Generation of epilepsy model animal bearing a genetic abnormality identified in autosomal dominant nocturnal frontal lobe epilepsy (ADNFLE) of human

• Project/Area Number: 18390316
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Psychiatric science
• Research Institution: Mie University (2007-2009); Hirosaki University (2006)
• Principal Investigator: OKADA Motohiro Mie University, 大学院・医学系研究科, 教授 (10281916)
• Co-Investigator(Kenkyū-buntansha): KANEKO Sunao 弘前大学, 大学院・医学系研究科, 教授 (40106852) ; WAKABAYASHI Koichi 弘前大学, 大学院・医学系研究科, 教授 (50240768) ; UNENO Shinya 弘前大学, 大学院・医学系研究科, 教授 (00312158) ; FUKUZAWA Masashi 弘前大学, 農学生命科学部, 准教授 (10231557) ; TANII Hisashi 三重大学, 大学院・医学系研究科, 准教授 (40346200) ; KANEMATSU Takashi 九州大学, 歯学研究科(研究院), 准教授 (10264053) ; ZHU Gang 弘前大学, 大学院・医学系研究科, 助教 (80400133) ; SUZUKI Dai 三重大学, 大学院・医学系研究科, 助教 (30378301) ; 弘前大学・医学部
• Project Period (FY): 2006 – 2009
• Project Status: Completed (Fiscal Year 2009)
• Budget Amount: ¥18,570,000 (Direct Cost: ¥15,300,000、Indirect Cost: ¥3,270,000); Fiscal Year 2009: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000); Fiscal Year 2008: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000); Fiscal Year 2007: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2006: ¥4,400,000 (Direct Cost: ¥4,400,000)
• Keywords: てんかん / 病態 / トランスジェニックラット / 遺伝子 / 分子生物学 / 神経伝逹 / 神経伝達 / 認知機能

Research Abstract

Mutations of genes encoding α4, 2 or α2 subunits (CHRNA4, CHRNB2, or CHRNA2, respectively) of neuronal nicotinic ACh receptor nAChR) cause nocturnal frontal lobe epilepsy (NFLE) in human. NFLE-related seizures are seen exclusively during sleep and are characterized by three distinct seizure phenotypes : "paroxysmal arousals," "paroxysmal dystonia," and "episodic wandering." We generated transgenic rat strains that harbor a missense mutation S284L, which had been identified in CHRNA4 in NFLE. The transgenic rats were free of biological abnormalities, such as dysmorphology in the CNS, and behavioral abnormalities. The transgenic rats showed epileptic seizure phenotypes during slow-wave sleep (SWS) similar to those in NFLE exhibiting three characteristic seizure phenotypes and thus fulfilled the diagnostic criteria of human NFLE. The rats exhibited two major abnormalities in neurotransmission : (1) enhanced AMPA/glutamatergic excitatory transmission in focus region and (2) abnormal glutamate release during SWS. The currently available genetically engineered animal models of epilepsy are limited to mice ; thus, our transgenic rats offer another dimension to the epilepsy research field.

Research Products

• [Journal Article] An event-related fNIRS investigation of Japanese word order (2010)
  • Author(s): Nishimura Y, Sugisaki K, Hattori N, Inokuchi Y, Komachi M, Ogawa M, Okada M, Okazaki Y, Taki W, Yamamoto T, Yoshida E, Ayano S
  • Journal Title: Exp Brain Res. (In press)
  • Peer Reviewed
• [Journal Article] Topiramate and zonisamide prevent paradoxical intoxication induced by carbamazepine and phenytoin. (2009)
  • Author(s): Yamamura, S., Hamaguchi, T., Ohoyama, K., Sugiura, Y., Suzuki, D., Kanehara, S., Nakagawa, M., Motomura, E., Matsumoto, T., Tanii, H., Shiroyama, T., Okada, M.
  • Journal Title: Epilepsy Res 84 Pages: 172-186
  • Peer Reviewed
• [Journal Article] Effects of quetiapine on monoamine, GABA, and glutamate release in rat prefrontal cortex. (2009)
  • Author(s): Yamamura, S., Ohoyama, K., Hamaguchi, T., Kashimoto, K., Nakagawa, M., Kanehara, S., Suzuki, D., Matsumoto, T., Motomura, E., Shiroyama, T., Okada, M.
