| Project/Area Number |
18390333
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Radiation science
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| Research Institution | Kyoto University |
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Principal Investigator |
NAGATA Yasushi Kyoto University, 医学研究科, Associate Professor (10228033)
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| Co-Investigator(Kenkyū-buntansha) |
MITSUMORI Michihide Kyoto University, 医学研究科, Lecturer (10263089)
MIZOWAKI Takashi Kyoto University, 医学研究科, Lecturer (90314210)
NARITA Yuichiro Kyoto University, 医学研究科, Lecturer (30311385)
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| Project Period (FY) |
2006 – 2007
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| Project Status |
Completed (Fiscal Year 2007)
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| Budget Amount *help |
¥13,310,000 (Direct Cost: ¥11,900,000、Indirect Cost: ¥1,410,000)
Fiscal Year 2007: ¥6,110,000 (Direct Cost: ¥4,700,000、Indirect Cost: ¥1,410,000)
Fiscal Year 2006: ¥7,200,000 (Direct Cost: ¥7,200,000)
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| Keywords | 4-dimensional treatment planning / radiotherapy / IGRT / respiratory gating / 4-d CT / stereotactic radiotherapy |
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| Research Abstract |
To develop a new four-dimensional image-guided radiotherapy (IGRT) system, the following systems were developed.
1. Four-dimensional treatment planning system
Four-dimensionally reconstructed CT images were obtained using MD-CT and gating signals. With these images, the movement of lung tumor could be more precisely evaluated.
2. Respiratory gating system
The relationship between the abdominal wall movement of a patient and lung tumor movement was evaluated. As a result, the correlation was so high (0.97). Therefore, the abdominal wall movement can be used as a surrogate signal for lung tumor.
3. Clinical application of SBRT
Two-hundreds and thirty patients have been treated with SBRT technique. Ninety percent of high local control rates had been achieved for the patients with T1NOMO and T2NOMO tumor. Serious complications greater than CTCAE Grade 3 were 1.5%. The clinical results for the patients with pulmonary oligometastases were also promising.
4. Development of an IGRT system
A new four-dimensional IGRT system was equipped with gimbaled X-ray system and ultralight C-band linear accelerator on a rigid 0-ring structure. The accuracy of the static beam positioning was 0.1mm.
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