The development of the transcatheter therapy using cationized gelatine in various disease

• Project/Area Number: 18390336
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Radiation science
• Research Institution: Tokai University
• Principal Investigator: FUKUYAMA Naoto Tokai University, 医学部, 准教授 (50349338)
• Co-Investigator(Kenkyū-buntansha): TAMAI Yoshifumi 東海大学, 医学部, 講師 (90207225) ; TSUJI Chizuko 医学部, 医学部, 講師 (80130079) ; NAGATA Naruhiko 東海大学, 医学部, 医学部 (60307254) ; MORI Hidezo 東海大学, 医学部, 教授 (90146598) ; 中澤 博江 東海大学, 医学部, 教授 (20110885)
• Project Period (FY): 2006 – 2008
• Project Status: Completed (Fiscal Year 2008)
• Budget Amount: ¥18,230,000 (Direct Cost: ¥15,500,000、Indirect Cost: ¥2,730,000); Fiscal Year 2008: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000); Fiscal Year 2007: ¥6,890,000 (Direct Cost: ¥5,300,000、Indirect Cost: ¥1,590,000); Fiscal Year 2006: ¥6,400,000 (Direct Cost: ¥6,400,000)
• Keywords: カテーテル治療 / 難治性疾患 / 肝細胞癌 / カテール治療 / 脳梗塞症 / 遺伝子治療 / 原発性肺高血圧症 / カテーテル / モノクロタリン

Research Abstract

本研究で、急性心筋梗塞、肝硬変、肝細胞癌や放射線肺臓炎などの治りにくい疾患に対してカテーテル(動脈内に挿入し、目的とする臓器に薬を投与する管)を用いた新たな治療法の開発を行った。具体的には、動物実験モデルを用いてそれぞれの疾患を作成し、カテーテル内に疾患の治癒を誘導するような細胞を投与し、新たな治療法となる可能性を見出した。この研究により、それぞれの治りにくい疾患への実際の診療現場で応用されることが期待される。

Research Products

• [Journal Article] Effect of sustained limb ischemia on norepinephrine release from skeletal musclesympathetic nerve endings. (2009)
  • Author(s): Y. Kuroko, N. Tokunaga, H. Moei, 他4名
  • Journal Title: Neurochem Int. 49 Pages: 448-453
  • Peer Reviewed
• [Journal Article] Validation of the Friedewald Equation for Evaluation of Plasma LDL-Cholesterol. (2008)
  • Author(s): N. Fukuyama, K. Homma, N. Wakana, K. Kudo, A. Suyama, H. Ohazama, C. Tsuji, K. Ishiwata, H. Nakazawa, E. Tanaka.
  • Journal Title: J. Clin. Biochem. Nutr. 43 Pages: 1-5
  • NAID: 130004466520
  • Peer Reviewed
• [Journal Article] Activation of Inducible nitric Oxide Synthase Increases MMP-2 and MMP-9 Levels in ApoE-knockout Mice. (2008)
  • Author(s): Y. Chen, Y. Aratani, T. Osawa, N. Fukuyama, C. Tsuji, H. Nakazawa
  • Journal Title: Tokai J Exp Clin Med. vol.33, No. 1 Pages: 28-34
  • Peer Reviewed
• [Journal Article] Quantitative Assessment of microllateral recruitment during coronary occlusion using real-time intravenous myocardial contrast echocardiography. (2008)
  • Author(s): F. Ishikura, K. Otani, H. Kayano, H. Mori, S. Beppu, 他5名
  • Journal Title: J American Society of Echocardiography 21 Pages: 139-145
  • Peer Reviewed
• [Journal Article] Role of Cu, Zn-SOD in the synthesis of endogeneous vasodilator hydrogen peroxide during reactive hyperemia in mouse mesenteric microcirculation in vivo. (2008)