  • Journal Title: Psychopharmacology (Berl) 206 Pages: 243-258
  • Peer Reviewed
• [Journal Article] Effects of zotepine on extracellular levels of monoamine, GABA and glutamate in rat prefrontal cortex. (2009)
  • Author(s): Yamamura, S., Ohoyama, K., Hamaguchi, T., Nakagawa, M., Suzuki, D., Matsumoto, T., Motomura, E., Tanii, H., Shiroyama, T., Okada, M.
  • Journal Title: Br J Pharmacol 157 Pages: 656-665
  • Peer Reviewed
• [Journal Article] Zonisamide enhances delta receptor-associated neurotransmitter release in striato-pallidal pathway. (2009)
  • Author(s): Yamamura, S., Ohoyama, K., Nagase, H., Okada, M.
  • Journal Title: Neuropharmacology 57 Pages: 322-331
  • Peer Reviewed
• [Journal Article] Effects of zonisamide on neurotransmitter release associated with inositol triphosphate receptors. (2009)
  • Author(s): Yamamura, S., Saito, H., Suzuki, N., Kashimoto, S., Hamaguchi, T., Ohoyama, K., Suzuki, D., Kanehara, S., Nakagawa, M., Shiroyama, T., Okada, M.
  • Journal Title: Neurosci Lett 454 Pages: 91-96
  • Peer Reviewed
• [Journal Article] Zonisamide enhances delta receptor-associated neurotransmitter release in striato-pallidal pathway (2009)
  • Author(s): Yamamura, S., Ohoyama, K., Naease, H., Okada, M.
  • Journal Title: Neuropharmacology 57 Pages: 322-331
  • Peer Reviewed
• [Journal Article] Effects of quetiapine on monoamine, GABA, and glutamate release in rat prefrontal cortex (2009)
  • Author(s): Yamamura S, Ohoyama K, Hamaguchi T, Kashimoto K, Nakagawa M, Kanehara S, Suzuki D, Matsumoto T, Motomura E, Shiroyama T, Okada M
  • Journal Title: Psychopharmacology 206 Pages: 243-258
  • Peer Reviewed
• [Journal Article] Effects of zotepine on extracellular levels of monoamine, GABA and glutamate in rat prefrontal cortex (2009)
  • Author(s): Yamamura S, Ohoyama K, Hamaguchi T, Nakagawa M, Suzuki D, Matsumoto T, Motomura E, Tanii H, Shiroyama T, Okada M
  • Journal Title: Br J Pharmacol 157 Pages: 656-665
  • Peer Reviewed
• [Journal Article] Knockdown of Cav2.1 calcium channels is sufficient to induce neurological disorders observed in natural occurring Cacnala mutants in mice (2009)
  • Author(s): Saito H, Okada M, Miki T, Wakamori M, Futatsugi A, Mori Y, Mikoshiba K, Suzuki N
  • Journal Title: Biochem Biophys Res Commun 390 Pages: 1029-1033
  • Peer Reviewed
• [Journal Article] Topiramate and zonisamide prevent paradoxical intoxication induced by carbamazepine and phenytoin (2009)
  • Author(s): Yamamura S, Hamaguchi T, Ohoyama K, Sugiura Y, Suzuki D, Kanehara S, Nakagawa M, Motomura E, Matsumoto T, Tanii H, Shiroyama T, Okada M
  • Journal Title: Epilepsy Res 84 Pages: 172-186
  • Peer Reviewed
• [Journal Article] Lack of potassium current in W309R mutant KCNQ3 channel causing benign familial neonatal convulsions (BFNC) (2009)
  • Author(s): Sugiura Y, Nakatsu F, Hiroyasu K, Ishii A, Hirose S, Okada M, Jibiki I, Ohno H, Kaneko S, Ugawa Y
  • Journal Title: Epilepsy Res 84 Pages: 82-85
  • Peer Reviewed
• [Journal Article] Effects of zonisamide on neurotransmitter release associated with inositol triphosphate receptors (2009)
