tanaka, K.
    • Journal Title

      Report Jpn. Assoc. Biol. Func. Res. 11

      Pages: 12-18

    • Related Report
      2008 Final Research Report
  • [Journal Article] プロバイオティクスとウイルス感染2007

    • Author(s)
      野田敏司, 相場勇志
    • Journal Title

      日本医事新報 4347

      Pages: 95-97

    • Related Report
      2008 Final Research Report
  • [Journal Article] メモリーCD8+T細胞 : 生体内における細胞分化ならびに増殖・維持について2007

    • Author(s)
      畑明宏, 田中和生, 野田敏司
    • Journal Title

      生物機能研究会会誌 11

      Pages: 22-24

    • Related Report
      2008 Final Research Report
  • [Journal Article] Role of the indigenous microbiota in maintaining the virus-specific CD8 memory T cells in the lung of mice infected with murine CMV2007

    • Author(s)
      Tanaka, K, Sawamura, S, Satoh, T, Kobayashi, K, Noda, S
    • Journal Title

      J.Immunol. 178

      Pages: 5209-5216

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Protection from lethal viral infection by adoptive transfer of CD8 T cells genetically engineered to express viral-specific innate immune receptor2007

    • Author(s)
      Iizuka, K, Nakajima, K, Iizuka, YM, Takase, K, Kato, S, Noda, S, Tanaka, K, Kanagawa, O
    • Journal Title

      J.Immunol. 179

      Pages: 1122-1228

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] One-step generation of recombineering constructs by asymmet ric-end ligation and negative selection2007

    • Author(s)
      Ohtsuka, M, Mizutani, A, Kikuti, YY, Kulski, JK, Sato, M, Kimura, M, Tanaka, M, Inoko, H
    • Journal Title

      Anal.Biochem 360

      Pages: 306-308

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Myeloid cell contribution to cytomegalovirus pathogenesis and latency2007

    • Author(s)
      Noda, S, Mocarski, ES, Hata, A, Ito, H, Tanaka, K
    • Journal Title

      Report Jpn.Assoc.Biol.Func.Res. 11

      Pages: 12-18

    • Related Report
      2007 Annual Research Report
  • [Journal Article] プロパイオティクスとウイルス感染2007

    • Author(s)
      野田 敏司, 相場 勇志
    • Journal Title

      日本医事新報 4347

      Pages: 95-97

    • Related Report
      2007 Annual Research Report
  • [Journal Article] メモリーCD8+T細胞=生体内における細胞分化ならびに増殖維持について2007

    • Author(s)
      畑明 宏, 田中 和生, 野田 敏司
    • Journal Title

      生物幾能研究会会誌 11

      Pages: 22-24

    • Related Report
      2007 Annual Research Report
  • [Journal Article] Cytomegalovirus MCK-2 controls mobilization and recruitment of myeloid progenitor cells to facilitate dissemination.2006

    • Author(s)
      Noda S, Aguirre SA, BitMansour A, Brown JM, Sparer TE, Huang J, Mocarski ES.
    • Journal Title

      Blood 107

      Pages: 30-38

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Myeloid cell recruitment and function by a virus-encoded chemokine homolog in cytomegalovirus infection.2006

    • Author(s)
      Noda, S., Hata, A., Mocarski E. S.
    • Journal Title

      Report Jpn. Assoc. Biol. Func. Res. 10

      Pages: 1-8

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Cytomegalovirus MCK-2 controls mobilization and recruitment of myeloid progenitor cells to facilitate dissemination2006

    • Author(s)
      Noda, S, Aguirre, SA, BitMansour, A., Brown, JM, Sparer, TE, Huang, J, Mocarski, ES.
    • Journal Title

      Blood 107

      Pages: 30-38

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Myeloid cell recruitment and function by a virus-encoded chemokine homolog in cytomegalovirus infection.2006

    • Author(s)
      Noda, S., Hata, A., Mocarski E.S.
    • Journal Title

      Report of Japanese Association for. Biological Function Research. 10

      Pages: 1-8

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Construction of mouse 129/Ola BAC library for targeting experiments using E14 embryonic stem cells.2006

    • Author(s)
      Ohtsuka, M, Ishi, K, Kikuti, YY, Warita, T, Suzuki, D, Sato, M, Kimura, M, Inoko, H.
    • Journal Title

      Genes and genetic Systems 81

      Pages: 143-146

    • NAID

      10019162105

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Strain difference in tolerance to low-temperature treatment of fertilized mouse oocytes.2006

    • Author(s)
      Sakurai, T, Watanabe, S, Kimura, M, Sato, M
    • Journal Title