  • Author(s): T. Yada, J. Shimokawa, H. Mori, F. Kajiya, 他5名
  • Journal Title: Am J Physio Heart Circ Physiol. 294(1)
  • Peer Reviewed
• [Journal Article] Single injection of a sustained-release prostacyclin analog improves pulmonary hypertension in rats. (2008)
  • Author(s): H. Obata, Y. Sakai, H. Mori, N. Nagaya, 他5名
  • Journal Title: Am J Respir Crit Care Med. 177(2) Pages: 195-201
  • Peer Reviewed
• [Journal Article] Eight-week oral administration of meloxicam, a non- steroidal anti-inflammatory drug, prevents dose reduction of pegylated interferon alpha-2a in the treatment of chronic hepatitis C (2008)
  • Author(s): Kagawa, T. Shiozawa, H. Nagata, N. Mine, T, 他9名
  • Journal Title: Hepatol Res. 8 : 3 Pages: 259-66
  • Peer Reviewed
• [Journal Article] Validation of the Friedewald Equation for Evaluation of Plasma LDL-Cholesterol. (2008)
  • Author(s): Naoto Fukuyama
  • Journal Title: J. Clin. Biochem. Nutr 43 Pages: 1-5
  • NAID: 130004466520
  • Peer Reviewed
• [Journal Article] Activation of Inducible nitric Oxide Synthase Increases MMP-2 and MMP-9 Levels in ApoE-knockout Mice (2008)
  • Author(s): Yi Chen
  • Journal Title: Tokai J Exp Clin Med 433(1) Pages: 28-34
  • Peer Reviewed
• [Journal Article] 沖縄モズク由来アセチルフコイダンの癌抑制効果 (2007)
  • Author(s): 石渡一夫、静間 徹、中澤博江、盛英三、福山直人
  • Journal Title: 静脈経腸栄養 22(4) Pages: 489-494
  • NAID: 10026891755
  • Peer Reviewed
• [Journal Article] 黒酢もろみ末による大腸癌の抑制効果 -ヒト大腸癌細胞を移植した動物モデルを用いて- (2007)
  • Author(s): 静間 徹、石渡一夫、中澤博江、長野正信、盛英三、福山直人
  • Journal Title: 静脈経腸栄養 22(3) Pages: 337-342
  • NAID: 10019782965
  • Peer Reviewed
• [Journal Article] Effect of Kurozu (Brewed rice vinegar) on Neovascularization in Rat Ischemic Myocardial Tissue. (2007)
  • Author(s): N. Wakana, K. Homma, K. Kimura, N. Fukuyama, K. Myojin, M. Nagano, E. Tanaka.
  • Journal Title: 日本健康医学会雑誌 15(4) Pages: 22-26
  • NAID: 110009563511
  • Peer Reviewed
• [Journal Article] moromimatsu inhibits tumor growth of Lovo cells in a mouse model in vivo. (2007)
  • Author(s): Fukuyama, N., Jujo, S., Ito, I., Shizuma, T., Myojin, K., Ishiwata, K., Nagano, M., Nakazawa, H., Mori, H. Kurozu
  • Journal Title: Nutrition 23 (1) Pages: 81-86
  • Peer Reviewed
• [Journal Article] Intravenous injection of phagocytes transfected ex vivo with FGF4 DNA/ biodegradable gelatin complex promotes angiogenesis in a rat myocardial ischemia/reperfusion injury model. Basic Research in Cardiology. (2007)
  • Author(s): N. Fukuyama, E. Tanaka, Y. Tabata, H. Fujikura, M. Hagihara, H. Sakamoto, K. Ando, H. Nakazawa, H. Mori.
