Radiation sensitization though regulation of transcriptional factor Sp1

• Project/Area Number: 18390330
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Radiation science
• Research Institution: Niigata University (2008-2009); The University of Tokyo (2006-2007)
• Principal Investigator: HOSOI Yoshio Niigata University, 原爆放射線医科学研究所, 教授 (50238747)
• Co-Investigator(Kenkyū-buntansha): MATSUMOTO Yoshihisa 東京工業大学, 原子炉工学研究所, 助教授 (20302672) ; ENOMOTO Atsushi 東京大学, 大学院・医学系研究科, 助手 (20323602)
• Project Period (FY): 2006 – 2009
• Project Status: Completed (Fiscal Year 2009)
• Budget Amount: ¥18,500,000 (Direct Cost: ¥15,200,000、Indirect Cost: ¥3,300,000); Fiscal Year 2009: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000); Fiscal Year 2008: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000); Fiscal Year 2007: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000); Fiscal Year 2006: ¥4,200,000 (Direct Cost: ¥4,200,000)
• Keywords: 放射線 / Sp1 / ATM / DNA-PK

Research Abstract

The protein and mRNA levels of Sp1, Ku70, Ku80, DNA-PKcs, XRCC4, NBS1, MRE11 and MDC1 were down regulated by the Sp1-siRNA treatment. The DSBs-repair after 80 Gy irradiation and DNA-PK activity were suppressed by the Spl-siRNA treatment. The surviving fraction after irradiation was also suppressed by the Spl-siRNA treatment.

Research Products

• [Journal Article] Evacuation from the restricted zone of the damaged Fukushima nuclear power plant ; facing with the reality. (2011)
  • Author(s): Taniguchi K, Hirohashi N, Iwasaki Y, Hosoi Y, Kamiya K
  • Journal Title: Lancet Volume: (in press)
  • Peer Reviewed
• [Journal Article] 増殖因子受容体活性化によるDNA損傷修復の制御 (2011)
  • Author(s): 細井義夫
  • Journal Title: 細胞 The CELL Volume: 43 Pages: 207-210
• [Journal Article] Edaravone, a known free radical scavenger, enhances X-ray-induced apoptosis at low concentrations. (2010)
  • Author(s): Sasano N, Enomoto A, 細井義夫, Katsumura Y, Matsumoto Y, Morita A, Shiraishi K, Miyagawa K, Igaki H, Nakagawa K
  • Journal Title: Cancer Letters 293 Pages: 52-57
  • Peer Reviewed
• [Journal Article] Sodium orthovanadate inhibits p53-mediated apoptosis. (2010)
  • Author(s): Morita Q, Yamamoto S, Sang B, Tanaka, K, Suzuki N, Aoki S, Ito A, Nanao T, Ohya S, Yoshino M, Zhu J, Enomoto A, Matsumoto Y, Funatsu O, 細井義夫, Ikekita M
  • Journal Title: Cancer Research 70 Pages: 257-265
  • Peer Reviewed
• [Journal Article] 増殖因子受容体活性化によるDNA損傷修復の制御 (2010)
  • Author(s): 細井義夫
  • Journal Title: 細胞The CELL 43 Pages: 207-210
• [Journal Article] 前立腺癌治療を例として考えるLQモデルと寡分割照射 (2010)
  • Author(s): 細井義夫
  • Journal Title: 癌の臨床 56 Pages: 445-449
• [Journal Article] Edaravone, a known free radical scavenger, enhances X-ray-induced apoptosis at low concentrations. (2010)
  • Author(s): Sasano N, Enomoto A, Hosoi Y, Katsumura Y, Matsumoto Y, Morita A, Shiraishi K, Miyagawa K, Igaki H, Nakagawa K
  • Journal Title: Cancer Letters Volume: 293 Pages: 52-57
  • Peer Reviewed
• [Journal Article] Sodium orthovanadate inhibits p53-mediated apoptosis. (2010)
  • Author(s): Morita A, Yamamoto S, Sang B, Tanaka, K, Suzuki N, Aoki S, Ito A, Nanao T, Ohya S, Yoshino M, Zhu J, Enomoto A, Matsumoto Y, Funatsu O, Hosoi Y, Ikekita M
  • Journal Title: Cancer Research Volume: 70 Pages: 257-265
  • Peer Reviewed
• [Journal Article] 前立腺癌治療を例として考えるLQモデルと寡分割照射 (2010)
  • Author(s): 細井義夫