      Reproductive Medicine and Biology 5

      Pages: 43-50

    • NAID

      10018116435

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Therapuetic effect of a traditional Chinese medicine, ren-shen-yanf-rong-tang(Japanse name : Ninjin'yoeito) on nitric oxide-mediating lung injury in a mouse infected with murine cytomegalovirus.2006

    • Author(s)
      Tanaka, K, Sawamura, S.
    • Journal Title

      Int. Immunopharmacol. 6

      Pages: 678-685

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Treatment of Natto, a fermented soybean preparation, to prevent excessive plasma vitamin K concentrations in patients taking Warfarin.2006

    • Author(s)
      Homma, K., Wakana, N., Suzuki, Y., Nukui, M., Daimatsu, T., Tanaka, E., Tanaka, K., Koga, Y., Nakajima, Y., Nakazawa, H.
    • Journal Title

      J. Nutr. Sci. Vitamiol. 52

      Pages: 297-301

    • NAID

      110005518939

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Production of Fab fragment corresponding to surface protein antigen of Streptococcus mutans serotype c-derived peptide by Escherichia coli and cultured tobacco cells.2006

    • Author(s)
      Yano, A., Takekoshi, M., Morita, E., Imai, S., Nisizawa, T., Hanada, N.
    • Journal Title

      J. Biosci. Bicengineer. 101

      Pages: 251-256

    • NAID

      110004704902

    • Related Report
      2006 Annual Research Report
  • [Journal Article] 抗体医薬によるウイルス感染症の予防と治療2006

    • Author(s)
      竹腰正隆, 前田史子
    • Journal Title

      PHARMSTAGE 6

      Pages: 30-35

    • Related Report
      2006 Annual Research Report
  • [Journal Article] In Vivo Killing Assay

    • Author(s)
      畑明宏, 田中和生, 野田敏司
    • Journal Title

      生物機能研究会会誌 in press

    • Related Report
      2008 Annual Research Report
  • [Journal Article] サイトメガロウイルス感染症の検査と治療

    • Author(s)
      野田敏司, 畑明宏, 石川裕樹, 前田康行, 志水恵子, 亀谷美恵, 伊東秀記, 田中和生
    • Journal Title

      生物機能研究会会誌 in press

    • Related Report
      2008 Annual Research Report
  • [Journal Article] Role of microbiota in oral tolerance induction and infection

    • Author(s)
      Tanaka, K, Noda, S, Ishikawa, H, Hata, A, Sawamura, S
    • Journal Title

      Int J.Prob.Preb (in press)

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Presentation] マウスサイトメガロウイルス特異的CD8陽性メモリーT細胞の維持における腸内細菌叢の役割2009

    • Author(s)
      田中和生, 畑明宏, 幸田力, 柳川容子, 野田敏司
    • Organizer
      日本無菌生物ノートバイオロジー学会
    • Place of Presentation
      大阪
    • Related Report
      2008 Final Research Report
  • [Presentation] マウスサイトメガロウイルス特異的CD8陽性メモリ-T細胞の維持における腸内細菌叢の役割2009

    • Author(s)
      田中和生, 畑明宏, 幸田力, 柳川容子, 野田敏司
    • Organizer
      第41回日本無菌生物ノートバイオロジー学会
    • Place of Presentation
      大阪
    • Related Report
      2008 Annual Research Report
  • [Presentation] マウスサイトメガロウイルス特異的CD8陽性メモリーT細胞in vivoでの細胞傷害活性の検討2008

    • Author(s)
      畑明宏, 野田敏司, 石川裕樹, 田中和生
    • Organizer
      第56回日本ウイルス学会
    • Place of Presentation
      岡山
    • Related Report
      2008 Annual Research Report 2008 Final Research Report
  • [Presentation] NKT cell deficient mice increases sysceptibility to influenza virus infection.2008

    • Author(s)
      Ishikawa, H, Kutsukake, E, Fukuyi, T, Hata, A, Noda, S, Tanaka, K., Masthumoto, T.
    • Organizer
      The 38^<th> Annual Meeting of the Japanese Society for Immunology
    • Place of Presentation
      Kyoto
    • Related Report
      2008 Final Research Report
  • [Presentation] NKT cell deficient mice increases sysceptibility to influenza virus infection.2008

    • Author(s)
      Ishikawa. H, Kutsukake, E, Fukui, T, Hata, A, Noda, S, Tanaka, K., Matsumoto, T
    • Organizer
      第38回日本免疫学会
    • Place of Presentation
      京都
    • Related Report
      2008 Annual Research Report
  • [Presentation] サイトメガロウイルス特異的CD8陽性メモリーT細胞の維持における常在細菌叢の役割2007