  • Journal Title: Basic Res Cardiol. 102(3) Pages: 209-216
  • Peer Reviewed
• [Journal Article] Novel monochromatic x-ray generators and their applications. Next Generation Photonics and Media Technologies (2007)
  • Author(s): E. Sato, T. Enomoto, H. Mori, S. Sato, 他7名
  • Journal Title: Photonics World Consortium. Pages: 34-39
  • Peer Reviewed
• [Journal Article] Tunable nnarrow- photon -neragy x-ray source using a silicon single crystal (2007)
  • Author(s): E. Sato, E. Tanaka, H. Mori, K. Takayama, 他8名
  • Journal Title: SPIE 6706(670610) Pages: 1-7
  • Peer Reviewed
• [Journal Article] Characterization of ouabain-induced noradrenaline and acetylcholine release from in situ cardiac autonomic nerve endings. (2007)
  • Author(s): T. Yamazaki, T. Akiyama, H. Mori, M. Sugimachi, 他4名
  • Journal Title: Acta Physiol (Oxf). 191(4) Pages: 275-284
  • Peer Reviewed
• [Journal Article] Role of Cu, Zn-SOD in the Synthesis of Endogenous Vasodilator Hydrogen Peroxide during Reactive Hyperemia in Mouse Mesenteric Microcirculation in Vivo. (2007)
  • Author(s): T. Yada, H. Shimokawa, H. Mori, F. Kajiya, 他5名
  • Journal Title: Am J Physiol Heart Circ Physiol.
  • Peer Reviewed
• [Journal Article] Important role of endogenous hydrogen peroxide in pacing-induced metabolic coronary vasodilation in dogs in vivo. (2007)
  • Author(s): T. Yada, H. Shimokawa, H. Mori, F.Kajiya, 他4名
  • Journal Title: J Am Coll Cardiol. 50(13) Pages: 1272-1278
  • Peer Reviewed
• [Journal Article] Crystal structure of RVV-X : An example of evolutionary gain of specificity by ADAM proteinases. (2007)
  • Author(s): S. Takeda, T. Igarashi, H. Mori.
  • Journal Title: FEBS Lett. 581(30) Pages: 5859-5864
  • Peer Reviewed
• [Journal Article] Edaravone preserves coronary microvascular endothelial function after ischemia/ reperfusion on the beating beacanine heart in vivo. (2007)
  • Author(s): R. Sukmawan, T. Yada, H. Mori, K. Yoshida, 他6名
  • Journal Title: J Pharmacol Sci. 104(4) Pages: 341-348
  • Peer Reviewed
• [Journal Article] K-edge magnification digital angiography using a 100-μm-focus tungsten tube. (2007)
  • Author(s): E. Sato, E. Tanaka, H. Mori, J.Onagawa, 他8名
  • Journal Title: Opt Eng. 46(026503) Pages: 1-6
  • Peer Reviewed
• [Journal Article] High-sensitive radiographysystem tilizing a pulse x-ray generator and a night-vision CCD camera (MLX)(Proc.). (2007)
  • Author(s): E. Sato, M. Sagae, H. Mori, Takayama, 他6名
  • Journal Title: SPIE. 6279(627941) Pages: 1-6
  • Peer Reviewed
• [Journal Article] Novel monochromatic x-ray generators and their applications to high-speed radiography (6279). (2007)
  • Author(s): E. Sato, R. Germer, H. Mori, K. Takayama, 他9名
  • Journal Title: SPIE 627906 Pages: 1-12
  • Peer Reviewed
• [Journal Article] Intense clean characteristic flash x-ray irradiation from an evaporating molybdenum diode. (2007)
  • Author(s): M. Sagae, H. Mori, H. Ido, 他8名
  • Journal Title: Opt. Eng. 46(026502) Pages: 1-7
  • Peer Reviewed
• [Journal Article] Single Injection of a Sustained -release Prostacyclin Analog Improves Pulmonary Hypertension in Rats. (2007)
  • Author(s): H. Obata, Y. Sakai, H. Mori, N. Nagaya, 他5名
  • Journal Title: Am J Respir Crit Care Med.