  • Author(s): Yamamura S, Saito H, Suzuki N, Kashimoto S, Hamaguchi T, Ohoyama K, Suzuki D, Kanehara S, Nakagawa M, Shiroyama T, Okada M
  • Journal Title: Neurosci Lett 454 Pages: 91-96
  • Peer Reviewed
• [Journal Article] Asymmetry of prefrontal cortex activities and catechol-O-methyltransferase Val158Met genotype in patients with panic disorder during a verbal fluency task : near-infrared spectroscopy study (2009)
  • Author(s): Tanii H, Nishimura Y, Inoue K, Koshimizu H, Matsumoto R, Takami T, Hara N, Nishida A, Okada M, Kaiya H, Okazaki Y
  • Journal Title: Neurosci Lett 452 Pages: 63-67
  • Peer Reviewed
• [Journal Article] A de novo KCNQ2 mutation detected in non-familial benign neonatal convulsions (2009)
  • Author(s): Ishii A, Fukuma G, Uehara A, Miyajima T, Makita Y, Hamachi A, Yasukochi M, Inoue T, Yasumoto S, Okada M, Kaneko S, Mitsudome A, Hirose S
  • Journal Title: Brain Dev 31 Pages: 27-33
  • NAID: 10025578186
  • Peer Reviewed
• [Journal Article] Intrasubject reproducibility of prefrontal cortex activities during a verbal fluency task over two repeated sessions using multi-channel near-infrared spectroscopy (2009)
  • Author(s): Kakimoto Y, Nishimura Y, Hara N, Okada M, Tanii H, Okazaki Y
  • Journal Title: Psychiatry Clin Neurosci 63 Pages: 491-499
  • Peer Reviewed
• [Journal Article] Relationship between the prefrontal function during a cognitive task and the severity of the symptoms in patients with panic disorder : a multi-channel NIRS study (2009)
  • Author(s): Nishimura Y, Tanii H, Hara N, Inoue K, Kaiya H, Nishida A, Okada M, Okazaki Y
  • Journal Title: Psychiatry Res 172 Pages: 168-172
  • Peer Reviewed
• [Journal Article] Specific panic attack symptoms in panic disorder patients with putative genetic factor (2009)
  • Author(s): Nishimura Y, Tanii H, Hara N, Inoue K, Nishida A, Okada M, Kaiya H, Okazaki Y
  • Journal Title: Psychiatry Clin Neurosci 63 Pages: 251-252
  • Peer Reviewed
• [Journal Article] Overexpression of the signal peptide whirlin isoform 2 is related to disease progression in colorectal cancer patients (2009)
  • Author(s): Toiyama Y, et al.
  • Journal Title: Int J Oncol. 35 Pages: 709-715
  • Peer Reviewed
• [Journal Article] Rac is involved in the interkinetic nuclear migration of cortical progenitor cells (2009)
  • Author(s): Minobe S, et al.
  • Journal Title: Neurosci Res. 63 Pages: 294-301
  • Peer Reviewed
• [Journal Article] Rab11 and its effector Rip11 participate in regulation of insulin granule exocytosis (2009)
  • Author(s): Sugawara K
  • Journal Title: Genes Cells. 14 Pages: 445-456
  • Peer Reviewed
• [Journal Article] Increased susceptibility to spontaneous lung cancer in mice lacking LIM-domain only 7 (2009)
  • Author(s): Genes Cells.
  • Journal Title: Cancer Sci. 100 Pages: 608-616
  • Peer Reviewed
• [Journal Article] Lack of potassium current in W309R mutant KCNQ3 channel causing benign familial neonatal convulsions (BFNC). (2009)
  • Author(s): Sugiura Y, Nakatsu F, Hiroyasu K, Ishii A, Hirose S, Okada M, Jibiki I, Ohno H, Kaneko S, Ugawa Y.
