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Radiation sensitization though regulation of transcriptional factor Sp1

Research Project

Project/Area Number 18390330
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Radiation science
Research InstitutionNiigata University (2008-2009)
The University of Tokyo (2006-2007)

Principal Investigator

HOSOI Yoshio  Niigata University, 原爆放射線医科学研究所, 教授 (50238747)

Co-Investigator(Kenkyū-buntansha) MATSUMOTO Yoshihisa  東京工業大学, 原子炉工学研究所, 助教授 (20302672)
ENOMOTO Atsushi  東京大学, 大学院・医学系研究科, 助手 (20323602)
Project Period (FY) 2006 – 2009
Project Status Completed (Fiscal Year 2009)
Budget Amount *help
¥18,500,000 (Direct Cost: ¥15,200,000、Indirect Cost: ¥3,300,000)
Fiscal Year 2009: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2008: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2007: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2006: ¥4,200,000 (Direct Cost: ¥4,200,000)
Keywords放射線 / Sp1 / ATM / DNA-PK
Research Abstract

The protein and mRNA levels of Sp1, Ku70, Ku80, DNA-PKcs, XRCC4, NBS1, MRE11 and MDC1 were down regulated by the Sp1-siRNA treatment. The DSBs-repair after 80 Gy irradiation and DNA-PK activity were suppressed by the Spl-siRNA treatment. The surviving fraction after irradiation was also suppressed by the Spl-siRNA treatment.

Report

(6 results)
  • 2009 Annual Research Report   Final Research Report ( PDF )
  • 2008 Annual Research Report   Self-evaluation Report ( PDF )
  • 2007 Annual Research Report
  • 2006 Annual Research Report
  • Research Products

    (93 results)

All 2011 2010 2009 2008 2007 2006 Other

All Journal Article (43 results) (of which Peer Reviewed: 26 results) Presentation (47 results) Book (3 results)

  • [Journal Article] Evacuation from the restricted zone of the damaged Fukushima nuclear power plant ; facing with the reality.2011

    • Author(s)
      Taniguchi K, Hirohashi N, Iwasaki Y, Hosoi Y, Kamiya K
    • Journal Title

      Lancet

      Volume: (in press)

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 増殖因子受容体活性化によるDNA損傷修復の制御2011

    • Author(s)
      細井義夫
    • Journal Title

      細胞 The CELL

      Volume: 43 Pages: 207-210

    • Related Report
      2009 Annual Research Report
  • [Journal Article] Edaravone, a known free radical scavenger, enhances X-ray-induced apoptosis at low concentrations.2010

    • Author(s)
      Sasano N, Enomoto A, 細井義夫, Katsumura Y, Matsumoto Y, Morita A, Shiraishi K, Miyagawa K, Igaki H, Nakagawa K
    • Journal Title

      Cancer Letters 293

      Pages: 52-57

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Sodium orthovanadate inhibits p53-mediated apoptosis.2010

    • Author(s)
      Morita Q, Yamamoto S, Sang B, Tanaka, K, Suzuki N, Aoki S, Ito A, Nanao T, Ohya S, Yoshino M, Zhu J, Enomoto A, Matsumoto Y, Funatsu O, 細井義夫, Ikekita M
    • Journal Title

      Cancer Research 70

      Pages: 257-265

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] 増殖因子受容体活性化によるDNA損傷修復の制御2010

    • Author(s)
      細井義夫
    • Journal Title

      細胞The CELL 43

      Pages: 207-210

    • Related Report
      2009 Final Research Report
  • [Journal Article] 前立腺癌治療を例として考えるLQモデルと寡分割照射2010

    • Author(s)
      細井義夫
    • Journal Title

      癌の臨床 56

      Pages: 445-449

    • Related Report
      2009 Final Research Report
  • [Journal Article] Edaravone, a known free radical scavenger, enhances X-ray-induced apoptosis at low concentrations.2010

    • Author(s)
      Sasano N, Enomoto A, Hosoi Y, Katsumura Y, Matsumoto Y, Morita A, Shiraishi K, Miyagawa K, Igaki H, Nakagawa K
    • Journal Title

      Cancer Letters

      Volume: 293 Pages: 52-57

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Sodium orthovanadate inhibits p53-mediated apoptosis.2010

    • Author(s)
      Morita A, Yamamoto S, Sang B, Tanaka, K, Suzuki N, Aoki S, Ito A, Nanao T, Ohya S, Yoshino M, Zhu J, Enomoto A, Matsumoto Y, Funatsu O, Hosoi Y, Ikekita M
    • Journal Title