  • Peer Reviewed
• [Journal Article] Visualization of intracerebral arteries by synchrotron radiation microangiography. (2007)
  • Author(s): K. Myojin, A. Taguchi, H. Mori, 他7名
  • Journal Title: Am J Neuroradiol. 28(5) Pages: 953-957
  • Peer Reviewed
• [Journal Article] Cardiac epinephrine synthesis and ischemia-induced myocardial epinephrine release. (2007)
  • Author(s): Y. Kuroko, T. Yamazaki, H. Mori, 他5名
  • Journal Title: Cardiovasc Res. 74(3) Pages: 438-444
  • Peer Reviewed
• [Journal Article] Regional difference in ischaemia-induced myointerstitial noradrenaline and acetylcholine releases. (2007)
  • Author(s): T. Kawada, T. Yamazaki, H. Mori, M. Sugimachi, 他8名
  • Journal Title: Auton Neurosci. 137(1-2) Pages: 44-50
  • Peer Reviewed
• [Journal Article] Angiotensin Iattenuates myocardial interstitial acetylcholine release in response to vagal stimulation. (2007)
  • Author(s): T. Kawada, T. Yamazaki, H. Mori, M. Sugimachi, 他4名
  • Journal Title: Am J Physiol Heart Circ Physiol 293(4)
  • Peer Reviewed
• [Journal Article] Hypothermia reduces ischemia- and stimulation-induced myocardial interstitial norepinephrine and acetylcholine releases. (2007)
  • Author(s): T. Kawada, H. Kitagawa, H. Mori, M. Sugimachi, 他4名
  • Journal Title: J Appl Physiol. 102(2) Pages: 622-627
  • Peer Reviewed
• [Journal Article] Crystal structures of catrocollastatin /VAP2B reveal a dynamic, modular architecture of ADAM/adamalysin /reprolysin family proteins. (2007)
  • Author(s): T. Igarashi, S. Araki, H. Mori, S. Takeda
  • Journal Title: FEBS Lett. 581(13) Pages: 2416-2422
  • Peer Reviewed
• [Journal Article] Synthesis of Sugar- Polysiloxane Hybrids Having Rigid Main-Chains and Formation of their Nano Aggregates. (2007)
  • Author(s): K. Beppu, Y. Kaneko, J. Kadokawa, H. Mori, T. Nishikawa.
  • Journal Title: Polymer Journal. 39 (10) Pages: 1065-1070
  • NAID: 10019764846
  • Peer Reviewed
• [Journal Article] A liver-derived immunosuppressive factor is an arginase : identification and mechan ism of immunosuppression. (2007)
  • Author(s): Ohtani, Y. Hiyoshi, M. Nagata, N. Tsuda, M, 他8名
  • Journal Title: Biomed Res. 28 : 1 Pages: 17-23
  • Peer Reviewed
• [Journal Article] 沖縄モズク由来アセチルフコイダンの癌抑制効果 (2007)
  • Author(s): 石渡 一夫
  • Journal Title: 静脈経腸栄養 22(4) Pages: 489-494
  • Peer Reviewed
• [Journal Article] 黒酢もろみ末による大腸癌の抑制効果-ヒト大腸癌細胞を移植した動物モデルを用いて-。 (2007)
  • Author(s): 静間 徹
  • Journal Title: 静脈経腸栄養 22(3) Pages: 337-342
  • Peer Reviewed
• [Journal Article] Effect of Kurozu (Brewed rice vinegar) on Neovascularization in Rat Ischemic Myocardial Tissue. (2007)
  • Author(s): Noriaki Wakana
  • Journal Title: 日本健康医学会雑誌 15・(4) Pages: 22-26
• [Journal Article] Kurozu moromimatsu inhibits tumor growth of Lovo cells in a mouse model in vivo. (2007)
  • Author(s): Fukuyama, N
  • Journal Title: Nutrition 23・(1) Pages: 81-86
• [Journal Article] Search for appropriate experimental methods to create stable hind-limb ischemia in mouse (2006)
  • Author(s): T. Goto, N. Fukuyama, A. Aki, K. Kanabuchi, K. Kimura, H. Taira, E. Tanaka, N. Wakana, H. MoriI and H. Ioue.
  • Journal Title: mouseTokai Journal of Experimental and Clinical Medicine 31(3) Pages: 128-132
  • Peer Reviewed
• [Journal Article] Efficient preparation of cationized gelatin for gene transduction. (2006)
  • Author(s): N. Fukuyama, T. Onuma, S. jujo, Y. Tamai, T. Suzuki, Y. Sug io, Y. Tabata, Y. Ishihara, J. Takano, H. Mori.