  • Journal Title: Epilepsy Res 83(In press)
  • Peer Reviewed
• [Journal Article] Topiramate and zonisamide prevent paradoxical intoxication induced by carbamazepine and phenytoin (2009)
  • Author(s): Yamamura S, Hamaguchi T, Ohoyama K, Sugiura Y, Suzuki D, Kanehara S, Nakagawa M, Motomura E, Matsumoto T, Tanii H, Shiroyama T, Okada M
  • Journal Title: Epilepsy Res 83(In press)
  • Peer Reviewed
• [Journal Article] Effects of zotepine on extracellular levels of monoamine, GABA and glutamate in rat prefrontal cortex (2009)
  • Author(s): Yamamura S, Hamaguchi T, Ohoyama K, Sugiura Y, Suzuki D, Kanehara S, Nakagawa M, Motomura E, Matsumoto T, Tanii H, Shiroyama T, Okada M
  • Journal Title: British Journal of Pharmacology 156(In press)
  • Peer Reviewed
• [Journal Article] Augmentation of antidepressants with perospirone for treatment-resistant major depressive disorder. (2009)
  • Author(s): Sato Y, Yasui-Furukori N, Nakagami T, Saito M, Kaneko S.
  • Journal Title: Prog Neuropsychopharmacol Biol Psychiatry 33(In press)
  • Peer Reviewed
• [Journal Article] A de novo KCNQ2 mutation detected in non-familial benign neonatal convulsions. (2009)
  • Author(s): Ishii A, Fukuma G, Uehara A Miyajima T, Makita Y, Hamachi A, Yasukochi M, Inoue T, Yasumoto S, Okada M, Kaneko S, Mitsudome A, Hirose S.
  • Journal Title: Brain Dev 31 Pages: 27-33
  • NAID: 10025578186
  • Peer Reviewed
• [Journal Article] Genome-wide association study of panic disorder in the Japanese population. (2009)
  • Author(s): Otowa T, Yoshida E, Sugaya N, Yasuda S, Nishimura Y, Inoue K, Tochigi M, Umekage T, Miyagawa T, Nishida N, Tokunaga K, Tanii H, Sasaki T, Kaiya H, Okazaki Y.
  • Journal Title: J Hum Genet 54 Pages: 122-126
  • Peer Reviewed
• [Journal Article] Rats harboring S284L Chrna4 mutation show attenuation of synaptic and extrasynaptic GABAergic transmission and exhibit the nocturnal frontal lobe epilepsy phenotype. (2008)
  • Author(s): Zhu, G., Okada, M., Yoshida, S., Ueno, S., Mori, F., Takahara, T., Saito, R., Miura, Y., Kishi, A., Tomiyama, M., Sato, A., Kojima, T., Fukuma, G., Wakabayashi, K., Hase, K., Ohno, H., Kijima, H., Takano, Y., Mitsudome, A., Kaneko, S., Hirose, S.
  • Journal Title: J Neurosci 28 Pages: 12465-12476
  • Peer Reviewed
• [Journal Article] 【神経科学の進歩と神経疾患治療】最新のてんかん理論と新しい抗てんかん薬 (2008)
  • Author(s): 岡田元宏, 松本卓也, 樫本香苗
  • Journal Title: 医薬ジャーナル 44 Pages: 710-714
• [Journal Article] Rats harboring S284L Chrna4 mutation show attenuation of synaptic and extrasynaptic GABAergic transmission and exhibit the nocturnal frontal lobe epilepsy phenotype (2008)
  • Author(s): Zhu G, Okada M, Yoshida S, Ueno S, Mori F, Takahara T, Saito R, Miura Y, Kishi A, Tomiyama M, Sato A, Kojima T, Fukuma G, Wakabayashi K, Hase K, Ohno H, Kijima H, Takano Y, Mitsudome A, Kaneko S, Hirose S.
  • Journal Title: J Neurosci 28 Pages: 12465-12476
  • Peer Reviewed
• [Journal Article] Rats harboring S284L Chrna4 mutation show attenuation of synaptic and extrasynaptic GABAergic transmission and exhibit the nocturnal frontal lobe epilepsy phenotype. (2008)
  • Author(s): Zhu G, Okada M, Yoshida S, Ueno S, Mori F, Takahara T, Saito R, Miura Y, Kishi A, Tomiyama M, Sato A, Kojima T, Fukuma G, Wakabayashi K, Hase K, Ohno H, Kijima H, Takano Y, Mitsudome A, Kaneko S, Hirose S.