      Cancer Research

      Volume: 70 Pages: 257-265

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 前立腺癌治療を例として考えるLQモデルと寡分割照射2010

    • Author(s)
      細井義夫
    • Journal Title

      癌の臨床

      Volume: 56 Pages: 445-449

    • Related Report
      2009 Annual Research Report
  • [Journal Article] Dysbindin-1, a schizophrenia-related protein, functionally interacts with the DNA-dependent protein kinase complex in an isoform dependent manner.2009

    • Author(s)
      Oyama S, Yamakawa H, Sasagawa N, 細井義夫, Futai E, Ishiura S
    • Journal Title

      PloS ONE 4

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Umani taste dysfunction in patients receiving radiotherapy for head and neck cancer.2009

    • Author(s)
      Yamashita H, Nakagawa K, 細井義夫, Kurokawa A., Fukuda Y, Matusmoto I, Misaka T, Abe K
    • Journal Title

      Oral Oncology 45

      Pages: 19-23

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] 放射線増感剤・防護剤の現状と展望2009

    • Author(s)
      細井義夫
    • Journal Title

      治療学 43

      Pages: 711-714

    • Related Report
      2009 Final Research Report
  • [Journal Article] Umani taste dysfunction in patients receiving radiotherapy for head and neck cancer.2009

    • Author(s)
      Yamashita H, Nakagawa K, Hosoi Y, Kurokawa A., Fukuda Y, Matusmoto I, Misaka T, Abe K
    • Journal Title

      Oral Oncology

      Volume: 45 Pages: 19-23

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Dysbindin-1, a schizophrenia-related protein, functionally interacts with the DNA-dependent protein kinase complex in an isoform-dependent manner.2009

    • Author(s)
      Oyama S, Yamakawa H, Sasagawa N, Hosoi Y, Futai E, Ishiura S
    • Journal Title

      PloS ONE

      Volume: 4 Pages: 1-12

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 放射線増感剤・防護剤の現状と展望2009

    • Author(s)
      細井義夫
    • Journal Title

      治療学

      Volume: 43 Pages: 711-714

    • Related Report
      2009 Annual Research Report
  • [Journal Article] Preoperative radiation response evaluated by 18-Fluorodeoxyglucose positron emission tomography predicts survival in locally advanced rectal cancer.2008

    • Author(s)
      Nakagawa K, Yamashita H, Nakamura N, Igaki H, Tago M, 細井義夫, Momose T, Ohtomo K, Muto T, Nagawa H
    • Journal Title

      Dis Colon Rectum 51

      Pages: 1055-1060

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Pathological changes in the gastrointestinal tract of a heavily radiation-exposed worker at the Tokai-mura criticality accident.2008

    • Author(s)
      Igaki H, Nakagawa K, Uozaki H, Akahane M, 細井義夫, Fukayama M, Miyagawa K, Akashi M, Ohtomo K, Maekawa K
    • Journal Title

      Journal of Radiation Research 49

      Pages: 55-62

    • NAID

      110006570528

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Negative regulation of MEKK1/2 signaling by Serine-Threonine Kinase 38 (STK38).2008

    • Author(s)
      Enomoto A, Kido N, Ito M, Morita A, Matsumoto Y, Takamatsu N, 細井義夫, Miyagawa K
    • Journal Title

      Oncogene 27

      Pages: 1930-1938

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Pathological changes in the gastrointestinal tract of a heavily radiation-exposed worker at the Tokai-mura criticality accident2008

    • Author(s)
      Igaki H, Nakagawa K, Uozaki H, Akahane M, Hosoi Y, Fukayama M, Miyagawa K, Akashi M, Ohtomo K, Maekawa K
    • Journal Title

      Journal of Radiation Research 49

      Pages: 55-62

    • NAID

      110006570528

    • Related Report
      2008 Self-evaluation Report 2007 Annual Research Report
  • [Journal Article] Negative regulation of MEKK1/2 signaling by Serine-Threonine Kinase 38 (STK38)2008

    • Author(s)
      Enomoto A, Kido N, Ito M, Morita A, Matsumoto Y, Takamatsu N, Hosoi Y, Miyagawa K
    • Journal Title

      Oncogene 27

      Pages: 1930-1938

    • Related Report
      2008 Self-evaluation Report
  • [Journal Article] Negative regulation of MEKK1/2 signaling by Serine-Threonine Kinase 38 (STK38).2008

    • Author(s)
      Enomoto A, Kido N, Ito M, Morita A, Matsumoto Y, Takamatsu N, Hosoi Y, Miyagawa K
    • Journal Title