  • Journal Title: 癌の臨床 Volume: 56 Pages: 445-449
• [Journal Article] Dysbindin-1, a schizophrenia-related protein, functionally interacts with the DNA-dependent protein kinase complex in an isoform dependent manner. (2009)
  • Author(s): Oyama S, Yamakawa H, Sasagawa N, 細井義夫, Futai E, Ishiura S
  • Journal Title: PloS ONE 4
  • Peer Reviewed
• [Journal Article] Umani taste dysfunction in patients receiving radiotherapy for head and neck cancer. (2009)
  • Author(s): Yamashita H, Nakagawa K, 細井義夫, Kurokawa A., Fukuda Y, Matusmoto I, Misaka T, Abe K
  • Journal Title: Oral Oncology 45 Pages: 19-23
  • Peer Reviewed
• [Journal Article] 放射線増感剤・防護剤の現状と展望 (2009)
  • Author(s): 細井義夫
  • Journal Title: 治療学 43 Pages: 711-714
• [Journal Article] Umani taste dysfunction in patients receiving radiotherapy for head and neck cancer. (2009)
  • Author(s): Yamashita H, Nakagawa K, Hosoi Y, Kurokawa A., Fukuda Y, Matusmoto I, Misaka T, Abe K
  • Journal Title: Oral Oncology Volume: 45 Pages: 19-23
  • Peer Reviewed
• [Journal Article] Dysbindin-1, a schizophrenia-related protein, functionally interacts with the DNA-dependent protein kinase complex in an isoform-dependent manner. (2009)
  • Author(s): Oyama S, Yamakawa H, Sasagawa N, Hosoi Y, Futai E, Ishiura S
  • Journal Title: PloS ONE Volume: 4 Pages: 1-12
  • Peer Reviewed
• [Journal Article] 放射線増感剤・防護剤の現状と展望 (2009)
  • Author(s): 細井義夫
  • Journal Title: 治療学 Volume: 43 Pages: 711-714
• [Journal Article] Preoperative radiation response evaluated by 18-Fluorodeoxyglucose positron emission tomography predicts survival in locally advanced rectal cancer. (2008)
  • Author(s): Nakagawa K, Yamashita H, Nakamura N, Igaki H, Tago M, 細井義夫, Momose T, Ohtomo K, Muto T, Nagawa H
  • Journal Title: Dis Colon Rectum 51 Pages: 1055-1060
  • Peer Reviewed
• [Journal Article] Pathological changes in the gastrointestinal tract of a heavily radiation-exposed worker at the Tokai-mura criticality accident. (2008)
  • Author(s): Igaki H, Nakagawa K, Uozaki H, Akahane M, 細井義夫, Fukayama M, Miyagawa K, Akashi M, Ohtomo K, Maekawa K
  • Journal Title: Journal of Radiation Research 49 Pages: 55-62
  • NAID: 110006570528
  • Peer Reviewed
• [Journal Article] Negative regulation of MEKK1/2 signaling by Serine-Threonine Kinase 38 (STK38). (2008)
  • Author(s): Enomoto A, Kido N, Ito M, Morita A, Matsumoto Y, Takamatsu N, 細井義夫, Miyagawa K
  • Journal Title: Oncogene 27 Pages: 1930-1938
  • Peer Reviewed
• [Journal Article] Pathological changes in the gastrointestinal tract of a heavily radiation-exposed worker at the Tokai-mura criticality accident (2008)
  • Author(s): Igaki H, Nakagawa K, Uozaki H, Akahane M, Hosoi Y, Fukayama M, Miyagawa K, Akashi M, Ohtomo K, Maekawa K
  • Journal Title: Journal of Radiation Research 49 Pages: 55-62
  • NAID: 110006570528
• [Journal Article] Negative regulation of MEKK1/2 signaling by Serine-Threonine Kinase 38 (STK38) (2008)
  • Author(s): Enomoto A, Kido N, Ito M, Morita A, Matsumoto Y, Takamatsu N, Hosoi Y, Miyagawa K
  • Journal Title: Oncogene 27 Pages: 1930-1938
• [Journal Article] Negative regulation of MEKK1/2 signaling by Serine-Threonine Kinase 38 (STK38). (2008)
  • Author(s): Enomoto A, Kido N, Ito M, Morita A, Matsumoto Y, Takamatsu N, Hosoi Y, Miyagawa K
  • Journal Title: Oncogene 27 Pages: 1930-1938
  • Peer Reviewed