  • Journal Title: J Neurosci 28 Pages: 12465-12476
  • Peer Reviewed
• [Journal Article] Association between dopamine-related polymorphisms and plasma concentrations of prolactin during risperidone treatment in schizophrenic patients. (2008)
  • Author(s): Yasui-Furukori N, Saito M, Tsuchimine S, Nakagami T, Sato Y, Sugawara N, Kaneko S.
  • Journal Title: Prog Neuropsychopharmacol Biol Psychiatry. 32 Pages: 1491-1495
  • Peer Reviewed
• [Journal Article] A functional near-infrared spectroscopy study on the basic word order in Japanese. (2008)
  • Author(s): Nishimura Y, Sugisaki K, Hattori N, Inokuchi Y, Nishimura Y, Ogawa M, Okada M, Okazaki Y, Taki W, Yamamoto T, Yoshida E, Ayano S.
  • Journal Title: Neuroreport 19 Pages: 915-919
  • Peer Reviewed
• [Journal Article] Dipole source analysis of temporal slow waves in the elderly. (2008)
  • Author(s): Motomura E, Inui K, Ogawa H, Nakase S, Hamanaka K, Honda T, Shiroyama T, Matsumoto T, Komori T, Okada M, Kakigi R.
  • Journal Title: Neuropsychobiology 57 Pages: 9-13
  • Peer Reviewed
• [Journal Article] Associations between psychotic-like experiences and mental health status and other psychopathologies among Japanese early teens. (2008)
  • Author(s): Nishida A, Tanii H, Nishimura Y, Kajiki N, Inoue K, Okada M, Sasaki T, Okazaki Y.
  • Journal Title: Schizophr Res (In press)
  • Peer Reviewed
• [Journal Article] Staphylococcal enterotoxin induces emesis through increasing serotonin release in intestine and it is downregulated by cannabinoid receptor 1. (2007)
  • Author(s): Hu, D.L., Zhu, G., Mori, F., Omoe, K., Okada, M., Wakabayashi, K., Kaneko, S., Shinagawa, K., Nakane, A.
  • Journal Title: Cell Microbiol 9 Pages: 2267-2277
  • Peer Reviewed
• [Journal Article] 【てんかん診療の新たなる展開】てんかん診療の新たなる展開 (2007)
  • Author(s): 八木和一, 高橋孝雄, 赤松直樹, 加藤天美, 岡田元宏
  • Journal Title: MEDICO 38
• [Journal Article] Carbamazepine prevents breakdown of neurotransmitter release induced by hyperactivation of ryanodine receptor (2007)
  • Author(s): Yoshida S, Okada M, Zhu G, Kaneko S
  • Journal Title: Neuropharmacology 52 Pages: 1538-1546
  • Peer Reviewed
• [Journal Article] Molecular basis for the GABAA receptor-mediated tonic inhibition in rat somatosensory cortex (2007)
  • Author(s): Yamada J, Furukawa T, Ueno S, Yamamoto S, Fukuda A
  • Journal Title: Cereb Cortex 17 Pages: 1782-1787
  • Peer Reviewed
• [Journal Article] Insertion of alpha7 nicotinic receptors at neocortical layer V GABAergic synapses is induced by a benzodiazepine, midazolam (2007)
  • Author(s): Yamamoto S, Yamada J, Ueno S, Kubota H, Furukawa T, Fukuda A
  • Journal Title: Cereb Cortex 17 Pages: 653-660
  • Peer Reviewed
• [Journal Article] Axonal {alpha}-synuclein aggregates herald centripetal degeneration of cardiac sympathetic nerve in Parkinson's disease. (2007)
  • Author(s): Orimo S, Uchihara T, Nakamura A, Mori F, Kakita A, Wakabayashi K, Takahashi H.
  • Journal Title: Brain 13(In press)
  • Peer Reviewed
• [Journal Article] Carbamazepine prevents breakdown of neurotransmitter release induced by hyperactivation of ryanodine receptor. (2007)
  • Author(s): Yoshida S, Okada M, Zhu G, Kaneko S.