      Oncogene 27

      Pages: 1930-1938

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Pathological changes in the gastrointestinal tract of a heavily radiation-exposed worker at the Tokai-mura criticality accident.2008

    • Author(s)
      Igaki H, Nakagawa K, Uozaki H, Akahane M, Hosoi Y, Fukayama M, Miyagawa K, Akashi M, Ohtomo K, Maekawa K
    • Journal Title

      Journal of Radiation Research 49

      Pages: 55-62

    • NAID

      110006570528

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Negative regulation of MEKK1/2 signaling by Serine-Threonine Kinase 38(STK38)2008

    • Author(s)
      Enomoto A, Kido N, Ito M, Morlta A, Matsumoto Y, Takamatsu N, Hosoi Y, Miyagawa K
    • Journal Title

      Oncogene 27

      Pages: 1930-1938

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Free radical scavenger Edaravone suppresses X-ray-induced apoptosis through p53 inhibition in MOLT-4 cells.2007

    • Author(s)
      Sasano N, Enomoto A, 細井義夫, Katsumura Y, Matsumoto Y, Shiraishi K, Miyagawa K, Igaki H, Nakagawa K
    • Journal Title

      Journal of Radiation Research 48

      Pages: 495-503

    • NAID

      110006452332

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Free radical scavenger Edaravone suppresses X-ray-induced apoptosis through p53 inhibition in MOLT-4 cells2007

    • Author(s)
      Sasano N, Enomoto A, Hosoi Y, Katsumura Y, Matsumoto Y, Shiraishi K, Miyagawa K, Igaki H, Nakagawa K
    • Journal Title

      Journal of Radiation Research 48

      Pages: 495-503

    • NAID

      110006452332

    • Related Report
      2008 Self-evaluation Report
  • [Journal Article] Free radical scavenger Edaravone suppresses X-ray-induced apoptosisthrough p53 inhibition in MOLT-4 cells2007

    • Author(s)
      Sasano N, Enomoto A, Hosoi X, Katsumura Y, Matsumoto Y, Shiraishi K, Miyagawa K, Igaki H, Nakaawa K
    • Journal Title

      Journal of Radiation Research 48

      Pages: 495-503

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Relation between acute & late irradiation impairment of four basic tastes and irradiated tongue volume in patients with head and neck cancer.2006

    • Author(s)
      Yamashita H, Nakamura N, Abe K, Asakage T, Ohmoto M, Okada S, Matsumoto I, 細井義夫, Sasano N, Yamakawa S, Ohtomo K, Nakagawa K
    • Journal Title

      International Journal of Radiation Oncology Biology Physics 66

      Pages: 1422-1429

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Suppression of anchorage-independent growth by expression of the ataxia-telangiectasia group D complementing gene, ATDC.2006

    • Author(s)
      細井義夫, Kapp LN, Murnane JP, Matsumoto Y, Enomoto A, Ono T, Miyagawa K
    • Journal Title

      Biochemical and Biophysical Research Communications 348

      Pages: 728-734

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Heterogeneous expression of DNA-dependent protein kinase in esophageal cancer and normal epithelium.2006

    • Author(s)
      Tonotsuka N, 細井義夫, Miyazaki S, Miyata G, Sugawara K, Mori T, Ouchi N, Satomi S, Matsumoto Y, Nakagawa K, Miyagawa K, Ono T
    • Journal Title

      International Journal of Molecular Medicine 18

      Pages: 441-447

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Anti-tuomor effects induced by low-dose total-body irradiation. Low-dose exposures and bio-defense system. Proceedings of the internationla symposium on low-dose radiation exposures and bio-defense system. Tanaka S, Fujikawa K, Oghiso Y.2006

    • Author(s)
      細井義夫
    • Journal Title

      Institute for Environmental Sciences, Japan.

      Pages: 27-29

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Preservation of ovarian function by ovarian shielding when undergoing total body irradiation for hematopoietic stem cell transplantation : a report of two successful cases.2006

    • Author(s)
      Nakagawa K, Kanda Y, Yamashita H, 細井義夫, Oshima K, Ohtomo I, Ban N, Yamakawa, S, Nakagawa S, Chiba S
    • Journal Title

      Bone Marrow Transplantation 37

      Pages: 583-587

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Src tyrosine kinase inhibitor PP2 suppresses ERK1/2 activation and epidermal growth factor receptor transactivation by X-irradiation.2006

    • Author(s)
      Li Z, 細井義夫, Cai K, Tanno Y, Matsumoto Y, Enomoto A, Morita A, Nakagawa K, Miyagawa K
    • Journal Title