  • Journal Title: Tokai J Exp Clin Med. 31(2) Pages: 39-42
  • Peer Reviewed
• [Journal Article] Triiodothyronine acutely increase blood flow in the ventricles and kidneys of anesthesized rabbits. (2006)
  • Author(s): Kimura K, Shinozaki Y, Jujo S, Shizuma T, Fukuyama N, Nakazawa H.
  • Journal Title: Thyroid 16(4) Pages: 357-60
  • Peer Reviewed
• [Journal Article] Cardioprotective role of endogenous hydrogen peroxide during ischemia-reperfusion injury in canine coronary microcirculation in vivo. (2006)
  • Author(s): T. Yada, H. Shimokawa, H. Mori, F, Kajiya, 他7名
  • Journal Title: Am J Physiol Heart Circ Physiol 291(3)
  • Peer Reviewed
• [Journal Article] Crystal structures of VAP1 reveal ADAMs' MDC domain architecture and its unique C-shaped scaffold. (2006)
  • Author(s): S. Takeda, T. Igarashi, H. Mori, S. Araki.
  • Journal Title: EMBO J. 25(11) Pages: 2388-2396
  • Peer Reviewed
• [Journal Article] Granulocyte colony-stimulating factor mediates cardioprotection against ischemia/ reperfusion injury via phosphatidylinositol-3-kinase/Akt pathway in canine hearts. (2006)
  • Author(s): H. Takahama, T. Minamino, H. Mori, M. Kitakaze, 他11名
  • Journal Title: Cardiovasc Drugs Ther. 20(3) Pages: 159-165
  • Peer Reviewed
• [Journal Article] Amphiphilic poly(N-propargylamide) with galactose and lauryloyl groups : synthesis and properties (2006)
  • Author(s): M. Suenaga, Y. Kaneko, H. Mori, M. Tabata, 他2名
  • Journal Title: Macromol Biosci 6(12) Pages: 1009-1018
  • Peer Reviewed
• [Journal Article] Does central nitric oxide elicpulmonary hypertension in conscious rats (2006)
  • Author(s): D. O .Schwenke, J. T, Pearson, H. Mori, M.Shirai.
  • Journal Title: Respir Physiol Neurobiol. 153(3) Pages: 250-260
  • Peer Reviewed
• [Journal Article] Long-term monitoring of pulmonary arterial pressure in conscious, unrestrained mice. (2006)
  • Author(s): D. O. Schwenke, J. T. Pearson. H. Mori, M.Shirai.
  • Journal Title: J Pharmacol Toxicol Methods. 53(3) Pages: 277-283
  • NAID: 130005448387
  • Peer Reviewed
• [Journal Article] Characteristic X-ray Generator Utilizing Angle Dependence of Bremsstrah- lung X-ray Distribution. (2006)
  • Author(s): E. Sato, E. Tanaka, H. Mori, J. Onagawa, 他5名.