• [Journal Article] Pathological changes in the gastrointestinal tract of a heavily radiation-exposed worker at the Tokai-mura criticality accident. (2008)
  • Author(s): Igaki H, Nakagawa K, Uozaki H, Akahane M, Hosoi Y, Fukayama M, Miyagawa K, Akashi M, Ohtomo K, Maekawa K
  • Journal Title: Journal of Radiation Research 49 Pages: 55-62
  • NAID: 110006570528
  • Peer Reviewed
• [Journal Article] Negative regulation of MEKK1/2 signaling by Serine-Threonine Kinase 38(STK38) (2008)
  • Author(s): Enomoto A, Kido N, Ito M, Morlta A, Matsumoto Y, Takamatsu N, Hosoi Y, Miyagawa K
  • Journal Title: Oncogene 27 Pages: 1930-1938
  • Peer Reviewed
• [Journal Article] Free radical scavenger Edaravone suppresses X-ray-induced apoptosis through p53 inhibition in MOLT-4 cells. (2007)
  • Author(s): Sasano N, Enomoto A, 細井義夫, Katsumura Y, Matsumoto Y, Shiraishi K, Miyagawa K, Igaki H, Nakagawa K
  • Journal Title: Journal of Radiation Research 48 Pages: 495-503
  • NAID: 110006452332
  • Peer Reviewed
• [Journal Article] Free radical scavenger Edaravone suppresses X-ray-induced apoptosis through p53 inhibition in MOLT-4 cells (2007)
  • Author(s): Sasano N, Enomoto A, Hosoi Y, Katsumura Y, Matsumoto Y, Shiraishi K, Miyagawa K, Igaki H, Nakagawa K
  • Journal Title: Journal of Radiation Research 48 Pages: 495-503
  • NAID: 110006452332
• [Journal Article] Free radical scavenger Edaravone suppresses X-ray-induced apoptosisthrough p53 inhibition in MOLT-4 cells (2007)
  • Author(s): Sasano N, Enomoto A, Hosoi X, Katsumura Y, Matsumoto Y, Shiraishi K, Miyagawa K, Igaki H, Nakaawa K
  • Journal Title: Journal of Radiation Research 48 Pages: 495-503
  • Peer Reviewed
• [Journal Article] Relation between acute & late irradiation impairment of four basic tastes and irradiated tongue volume in patients with head and neck cancer. (2006)
  • Author(s): Yamashita H, Nakamura N, Abe K, Asakage T, Ohmoto M, Okada S, Matsumoto I, 細井義夫, Sasano N, Yamakawa S, Ohtomo K, Nakagawa K
  • Journal Title: International Journal of Radiation Oncology Biology Physics 66 Pages: 1422-1429
  • Peer Reviewed
• [Journal Article] Suppression of anchorage-independent growth by expression of the ataxia-telangiectasia group D complementing gene, ATDC. (2006)
  • Author(s): 細井義夫, Kapp LN, Murnane JP, Matsumoto Y, Enomoto A, Ono T, Miyagawa K
  • Journal Title: Biochemical and Biophysical Research Communications 348 Pages: 728-734
  • Peer Reviewed
• [Journal Article] Heterogeneous expression of DNA-dependent protein kinase in esophageal cancer and normal epithelium. (2006)
  • Author(s): Tonotsuka N, 細井義夫, Miyazaki S, Miyata G, Sugawara K, Mori T, Ouchi N, Satomi S, Matsumoto Y, Nakagawa K, Miyagawa K, Ono T
  • Journal Title: International Journal of Molecular Medicine 18 Pages: 441-447
  • Peer Reviewed
• [Journal Article] Anti-tuomor effects induced by low-dose total-body irradiation. Low-dose exposures and bio-defense system. Proceedings of the internationla symposium on low-dose radiation exposures and bio-defense system. Tanaka S, Fujikawa K, Oghiso Y. (2006)
  • Author(s): 細井義夫
  • Journal Title: Institute for Environmental Sciences, Japan. Pages: 27-29
  • Peer Reviewed
• [Journal Article] Preservation of ovarian function by ovarian shielding when undergoing total body irradiation for hematopoietic stem cell transplantation : a report of two successful cases. (2006)