      Biochemical and Biophysical Research Communications 342

      Pages: 363-368

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] The association of DNA-dependent protein kinase activity with chromosomal instability and risk of cancer.2006

    • Author(s)
      Someya M, Sakata K, Matsumoto Y, Yamamoto H, Monobe M, Ikeda H, Aono K, 細井義夫, Suzuki N, Hareyama M
    • Journal Title

      Carcinogenesis 27

      Pages: 117-122

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Sodium orthovanadate suppresses DNA damage-induced caspase activation and apoptosis by inactivating p53.2006

    • Author(s)
      Morita A, Zhu J, Suzuki N, Enomoto A, Matsumoto Y, Tomita T, Suzuki T, Ohtomo K, 細井義夫
    • Journal Title

      Cell Death and Differentiation 13

      Pages: 499-511

    • NAID

      130006999522

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Sodium orthovanadate suppresses DNA damage-induced caspase activation and apoptosis by inactivating p532006

    • Author(s)
      Morita A, Zhu J, Suzuki N, Enomoto A, Matsumoto Y, Tomita T, Suzuki T, Ohtomo K, Hosoi Y
    • Journal Title

      Death and Differentiation 13

      Pages: 499-511

    • NAID

      130006999522

    • Related Report
      2006 Annual Research Report
  • [Journal Article] The association of DNA-dependent protein kinase activity with chromosomal instability and risk of cancer.2006

    • Author(s)
      Someya M, Sakata K, Matsumoto Y, Yamamoto H, Monobe M, Ikeda H, Aono K, Hosoi Y, Suzuki N, Hareyama M
    • Journal Title

      Carcinogenesis 27

      Pages: 117-122

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Src tyrosine kinase inhibitor PP2 suppresses ERK1/2 activation and epidermal growth factor receptor transactivation by X-irradiation.2006

    • Author(s)
      Li Z, Hosoi Y, Cai K, Tanno Y, Matsumoto Y, Enomoto A, Morita A, Nakagawa K, Miyagawa K
    • Journal Title

      Biochemical and Biophysical Research Communications 342

      Pages: 363-368

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Preservation of ovarian function by ovarian shielding when undergoing total body irradiation for hematopoietic stem cell transplantation : a report of two successful cases.2006

    • Author(s)
      Nakagawa K, Kanda Y, Yamashita H, Hosoi Y, Oshima K, Ohtomo I, Ban N, Yamakawa, S, Nakagawa S, Chiba S
    • Journal Title

      Bone Marrow Transplantation 37

      Pages: 583-587

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Heterogeneous expression of DNA-dependent protein kinase in esophageal cancer and normal epithelium.2006

    • Author(s)
      Tonotsuka N, Hosoi Y, Miyazaki S, Miyata G, Sugawara K, Mori T, Ouchi N, Satomi S, Matsumoto Y, Nakagawa K, Miyagawa K, Ono T
    • Journal Title

      International Journal of Molecular Medicine 18

      Pages: 441-447

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Suppression of anchorage-independent growth by expression of the ataxia-telangiectasia group D complementing gene, ATDC.2006

    • Author(s)
      Hosoi Y, Kapp LN, Murnane JP, Matsumoto Y, Enomoto A, Ono T, Miyagawa K
    • Journal Title

      Biochemical and Biophysical Research Communications 348

      Pages: 728-734

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Evacuation from the restricted zone of the damaged Fukushima nuclear power plant ; facing with the reality.

    • Author(s)
      Taniguchi K, Hirohashi N, Iwasaki Y, 細井義夫, Kamiya K
    • Journal Title

      Lancet in press.

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Umani taste dysfunction in patients receiving radiotherapy for head and neck cancer

    • Author(s)
      Yamashita H, Nakagawa K, Hosoi Y, urokawa A., Fukuda Y, Matusmoto I, Misaka T, Abe K
    • Journal Title

      Oral Oncology (in press)

    • Related Report
      2008 Self-evaluation Report
  • [Journal Article] Preoperative radiation response evaluated by 18-Fluorodeoxyglucose positron emission tomography predicts survival in locally advanced rectal cancer

    • Author(s)
      Nakagawa K, Yamashita H, Nakamura N, Igaki H, Tago M, Hosoi Y, Momose T, Ohtomo K, Muto T, Nagawa H
    • Journal Title

      Dis Colon Rectum (in press)

    • Related Report
      2008 Self-evaluation Report
  • [Presentation] 前立腺癌を例として考えるLQモデルと寡分割照射2010