  • Journal Title: Jpn J Appl Phys. 45(No.4A) Pages: 2845-2849
  • NAID: 40007227523
  • Peer Reviewed
• [Journal Article] Demonstration of enhancedK-edge angiography using a samarium target x-ray generator (2006)
  • Author(s): E. Sato, E. Tanaka, H. Mori, K. Takayama, 他7名
  • Journal Title: SPIE 6319(63190L) Pages: 1-6
  • Peer Reviewed
• [Journal Article] Super-charcteristic x-ray generator utilizing a pipe and rod target. (2006)
  • Author(s): E. Sato, E. Tanaka, H. Mori, K, Takayama, 他7名
  • Journal Title: SPIE 6319(63190Q) Pages: 1-6
  • Peer Reviewed
• [Journal Article] Enhanced real-time magnification angiography utilizing a 100-μm-focus x-ray generator in conjunction with an image intensifier (2006)
  • Author(s): E. Sato, E. Tanaka, H. Mori, K.Takayama, 他7名
  • Journal Title: SPIE 6319(63190J) Pages: 1-7
  • Peer Reviewed
• [Journal Article] Tunable narrow-photon-energy x-ray generator utilizing a tungsten-target tube. (2006)
  • Author(s): E. Sato, H. Sugiyama, H. Mori, H. Ido, 他7名
  • Journal Title: Rad Phys Chem. 75 Pages: 2008-2013
  • Peer Reviewed
• [Journal Article] Preliminary study for producing higher harmonic hard x-rays from weakionized nickel plasma. (2006)
  • Author(s): E.Sato, Y.Hayasi, H. Mori, H. Ido, 他7名
  • Journal Title: Rad Phys Chem. 75 Pages: 1812-1818
  • Peer Reviewed
• [Journal Article] K-edge angiography utilizing a tungsten plasma x-ray generator in conjunction with gadolinium-based contrast media. (2006)
  • Author(s): E.Sato, Y.Hayasi, H.Mori, H.Ido, 他6名
  • Journal Title: Rad Phys Chem. 75 Pages: 1841-1849
  • Peer Reviewed
• [Journal Article] X-ray Spectra from WeaklyIonized Linear Copper Plasma. (2006)
  • Author(s): E. Sato, Y. Hayashi, H. Mori, J. Onagawa, 他7名
  • Journal Title: Jpn J Appl Phys 45(6A) Pages: 5301-5306
  • Peer Reviewed
• [Journal Article] Beraprost sodiuenhances neovascularization in ischemic myocardium by mobilizing bone marrow cells in rats. (2006)
  • Author(s): Y. Miyahara, S. Ohnishi, H. Mori, N. Nagaya, 他5名
  • Journal Title: Biochem Biophys Res Commun 349(4) Pages: 1242-1249
  • Peer Reviewed
• [Journal Article] Monolayered mesenchymal stem cells repair scarred myocardium after myocardial infarction (2006)
  • Author(s): Y. Miyahara, N. Nagaya, H. Mori, 他11名
  • Journal Title: Nat Med. 12(4) Pages: 459-465
  • Peer Reviewed
• [Journal Article] Endophilin BARdomain drives membrane curvature by two newly identified structure-based mechanisms. (2006)
  • Author(s): M. Masuda, S. Takeda, H. Mori, N. Mochizuki, 他3名
  • Journal Title: EMBO J. 25(12) Pages: 2889-2897
  • Peer Reviewed
• [Journal Article] Effects of Ca^<2+> channel antagonists on nerv stimulation- induced and ischemia-induced myocardial interstitial acetylcholine release in cats. (2006)
  • Author(s): T. Kawada, T. Yamazaki, H. Mori, M. sugimachi, 他4名
  • Journal Title: Am J Physiol Heart Circ Physiol. 291(5)
  • Peer Reviewed
• [Journal Article] Vagal stimulation suppresses ischemia-induced myocardial interstitial norepinephrine release. (2006)
  • Author(s): T. Kawada, T. Yamazaki, H. Mori, M. Sugimachi, 他4名
  • Journal Title: Life Sci. 78(8) Pages: 882-887
  • Peer Reviewed
• [Journal Article] Crystallization and preliminary X-ray crystallographic analysis of two vascular apoptosis-inducing proteins (VAPs) from Crotalus atrox venom. (2006)
  • Author(s): T. Igarashi, Y. Oishi, S. Araki, H. Mori, S. Takeda.