  • Journal Title: Neuropharmacology 52 Pages: 1538-1546
  • Peer Reviewed
• [Journal Article] Staphylococcal enterotoxin induces emesis through increasing serotonin release in intestine and it is downregulated by cannabinoid receptor 1. (2007)
  • Author(s): Hu DL, Zhu G, Mori F, Omoe K, Okada M, Wakabayashi K, Kaneko S, Shinagawa K, Nakane A.
  • Journal Title: Cell Microbiol 9 Pages: 2267-2277
  • Peer Reviewed
• [Journal Article] Frontal dysfunction during a cognitive task in drug-naive patients with panic disorder as investigated by multi-channel near-infared spectroscopy imaging. (2007)
  • Author(s): Nishimura Y, Tanii H, Fukuda M, Kajiki N, Inoue K, Kaiya H, Nishida A, Okada M, Okazaki Y.
  • Journal Title: Neurosci Res. 59 Pages: 107-112
  • Peer Reviewed
• [Journal Article] Molecular basis for the GABAA receptor-mediated tonic inhibition in rat somatosensory cortex. (2007)
  • Author(s): Yamada J, Furukawa T, Ueno S, Yamamoto S, Fukuda A.
  • Journal Title: Cereb Cortex 17 Pages: 1782-1787
  • Peer Reviewed
• [Journal Article] Insertion of alpha7 nicotinic receptors at neocortical layer V GABAergic synapses is induced by a benzodiazepine, midazolam. (2007)
  • Author(s): Yamamoto S, Yamada J, Ueno S, Kubota H, Furukawa T, Yamamoto S, Fukuda A.
  • Journal Title: Cereb Cortex 17 Pages: 653-660
  • Peer Reviewed
• [Journal Article] Involvement of Ca2+-induced Ca2+ releasing system in interleukin-1beta-associated adenosine release. (2006)
  • Author(s): Zhu, G., Okada, M., Yoshida, S., Mori, F., Hirose, S., Wakabayashi, K., Kaneko, S.
  • Journal Title: Eur J Pharmacol 532 Pages: 246-252
  • Peer Reviewed
• [Journal Article] Effects of interleukin-1beta on hippocampal glutamate and GABA releases associated with Ca2+-induced Ca2+ releasing systems. (2006)
  • Author(s): Zhu, G., Okada, M., Yoshida, S., Mori, F., Ueno, S., Wakabayashi, K., Kaneko, S.
  • Journal Title: Epilepsy Res 71 Pages: 107-116
  • Peer Reviewed
• [Journal Article] Epilep patitmal/Zarontin. (2006)
  • Author(s): 岡田元宏, 兼子直
  • Journal Title: こころの治療ハンドブック第4版(青葉安里, 諸川由実代 (Eds.)) Pages: 166-167
• [Journal Article] Excegran. (2006)
  • Author(s): 岡田元宏, 兼子直
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• [Journal Article] Effects of interleukin-1beta on hippocampal glutamate and GABA releases associated with Ca2+-induced Ca2+ releasing systems (2006)
  • Author(s): Zhu G, Okada M, Yoshida S, Mori F, Ueno S, Wakabayashi K, Kaneko S
  • Journal Title: Epilepsy Res 71 Pages: 107-116
  • Peer Reviewed
• [Journal Article] Effects of interleukin-1beta on hippocampal glutamate and GABA releases associated with Ca2+-induced Ca2+ releasing systems. (2006)
  • Author(s): Zhu, G., et al.
  • Journal Title: Epilepsy Res 71 Pages: 107-107
• [Journal Article] Regulation of Dictyostelium prestalk-specific gene expression by a SHAQKY family MYB transcription factor. Development. (2006)
  • Author(s): Fukuzawa, M., et al.
  • Journal Title: Development 133 Pages: 439-439
• [Journal Article] Molecular Basis for the GABAA Receptor-Mediated Tonic Inhibition in Rat Somatosensory Cortex. (2006)
  • Author(s): Yamada, J., et al.
  • Journal Title: Cereb Cortex
• [Journal Article] Insertion of {alpha} 7 Nicotinic Receptors at Neocortical Layer V GABAergic Synapses Is Induced by a Benzodiazepine, Midazolam. (2006)
  • Author(s): Yamada, J., et al.