    • Author(s)
      細井義夫
    • Organizer
      第40回放射線による制癌シンポジウム
    • Place of Presentation
      札幌市
    • Year and Date
      2010-07-10
    • Related Report
      2009 Annual Research Report 2009 Final Research Report
  • [Presentation] 過酸化水素・放射線によるATMを介したp53 Ser15のリン酸化2010

    • Author(s)
      佐藤元俊、川口弦、青山英史、笹井啓資、細井義夫
    • Organizer
      第49回日本医学放射線学会生物部会学術大会
    • Place of Presentation
      札幌市
    • Year and Date
      2010-07-09
    • Related Report
      2009 Annual Research Report 2009 Final Research Report
  • [Presentation] 放射線によるEGF受容体・ERK1/2活性化の機序解明2010

    • Author(s)
      川口弦、佐藤元俊、青山英史、笹井啓資、細井義夫
    • Organizer
      第49回日本医学放射線学会生物部会学術大会
    • Place of Presentation
      札幌市
    • Year and Date
      2010-07-09
    • Related Report
      2009 Annual Research Report 2009 Final Research Report
  • [Presentation] 放射線によるDNA損傷と修復2010

    • Author(s)
      細井義夫
    • Organizer
      第1回放射線生物学セミナ
    • Place of Presentation
      東京都
    • Year and Date
      2010-03-13
    • Related Report
      2009 Final Research Report
  • [Presentation] 転写因子Sp1を分子標的とした放射線増感2009

    • Author(s)
      細井義夫
    • Organizer
      日本放射線影響学会第52回大会
    • Place of Presentation
      広島市
    • Year and Date
      2009-11-11
    • Related Report
      2009 Final Research Report
  • [Presentation] 転写因子Sp1を分子標的とした放射線増感2009

    • Author(s)
      細井義夫
    • Organizer
      転写因子Sp1を分子標的とした放射線増感
    • Place of Presentation
      広島市
    • Year and Date
      2009-11-11
    • Related Report
      2009 Annual Research Report
  • [Presentation] 過酸化水素・放射線によるATMを介したp53 Ser-15のリン酸化2009

    • Author(s)
      佐藤元俊、川口弦、竹原和宏、奥山圭介、笹井啓資、細井義夫
    • Organizer
      第121回日本医学放射線学会北日本地方会
    • Place of Presentation
      仙台市
    • Year and Date
      2009-11-06
    • Related Report
      2009 Annual Research Report 2009 Final Research Report
  • [Presentation] 細胞の増殖状態によるDNA2重鎖切断修復酵素の発現と放射線感受性2009

    • Author(s)
      竹原和宏、奥山幸介、川口弦、佐藤元俊、笹井啓資、細井義夫
    • Organizer
      第48回日本医学放射線学会生物部会学術大会
    • Place of Presentation
      富山市
    • Year and Date
      2009-07-10
    • Related Report
      2009 Annual Research Report 2009 Final Research Report
  • [Presentation] 低線量重粒子線照射によるERK1/2活性化2009

    • Author(s)
      奥山幸介、竹原和宏、川口弦、佐藤元俊、笹井啓資、宮川清、加藤宝光、関根絵美子、高橋桃子、岡安隆一、細井義夫
    • Organizer
      第48回日本医学放射線学会生物部会学術大会
    • Place of Presentation
      富山市
    • Year and Date
      2009-07-10
    • Related Report
      2009 Annual Research Report 2009 Final Research Report
  • [Presentation] 臨床的放射線生物学2008

    • Author(s)
      細井義夫
    • Organizer
      第44回日本医学放射線学会秋季臨床大会
    • Place of Presentation
      郡山市
    • Year and Date
      2008-10-22
    • Related Report
      2009 Final Research Report 2008 Annual Research Report
  • [Presentation] 分子放射線治療学-分子生物学は放射線治療を変えられるか-2008

    • Author(s)
      細井義夫
    • Organizer
      第102回新潟臨床放射線学会
    • Place of Presentation
      長岡市
    • Year and Date
      2008-07-05
    • Related Report
      2009 Final Research Report
  • [Presentation] “分子放射線治療学"-分子生物学は放射線治療を変えられるか? -2008

    • Author(s)
      細井義夫
    • Organizer
      第102回新潟臨床放射線学会
    • Place of Presentation
      長岡市
    • Year and Date
      2008-07-05
    • Related Report
      2008 Annual Research Report
  • [Presentation] 低濃度エダラボンによる放射線増感効果2008

    • Author(s)
      笹野仲史、榎本敦、細井義夫、松本義久、勝村庸介、森田明典、宮川清、中川恵一
    • Organizer
      第47回日本医学放射線学会生物部会学術大会
    • Place of Presentation
      高知市
    • Year and Date
      2008-06-20
    • Related Report
      2009 Final Research Report 2008 Annual Research Report
  • [Presentation] p53を介したエアダラボン(ラジカット)による放射線防護効果2008

