• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Molecular mechanisms of cell-to-cell signaling in bacteria, and its manipulation for novel therapeutic strategies

Research Project

Project/Area Number 18390294
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field 膠原病・アレルギー・感染症内科学
Research InstitutionToho University

Principal Investigator

TATEDA Kazuhiro  Toho University, 医学部, 准教授 (20236558)

Co-Investigator(Kenkyū-buntansha) ISHII Yoshikazu  東邦大学, 医学部, 助教 (90246695)
KIMURA Soichiro  東邦大学, 医学部, 助教 (60408870)
MIYAIRI Shinichi  日本大学, 薬学部, 教授 (50209855)
HORIKAWA Manabu  サントリー生物有機科学研究所, 研究員 (70270569)
FUKUSHIMA Jun  秋田県立大学, 生物資源科学部, 准教授 (00181256)
GOTO Naomasa  京都薬科大学, 薬学部, 教授 (30121560)
Project Period (FY) 2006 – 2009
Project Status Completed (Fiscal Year 2009)
Budget Amount *help
¥18,270,000 (Direct Cost: ¥15,300,000、Indirect Cost: ¥2,970,000)
Fiscal Year 2009: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2008: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2007: ¥6,500,000 (Direct Cost: ¥5,000,000、Indirect Cost: ¥1,500,000)
Fiscal Year 2006: ¥5,400,000 (Direct Cost: ¥5,400,000)
Keywords感染症 / 病原因子 / 治療法 / 細菌間情報伝達 / Quorum-sensing機構 / 緑膿菌 / 新規治療戦略 / Quorum-sensing / 新規治療法 / ワクチン
Research Abstract

We performed the project "Molecular mechanisms of cell-to-cell signaling in bacteria, and its manipulation for novel therapeutic strategies" for 4 years and the significant insight and progress were obtained for further development of this research and clinical application. Especially, the new data regarding interspecies communication observed by pseudomonas autoinducer molecules may be promising.

Report

(6 results)
  • 2009 Annual Research Report   Final Research Report ( PDF )
  • 2008 Annual Research Report   Self-evaluation Report ( PDF )
  • 2007 Annual Research Report
  • 2006 Annual Research Report
  • Research Products

    (65 results)

All 2010 2009 2008 2007 2006

All Journal Article (32 results) (of which Peer Reviewed: 26 results) Presentation (30 results) Book (3 results)

  • [Journal Article] Anti-Clostridium difficile potential of tetramic acid derivatives from Pseudomonas aeruginosa quorum-sensing autoinducers.2010

    • Author(s)
      Ueda C, Tateda K, Horikawa M, Kimura S, Ishii Y, Nomura K, Yamada K, Suematsu T, Inoue Y, Ishiguro M, Miyairi S, Yamaguchi K.
    • Journal Title

      Antimicrob Agents Chemother 54

      Pages: 683-8

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Anti-Clostridium difficile potential of tetramic acid derivatives from P.aeruginosa quorum-sensing autoinducers2010

    • Author(s)
      Ueda C, et al.
    • Journal Title

      Antimicrob Agents Chemother 54

      Pages: 683-8

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Sequential changes of Legionella antigens and bacterial load in the lungs and urines of a mouse model of pneumonia2010

    • Author(s)
      Chen Y, et al.
    • Journal Title

      Diagn Microbiol Infect Dis. 66

      Pages: 253-60

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Hyperoxia exaggerates bacterial dissemination and lethality in Pseudomonas aeruginosa pneumonia.2009

    • Author(s)
      Kikuchi Y, Tateda K, Fuse ET, Matsumoto T, Gotoh N, Fukushima J, Takizawa H, Nagase T, Standiford TJ, Yamaguchi K.
    • Journal Title

      Pulm Pharmacol Ther 22

      Pages: 333-9

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Efficacy of colistin combination therapy in a mouse model of pneumonia caused by multidrug-resistant Pseudomonas aeruginosa.2009