    • Author(s)
      田中和生, 野田敏司, 澤村貞昭
    • Organizer
      第40回日本無菌性物ノートバイオロジー学会
    • Place of Presentation
      横浜
    • Related Report
      2008 Final Research Report
  • [Presentation] Protective role of the oral administration of Bacillus coagulans, a spore-forming lactic acid bateria, againt murine CMV (MCMV) infection2007

    • Author(s)
      野田敏司, 志水恵子, 畑明宏, 相場勇志, 田中和生
    • Organizer
      第55回日本ウイルス学会
    • Place of Presentation
      札幌
    • Related Report
      2008 Final Research Report
  • [Presentation] サイトメガロウイルス特異的CD8陽性メモリーT細胞の維持における常在細菌叢の役割2007

    • Author(s)
      田中和生, 畑明宏, 澤村貞昭, 野田敏司
    • Organizer
      第55回日本ウイルス学会
    • Place of Presentation
      札幌
    • Related Report
      2008 Final Research Report
  • [Presentation] Protective role of the oral administration of Bacillus coagulan,a spore-forming lactic acid bacteria,against murine CMV (MCMV)infection2007

    • Author(s)
      野田 敏司, 志水 恵子, 畑明 宏, 相場 勇志, 田中 和生
    • Organizer
      第55回日本ウイルス学会
    • Place of Presentation
      横浜
    • Related Report
      2007 Annual Research Report
  • [Presentation] サイトメガロウイルス特異的CD8陽性メモリーT細胞の維持における常在細菌叢の役割2007

    • Author(s)
      田中 和生, 畑明 宏, 澤村 貞昭, 野田 敏司
    • Organizer
      第55回日本ウイルス学会
    • Place of Presentation
      横浜
    • Related Report
      2007 Annual Research Report
  • [Presentation] Protection of mice from lethal viral infection by CD8 T-cells expressing virus-specific innate immune receptor2006

    • Author(s)
      Kato, T., Nakajima, C., Iizuka-Matsubayashi, Y., Takase, M., Noda, S., Tanaka, K., Kanagawa, O., Iizuka, K.
    • Organizer
      第36回日本免疫学会
    • Place of Presentation
      大阪
    • Related Report
      2008 Final Research Report
  • [Book] Myeloid cell recruitment and function in pathogenesis and latency. In : Reddehase, M.J., ed. Cytomegaloviruses : Molecular Biology and Immunology.(64)2006

    • Author(s)
      Mocarski, E.S., G. Hahn, K.L. White, J.Xu, B. Slobedman, L. Hertel, S.A. Aguirre, S. Noda.
    • Publisher
      Hethersettorfolk, Udom : Caister Academic Press
    • Related Report
      2008 Final Research Report
  • [Book] サイトメがロウイルス感染における免疫応答、日本臨床2006

    • Author(s)
      田中和生, 野田敏司
    • Publisher
      東京, 日本臨床社
    • Related Report
      2008 Final Research Report
  • [Book] ヘルペスウイルス学-基礎・臨床研究の進歩- : ヒト型モノクローナル抗体の開発、日本臨床(64)2006

    • Author(s)
      竹腰正隆, 前田史子
    • Publisher
      東京, 日本臨床社
    • Related Report
      2008 Final Research Report
  • [Book] Cytomegaloviruses : Molecular Biology and Immunology : Myeloid cell recruitment and function in pathogenesis and latency.2006

    • Author(s)
      Mocarski, E.S., G.Hahn, K.L.White, J.Xu, B.Slobedman, L.Hertel, S.A.Aguirre, S.Noda.
    • Publisher
      Caister Academic Press, Hethersett, Norfolk, United Kingdom
    • Related Report
      2006 Annual Research Report
  • [Book] ヘルペスウイルス学-基礎・臨床研究の進歩- : サイトメガロウイルス感染における免疫応答2006

    • Author(s)
      野田敏司, 田中和生
    • Total Pages
      696
    • Publisher
      日本臨床社、東京
    • Related Report
      2006 Annual Research Report
  • [Book] ヘルペスウイルス学-基礎・臨床研究の進歩- : ヒト型モノクローナル抗体の開発2006

    • Author(s)
      竹腰正隆, 前田史子
    • Total Pages
      696
    • Publisher
      日本臨床社、東京
    • Related Report
      2006 Annual Research Report

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Published: 2006-04-01   Modified: 2016-04-21  

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