| Budget Amount *help |
¥18,500,000 (Direct Cost: ¥15,200,000、Indirect Cost: ¥3,300,000)
Fiscal Year 2009: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2008: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2007: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2006: ¥4,200,000 (Direct Cost: ¥4,200,000)
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| Research Abstract |
The protein and mRNA levels of Sp1, Ku70, Ku80, DNA-PKcs, XRCC4, NBS1, MRE11 and MDC1 were down regulated by the Sp1-siRNA treatment. The DSBs-repair after 80 Gy irradiation and DNA-PK activity were suppressed by the Spl-siRNA treatment. The surviving fraction after irradiation was also suppressed by the Spl-siRNA treatment.
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