  • Journal Title: Cereb Cortex
• [Journal Article] Listeria monocytogenes induces the expression of retinoic acid-inducible gene-I. (2006)
  • Author(s): Imaizumi, T., et al.
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  • Author(s): Wakabayashi, K., et al.
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• [Journal Article] Carbamazepine prevents breakdown of neurotransmitter release induced by hyperactivation of ryanodine receptor.
  • Author(s): Yoshida, S., Okada, M., Zhu, G., Kaneko, S.
  • Journal Title: Neuropharmacology 52 Pages: 1538-1546
  • Peer Reviewed
• [Presentation] ADNFLE共存症病態の行動学的解析. (2009)
  • Author(s): 岸昭宏, 吉田淑子, 朱剛, 上野伸哉, 廣瀬伸一, 兼子直, 岡田元宏
  • Organizer: 第43回日本てんかん学会
  • Place of Presentation: 弘前
  • Year and Date: 2009-10-22
• [Presentation] プロテインキナーゼCに対するトピラマートの効果の検討. (2009)
  • Author(s): 吉田淑子, 岡田元宏, 吉田秀一, 兼子直
  • Organizer: 第43回日本てんかん学会
  • Place of Presentation: 弘前
  • Year and Date: 2009-10-22
• [Presentation] P型電位依存性カルシウムチャネルコンディショナルノックダウンマウスを用いたてんかん分子病態の解析. (2009)
  • Author(s): 山村哲史, 小西康信, 齊藤浩充, 兼子直, 鈴木昇, 岡田元宏
  • Organizer: 第43回日本てんかん学会
  • Place of Presentation: 弘前
  • Year and Date: 2009-10-22
• [Presentation] S284Lトランスジェニックラット自発性けいれん発現機序の解明. (2009)
  • Author(s): 朱剛, 岡田元宏, 吉田淑子, 上野伸哉, 森文秋, 岸昭宏, 若林孝一, 廣瀬伸一, 兼子直
  • Organizer: 第43回日本てんかん学会
  • Place of Presentation: 弘前
  • Year and Date: 2009-10-22
• [Presentation] ADNFLEモデルラットにおけるGABA伝達の障害機構. (2009)
  • Author(s): 上野伸哉, 山田順子, 右田啓介, 冨山誠彦, 吉田淑子, 岡田元宏, 森文秋, 若林孝一, 朱剛, 廣瀬伸一, 兼子直
  • Organizer: 第43回日本てんかん学会
  • Place of Presentation: 弘前
  • Year and Date: 2009-10-22
• [Presentation] 夜間前頭葉てんかんの変異遺伝子(S284L)導入ラット脳におけるニコチン性アセチルコリン受容体の発現. (2009)
  • Author(s): 森文秋, 冨山誠彦, 上野伸哉, 吉田淑子, 岡田元宏, 廣瀬伸一, 兼子直
  • Organizer: 第43回日本てんかん学会
  • Place of Presentation: 弘前
  • Year and Date: 2009-10-22
• [Presentation] De novo KCNQ2遺伝子変異が見出された良性新生児けいれんから中心一側頭部棘波を伴う小児良性てんかんへの移行症例. (2009)
  • Author(s): 石井敦士, 福間五龍, 上原明, 宮島祐, 蒔田芳男, 安元佐和, 井上貴仁, 岡田元宏, 兼子直, 廣瀬伸一
  • Organizer: 第43回日本てんかん学会
  • Place of Presentation: 弘前
  • Year and Date: 2009-10-22
• [Remarks] てんかん・熱性けいれん遺伝子解析グループ
  • URL: http://www.epigene.org/
• [Patent(Industrial Property Rights)] けいれん性疾患に関連する遺伝子変異とけいれん性疾患診断方法 (2006)
  • Inventor(s): 小島俊男・廣瀬伸一・岡田元宏・兼子直
  • Industrial Property Rights Holder: 国立大学法人弘前大学・独立行政法人理化学研究所・学校法人福岡大学
  • Patent Publication Number: 2006-325500
  • Acquisition Date: 2006-12-07