    • Author(s)
      Aoki N, Tateda K, Kikuchi Y, Kimura S, Miyazaki C, Ishii Y, Tanabe Y, Gejyo F, Yamaguchi K.
    • Journal Title

      J Antimicrob Chemother 63

      Pages: 534-42

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Pseudomonas aeruginosa Las quorum sensing autoinducer suppress growth and biofilm production in Legionella species.2009

    • Author(s)
      Kimura S, Tateda K, Ishii Y, Horikawa M, Miyairi S, Gotoh N, Ishiguro M, Yamaguchi K.
    • Journal Title

      Microbiology 155

      Pages: 1934-9

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] A low concentration of azithromycin inhibits the mRNA expression of N-acyl homoserine lactone synthesis enzymes, upstream of lasI or rhlI, in Pseudomonas aeruginosa.2009

    • Author(s)
      Kai T, Tateda K, Kimura S, Ishii Y, Ito H, Yoshida H, Kimura T, Yamaguchi K.
    • Journal Title

      Pulmonary Pharmacology & Therapeutics 22

      Pages: 483-6

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] A low concentration of azithromycin inhibits the mRNA expression of N-acyl homoserine lactone synthesis enzymes, upstream of lasI or rhlI, in Pseudomonas aeruginosa2009

    • Author(s)
      Kai T, et al.
    • Journal Title

      Pulmonary Pharmacology & Therapeutics 22

      Pages: 483-6

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Hyperoxia exaggerates bacterial dissemination and lethality in Pseudomonas aeruginosa pneumonia2009

    • Author(s)
      Kikuchi Y, Tateda K, Fuse ET, Matsumoto T, Gotoh N, Fukushima J, Takizawa H, Nagase T, Standiford TJ, Yamaguchi K.
    • Journal Title

      Pulm Pharmacol Ther (Epub ahead of print)

    • Related Report
      2008 Self-evaluation Report
    • Peer Reviewed
  • [Journal Article] Efficacy of colistin combination therapy in a mouse model of pneumonia caused by multidrug-resistant Pseudomonas aeruginosa2009

    • Author(s)
      Aoki N, Tateda K, Kikuchi Y, Kimura S, Miyazaki C, Ishii Y, Tanabe Y, Gejyo F, Yamaguchi K.
    • Journal Title

      J Antimicrob Chemother 63

      Pages: 534-42

    • Related Report
      2008 Self-evaluation Report
    • Peer Reviewed
  • [Journal Article] Hyperoxia exaggerates bacterial dissemination and lethality in Pseudomonas aeruginosa pneumonia2009

    • Author(s)
      Kikuchi Y, Tateda K, et al.
    • Journal Title

      Pulm Pharmacol Ther. (in press)

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Efficacy of colistin combination therapy in a mouse model of pneumonia caused by multidrug-resistant Pseudomonas aeruginosa.2009

    • Author(s)
      Aoki N, Tateda K, et al.
    • Journal Title

      J. Antimicrob. Chemother 63

      Pages: 534-542

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Paradoxically high resistance of natural killer T(NKT)cell-deficient mice to Legionella pneumophila : another aspect of NKT cells for modulation of host responses2008

    • Author(s)
      Hayakawa K, Tateda K, Fuse ET, Matsumoto T, Akasaka Y, Ishii T, Nakayama T, Taniguchi M, Kaku M, Standiford TJ, Yamaguchi K.
    • Journal Title

      J Med Microbiol 57

      Pages: 1340-8

    • Related Report
      2008 Self-evaluation Report
    • Peer Reviewed
  • [Journal Article] Clinical and radiological features of Pneumocystis pneumonia in patients with rheumatoid arthritis, in comparison with methotrexate pneumonitis and Pneumocystis pneumonia in acquired immunodeficiency syndrome : a multicenter study2008

