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Integrative approach toward understanding impaired glutamatergic neurotransmission in schizophrenia

Research Project

Project/Area Number 18390319
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Psychiatric science
Research InstitutionThe University of Tokyo

Principal Investigator

KASAI Kiyoto  The University of Tokyo, 医学部・附属病院, 教授 (80322056)

Co-Investigator(Kenkyū-buntansha) 橋本 謙二  千葉大学, 社会精神保健教育研究センター, 教授 (10189483)
佐々木 司  東京大学, 保健センター, 准教授 (50235256)
青木 茂樹  東京大学, 医学部附属病院, 准教授 (80222470)
阿部 修  東京大学, 医学部附属病院, 講師 (50302716)
山田 晴耕  帝京大学, ちば総合医療センター, 准教授 (70359610)
Co-Investigator(Renkei-kenkyūsha) HASHIMOTO Kenji  千葉大学, 社会精神保健教育研究センター, 教授 (10189483)
SASAKI Tsukasa  東京大学, 学生相談ネットワーク本部, 教授 (50235256)
AOKI Shigeki  順天堂大学, 医学部, 教授 (80222470)
ABE Osamu  東京大学, 医学部・附属病院, 准教授 (50302716)
YAMADA Haruyasu  帝京大学, ちば総合医療センター, 准教授 (70359610)
Project Period (FY) 2006 – 2008
Project Status Completed (Fiscal Year 2008)
Budget Amount *help
¥8,660,000 (Direct Cost: ¥7,400,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2008: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Fiscal Year 2007: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
Fiscal Year 2006: ¥3,200,000 (Direct Cost: ¥3,200,000)
Keywords脳・神経 / 遺伝子 / 神経画像 / 中間表現型 / グルタミン酸 / 統合失調症
Research Abstract

統合失調症におけるグルタミン酸神経伝達系の異常を明らかにするために、遺伝子、血液生化学マーカー、神経画像計測を統合したアプローチを行った。その結果、統合失調症において、グルタミン酸神経伝達系のプローブとなる各指標の異常が相互関連していることを明らかにした。この結果は、統合失調症のグルタミン酸神経伝達系異常仮説に依拠した補助診断法開発や分子標的治療研究への基盤となるものである。

Report

(4 results)
  • 2008 Annual Research Report   Final Research Report ( PDF )
  • 2007 Annual Research Report
  • 2006 Annual Research Report
  • Research Products

    (51 results)

All 2009 2008 2007 2006 Other

All Journal Article (31 results) (of which Peer Reviewed: 27 results) Presentation (5 results) Book (12 results) Remarks (2 results) Patent(Industrial Property Rights) (1 results)

  • [Journal Article] Association between sigma-1 receptor gene polymorphism and prefrontal hemodynamic response induced by cognitive activation in schizophrenia2009

    • Author(s)
      Takizawa et al.
    • Journal Title

      Prog Neuropsychopharmacol Biol Psychiatry (In press)

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Tract-specific analysis of the superior occipitofrontal fasciculus in schizophrenia2008

    • Author(s)
      Kunimatsu N, Aoki S, Kunimatsu A, Yoshida M, Abe O, Yamada H, Masutani Y, Kasai K, Yamasue H, Ohtsu H, Ohtomo K
    • Journal Title

      Psychiatry Res Neuroimaging 164

      Pages: 198-205

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Association and interaction analyses of NRG1 and ERBB4 genes with schizophrenia in a Japanese population2008

    • Author(s)
      Shiota S, Tochigi M, Shimada H, Ohashi J, Kasai K, Kato N, Tokunaga K, Sasaki T
    • Journal Title

      J Hum Genet 53

      Pages: 929-935

    • NAID

      10022603158

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Disrupted integrity of the fornix is associated with impaired memory organization in schizophrenia2008

    • Author(s)
      Takei K, Yamasue H, Abe O, Yamada H, Inoue H, Suga M, Sekita K, Sasaki H, Rogers MA, Aoki S, Kasai K
    • Journal Title

      Schizophr Res 103

      Pages: 52-61

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Reduced frontopolar activation during verbal fluency task in schizophrenia : a multi-channel near-infrared spectroscopy study2008

    • Author(s)
      Takizawa R, Kasai K, Kawakubo Y, Marumo K, Kawasaki S, Yamasue H, Fukuda M
    • Journal Title

      Schizophr Res 99

      Pages: 250-262

    • NAID

      10026933323

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Reduced frontopolar activation during verbal fluency task in schizophrenia: a multi-channel near-infrared spectroscopy study2008