  • Author(s): Nakagawa K, Kanda Y, Yamashita H, 細井義夫, Oshima K, Ohtomo I, Ban N, Yamakawa, S, Nakagawa S, Chiba S
  • Journal Title: Bone Marrow Transplantation 37 Pages: 583-587
  • Peer Reviewed
• [Journal Article] Src tyrosine kinase inhibitor PP2 suppresses ERK1/2 activation and epidermal growth factor receptor transactivation by X-irradiation. (2006)
  • Author(s): Li Z, 細井義夫, Cai K, Tanno Y, Matsumoto Y, Enomoto A, Morita A, Nakagawa K, Miyagawa K
  • Journal Title: Biochemical and Biophysical Research Communications 342 Pages: 363-368
  • Peer Reviewed
• [Journal Article] The association of DNA-dependent protein kinase activity with chromosomal instability and risk of cancer. (2006)
  • Author(s): Someya M, Sakata K, Matsumoto Y, Yamamoto H, Monobe M, Ikeda H, Aono K, 細井義夫, Suzuki N, Hareyama M
  • Journal Title: Carcinogenesis 27 Pages: 117-122
  • Peer Reviewed
• [Journal Article] Sodium orthovanadate suppresses DNA damage-induced caspase activation and apoptosis by inactivating p53. (2006)
  • Author(s): Morita A, Zhu J, Suzuki N, Enomoto A, Matsumoto Y, Tomita T, Suzuki T, Ohtomo K, 細井義夫
  • Journal Title: Cell Death and Differentiation 13 Pages: 499-511
  • NAID: 130006999522
  • Peer Reviewed
• [Journal Article] Sodium orthovanadate suppresses DNA damage-induced caspase activation and apoptosis by inactivating p53 (2006)
  • Author(s): Morita A, Zhu J, Suzuki N, Enomoto A, Matsumoto Y, Tomita T, Suzuki T, Ohtomo K, Hosoi Y
  • Journal Title: Death and Differentiation 13 Pages: 499-511
  • NAID: 130006999522
• [Journal Article] The association of DNA-dependent protein kinase activity with chromosomal instability and risk of cancer. (2006)
  • Author(s): Someya M, Sakata K, Matsumoto Y, Yamamoto H, Monobe M, Ikeda H, Aono K, Hosoi Y, Suzuki N, Hareyama M
  • Journal Title: Carcinogenesis 27 Pages: 117-122
• [Journal Article] Src tyrosine kinase inhibitor PP2 suppresses ERK1/2 activation and epidermal growth factor receptor transactivation by X-irradiation. (2006)
  • Author(s): Li Z, Hosoi Y, Cai K, Tanno Y, Matsumoto Y, Enomoto A, Morita A, Nakagawa K, Miyagawa K
  • Journal Title: Biochemical and Biophysical Research Communications 342 Pages: 363-368
• [Journal Article] Preservation of ovarian function by ovarian shielding when undergoing total body irradiation for hematopoietic stem cell transplantation : a report of two successful cases. (2006)
  • Author(s): Nakagawa K, Kanda Y, Yamashita H, Hosoi Y, Oshima K, Ohtomo I, Ban N, Yamakawa, S, Nakagawa S, Chiba S
  • Journal Title: Bone Marrow Transplantation 37 Pages: 583-587
• [Journal Article] Heterogeneous expression of DNA-dependent protein kinase in esophageal cancer and normal epithelium. (2006)
  • Author(s): Tonotsuka N, Hosoi Y, Miyazaki S, Miyata G, Sugawara K, Mori T, Ouchi N, Satomi S, Matsumoto Y, Nakagawa K, Miyagawa K, Ono T
  • Journal Title: International Journal of Molecular Medicine 18 Pages: 441-447
• [Journal Article] Suppression of anchorage-independent growth by expression of the ataxia-telangiectasia group D complementing gene, ATDC. (2006)
  • Author(s): Hosoi Y, Kapp LN, Murnane JP, Matsumoto Y, Enomoto A, Ono T, Miyagawa K
  • Journal Title: Biochemical and Biophysical Research Communications 348 Pages: 728-734
• [Journal Article] Evacuation from the restricted zone of the damaged Fukushima nuclear power plant ; facing with the reality.
