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An integrated imaging approach to tumor model animals using bioluminescence imaging and magnetic resonance imaging

Research Project

Project/Area Number 18390329
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Radiation science
Research InstitutionThe University of Tokyo

Principal Investigator

INOUE Yusuke  The University of Tokyo, 医科学研究所, 准教授 (40232566)

Co-Investigator(Kenkyū-buntansha) TOJO Arinobu  東京大学, 医科学研究所, 教授 (00211681)
YOSHIKAWA Kohki  駒澤大学, 医療健康科学部, 教授 (10272494)
MASUTANI Yoshitaka  東京大学, 医学部・附属病院, 講師 (20345193)
Co-Investigator(Renkei-kenkyūsha) TOJO Arinobu  東京大学, 医科学研究所, 教授 (00211681)
YOSHIKAWA Kohki  駒澤大学, 医療健康科学部, 教授 (10272494)
MASUTANI Yoshitaka  東京大学, 医学部・附属病院, 講師 (20345193)
Project Period (FY) 2006 – 2008
Project Status Completed (Fiscal Year 2008)
Budget Amount *help
¥7,440,000 (Direct Cost: ¥6,300,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2008: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Fiscal Year 2007: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Fiscal Year 2006: ¥2,500,000 (Direct Cost: ¥2,500,000)
Keywords光画像 / 磁気共鳴画像 / 融合画像 / 造血器腫瘍 / マウス / ルシフェラーゼ / マルチモダリティイメージング / 分子イメージング
Research Abstract

生体発光画像法と磁気共鳴融合画像法の融合画像システムを開発し、本システムを腫瘍モデル動物実験に応用して、詳細な病態解析に有用なことを示した。さらに、融合画像の作成のために、生体発光画像法や磁気共鳴融合画像法によるマウス撮影法についても技術開発・改良を行い、蛍光画像法の併用技術も開発した。これらの成果は、新規治療法の前臨床試験の信頼性向上に有益と考えられた。

Report

(4 results)
  • 2008 Annual Research Report   Final Research Report ( PDF )
  • 2007 Annual Research Report
  • 2006 Annual Research Report
  • Research Products

    (31 results)

All 2009 2008 2007 2006 Other

All Journal Article (15 results) (of which Peer Reviewed: 9 results) Presentation (13 results) Remarks (3 results)

  • [Journal Article] Comparison of subcutaneous and intraperitoneal injection of D-luciferin for in vivo bioluminescence imaging2009

    • Author(s)
      Yusuke Inoue
    • Journal Title

      European Journal of Nuclear Medicine and Molecular Imaging 36

      Pages: 771-779

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Evaluation of Gd-EOB-DTPA as a contrast agent for mouse liver imaging: comparison with Gd-BOPTA2009

    • Author(s)
      Shigeru Kiryu
    • Journal Title

      Magnetic Resonance Imaging 29

      Pages: 880-886

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Bioluminescent evaluation of the therapeutic effects of total body irradiation in a murine hematological malignancy model2008

    • Author(s)
      Yusuke Inoue, Kiyoko Izawa, Shigeru Kiryu, Seiichiro Kobayashi, Arinobu Tojo, Kuni Ohtomo
    • Journal Title

      Exp Hematol 36

      Pages: 1634-41

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] 生体イメージング技術を用いた疾患モデルマウスの病態解析2008

    • Author(s)
      井上優介, 東條有伸
    • Journal Title

      臨床血液 49

      Pages: 437-444

    • NAID

      130004501168

    • Related Report
      2008 Final Research Report
  • [Journal Article] Bioluminescent evaluation of the therapeutic effects of total body irradiation in a murine hematological malignancy model2008

    • Author(s)
      Yusuke Inoue
    • Journal Title

      Experimental Hematology 36

      Pages: 1634-1641

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 生体イメージング技術を用いた疾患モデルマウスの病態解析2008

    • Author(s)
      井上優介
    • Journal Title

      臨床血液 49

      Pages: 437-444

    • NAID

      10021931178

    • Related Report
      2008 Annual Research Report
  • [Journal Article] Diet and abdominal autofluorescence detected by in vivo fluorescence imaging of living mice2008

    • Author(s)
      Yusuke Inoue
    • Journal Title

      Molecular Imaging 7

      Pages: 21-27

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] In vivo fluorescence imaging of the reticuloendothelial system using quantum dots in combination with bioluminescent tumour monitoring2007

    • Author(s)
      Yusuke Inoue, Kiyoko Izawa, Kohki Yoshikawa, Haruyasu Yamada, Arinobu Tojo, Kuni Ohtomo
    • Journal Title

      Eur J Nucl Med Mol Imaging 34

      Pages: 2048-56

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Monitoring of disease progression by bioluminescence imaging and magnetic resonance imaging in an animal model of hematological malignancy2007

    • Author(s)
      Yusuke Inoue, Kiyoko Izawa, Arinobu Tojo, Yukihiro Nomura, Rieko Sekine, Naoki Oyaizu, Kuni Ohtomo
    • Journal Title

      Exp Hematol 35

      Pages: 407-15

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Gadobenate dimeglumine as a contrast agent for magnetic resonance imaging of the mouse liver2007

    • Author(s)
      Yusuke Inoue
    • Journal Title

      NMR in Biomedicine 20

      Pages: 726-732

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] In vivo fluorescence imaging of the reticuloendothelial system using quantum dots in combination with bioluminescent tumour monitoring2007

    • Author(s)
      Yusuke Inoue
    • Journal Title

      European Journal of Nuclear Medicine and Molecular Imaging 34

      Pages: 2048-2056

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Monitoring of disease proression by bioluminescence imaging and magnetic resonance imaging in an animal model of hematological malignancy2007