    • Author(s)
      Tokuda H, Sakai F, Yamada H, Johkoh T, Imamura A, Dohi M, Hirakata M, Yamada T, Kamatani N, Kikuchi Y, Sugii S, Takeuchi T, Kamatani N, Kikuchi Y, Sugii S, Takeuchi T,Kamatani N, Kikuchi Y, Sugii S, Takeuchi T, Tateda K, Goto H.
    • Journal Title

      Intern Med. 47

      Pages: 915-23

    • NAID

      130000078679

    • Related Report
      2008 Self-evaluation Report
    • Peer Reviewed
  • [Journal Article] Paradoxically high resistance of natural killer T(NKT)cell-deficient mice to Legionella pneumophila : another aspect of NKT cells for modulation of host responses.2008

    • Author(s)
      Hayakawa K, Tateda K, et al.
    • Journal Title

      J. Med. Microbiol. 57

      Pages: 1340-1348

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Role of Toll-like receptor 2 in recognition of Legionella pneumophila in a murine pneumonia model.2007

    • Author(s)
      Fuse ET, Tateda K, Kikuchi Y, Matsumoto T, Gondaira F, Azuma A, Kudoh S, Standiford TJ, Yamaguchi K.
    • Journal Title

      J Med Microbiol 56

      Pages: 305-12

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Predictive analysis of ceftazidime hydrolysis in CTX-M-type beta-lactamase family members with a mutational substitution at position 167.2007

    • Author(s)
      Kimura S, Ishii Y, Tateda K, Yamaguchi K.
    • Journal Title

      Int J Antimicrob Agents 29

      Pages: 326-331

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Suppression of Pseudomonas aeruginosa quorum-sensing systems by macrolides: a promising strategy or an oriental mystery2007

    • Author(s)
      Tateda K, Ishii Y, Kimura S, Horikawa M, Miyairi S, Yamaguchi K.
    • Journal Title

      J Infect Chemother 13

      Pages: 357-367

    • NAID

      10020023264

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Suppression of Pseudomonas aeruginosa quorum-sensing systems by macrolides: a promising strategy or an oriental mystery?2007

    • Author(s)
      Tateda K., et. al.
    • Journal Title

      J Infect Chemother 13

      Pages: 357-367

    • NAID

      10020023264

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Role of Toll-like receptor 2 in recognition of Legionella pneumophila in a murine pneumonia model.2007

    • Author(s)
      Fuse ET, Tateda K, et. al.
    • Journal Title

      J Med Microbiol 56

      Pages: 305-312

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Multi-Center Study to Evaluate Blood Stream Infection with Helicobacter cinaedi in Japan.2007

    • Author(s)
      Matsumoto T, et. al.
    • Journal Title

      J Clin Microbiol 45

      Pages: 2853-2857

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Efficacy of Bacteriophage Therapy against Gut-Derived Sepsis Caused by Pseudomonas aeruginosa in Mice.2007

    • Author(s)
      Watanabe R, et. al.
    • Journal Title

      Antimicrob Agents Chemother 51

      Pages: 446-452

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Predictive analysis of ceftazidime hydrolysis in CTX-M-type beta-lactamase family members with a mutational substitution at position 167.2007

    • Author(s)
      Kimura S, et. al.
    • Journal Title

      Int J Antimicrob Agents. 29

      Pages: 326-331

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Synthesis of Pseudomonas quorum-sensing autoinducer analogs and structural entities required for induction of apoptosis in macrophages.2006

    • Author(s)
      Horikawa M, Tateda K, Tuzuki E, Ishii Y, Ueda C, Takabatake T, Miyairi S, Yamaguchi K, Ishiguro M.
    • Journal Title

      Bioorg Med Chem Lett 16

      Pages: 2130-3

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Semi-quantitative analysis of Streptococcus pneumoniae urinary antigen: Kinetics of antigen titers and severity of diseases.2006

    • Author(s)
      Tateda K, Kusano E, Matsumoto T, Kimura K, Uchida K, Nakata K, Yamaguchi K.
    • Journal Title