  • Author(s): Taniguchi K, Hirohashi N, Iwasaki Y, 細井義夫, Kamiya K
  • Journal Title: Lancet in press.
  • Peer Reviewed
• [Journal Article] Umani taste dysfunction in patients receiving radiotherapy for head and neck cancer
  • Author(s): Yamashita H, Nakagawa K, Hosoi Y, urokawa A., Fukuda Y, Matusmoto I, Misaka T, Abe K
  • Journal Title: Oral Oncology (in press)
• [Journal Article] Preoperative radiation response evaluated by 18-Fluorodeoxyglucose positron emission tomography predicts survival in locally advanced rectal cancer
  • Author(s): Nakagawa K, Yamashita H, Nakamura N, Igaki H, Tago M, Hosoi Y, Momose T, Ohtomo K, Muto T, Nagawa H
  • Journal Title: Dis Colon Rectum (in press)
• [Presentation] 前立腺癌を例として考えるLQモデルと寡分割照射 (2010)
  • Author(s): 細井義夫
  • Organizer: 第40回放射線による制癌シンポジウム
  • Place of Presentation: 札幌市
  • Year and Date: 2010-07-10
• [Presentation] 過酸化水素・放射線によるATMを介したp53 Ser15のリン酸化 (2010)
  • Author(s): 佐藤元俊、川口弦、青山英史、笹井啓資、細井義夫
  • Organizer: 第49回日本医学放射線学会生物部会学術大会
  • Place of Presentation: 札幌市
  • Year and Date: 2010-07-09
• [Presentation] 放射線によるEGF受容体・ERK1/2活性化の機序解明 (2010)
  • Author(s): 川口弦、佐藤元俊、青山英史、笹井啓資、細井義夫
  • Organizer: 第49回日本医学放射線学会生物部会学術大会
  • Place of Presentation: 札幌市
  • Year and Date: 2010-07-09
• [Presentation] 放射線によるDNA損傷と修復 (2010)
  • Author(s): 細井義夫
  • Organizer: 第1回放射線生物学セミナ
  • Place of Presentation: 東京都
  • Year and Date: 2010-03-13
• [Presentation] 転写因子Sp1を分子標的とした放射線増感 (2009)
  • Author(s): 細井義夫
  • Organizer: 日本放射線影響学会第52回大会
  • Place of Presentation: 広島市
  • Year and Date: 2009-11-11
• [Presentation] 転写因子Sp1を分子標的とした放射線増感 (2009)
  • Author(s): 細井義夫
  • Organizer: 転写因子Sp1を分子標的とした放射線増感
  • Place of Presentation: 広島市
  • Year and Date: 2009-11-11
• [Presentation] 過酸化水素・放射線によるATMを介したp53 Ser-15のリン酸化 (2009)
  • Author(s): 佐藤元俊、川口弦、竹原和宏、奥山圭介、笹井啓資、細井義夫
  • Organizer: 第121回日本医学放射線学会北日本地方会
  • Place of Presentation: 仙台市
  • Year and Date: 2009-11-06
• [Presentation] 細胞の増殖状態によるDNA2重鎖切断修復酵素の発現と放射線感受性 (2009)
  • Author(s): 竹原和宏、奥山幸介、川口弦、佐藤元俊、笹井啓資、細井義夫
  • Organizer: 第48回日本医学放射線学会生物部会学術大会
  • Place of Presentation: 富山市
  • Year and Date: 2009-07-10
• [Presentation] 低線量重粒子線照射によるERK1/2活性化 (2009)
  • Author(s): 奥山幸介、竹原和宏、川口弦、佐藤元俊、笹井啓資、宮川清、加藤宝光、関根絵美子、高橋桃子、岡安隆一、細井義夫
  • Organizer: 第48回日本医学放射線学会生物部会学術大会
  • Place of Presentation: 富山市
  • Year and Date: 2009-07-10
• [Presentation] 臨床的放射線生物学 (2008)
  • Author(s): 細井義夫
  • Organizer: 第44回日本医学放射線学会秋季臨床大会
  • Place of Presentation: 郡山市
  • Year and Date: 2008-10-22
• [Presentation] 分子放射線治療学-分子生物学は放射線治療を変えられるか- (2008)
  • Author(s): 細井義夫