  • Journal Title: ActCrystallograph Sect F Struct Biol Cryst Commun. 62 Pages: 688-691
  • Peer Reviewed
• [Journal Article] Erythropoietin enhancesneovascularization of ischemic myocardium and improves left ventricular dysfunction after myocardial infarction in dogs. (2006)
  • Author(s): A. Hirata, T. Minamino, H. Mori, M. Hori, 他12名
  • Journal Title: J Am Coll Cardiol. 48(1) Pages: 176-184
  • Peer Reviewed
• [Journal Article] Enhanced magnification angiography using 20μm-focus tungstentube (2006)
  • Author(s): T. Enomoto, E.Sato, H. Mori, S. Sato, 他8名
  • Journal Title: Jpn J Appl Phys. 45 Pages: 8005-8009
  • Peer Reviewed
• [Journal Article] Heavy ion radiation up-regulates Cx43 and ameliorates arrhythmogenic substrates in hearts after myocardial infarction. (2006)
  • Author(s): M.Amino, K.Yoshiokam, H. Mori, I.. Kodama, 他8名
  • Journal Title: Cardiovasc Res. 72(3) Pages: 412-421
  • NAID: 10019861094
  • Peer Reviewed
• [Journal Article] Taurolithocholate impairs bile canalicular motility and canalicular bile secretion in isolated rat hepatocyte couplets. (2006)
  • Author(s): Watanabe, N. Kagawa, T. Nagata, N. Mine, T, 他3名
  • Journal Title: World J Gastroen terol. 12 : 33 Pages: 6320-5
  • Peer Reviewed
• [Journal Article] Intravenous injection of phagocytes transfected ex vivo with FGF4 DNA/biodegradable gelatin complex promotes angiogenesis in a rat myocardial ischemia/reperfusion injury model. (2006)
  • Author(s): Naoto Fukuyama
  • Journal Title: Basic Res Cardiol (ONLINE)
• [Journal Article] Efficient preparation of cationized gelatin for gene transduction. (2006)
  • Author(s): Naoto Fukuyama
  • Journal Title: Tokai J Exp Clin Med 31・(2) Pages: 39-42
• [Journal Article] Triiodothyronine acutely increases blood flow in the ventricles and kidneys of anesthesized rabbits. (2006)
  • Author(s): Kimura K
  • Journal Title: Thyroid 16・(4) Pages: 357-360
• [Journal Article] Validation of the Friedewald Equation for Evaluation of Plasma LDL-Cholesterol.
  • Author(s): Naoto Fukuyama
  • Journal Title: JCBN (in press)
  • NAID: 130004466520
  • Peer Reviewed
• [Presentation] n-hospital micro- angiography for vascular regeneration therapy. (2009)
  • Author(s): Yoshimori Ikeya. Naoto Fukuyama.
  • Organizer: The 73^<rd> Annual Scientific Meeting of the Japanese Circulation Society
  • Place of Presentation: Osaka
• [Presentation] Development of Microangiographic Systems for Visualization, Quantification andTherapeutic Evaluation of Angiogenic Vessels. (2009)
  • Author(s): T. Fujii. N. Fukuyama.
  • Organizer: The 11th International Symposium on Anti-Angiogenic Agents.
  • Place of Presentation: San Diego, California
• [Presentation] 動物モデルを用いた、肝虚血後再灌流による肝障害に対するフラボノイドの効果 (2009)
  • Author(s): 静間徹、福山直人
  • Organizer: 第24回日本静脈経腸栄養学会
  • Place of Presentation: 鹿児島
• [Presentation] 経腸栄養剤の変更により下痢が消失したPEG造設症例 (2009)
  • Author(s): 静間徹、福山直人
  • Organizer: 第24回日本静脈経腸栄養学会
  • Place of Presentation: 鹿児島
• [Presentation] In-hospital microangiography for vascular regeneration therapy. (2009)
  • Author(s): Yoshimori Ikeya
  • Organizer: 第73回日本循環器学会総会・学術集会
  • Place of Presentation: 大阪
• [Presentation] Development of Microangiographic Systems for Visualization, Quantification and Therapeutic Evaluation of Angiogenic Vessels. (2009)
  • Author(s): T. Fujii
  • Organizer: The 11th International Symposium on Anti-Angiogenic Agents.
