| Project/Area Number |
18390323
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Psychiatric science
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| Research Institution | Tokyo Metropolitan Organization for Medical Research |
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Principal Investigator |
ITOKAWA Masanari Tokyo Metropolitan Organization for Medical Research, Tokyo Institute of Psychiatry, Project Leader (40332324)
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| Co-Investigator(Kenkyū-buntansha) |
YOSHIKAWA Takeo RIKEN, BSI, Lab.Molecular Psychiatry, Team Leader (30249958)
TATEBAYASHI Yoshitaka Tokyo Institute of Psychiatry, Project Leader (80342814)
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| Project Period (FY) |
2006 – 2007
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| Project Status |
Completed (Fiscal Year 2007)
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| Budget Amount *help |
¥17,380,000 (Direct Cost: ¥15,700,000、Indirect Cost: ¥1,680,000)
Fiscal Year 2007: ¥7,280,000 (Direct Cost: ¥5,600,000、Indirect Cost: ¥1,680,000)
Fiscal Year 2006: ¥10,100,000 (Direct Cost: ¥10,100,000)
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| Keywords | polymorphism / schizophrenia / case-control study / CDCV hypothesis / missense mutation / resequence / CDMRV hypothesis / linkage disequilibrium / トランスポーター / 連鎖不平衡(LD) / 関連研究 / グルタミン酸 / ハプロタイプ |
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| Research Abstract |
We performed case-control association study for VGLUT1/2 and ASCT1/2 gene based upon the hypoglutamatergic hypothesis of schizophrenia. A LD block was detected in VGLUT1 gene region and haplotype analysis showed nominally significant association (P=0.06). IVS2+87A>G displayed significant association with paranoid type schizophrenia (P = 0.01). Two LD blocks were detected in VGLUT2 gene region but haplytype frequencies showed no significant different between cases and controls. IVS2-49G>A was significantly associated with female schizophrenia (P = 0.02). Those associations were not significant after Bonffeioni's correction.
We resequenced DISC1 gene using 50 schizophrenia having affected relatives. We detected 32 novel mutations including 10 missense variants. These results supported common disease multiple rare variants hypothesis.
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