      Scand J Infect Dis 38

      Pages: 166-71

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Immunization with 3-oxododecanoyl-L-homoserine lactone-protein conjugate protects mice from lethal Pseudomonas aeruginosa lung infection.2006

    • Author(s)
      Miyairi S, Tateda K, Fuse ET, Ueda C, Saito H, Takabatake T, Ishii Y, Horikawa M, Ishiguro M, Standiford TJ, Yamaguchi K.
    • Journal Title

      J Med Microbiol 55

      Pages: 1381-7

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Synthesis of Pseudomonas quorum-sensing autoinducer analogs and structural entities required for induction of apoptosis in macrophages.2006

    • Author(s)
      Horikawa M, Takeda K et al.
    • Journal Title

      Bioorg Med Chem Lett. 16・8

      Pages: 2130-3

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Semi-quantitative analysis of Streptococcus pneumoniae urinary antigen : Kinetics of antigen titers and severity of diseases.2006

    • Author(s)
      Tateda K, Kusano E
    • Journal Title

      Scand J Infect Dis. 38・3

      Pages: 166-71

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Identification of biochemically atypical Staphylococcus aureus clinical isolates with three automated identification systems.2006

    • Author(s)
      Ishii Y, Tateda K et al.
    • Journal Title

      J Med Microbiol. 55・4

      Pages: 387-92

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Crysolic recognition of flagellin by mouse macrophages restricts Legionella pneumophila infection.2006

    • Author(s)
      Molofsky AB, Tateda K et al.
    • Journal Title

      J Exp Med. 203・4

      Pages: 1093-104

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Break-point Checkerboard Plate' for screening of appropriate antibiotic combinations against multidrug-resistant Pseudomonas aeruginosa.2006

    • Author(s)
      Tateda K et al.
    • Journal Title

      Scand J Infect Dis. 38・4

      Pages: 268-272

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Immunization with 3-oxododecanoyl-L-homoserine lactone-protein conjugate protects mice from lethal Pseudomonas aeruginosa lung infection.2006

    • Author(s)
      Miyairi S, Tateda K et al.
    • Journal Title

      J Med Microbiol. 55・10

      Pages: 1381-7

    • Related Report
      2006 Annual Research Report
  • [Presentation] 病院感染防御におけるワクチンへの期待と展望2010

    • Author(s)
      舘田一博
    • Organizer
      第83回日本細菌学会総会
    • Place of Presentation
      横浜
    • Year and Date
      2010-03-27
    • Related Report
      2009 Annual Research Report
  • [Presentation] Macrolides modulate virulence factors through an intracellular signaling in Pseudomonas aeruginosa.2009

    • Author(s)
      Kimura S, Tateda K, Mori N, Ishii Y, Yamaguchi K.
    • Organizer
      49th ICAAC
    • Place of Presentation
      San Francisco
    • Year and Date
      2009-09-23
    • Related Report
      2009 Final Research Report
  • [Presentation] New evidence of intravenous immunoglobulin as a critical supportive therapy against Clostridium difficile toxin-mediated lethality in mice.2009

    • Author(s)
      Saito T, Tateda K, Hosono N, Kimura S, Sumiyama Y, Kusachi S, Nagao J, Yamaguchi K.
    • Organizer
      49th ICAAC
    • Place of Presentation
      San Francisco
    • Year and Date
      2009-09-23
    • Related Report
      2009 Final Research Report
  • [Presentation] Re-evaluation of diagnosis and host responses of Legionella pneumophila pneumonia in a mouse model.2009

    • Author(s)
      Chen Y, Tateda K, Kimura S, Ishii Y, Yamaguchi K.
    • Organizer
      49th ICAAC
    • Place of Presentation
      San Francisco
    • Year and Date
      2009-09-23
    • Related Report
      2009 Final Research Report
  • [Presentation] Antibacterial Potential of Tetramic Acid Derived from Pseudomonas Quorum-Sensing Autoinducer against Clostridium difficile and Clostridium perfringens.2008