    • Author(s)
      細井義夫、笹野仲史、榎本敦、中川恵一
    • Organizer
      第38回放射線による制癌シンポジウム-基礎と臨床の対話-
    • Place of Presentation
      高知市
    • Year and Date
      2008-06-20
    • Related Report
      2009 Final Research Report 2008 Annual Research Report
  • [Presentation] 重粒子線照射によるEGF受容体の活性化2008

    • Author(s)
      細井義夫、榎本敦、笹野仲史、加藤宝光、関根絵美子、岡安隆一、宮川清
    • Organizer
      第67回日本医学放射線学会総会
    • Place of Presentation
      横浜市
    • Related Report
      2009 Final Research Report 2008 Annual Research Report
  • [Presentation] 重力と低線量放射線の情報伝達経路2008

    • Author(s)
      細井義夫
    • Organizer
      宇宙利用シンポジウム(第24回)
    • Place of Presentation
      東京都
    • Related Report
      2009 Final Research Report
  • [Presentation] 重粒子線照射によるEGF受容体の活性化2007

    • Author(s)
      細井 義夫、榎本 敦、笹野 仲史、加藤 宝光、関根 絵美子、岡安 隆一、宮川 清
    • Organizer
      第46回日本医学放射線学会生物部会学術大会.
    • Place of Presentation
      つくば市
    • Year and Date
      2007-07-20
    • Related Report
      2007 Annual Research Report
  • [Presentation] 放射線によるphosphatase不活化を介したEGF受容体活性化・放射線抵抗性化.2007

    • Author(s)
      細井 義夫、松本 義久、榎本 敦、桂 真理、宮川 清
    • Organizer
      第66回日本医学放射線学会学術集会
    • Place of Presentation
      横浜市
    • Year and Date
      2007-04-06
    • Related Report
      2007 Annual Research Report
  • [Presentation] エダラボンの放射線防護効果2007

    • Author(s)
      笹野仲史、榎本敦、細井義夫、勝村庸介、井垣浩、白石憲史郎、宮川清、中川恵一
    • Organizer
      日本放射線腫瘍学会第20回学術大会
    • Place of Presentation
      福岡市
    • Related Report
      2009 Final Research Report
  • [Presentation] 重粒子線のよるEGF受容体活性化2007

    • Author(s)
      細井義夫、榎本敦、笹野仲史、加藤宝光、関根絵美子、岡安隆一、宮川清
    • Organizer
      日本放射線腫瘍学会第20回学術大会
    • Place of Presentation
      福岡市
    • Related Report
      2009 Final Research Report 2007 Annual Research Report
  • [Presentation] エダラボンの放射線防護効果2007

    • Author(s)
      笹野仲史、榎本敦、細井義夫、白石憲史郎、宮川清、勝村庸介、中川恵一
    • Organizer
      日本放射線影響学会第50回大会
    • Place of Presentation
      千葉市
    • Related Report
      2009 Final Research Report
  • [Presentation] 新規MAP3K結合因子の機能解析2007

    • Author(s)
      榎本敦、木戸直樹、伊藤道彦、森田明典、細井義夫、宮川清
    • Organizer
      日本放射線影響学会第50回大会
    • Place of Presentation
      千葉市
    • Related Report
      2009 Final Research Report
  • [Presentation] オルトバナジン酸ナトリウムによるp53制御メカニズムの解明2007

    • Author(s)
      山本真一、森田明典、伊藤あずさ、榎本敦、松本義久、船津修、細井義夫、鈴木紀夫、池北雅彦
    • Organizer
      日本放射線影響学会第50回大会
    • Place of Presentation
      千葉市
    • Related Report
      2009 Final Research Report
  • [Presentation] 重粒子線によるEGF受容体を介したERKの活性化2007

    • Author(s)
      細井義夫、榎本敦、笹野仲史、加藤宝光、関根絵美子、藤井義大、岡安隆一、宮川清
    • Organizer
      日本放射線影響学会第50回大会
    • Place of Presentation
      千葉市
    • Related Report
      2009 Final Research Report 2007 Annual Research Report
  • [Presentation] Transactivation of EGF receptor by X-irradiation. The 100th Anniversary of Tohoku University2007

    • Author(s)
      細井義夫
    • Organizer
      The 5th Japan-US Cancer Therapy Symposium & The 5th S. Takahashi Memorial International Joint Symposium.
    • Place of Presentation
      仙台市
    • Related Report
      2009 Final Research Report
  • [Presentation] エダラボンの放射線防護効果2007