    • Author(s)
      Takizawa et al.
    • Journal Title

      Schizophr Res 99

      Pages: 250-262

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Disrupted integrity of the fornix is associated with impaired memory organization in schizophrenia2008

    • Author(s)
      Takei et al.
    • Journal Title

      Schizophr Res 103

      Pages: 52-61

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Disrupted integrity of the fornix is associated with impairted memory organization in schizophrenia2008

    • Author(s)
      Takei K, et. al.
    • Journal Title

      Schizophr Res (in press)

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Reduced frontopolar activation during verbal fiuency task in schizophrenia:a multi-channel near-infrared spectroscopy study2008

    • Author(s)
      Takizawa R, et. al.
    • Journal Title

      Schizophr Res 99

      Pages: 250-262

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Increased positive thought disorder with illness duration in patients with schizophrenia2007

    • Author(s)
      Maeda K, Kasai K, Uetsuki M, Araki T, Yamasue H, Hata A, Kato N, Iwanami A
    • Journal Title

      Psychiatry Clin Neurosci 61

      Pages: 687-690

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Reduced planum temporale volume and delusional behavior in patients with schizophrenia2007

    • Author(s)
      Yamasaki S, Yamasue H, Abe O, Yamada H, Iwanami A, Hirayasu Y, Nakamura M, Furukawa S, Rogers MA, Tanno Y, Aoki S, Kato N, Kasai K
    • Journal Title

      Eur Arch Psychiatry Clin Neurosci 257

      Pages: 318-324

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Phonetic mismatch negativity predicts social skills acquisition in schizophrenia2007

    • Author(s)
      Kawakubo Y, Kamio S, Nose T, Iwanami A, Nakagome K, Fukuda M, Kato N, Rogers MA, Kasai K
    • Journal Title

      Psychiatry Res 152

      Pages: 261-265

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Progressive and interrelated functional and structural evidence for post-onset brain reduction in schizophrenia2007

    • Author(s)
      Salisbury DF, Kuroki N, Kasai K, Shenton ME, McCarley RW
    • Journal Title

      Arch Gen Psychiatry 64

      Pages: 521-529

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Reduced planum telnporale volume and delusional behavior in patients with schizophrenia2007

    • Author(s)
      Yamasaki S, et. al.
    • Journal Title

      Eur Arch Psychiatry Clin Neurosci 257

      Pages: 318-324

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] No association between the metabotropic glutamate receptor 3 gene(GRM3)and schizophrenia in a Japanese population2006

    • Author(s)
      Tochigi M, Suga M, Ohashi J, Otowa T, Yamasue H, Kasai K, Kato T, Okazaki Y, Kato N, Sasaki T
    • Journal Title

      Schizophr Res 88

      Pages: 260-264

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Auditory P300 latency prolongation with age in schizophrenia : gender and subcomponent effects2006

    • Author(s)
      Araki T, Kasai K, Kirihara K, Yamasue H, Kato N, Kudo N, Nakagome K, Iwanami A
    • Journal Title

      Schizophr Res 88

      Pages: 217-221

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] No evidence for an associatin between the BDNF Val66Met polymorphism and schizophrenia or personality traits2006

    • Author(s)
      Tochigi M, Otowa T, Suga M, Rogers M, Minato T, Yamasue H, Kasai K, Kato N, Sasaki T
    • Journal Title

      Schizophr Res 87

      Pages: 45-47

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Support for an association between mismatch negativity and social functioning in schizophrenia2006

    • Author(s)
      Kawakubo Y, Kasai K
    • Journal Title

      Prog Neuropsychopharmacol Biol Psychiatry 30

      Pages: 1367-1368

    • Related Report
      2008 Final Research Report 2006 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Procedural memory predicts social skills in persons with schizophrenia2006

    • Author(s)
      Kawakubo Y, Rogers MA, Kasai K
    • Journal Title

      J Nerv Ment Dis 194

      Pages: 625-627

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Effect of subjective reasoning and neurocognition on medication adherence for persons with schizophrenia2006

    • Author(s)
      Maeda K, Kasai K, Watanabe A, Henomatsu K, Rogers MA, Kato N
    • Journal Title

      Psychiatr Serv 57

      Pages: 1203-1205

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Phonetic mismatch negativity predicts verbal memory deficits in schizophrenia2006

    • Author(s)
      Kawakubo Y, Kasai K, Kudo N, Rogers MA, Nakagome K, Itoh K, Kato N
    • Journal Title

      Neuroreport 17

      Pages: 1043-1046

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] The effect of perospirone on auditory P300 in schizophrenia : a preliminary study2006