  • Organizer: 第102回新潟臨床放射線学会
  • Place of Presentation: 長岡市
  • Year and Date: 2008-07-05
• [Presentation] “分子放射線治療学"-分子生物学は放射線治療を変えられるか? - (2008)
  • Author(s): 細井義夫
  • Organizer: 第102回新潟臨床放射線学会
  • Place of Presentation: 長岡市
  • Year and Date: 2008-07-05
• [Presentation] 低濃度エダラボンによる放射線増感効果 (2008)
  • Author(s): 笹野仲史、榎本敦、細井義夫、松本義久、勝村庸介、森田明典、宮川清、中川恵一
  • Organizer: 第47回日本医学放射線学会生物部会学術大会
  • Place of Presentation: 高知市
  • Year and Date: 2008-06-20
• [Presentation] p53を介したエアダラボン(ラジカット)による放射線防護効果 (2008)
  • Author(s): 細井義夫、笹野仲史、榎本敦、中川恵一
  • Organizer: 第38回放射線による制癌シンポジウム-基礎と臨床の対話-
  • Place of Presentation: 高知市
  • Year and Date: 2008-06-20
• [Presentation] 重粒子線照射によるEGF受容体の活性化 (2008)
  • Author(s): 細井義夫、榎本敦、笹野仲史、加藤宝光、関根絵美子、岡安隆一、宮川清
  • Organizer: 第67回日本医学放射線学会総会
  • Place of Presentation: 横浜市
• [Presentation] 重力と低線量放射線の情報伝達経路 (2008)
  • Author(s): 細井義夫
  • Organizer: 宇宙利用シンポジウム(第24回)
  • Place of Presentation: 東京都
• [Presentation] 重粒子線照射によるEGF受容体の活性化 (2007)
  • Author(s): 細井 義夫、榎本 敦、笹野 仲史、加藤 宝光、関根 絵美子、岡安 隆一、宮川 清
  • Organizer: 第46回日本医学放射線学会生物部会学術大会.
  • Place of Presentation: つくば市
  • Year and Date: 2007-07-20
• [Presentation] 放射線によるphosphatase不活化を介したEGF受容体活性化・放射線抵抗性化. (2007)
  • Author(s): 細井 義夫、松本 義久、榎本 敦、桂 真理、宮川 清
  • Organizer: 第66回日本医学放射線学会学術集会
  • Place of Presentation: 横浜市
  • Year and Date: 2007-04-06
• [Presentation] エダラボンの放射線防護効果 (2007)
  • Author(s): 笹野仲史、榎本敦、細井義夫、勝村庸介、井垣浩、白石憲史郎、宮川清、中川恵一
  • Organizer: 日本放射線腫瘍学会第20回学術大会
  • Place of Presentation: 福岡市
• [Presentation] 重粒子線のよるEGF受容体活性化 (2007)
  • Author(s): 細井義夫、榎本敦、笹野仲史、加藤宝光、関根絵美子、岡安隆一、宮川清
  • Organizer: 日本放射線腫瘍学会第20回学術大会
  • Place of Presentation: 福岡市
• [Presentation] エダラボンの放射線防護効果 (2007)
  • Author(s): 笹野仲史、榎本敦、細井義夫、白石憲史郎、宮川清、勝村庸介、中川恵一
  • Organizer: 日本放射線影響学会第50回大会
  • Place of Presentation: 千葉市
• [Presentation] 新規MAP3K結合因子の機能解析 (2007)
  • Author(s): 榎本敦、木戸直樹、伊藤道彦、森田明典、細井義夫、宮川清
  • Organizer: 日本放射線影響学会第50回大会
  • Place of Presentation: 千葉市
• [Presentation] オルトバナジン酸ナトリウムによるp53制御メカニズムの解明 (2007)
  • Author(s): 山本真一、森田明典、伊藤あずさ、榎本敦、松本義久、船津修、細井義夫、鈴木紀夫、池北雅彦
  • Organizer: 日本放射線影響学会第50回大会
  • Place of Presentation: 千葉市
• [Presentation] 重粒子線によるEGF受容体を介したERKの活性化 (2007)
  • Author(s): 細井義夫、榎本敦、笹野仲史、加藤宝光、関根絵美子、藤井義大、岡安隆一、宮川清
  • Organizer: 日本放射線影響学会第50回大会
  • Place of Presentation: 千葉市
• [Presentation] Transactivation of EGF receptor by X-irradiation. The 100th Anniversary of Tohoku University (2007)
  • Author(s): 細井義夫
  • Organizer: The 5th Japan-US Cancer Therapy Symposium & The 5th S. Takahashi Memorial International Joint Symposium.