    • Author(s)
      笹野仲史、榎本敦、細井義夫、白石憲史郎、井垣浩、勝村庸介、宮川清、中川恵一
    • Organizer
      第46回日本医学放射線学会生物部会学術大会
    • Place of Presentation
      つくば市
    • Related Report
      2009 Final Research Report
  • [Presentation] 重粒子線照射によるEGF受容体の活性化2007

    • Author(s)
      細井義夫、榎本敦、笹野仲史、加藤宝光、関根絵美子、岡安隆一、宮川清
    • Organizer
      第46回日本医学放射線学会生物部会学術大会
    • Place of Presentation
      つくば市
    • Related Report
      2009 Final Research Report
  • [Presentation] Missing links in the mechanism of DNA double-strand break repair through the non-homologous end-joining pathway.2007

    • Author(s)
      松本義久、Sushima M.Bhosle、富田雅典、鈴木紀夫、細井義夫、宮川清
    • Organizer
      13th International Congress of Radiation Research
    • Place of Presentation
      サンフランシスコ市
    • Related Report
      2009 Final Research Report
  • [Presentation] Src tyrosine kinase inhibitor PP2 suppresses activation of ERK1/2 and epidermal growth factor receptor induced by X-irradiation.2007

    • Author(s)
      細井義夫、宮川清
    • Organizer
      13th International Congress of Radiation Research
    • Place of Presentation
      サンフランシスコ市
    • Related Report
      2009 Final Research Report
  • [Presentation] 放射線によるphosphatase不活化を介したEGF受容体活性化・放射線抵抗性化2007

    • Author(s)
      細井義夫、松本義久、榎本敦、桂真理、宮川清
    • Organizer
      第66回日本医学放射線学会学術集会
    • Place of Presentation
      横浜市
    • Related Report
      2009 Final Research Report
  • [Presentation] エダラボンの放射線防護効果2007

    • Author(s)
      笹野仲史、榎本敦、松本義久、細井義夫、宮川清、中川恵一
    • Organizer
      第9回癌治療増感研究シンポジウム
    • Place of Presentation
      奈良市
    • Related Report
      2009 Final Research Report
  • [Presentation] 放射線によるphosphatase 不活化を介したEGF受容体活性化・放射線抵抗性化2007

    • Author(s)
      細井義夫、松本義久、榎本敦、桂真理、宮川清
    • Organizer
      第66 回日本医学放射線学会学術集会
    • Place of Presentation
      横浜市
    • Related Report
      2008 Self-evaluation Report
  • [Presentation] 低線量全身照射による癌転移抑制効果2006

    • Author(s)
      細井義夫
    • Organizer
      平成18年度サマースクールーナノの世界から宇宙まで一((社)日本アイソトープ協会主催)
    • Place of Presentation
      箱根町
    • Year and Date
      2006-07-27
    • Related Report
      2009 Final Research Report
  • [Presentation] Sp1によるDNA2重鎖切断修復酵素の転写制御と放射線感受性制御2006

    • Author(s)
      細井義夫、丹野悠司、松本義久、榎本敦、高倉かおる、宮川清
    • Organizer
      第4回日本医学放射線学会生物部会学術大会
    • Place of Presentation
      弘前市
    • Year and Date
      2006-07-01
    • Related Report
      2009 Final Research Report 2008 Self-evaluation Report
  • [Presentation] 時間が修復に及ぼす影響の分子機構2006

    • Author(s)
      細井義夫
    • Organizer
      第36回放射線による制癌シンポジウム-基礎と臨床の対話
    • Place of Presentation
      弘前市
    • Year and Date
      2006-06-30
    • Related Report
      2009 Final Research Report
  • [Presentation] Biological basis for chemo-radiotherapy.ology.2006

    • Author(s)
      細井義夫
    • Organizer
      IAEA/RCA Reginal Training Course on Radiation Biology for Radiation Onc
    • Place of Presentation
      千葉市
    • Year and Date
      2006-05-18
    • Related Report
      2009 Final Research Report
  • [Presentation] Sp1によるDNA2重鎖切断修復酵素の転写制御と放射線感受性制御2006

    • Author(s)
      細井義夫、丹野悠司、松本義久、榎本敦、冨田雅典、高倉かほる、宮川清
    • Organizer
      日本放射線腫瘍学会第19回学術大会
    • Place of Presentation
      仙台市
    • Related Report
      2009 Final Research Report
  • [Presentation] 新規JNKカスケード制御因子の機能解析とそれを標的としたアポトーシス増感2006