    • Author(s)
      Araki T, Kasai K, Rogers MA, Kato N, Iwanami A
    • Journal Title

      Prog Neuropsychopharmacol Biol Psychiatry 30

      Pages: 1083-1090

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Perospirone in the treatment of schizophrenia : effect on verbal memory organization2006

    • Author(s)
      Araki T, Yamasue H, Sumiyoshi T, Kuwabara H, Suga M, Iwanami A, Kato N, Kasai K
    • Journal Title

      Prog Neuropsychopharmacol Biol Psychiatry 30

      Pages: 204-208

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] No association between the metabotropic glutamate receptor type 3 gene (GRM#) and schizophrenia in a Japanese population.2006

    • Author(s)
      Tochigi M, Suga M, Ohashi J, Otowa T, Yamasue H, Kasai K, et al.
    • Journal Title

      Schizophr Res 88

      Pages: 260-264

    • Related Report
      2006 Annual Research Report
  • [Journal Article] No evidence for an association between the BDNF Va166Met polymorphism and schizophrenia or personality traits.2006

    • Author(s)
      Tochigi M, Otowa T, Suga M, Rogers M, Minato T, Yamasue H, Kasai K, et al.
    • Journal Title

      Schizophr Res 87

      Pages: 45-47

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Phonetic mismatch negativity predicts verbal memory deficits in schizophrenia.2006

    • Author(s)
      Kawakubo Y, Kasai K, et al.
    • Journal Title

      Neuroreport 17

      Pages: 1043-1046

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Structural disruption of the dorsal cingulum bundle is associated with impaired Stroop performance in patients with schizophrenia

    • Author(s)
      Takei K, Yamasue H, Abe O, Yamada H, Inoue H, Suga M, Muroi M, Sasaki H, Aoki S, Kasai K
    • Journal Title

      Schizophr Res (in press)

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Association study between auditory P3a/P3b event-related potentials and thought disorder in schizophrenia

    • Author(s)
      Kirihara K, Araki T, Uetsuki M, Yamasue H, Hata A, Rogers MA, Iwanami A, Kasai K
    • Journal Title

      Brain Imaging Behav (in press)

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Association between catechol-o-methyltrasferase val108/158met genotype and prefrontal hemodynamic response in schizophrenia

    • Author(s)
      Takizawa R, Tochigi M, Kawakubo Y, Marumo K, Sasaki T, Fukuda M, Kasai K
    • Journal Title

      PLoS ONE (in press)

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Association between sigma-1 receptor gene polymorphism and prefrontal hemodynamic response induced by cognitive activation in schizophrenia

    • Author(s)
      Takizawa R, Hashimoto K, Tochigi M, Kawakubo Y, Marumo K, Sasaki T, Fukuda M, Kasai K
    • Journal Title

      Prog Neuropsychopharmacol Biol Psychiatry (in press)

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Progressive and interrelated functional and structural evidence for post-onset brain reduction in schizophrenia

    • Author(s)
      Salisbury DF, Kuroki N, Kasai K, et al.
    • Journal Title

      Arch Gen Psychiatry (In Press)

    • Related Report
      2006 Annual Research Report
  • [Presentation] Mismatch negativity as a functional probe for glutamatergic/synaptic dysfunction in schizophrenia2008

    • Author(s)
      Kasai K
    • Organizer
      World Federation of Societies of Biological Psychiatry 2^<nd> WFSBP Asia-Pacific Congress and Annual Meeting of JSBP
    • Place of Presentation
      Toyama, Japan[Symposium]
    • Year and Date
      2008-09-12
    • Related Report
      2008 Final Research Report
  • [Presentation] Mismatch negativity as a functional probe for glutamatergic/synaptic dysfunction in schizophrenia2008

    • Author(s)
      Kasai K
    • Organizer
      2nd WFSBP Asia-Pacific Congress
    • Place of Presentation
      Toyama, Japan
    • Year and Date
      2008-09-12
    • Related Report
      2008 Annual Research Report
  • [Presentation] 統合失調症の発症初期における進行性脳病態仮説について2008

    • Author(s)
      笠井 清登
    • Organizer
      第3回日本統合失調症学会
    • Place of Presentation
      東京
    • Year and Date
      2008-03-14
    • Related Report
      2007 Annual Research Report
  • [Presentation] Phonetic magnetic mismatch field (MMF) as a functional probe for glutamatergic /synaptic dysfunction in schizophrenia2007