  • Place of Presentation: 仙台市
• [Presentation] エダラボンの放射線防護効果 (2007)
  • Author(s): 笹野仲史、榎本敦、細井義夫、白石憲史郎、井垣浩、勝村庸介、宮川清、中川恵一
  • Organizer: 第46回日本医学放射線学会生物部会学術大会
  • Place of Presentation: つくば市
• [Presentation] 重粒子線照射によるEGF受容体の活性化 (2007)
  • Author(s): 細井義夫、榎本敦、笹野仲史、加藤宝光、関根絵美子、岡安隆一、宮川清
  • Organizer: 第46回日本医学放射線学会生物部会学術大会
  • Place of Presentation: つくば市
• [Presentation] Missing links in the mechanism of DNA double-strand break repair through the non-homologous end-joining pathway. (2007)
  • Author(s): 松本義久、Sushima M.Bhosle、富田雅典、鈴木紀夫、細井義夫、宮川清
  • Organizer: 13th International Congress of Radiation Research
  • Place of Presentation: サンフランシスコ市
• [Presentation] Src tyrosine kinase inhibitor PP2 suppresses activation of ERK1/2 and epidermal growth factor receptor induced by X-irradiation. (2007)
  • Author(s): 細井義夫、宮川清
  • Organizer: 13th International Congress of Radiation Research
  • Place of Presentation: サンフランシスコ市
• [Presentation] 放射線によるphosphatase不活化を介したEGF受容体活性化・放射線抵抗性化 (2007)
  • Author(s): 細井義夫、松本義久、榎本敦、桂真理、宮川清
  • Organizer: 第66回日本医学放射線学会学術集会
  • Place of Presentation: 横浜市
• [Presentation] エダラボンの放射線防護効果 (2007)
  • Author(s): 笹野仲史、榎本敦、松本義久、細井義夫、宮川清、中川恵一
  • Organizer: 第9回癌治療増感研究シンポジウム
  • Place of Presentation: 奈良市
• [Presentation] 放射線によるphosphatase 不活化を介したEGF受容体活性化・放射線抵抗性化 (2007)
  • Author(s): 細井義夫、松本義久、榎本敦、桂真理、宮川清
  • Organizer: 第66 回日本医学放射線学会学術集会
  • Place of Presentation: 横浜市
• [Presentation] 低線量全身照射による癌転移抑制効果 (2006)
  • Author(s): 細井義夫
  • Organizer: 平成18年度サマースクールーナノの世界から宇宙まで一((社)日本アイソトープ協会主催)
  • Place of Presentation: 箱根町
  • Year and Date: 2006-07-27
• [Presentation] Sp1によるDNA2重鎖切断修復酵素の転写制御と放射線感受性制御 (2006)
  • Author(s): 細井義夫、丹野悠司、松本義久、榎本敦、高倉かおる、宮川清
  • Organizer: 第4回日本医学放射線学会生物部会学術大会
  • Place of Presentation: 弘前市
  • Year and Date: 2006-07-01
• [Presentation] 時間が修復に及ぼす影響の分子機構 (2006)
  • Author(s): 細井義夫
  • Organizer: 第36回放射線による制癌シンポジウム-基礎と臨床の対話
  • Place of Presentation: 弘前市
  • Year and Date: 2006-06-30
• [Presentation] Biological basis for chemo-radiotherapy.ology. (2006)
  • Author(s): 細井義夫
  • Organizer: IAEA/RCA Reginal Training Course on Radiation Biology for Radiation Onc
  • Place of Presentation: 千葉市