    • Author(s)
      榎本敦、木戸直樹、森田明典、伊藤道彦、松本義久、細井義夫、宮川清
    • Organizer
      日本放射線影響学会第49回大会
    • Place of Presentation
      札幌市
    • Related Report
      2009 Final Research Report
  • [Presentation] Sp1によるDNA2重鎖切断修復酵素の転写制御と放射線感受性制御2006

    • Author(s)
      細井義夫、丹野悠司、松本義久、榎本敦、桂真理、高倉かほる、宮川清
    • Organizer
      日本放射線影響学会第49回大会
    • Place of Presentation
      札幌市
    • Related Report
      2009 Final Research Report
  • [Presentation] NHEJ修復酵素群のDNA二重鎖切断部位への動員とリン酸化による制御2006

    • Author(s)
      松本義久、BHOSLE Sushma M.、冨田雅典、榎本敦、森田明典、鈴木紀夫、細井義夫、宮川清
    • Organizer
      日本放射線影響学会第49回大会
    • Place of Presentation
      札幌市
    • Related Report
      2009 Final Research Report
  • [Presentation] 高LET重イオンによるDNA損傷へのKu80の反応2006

    • Author(s)
      和田成一、松本義久、大戸貴代、浜田信行、原孝光、船山知夫、坂下哲哉、深本花菜、柿崎竹彦、鈴木芳代、細井義夫、鈴木紀夫、小林泰彦
    • Organizer
      日本放射線影響学会第49回大会
    • Place of Presentation
      札幌市
    • Related Report
      2009 Final Research Report
  • [Presentation] 重イオンによる細胞致死効果とDNA依存性プロテインキナーゼの応答2006

    • Author(s)
      冨田雅典、松本義久、細井義夫、古澤佳也、矢野安重、酒井一夫
    • Organizer
      日本放射線影響学会第49回大会
    • Place of Presentation
      札幌市
    • Related Report
      2009 Final Research Report
  • [Presentation] エダラボンの放射線防護効果2006

    • Author(s)
      笹野仲史、細井義夫、白石憲史郎、榎本敦、宮川清、勝村庸介、中川恵一
    • Organizer
      日本放射線影響学会第49回大会
    • Place of Presentation
      札幌市
    • Related Report
      2009 Final Research Report
  • [Presentation] 転写因子Sp1によるDNA2重鎖切断修復酵素の転写制御と放射線増感2006

    • Author(s)
      細井義夫
    • Organizer
      第65回日本医学放射線学会学術集会
    • Place of Presentation
      横浜市
    • Related Report
      2009 Final Research Report
  • [Presentation] Sp1によるDNA2重鎖切断修復酵素の転写制御と放射線感受性制御2006

    • Author(s)
      細井義夫、丹野悠司、松本義久、榎本敦、冨田雅典、高倉かほる、宮川清
    • Organizer
      日本放射線腫瘍学会第19 回学術大会
    • Place of Presentation
      日仙台市
    • Related Report
      2008 Self-evaluation Report
  • [Presentation] Sp1によるDNA2重鎖切断修復酵素の転写制御と放射線感受性制御2006

    • Author(s)
      細井義夫, 丹野悠司, 松本義久, 榎本敦, 桂真理, 高倉かほる, 宮川清
    • Organizer
      日本放射線影響学会第49 回大会
    • Place of Presentation
      札幌市
    • Related Report
      2008 Self-evaluation Report
  • [Presentation] 転写因子Sp1によるDNA2 重鎖切断修復酵素の転写制御と放射線増感2006

    • Author(s)
      細井義夫
    • Organizer
      第65回日本医学放射線学会学術集会
    • Place of Presentation
      横浜市
    • Related Report
      2008 Self-evaluation Report
  • [Book] がん放射線療法 20102010

    • Author(s)
      細井義夫(分担) 大西洋, 唐澤克之, 唐澤久美子監修
    • Total Pages
      1247
    • Publisher
      (株)篠原出版者
    • Related Report
      2009 Annual Research Report
  • [Book] 放射線医科学-生体と放射線・電磁波・超音波-(放射線によるDNA損傷と染色体異常)(大西武雄監修)2007

    • Author(s)
      細井義夫
    • Publisher
      学会出版センター
    • Related Report
      2009 Final Research Report
  • [Book] がん放射線療法2010(大西洋, 唐澤克之, 唐澤久美子監修)(放射線腫瘍学の生物学的基礎)

    • Author(s)
      細井義夫
    • Publisher
      (株)篠原出版社
    • Related Report
      2009 Final Research Report

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Published: 2006-04-01   Modified: 2016-04-21  

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