    • Author(s)
      Ueda C, Tateda K, et al.
    • Organizer
      48^<rd> ICAAC
    • Place of Presentation
      Washington DC
    • Year and Date
      2008-10-26
    • Related Report
      2008 Annual Research Report
  • [Presentation] Virulence-Suppressing Effects of Linezolid on MRSA: Possible Contribution to Early Defervescence.2008

    • Author(s)
      Yoshizawa S, Tateda K, Yamaguchi K.
    • Organizer
      48rd ICAAC
    • Place of Presentation
      Washington DC
    • Year and Date
      2008-10-15
    • Related Report
      2009 Final Research Report
  • [Presentation] Antibacterial Potential of Tetramic Acid Derived from Pseudomonas Quorum-Sensing Autoinducer against Clostridium difficile and Clostridium perfringens.2008

    • Author(s)
      Ueda C, Tateda K, Kimura S, Ishii Y, Horikawa M, Yamaguchi K.
    • Organizer
      48rd ICAAC
    • Place of Presentation
      Washington DC
    • Year and Date
      2008-10-15
    • Related Report
      2009 Final Research Report
  • [Presentation] In Vivo Efficacy of Tomopenem (formerly CS-023) Human-simulated Exposure against Pseudomonas aeruginosa and MRSA.2008

    • Author(s)
      Tateda K, Sugihara K, Yamamura N, Koga T, Sugihara C, Yamaguchi K.
    • Organizer
      48rd ICAAC
    • Place of Presentation
      Washington DC
    • Year and Date
      2008-10-15
    • Related Report
      2009 Final Research Report
  • [Presentation] A novel aspect of interspecies communication in Candida and Pseudomonas: Co-existence of Candida modulates dissemination of and lethality in Pseudomonas aeruginosa pulmonary infection.2008

    • Author(s)
      Fujita K, Tateda K, Kimura S, Saga T, Ishii Y, Yamaguchi K.
    • Organizer
      48rd ICAAC
    • Place of Presentation
      Washington DC
    • Year and Date
      2008-10-15
    • Related Report
      2009 Final Research Report
  • [Presentation] Potential of macrolide antibiotics as quorum-sensing inhibitor against Pseudomonas.2008

    • Author(s)
      Tateda K
    • Organizer
      NIH-Novel antimicrobials in respiratory infections
    • Place of Presentation
      ワシントンDC
    • Year and Date
      2008-02-27
    • Related Report
      2007 Annual Research Report
  • [Presentation] Virulence-Suppressing Effects of Linezolid Virulence-Suppressing Effects of Linezolid Defervescence2008

    • Author(s)
      Yoshizawa S, Tateda K, Yamaguchi K.
    • Organizer
      48^<rd> ICAAC
    • Place of Presentation
      Washington DC
    • Related Report
      2008 Self-evaluation Report
  • [Presentation] Antibacterial Potential of Tetramic Acid Derived from Pseudomonas Quorum-Sensing Autoinducer against Clostridium difficile and Clostridium perfringens2008

    • Author(s)
      Ueda C, Tateda K, Kimura S, Ishii Y, Horikawa M, Yamaguchi K.
    • Organizer
      48^<rd> ICAAC
    • Place of Presentation
      Washington DC
    • Related Report
      2008 Self-evaluation Report
  • [Presentation] In Vivo Efficacy of Tomopenem(formerly CS-023)Human-simulated Exposure against Pseudomonas aeruginosa and MRSA2008

    • Author(s)
      Tateda K, Sugihara K, Yamamura N, Koga T, Sugihara C, Yamaguchi K.
    • Organizer
      48^<rd> ICAAC
    • Place of Presentation
      Washington DC
    • Related Report
      2008 Self-evaluation Report
  • [Presentation] A novel aspect of interspecies communication in Candida and Pseudomonas : Co-existence of Candida modulates dissemination of and lethality in Pseudomonas aeruginosa pulmonary infection2008