    • Author(s)
      Kasai K
    • Organizer
      International Society for the Advancement of Clinical Magnetoencephalography
    • Place of Presentation
      Matsushima, Japan[Symposium]
    • Year and Date
      2007-08-28
    • Related Report
      2008 Final Research Report
  • [Presentation] a probe for glutamatergic dysfunction in schizophrenia2006

    • Author(s)
      Kasai K
    • Organizer
      14^<th> Biennal Congress on International Pharmaco-EEG Society(Mismatch negativity (MMN))
    • Place of Presentation
      Awaji, Japan[invited lecture]
    • Year and Date
      2006-09-07
    • Related Report
      2008 Final Research Report
  • [Book] 精神疾患と脳画像、専門医のための精神科臨床リュミエール2(統合失調症の脳構造)2008

    • Author(s)
      井上秀之、山末英典、笠井清登
    • Publisher
      中山書店、東京
    • Related Report
      2008 Final Research Report
  • [Book] 精神疾患の脳画像解析・診断学(笠井清登編)2008

    • Author(s)
      平安良雄
    • Publisher
      南山堂、東京
    • Related Report
      2008 Final Research Report
  • [Book] 統合失調症の脳構造.In:精神疾患と脳画像、専門医のための精神科臨床リュミエール22008

    • Author(s)
      井上秀之、山末英典、笠井清登
    • Total Pages
      248
    • Publisher
      中山書店
    • Related Report
      2008 Annual Research Report
  • [Book] Psychology and Schizophrenia(Pletson JE)(Nova Science Publishers, Hauppauge, NY, USAUsing advanced neuroimaging techniques toward understanding schizophrenia)2007

    • Author(s)
      Yamasue H, Kasai K, Fukuda M
    • Publisher
      Nova Science Publishers, Hauppauge, NY, USA
    • Related Report
      2008 Final Research Report
  • [Book] Psychology and Schizophrenia(Pletson JE,)(Executive deficits in schizophrenia and mood disorder)2007

    • Author(s)
      Rogers M, Kasai K, Fukuda M
    • Publisher
      Nova Science Publishers Publishers, Hauppauge, NY, USA
    • Related Report
      2008 Final Research Report
  • [Book] 統合失調症の治療-基礎と臨床-(脳の電気生理学的評価)2007

    • Author(s)
      笠井清登
    • Related Report
      2008 Final Research Report
  • [Book] TEXT 精神医学、コラム(精神疾患のNIRS)2007

    • Author(s)
      滝沢龍、笠井清登
    • Publisher
      南山堂、東京
    • Related Report
      2008 Final Research Report
  • [Book] 認知療法2006(貝谷久宣)(統合失調症における非薬理学的介入の効果の脳基盤)2006

    • Author(s)
      笠井清登
    • Publisher
      星和書店
    • Related Report
      2008 Final Research Report
  • [Book] EBM精神疾患の治療2006-2007, 各論、I統合失調症(器質性変化は臨床症状や社会的予後と関連するか?)2006

    • Author(s)
      管心、山末英典、笠井清登
    • Publisher
      中外医学社、東京
    • Related Report
      2008 Final Research Report
  • [Book] EBM精神疾患の治療2006-2007, 各論、I統合失調症(どこまで脳器質性障害と言えるか?)2006

    • Author(s)
      山末英典、管心、笠井清登
    • Publisher
      中外医学社、東京
    • Related Report
      2008 Final Research Report
  • [Book] 専門医のための精神科臨床リュミエール7(初回エピソード統合失調症の画像・神経生理)

    • Author(s)
      高野洋輔、切原賢治、笠井清登
    • Publisher
      中山書店、東京(印刷中)
    • Related Report
      2008 Final Research Report
  • [Book] 精神疾患とNIRS(福田正人)(統合失調症・自閉症の前頭葉機能障害とNIRSの臨床応用)

    • Author(s)
      滝沢龍、川久保友紀、桑原斉、笠井清登
    • Publisher
      中山書店、東京(印刷中)
    • Related Report
      2008 Final Research Report
  • [Remarks] 研究室ホームページ

    • URL

      http://npsy.umin.jp/study/cp.html

    • Related Report
      2008 Final Research Report
  • [Remarks]

    • URL

      http://npsy.umin.jp/studv/cp.html

    • Related Report
      2008 Annual Research Report
  • [Patent(Industrial Property Rights)] 生体光計測装置における刺激課題呈示装置及び刺激課題呈示方法2008

    • Inventor(s)
      笠井ら
    • Industrial Property Rights Holder
      川崎ら
    • Filing Date
      2008-06-04
    • Related Report
      2008 Annual Research Report

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Published: 2006-04-01   Modified: 2016-04-21  

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