  • Year and Date: 2006-05-18
• [Presentation] Sp1によるDNA2重鎖切断修復酵素の転写制御と放射線感受性制御 (2006)
  • Author(s): 細井義夫、丹野悠司、松本義久、榎本敦、冨田雅典、高倉かほる、宮川清
  • Organizer: 日本放射線腫瘍学会第19回学術大会
  • Place of Presentation: 仙台市
• [Presentation] 新規JNKカスケード制御因子の機能解析とそれを標的としたアポトーシス増感 (2006)
  • Author(s): 榎本敦、木戸直樹、森田明典、伊藤道彦、松本義久、細井義夫、宮川清
  • Organizer: 日本放射線影響学会第49回大会
  • Place of Presentation: 札幌市
• [Presentation] Sp1によるDNA2重鎖切断修復酵素の転写制御と放射線感受性制御 (2006)
  • Author(s): 細井義夫、丹野悠司、松本義久、榎本敦、桂真理、高倉かほる、宮川清
  • Organizer: 日本放射線影響学会第49回大会
  • Place of Presentation: 札幌市
• [Presentation] NHEJ修復酵素群のDNA二重鎖切断部位への動員とリン酸化による制御 (2006)
  • Author(s): 松本義久、BHOSLE Sushma M.、冨田雅典、榎本敦、森田明典、鈴木紀夫、細井義夫、宮川清
  • Organizer: 日本放射線影響学会第49回大会
  • Place of Presentation: 札幌市
• [Presentation] 高LET重イオンによるDNA損傷へのKu80の反応 (2006)
  • Author(s): 和田成一、松本義久、大戸貴代、浜田信行、原孝光、船山知夫、坂下哲哉、深本花菜、柿崎竹彦、鈴木芳代、細井義夫、鈴木紀夫、小林泰彦
  • Organizer: 日本放射線影響学会第49回大会
  • Place of Presentation: 札幌市
• [Presentation] 重イオンによる細胞致死効果とDNA依存性プロテインキナーゼの応答 (2006)
  • Author(s): 冨田雅典、松本義久、細井義夫、古澤佳也、矢野安重、酒井一夫
  • Organizer: 日本放射線影響学会第49回大会
  • Place of Presentation: 札幌市
• [Presentation] エダラボンの放射線防護効果 (2006)
  • Author(s): 笹野仲史、細井義夫、白石憲史郎、榎本敦、宮川清、勝村庸介、中川恵一
  • Organizer: 日本放射線影響学会第49回大会
  • Place of Presentation: 札幌市
• [Presentation] 転写因子Sp1によるDNA2重鎖切断修復酵素の転写制御と放射線増感 (2006)
  • Author(s): 細井義夫
  • Organizer: 第65回日本医学放射線学会学術集会
  • Place of Presentation: 横浜市
• [Presentation] Sp1によるDNA2重鎖切断修復酵素の転写制御と放射線感受性制御 (2006)
  • Author(s): 細井義夫、丹野悠司、松本義久、榎本敦、冨田雅典、高倉かほる、宮川清
  • Organizer: 日本放射線腫瘍学会第19 回学術大会
  • Place of Presentation: 日仙台市
• [Presentation] Sp1によるDNA2重鎖切断修復酵素の転写制御と放射線感受性制御 (2006)
  • Author(s): 細井義夫, 丹野悠司, 松本義久, 榎本敦, 桂真理, 高倉かほる, 宮川清
  • Organizer: 日本放射線影響学会第49 回大会
  • Place of Presentation: 札幌市
• [Presentation] 転写因子Sp1によるDNA2 重鎖切断修復酵素の転写制御と放射線増感 (2006)
  • Author(s): 細井義夫
  • Organizer: 第65回日本医学放射線学会学術集会
  • Place of Presentation: 横浜市
• [Book] がん放射線療法 2010 (2010)
  • Author(s): 細井義夫(分担) 大西洋, 唐澤克之, 唐澤久美子監修
  • Total Pages: 1247
  • Publisher: (株)篠原出版者
• [Book] 放射線医科学-生体と放射線・電磁波・超音波-(放射線によるDNA損傷と染色体異常)(大西武雄監修) (2007)
  • Author(s): 細井義夫
  • Publisher: 学会出版センター
• [Book] がん放射線療法2010(大西洋, 唐澤克之, 唐澤久美子監修)(放射線腫瘍学の生物学的基礎)
  • Author(s): 細井義夫
  • Publisher: (株)篠原出版社