    • Author(s)
      Fujita K, Tateda K, Kimura S, Saga T, Ishii Y, Yamaguchi K.
    • Organizer
      48^<rd> ICAAC
    • Place of Presentation
      Washington DC
    • Related Report
      2008 Self-evaluation Report
  • [Presentation] Roles of Pseudomonas aeruginosa autoinducers and their degradation products, tetramic acids, in bacterial survival and behavior in ecological niches.2007

    • Author(s)
      Hosono N, Tateda K, Ueda C, Horikawa M, Yamaguchi K
    • Organizer
      47rd ICAAC
    • Place of Presentation
      Chicago
    • Year and Date
      2007-09-17
    • Related Report
      2009 Final Research Report
  • [Presentation] Antibacterial potential of Pseudomonas aeruginosa quorum-sensing autoinducers and their degradation products, tetramic acids, against Clostridium difficile.2007

    • Author(s)
      Ueda C, Tateda K, Horikawa M, Kimura S, Ishii Y, Yamaguchi K
    • Organizer
      47rd ICAAC
    • Place of Presentation
      Chicago
    • Year and Date
      2007-09-17
    • Related Report
      2009 Final Research Report
  • [Presentation] Efficacy of colistin combination therapy in a mouse model of pneumonia by multiple drug-resistant Pseudomonas aeruginosa.2007

    • Author(s)
      Aoki N, Tateda K, Kimura S, Ishii Y, Yamaguchi K
    • Organizer
      47rd ICAAC
    • Place of Presentation
      Chicago
    • Year and Date
      2007-09-17
    • Related Report
      2009 Final Research Report
  • [Presentation] Carbapenemase stability of CS-023 (RO4908463) and other carbapenems.2007

    • Author(s)
      Sugihara K, Ishii Y, Tateda K, Yamaguchi K
    • Organizer
      47rd ICAAC
    • Place of Presentation
      Chicago
    • Year and Date
      2007-09-17
    • Related Report
      2009 Final Research Report
  • [Presentation] In vitro activity of CS-023 (RO4908463) against variousβ-lactamase producing pathogens.2007

    • Author(s)
      Sugihara K, Ishii Y, Tateda K, Yamaguchi K
    • Organizer
      47rd ICAAC
    • Place of Presentation
      Chicago
    • Year and Date
      2007-09-17
    • Related Report
      2009 Final Research Report
  • [Presentation] In vitro activity of S-013420, a novel bicyclolide against clinical isolates in Japan including acrolide-resistant gram-positive cocci.2007

    • Author(s)
      Sato T, Tateda K, Ishii Y, Kimura S, Ohno A, Miyazaki S, Yamaguchi K
    • Organizer
      47rd ICAAC
    • Place of Presentation
      Chicago
    • Year and Date
      2007-09-17
    • Related Report
      2009 Final Research Report
  • [Presentation] Bactericida activity and persistent effect of S-013420, a novel bicyclolide against Legionella pneumophila in epithelial cells and macrophages.2007

    • Author(s)
      Sato T, Tateda K, Ishii Y, Kimura S, Ohno A, Miyazaki S, Yamaguchi K
    • Organizer
      47rd ICAAC
    • Place of Presentation
      Chicago
    • Year and Date
      2007-09-17
    • Related Report
      2009 Final Research Report
  • [Presentation] Bactericida activity and persistent effect of S-013420, a novel bicyclolide against Haemophilus influenzae in epithelial cell layers.2007

    • Author(s)
      Sato T, Tateda K, Ishii Y, Kimura S, Ohno A, Miyazaki S, Yamaguchi K
    • Organizer
      47rd ICAAC
    • Place of Presentation
      Chicago
    • Year and Date
      2007-09-17
    • Related Report
      2009 Final Research Report
  • [Presentation] In vitro synesgistic effects of combination of CP3242, as a novel metallo-b-lactamase inhibitor, and carbapenems against carbapenemae producing organisms.2007