  • Place of Presentation: San Diego, USA
• [Presentation] 難治性肝疾患における各種ラジカルスカベンジャーの効果-肝機能障害改善作用を有する経腸栄養剤の開発- (2009)
  • Author(s): 福山 直人
  • Organizer: 第24回日本静脈経腸栄養学会
  • Place of Presentation: 鹿児島
• [Presentation] 動物モデルを用いた、肝虚血後再灌流による肝障害に対するフラボノイドの効果。 (2009)
  • Author(s): 静間 徹
  • Organizer: 第24回日本静脈経腸栄養学会
  • Place of Presentation: 鹿児島
• [Presentation] Microangiography with reverse Compton scattering X-ray(rCX)system. (2008)
  • Author(s): Fukuyama Naoto
  • Organizer: 第85回日本生理学会大会
  • Place of Presentation: 京王プラザホテル東京
  • Year and Date: 2008-03-27
• [Presentation] 機能性食品や薬物を用いた栄養代謝制御の試み 黒酢による大腸炎および大腸癌・肝細胞癌の抑制効果 動物モデルにおける検討 (2008)
  • Author(s): 静間徹、福山直人
  • Organizer: 第39回 日本消化吸収学会総会
  • Place of Presentation: 東京・高輪
• [Presentation] Intravenous injection of phagocytes transfected ex vivo with FGF4 DNA/ biodegradable gelatin complex promotes angiogenesis in a rat myocardial ischemia/reperfusion injury model (2008)
  • Author(s): Naoto Fukuyama
  • Organizer: The25th Annual Meeting of International Society for Heart Research Japanese Section
  • Place of Presentation: Yokohama
• [Presentation] Kurozu moromimatsu inhibits tumor growth of Lovo cells in a mouse model in vivo (2008)
  • Author(s): Yokohama
  • Organizer: 30^<th>ESPEN Congress
  • Place of Presentation: Florence
• [Presentation] 逆コンプトン散乱X線源を用いた微小血管造影-犬心臓と家兎耳 (2008)
  • Author(s): Florence
  • Organizer: 第85回日本生理学会大会
  • Place of Presentation: 東京
• [Presentation] DEN誘発性肝臟癌動物モデルを用いた、黒酢もろみ末の癌抑制効果 (2008)
  • Author(s): 静間徹、福山直人
  • Organizer: 静脈経腸栄養・23巻増刊page207、第23回静脈経腸栄養学会
  • Place of Presentation: 京都
• [Presentation] 機能性食品や薬物を用いた栄養代謝制御の試み黒酢による大腸炎および大腸癌・肝細胞癌の抑制効果 動物モデルにおける検討。 (2008)
  • Author(s): 静間 徹
  • Organizer: 第39回 日本消化吸収学会総会
  • Place of Presentation: 東京
• [Presentation] Intravenous injection of phagocytes transfected ex vivo with FGF4 DNA/biodegradable gelatin complex promotes angioge nesis in a rat myocardial ischemia/reperfusion injury model. (2008)
  • Author(s): Naoto Fukuyama
  • Organizer: The 25th Annual Meeting of International Society for Heart Research Japanese Section
  • Place of Presentation: 横浜
• [Presentation] Kurozu moromimatsu inhibits tumor growth of Lovo cells in a mouse model in vivo. (2008)
  • Author(s): Naoto Fukuyama
  • Organizer: 30th ESPEN Congress
  • Place of Presentation: Florence, ITALY
• [Presentation] 経腸栄養剤の半固形化により、下痢・栄養状態の改善を認めた1例 (2008)
  • Author(s): 静間 徹
  • Organizer: 第23回日本静脈経腸栄養学会
  • Place of Presentation: 国立京都国際会館
• [Presentation] 短期間に著名な体重増減を認め、refeeding edemaの関与が推測された摂食障害の1例 (2008)
  • Author(s): 静間 徹
  • Organizer: 第23回日本静脈経腸栄養学会
  • Place of Presentation: 国立京都国際会館
• [Presentation] DEN誘発性肝臓癌モデルを用いた、黒酢もろみ末の癌抑制効果 (2008)
  • Author(s): 静間 徹
  • Organizer: 第23回日本静脈経腸栄養学会
  • Place of Presentation: 国立京都国際会館
• [Presentation] 黒酢による大腸癌細胞の増殖およびgelatinasesの抑制作用 (2006)
  • Author(s): 静間徹、福山直人
  • Organizer: 胞の増殖およびgelatinasesの抑制作用
  • Place of Presentation: 札幌