    • Author(s)
      Yusuke Inoue
    • Journal Title

      Experimental Hematology 35・3

      Pages: 407-415

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Imaging of living mice using a l-T compact magnetic resonance imaging system2006

    • Author(s)
      Yusuke Inoue
    • Journal Title

      Journal of Magnetic Resonance Imaging 24・4

      Pages: 901-907

    • Related Report
      2006 Annual Research Report
  • [Journal Article] 分子イメージング : インビボ生体発光イメージング2006

    • Author(s)
      井上 優介
    • Journal Title

      BIO Clinica 21・11

      Pages: 55-60

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Gadobenate dimeglumine as a contrast agent for magnetic resonance imaging of the mouse liver

    • Author(s)
      Yusuke Inoue
    • Journal Title

      NMR in Biomedicine (in press)

    • Related Report
      2006 Annual Research Report
  • [Presentation] 生体発光画像法を用いたマウス腫瘍モニタリング2009

    • Author(s)
      井上優介
    • Organizer
      放射線診療研究会
    • Place of Presentation
      東京
    • Year and Date
      2009-02-16
    • Related Report
      2008 Annual Research Report
  • [Presentation] Comparison of Subcutaneous and Intraperitoneal Injections of D-Luciferin for in vivo Bioluminescence Imaging2009

    • Author(s)
      Yusuke Inoue
    • Organizer
      World Molecular Imaging Congress
    • Place of Presentation
      Nice
    • Related Report
      2008 Annual Research Report
  • [Presentation] In vivo bioluminescence imaging in hematological malignancy2008

    • Author(s)
      Yusuke Inoue
    • Organizer
      Hwasun Molecular Imaging Symposium
    • Place of Presentation
      Hwasun
    • Year and Date
      2008-12-05
    • Related Report
      2008 Annual Research Report 2008 Final Research Report
  • [Presentation] 光イメージングを用いた小動物の遺伝子発現画像化について2008

    • Author(s)
      井上優介
    • Organizer
      千葉ベイシティカンファランス
    • Place of Presentation
      千葉
    • Year and Date
      2008-07-14
    • Related Report
      2008 Annual Research Report
  • [Presentation] 光イメージング(シンポジウム)2008

    • Author(s)
      井上優介
    • Organizer
      第27回日本画像医学会
    • Place of Presentation
      東京
    • Year and Date
      2008-02-22
    • Related Report
      2008 Final Research Report
  • [Presentation] 生体発光画像法を用いた血液腫瘍モデルマウスにおける全身放射線照射効果の評価2008

    • Author(s)
      井上優介
    • Organizer
      日本分子イメージング学会第3回総会・学術集会
    • Place of Presentation
      埼玉
    • Related Report
      2008 Annual Research Report
  • [Presentation] Bioluminescent Evaluation of Response to Total Body Irradiation in Mice of a Hematological Malignancy Model2008

    • Author(s)
      Yusuke Inou
    • Organizer
      World Molecular Imaging Congress
    • Place of Presentation
      Nice
    • Related Report
      2008 Annual Research Report
  • [Presentation] 生体イメージング技術を用いた疾患モデルマウスの病態解析(シンポジウム)2007

    • Author(s)
      井上優介、東條有伸
    • Organizer
      日本血液学会・日本臨床血液学会合同総会
    • Place of Presentation
      横浜
    • Year and Date
      2007-10-11
    • Related Report
      2008 Final Research Report
  • [Presentation] 生体イメージング技術を用いた疾患モデルマウスの病態解析2007

    • Author(s)
      井上 優介
    • Organizer
      日本血液学会・日本臨床血液学会合同総会
    • Place of Presentation
      横浜
    • Year and Date
      2007-10-11
    • Related Report
      2007 Annual Research Report
  • [Presentation] 光イメージングにおける留意点と応用2007

    • Author(s)
      井上 優介
    • Organizer
      IVIS Imaging Systemユーザー会
    • Place of Presentation
      横浜
    • Year and Date
      2007-10-02
    • Related Report
      2007 Annual Research Report
  • [Presentation] 量子ドットを用いたマウス細網内皮系イメージング2007

    • Author(s)
      井上 優介
    • Organizer
      放射線診療研究会
    • Place of Presentation
      東京
    • Year and Date
      2007-06-11
    • Related Report
      2007 Annual Research Report
  • [Presentation] 量子ドットを用いたマウス細網内皮系の画像化と生体発光腫瘍モニタリングとの併用2007

    • Author(s)
      井上 優介
    • Organizer
      日本分子イメージング学会
    • Place of Presentation
      京都
    • Related Report
      2007 Annual Research Report
  • [Presentation] In vivo fluorescence imaging of the reticUloendothelial system using quantum dots in combination with bioluminescent tumor monitoring2007

    • Author(s)
      Yusuke Inoue
    • Organizer
      AMI/SMI Joint Molecular Imaging Conference
    • Place of Presentation
      ProVidence
    • Related Report
      2007 Annual Research Report
  • [Remarks]

    • URL

      http://www.ims.u-tokyo.ac.jp/radiology/index.html

    • Related Report
      2008 Final Research Report
  • [Remarks]

    • URL

      http://www.ims.u-tokyo.ac.jp/radiology/index.html

    • Related Report
      2008 Annual Research Report
  • [Remarks]

    • URL

      http://www.ims.u-tokyo.ac.jp/radiology/index.html

    • Related Report
      2007 Annual Research Report

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Published: 2006-04-01   Modified: 2016-04-21  

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