    • Author(s)
      Ishii Y, Sugihara K, Tateda K, Yamaguchi K
    • Organizer
      47rd ICAAC
    • Place of Presentation
      Chicago
    • Year and Date
      2007-09-17
    • Related Report
      2009 Final Research Report
  • [Presentation] 抗菌薬耐性・難治性感染症に対する新しい治療戦略-緑膿菌感染症をモデルとして-2007

    • Author(s)
      舘田一博
    • Organizer
      第27回日本医学会総会
    • Place of Presentation
      大阪
    • Year and Date
      2007-04-07
    • Related Report
      2007 Annual Research Report
  • [Presentation] An evidence for sensing of quorum-sensing autoinducer molecules by intracellular organism Legionella.2006

    • Author(s)
      Kimura S, Tateda K, Ishii Y, Fuse E, Yamaguchi K
    • Organizer
      46rd ICAAC
    • Place of Presentation
      San Francisco
    • Year and Date
      2006-09-19
    • Related Report
      2009 Final Research Report
  • [Presentation] Different impact of steroid hormone on pulmonary growth of Legionella pneumophila and host responses in A/J and other strains of mice.2006

    • Author(s)
      Sato T, Tateda K, Yamaguchi K
    • Organizer
      46rd ICAAC
    • Place of Presentation
      San Francisco
    • Year and Date
      2006-09-19
    • Related Report
      2009 Final Research Report
  • [Presentation] Paradoxiacally high survival of NKT cell-deficient mice in Legionella pneumophila pneumonia.2006

    • Author(s)
      Hayakawa K, Tateda K, Fuse ET, Matsumoto T, Yamaguchi K
    • Organizer
      46rd ICAAC
    • Place of Presentation
      San Francisco
    • Year and Date
      2006-09-19
    • Related Report
      2009 Final Research Report
  • [Presentation] Prevalence of metallo-b-lactamase in Pseudomonas aeruginosa and other gram-negative bacilli: results of the Japanese nationwide survey (2004).2006

    • Author(s)
      Ishii Y, Kimura S, Tateda K, Yamaguchi K
    • Organizer
      46rd ICAAC
    • Place of Presentation
      San Francisco
    • Year and Date
      2006-09-19
    • Related Report
      2009 Final Research Report
  • [Presentation] Anti-Legionella activity of S-013420, a first-in-class bridged bicyclic macrolide.2006

    • Author(s)
      Sato T, Tateda K, Ishii Y, Kimura S, Ohno A, Miyazaki S, Yamaguchi K
    • Organizer
      46rd ICAAC
    • Place of Presentation
      San Francisco
    • Year and Date
      2006-09-19
    • Related Report
      2009 Final Research Report
  • [Presentation] Multi-center study to evaluate blood stream infection with Helicobacter cinaedi in Japan.2006

    • Author(s)
      Matsumoto T, Goto M, Murakami H, Tanaka T, Nishiyama H, Ono E, Okada C, Sawabe E, Yagoshi M, Yoneyama A, Okuzumi K, Tateda K, Misawa N, Yamaguchi K
    • Organizer
      46rd ICAAC
    • Place of Presentation
      San Francisco
    • Year and Date
      2006-09-19
    • Related Report
      2009 Final Research Report
  • [Book] 感染症診療の基礎と臨床-耐性菌の制御に向けて-2010

    • Author(s)
      舘田一博(分担執筆)
    • Total Pages
      300
    • Publisher
      医薬ジャーナル社
    • Related Report
      2009 Annual Research Report
  • [Book] 呼吸器疾患State of arts2007

    • Author(s)
      舘田一博
    • Total Pages
      3
    • Publisher
      医歯薬出版株式会社
    • Related Report
      2007 Annual Research Report
  • [Book] 呼吸器疾患最新の治療2007-20092007

    • Author(s)
      舘田一博
    • Total Pages
      4
    • Publisher
      南江堂
    • Related Report
      2007 Annual Research Report

URL: 

Published: 2006-04-01   Modified: 2016-04-21  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi