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A basic study on the development of bioartificial pancreas using a highly differentiated human pancreatic beta cell line.

Research Project

Project/Area Number 18390347
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field General surgery
Research InstitutionOkayama University

Principal Investigator

KOBAYASHI Naoya  Okayama University, Hospital of Medicine and Dentistry, Senior Assistant Professor (10325102)

Co-Investigator(Kenkyū-buntansha) YAMATSUJI Tomoki  Okayama University, Hospital of Medicine and Dentistry, Assistant Professor (40379730)
TABATA Yasuhiko  Kyoto University, Institute for Frontier Medical Sciences, Professor (50211371)
KUWAGI Kenya  Okayama University of Science, Faculty of Engineeting, Associate Professor (80302917)
KATO Jun  Okayama University, Hospital of Medicine and Dentdstry, Assistant Professor (90379743)
KONDO Eisaku  Okayama University, Graduate School of Medicine, Dentistry and Pharmaceutical Sriences, Associate Professor (30252951)
岩垣 博巳  岡山大学, 医学部・歯学部附属病院, 講師 (50240867)
Project Period (FY) 2006 – 2007
Project Status Completed (Fiscal Year 2007)
Budget Amount *help
¥17,970,000 (Direct Cost: ¥15,300,000、Indirect Cost: ¥2,670,000)
Fiscal Year 2007: ¥11,570,000 (Direct Cost: ¥8,900,000、Indirect Cost: ¥2,670,000)
Fiscal Year 2006: ¥6,400,000 (Direct Cost: ¥6,400,000)
KeywordsDiabetes / Cell Tissue / Tissue Eneineerin / Regenerative Medicine / Biotechnology
Research Abstract

We originally established a highly differentiated human pancreatic beta cell line. Therefore, we performed a basic study on the development of an implantable typed bioartificial pancreas (BAP) using the cell line for the treatment of diabetes.
1. The human pancreatic beta cell line was functionally cultured with a self-assembling peptide, PuraMatrix, to form islet-like struchture.
2. We constructed a BAP device in which the inner side is composed of high-density polyethylene (HDPE) coated with cellular adhesive polypeptides and the outer side is the membrane of ethylene venyl alcohol (EVAL). Freshly isolated rat islets attached on the surface of HDPE very well.
3. The BAP device was implanted in the intraabdominal cavity with be lapped by the greater omentum. When the outer side of the BAP device was coated by gelatinized bFGF, the number of the induced vessels around the device increased at 1.2-fold.
4. When 2,000 of freshly isolated rat islets injected into the BAP device, function of the islets were maintained for 28 days in vitro.

Report

(3 results)
  • 2007 Annual Research Report   Final Research Report Summary
  • 2006 Annual Research Report
  • Research Products

    (59 results)

All 2007 2006

All Journal Article (19 results) (of which Peer Reviewed: 5 results) Presentation (40 results)

  • [Journal Article] Cell-permeable pentapeptide V5 inhibits apoptosis and enhances insulin secretion, allowing experimental single-donor islet transplantation in mice.2007

    • Author(s)
      Jorge David Rivas-Carrillo
    • Journal Title

      Diabetes 56

      Pages: 1259-1267

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] バイオ人工膵臓2007

    • Author(s)
      小林直哉
    • Journal Title

      移植 42

      Pages: 112-123

    • NAID

      10020166564

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Pancreas development and beta-cell differentiation of embryonic stem cells.2007

    • Author(s)
      Jorge David Rivas-Carrillo
    • Journal Title

      Current medicinal chemistry 14

      Pages: 1573-1578

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Cell-permeable pentapeptide V5 inhibits apoptosis and enhances insulin secretion, allowing experimental single-donor islet transplantation in mice2007

    • Author(s)
      Jorge, David, Rivas-Carrillo
    • Journal Title

      Diabetes 56(5)

      Pages: 1259-1267

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Bioartificial pancreas(in Japanese)2007

    • Author(s)
      Naoya, Kobayashi
    • Journal Title

      Isyoku (Japanese Journal of Transplantation) 42(2)

      Pages: 112-123

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Pancreas development and beta-cell differentiation of embryonic stem cells2007

    • Author(s)
      Jorge, David, Rivas-Carrillo
    • Journal Title

      Current medicinal chemistry 14(14)

      Pages: 1573-1578

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] バイオ人工膵臓.2007

    • Author(s)
      小林 直哉
    • Journal Title

      移植 42(2)

      Pages: 112-123

    • NAID

      10020166564

    • Related Report
      2007 Annual Research Report
  • [Journal Article] Pancreas development and beta-cell differentiation of embryonic stem cells.2007

    • Author(s)
      Rivas-Carrillo J.D.
    • Journal Title

      Current medicinal chemistry 14(14)

      Pages: 1573-1578

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Cell-permeable Pentapeptide V5 Inhibits Apoptosis and Enhances Insulin Secretion, Allowing Experimental Single- donor Islet Transplantation In Mice.2007

    • Author(s)
      Rivas-Carrillo, Jorge David
    • Journal Title

      Diabetes 13(4)(印刷中)

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Cell therapy for diabetes mellitus.2006

    • Author(s)
      Naoya Kobayashi
    • Journal Title

      Cell Transplantation 15

      Pages: 849-854

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Amelioration of diabetes in mice after single-donor islet transplantation using the controlled release of gelatinized FGF-2.2006

    • Author(s)
      Jorge David Rivas-Carrillo
    • Journal Title

      Cell Transplantation 15

      Pages: 939-944

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] 糖尿病を標的としたバイオ人工膵臓の開発.2006

    • Author(s)
      三木 厚
    • Journal Title

      Organ Biology 13

      Pages: 401-410

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Cell therapy for diabetes mellitus2006

    • Author(s)
      Naoya, Kobayashi
    • Journal Title

      Cell Transplantation 15(10)

      Pages: 849-854

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Amelioration of diabetes in mice after single-donor islet transplantation using the controlled release of gelatinized FGF-22006

    • Author(s)
      Jorge, David, Rivas-Carrillo
    • Journal Title

      Cell Transplantation 15(10)

      Pages: 939-944

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Development of a bioartificial pancreas for the treatment of diabetes mellitus (in Japanese)2006

    • Author(s)
      Atsushi, Miki
    • Journal Title

      Organ Biology 13(4)

      Pages: 401-410

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Cell Therapy for Diabetes mellitus.2006

    • Author(s)
      Kobayashi, Naoya
    • Journal Title

      Cell Transplantation 15(10)

      Pages: 849-854

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Maintenance of Neovascularization at the Implantation Site of an Artificial Device By bFGF and Endothelial Cell Transplant.2006

    • Author(s)
      Miki, Atsushi
    • Journal Title

      Cell Transplantation 15(10)

      Pages: 893-901

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Amelioration of Diabetes in Mice After Single-Donor Islet Transplantation Using the Controlled Release of Gelatinized FGF-2.2006

    • Author(s)
      Rivas-Carrillo, Jorge David
    • Journal Title

      Cell Transplantation 15(10)

      Pages: 939-944

    • Related Report
      2006 Annual Research Report
  • [Journal Article] 糖尿病を標的としたバイオ人工膵臓の開発.2006

    • Author(s)
      三木 厚
    • Journal Title

      Organ Biology 13(4)

      Pages: 401-410

    • Related Report
      2006 Annual Research Report
  • [Presentation] 腹腔内埋め込み式バイオ人工膵臓に関する基礎的検討.2007

    • Author(s)
      湯淺 壮司
    • Organizer
      第69回日本臨床外科学会総会
    • Place of Presentation
      横浜市
    • Year and Date
      2007-11-29
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Annual Research Report 2007 Final Research Report Summary
  • [Presentation] Basic study on the development of an implantable typed bioartificial pancreas2007

    • Author(s)
      Takeshi, Yuasa
    • Organizer
      The 69th Annual Congress of the Japan Surgical Association
    • Place of Presentation
      Yokohama, Japan (in Japanese)
    • Year and Date
      2007-11-29
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 埋め込み式バッグ型バイオ人工膵臓を用いた糖尿病犬治療.2007

    • Author(s)
      小林 直哉
    • Organizer
      第34回日本臓器保存生物医学会定期学術集会
    • Place of Presentation
      札幌市
    • Year and Date
      2007-11-17
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Annual Research Report 2007 Final Research Report Summary
  • [Presentation] 体内埋め込み式バッグ型バイオ人工膵臓の腹腔内移植・大網被覆の検討.2007

    • Author(s)
      湯淺 壮司
    • Organizer
      第34回日本臓器保存生物医学会定期学術集会
    • Place of Presentation
      札幌市
    • Year and Date
      2007-11-17
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Annual Research Report 2007 Final Research Report Summary
  • [Presentation] 新鮮分離イヌ膵島の機能的な培養法に関する基礎的研究.2007

    • Author(s)
      窪田 康浩
    • Organizer
      第34回日本臓器保存生物医学会定期学術集会
    • Place of Presentation
      札幌市
    • Year and Date
      2007-11-17
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Annual Research Report 2007 Final Research Report Summary
  • [Presentation] Treatment of diabetic dogs with an implantable typed bioartificial pancreas2007

    • Author(s)
      Naoya, Kobayashi
    • Organizer
      34th Annual Congress of the Japan Society for Organ Preservation and Medical Biology
    • Place of Presentation
      Sapporo, Japan (in Japanese)
    • Year and Date
      2007-11-17
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Evaluation of omental rapping for the development of an implantable typed bioartificial pancreas2007

    • Author(s)
      Takeshi, Yuasa
    • Organizer
      34th Annual Congress of the Japan Society for Organ Preservation and Medical Biology
    • Place of Presentation
      Sapporo, Japan (in Japanese)
    • Year and Date
      2007-11-17
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Basic study on the functional culture of freshly isolated canine islets2007

    • Author(s)
      Yasuhiro, Kubota
    • Organizer
      34th Annual Congress of the Japan Society for Organ Preservation and Medical Biology
    • Place of Presentation
      Sapporo, Japan (in Japanese)
    • Year and Date
      2007-11-17
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Cell-permeable pentapeptide V5 inhibits apoptosis and enhances insulinsecretion, allowing experimental single-donor islet transplantation in mice.2007

    • Author(s)
      Jorge David Rivas-Carrillo
    • Organizer
      第34回膵・膵島移植研究会
    • Place of Presentation
      大阪市
    • Year and Date
      2007-03-30
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Cell-permeable pentapeptide V5 inhibits apoptosis and enhances insulin secretion, allowing experimental single-donor islet transplantation in mice2007

    • Author(s)
      Jorge, David, Rivas-Carrillo
    • Organizer
      The 34th Annual Congress of the Japan Society for Pancreas and Islet Transplantation
    • Place of Presentation
      Osaka, Japan
    • Year and Date
      2007-03-30
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 自己組織化ナノファイバーを用いた膵島の機能維持.2007

    • Author(s)
      Nalu Navarro-Alvarez
    • Organizer
      第6回日本再生医療学会総会
    • Place of Presentation
      横浜市
    • Year and Date
      2007-03-14
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Maintenance of islet function using a self-assembling peptide PuraMatrix2007

    • Author(s)
      Nalu, Navarro-Alvarez
    • Organizer
      The 6th Congress of the Japanese Society for Regenerative Medicine
    • Place of Presentation
      Yokohama, Japan
    • Year and Date
      2007-03-14
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Establishment of a human pancreatic beta cell line to develop a bioartificial pancreas.2006

    • Author(s)
      Naoya Kobayashi
    • Organizer
      The 3rd Symposium on Islet Transplantation
    • Place of Presentation
      ソウル(韓国)
    • Year and Date
      2006-11-25
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Establishment of a human pancreatic beta cell line to develop a bioartificial pancreas2006

    • Author(s)
      Naoya, Kobayashi
    • Organizer
      The 3rd Symposium on Islet Transplantation
    • Place of Presentation
      Seoul, Korea
    • Year and Date
      2006-11-25
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Signaling during pancreatic regeneration induces endocrine differentiation of pancreatic committed-endoderm derived from ES cells2006

    • Author(s)
      Jorge David Rivas-Carrillo
    • Organizer
      第33回日本臓器保存生物医学会総会
    • Place of Presentation
      東京都
    • Year and Date
      2006-11-23
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] An extra-cellular matrix-coated intelligent fabric maintains and improve islet function.2006

    • Author(s)
      Alejandro Soto-Gutierrez
    • Organizer
      第33回日本臓器保存生物医学会総会
    • Place of Presentation
      東京都
    • Year and Date
      2006-11-23
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Development of a newly implantable bio-artificial pancreas for treatment of diabetes.2006

    • Author(s)
      Jorge David Rivas-Carrillo
    • Organizer
      第33回日本臓器保存生物医学会総会
    • Place of Presentation
      東京都
    • Year and Date
      2006-11-23
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Maintenance of human islet function using self-assembling peptide nanofibers.2006

    • Author(s)
      Nalu Navarro-Alvarez
    • Organizer
      第33回日本臓器保存生物医学会総会
    • Place of Presentation
      東京都
    • Year and Date
      2006-11-23
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Signaling during pancreatic regeneration induces endocrine differentiation of pancreatic committed-endoderm derived from ES cells2006

    • Author(s)
      Jorge, David, Rivas-Carrillo
    • Organizer
      33rd Annual Congress of the Japan Society for Organ Preservation and Medical Biology
    • Place of Presentation
      Tokyo, Japan
    • Year and Date
      2006-11-23
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] An extra-cellular matrix-coated intelligent fabric maintains and improves islet function2006

    • Author(s)
      Alejandro, Soto-Gutierrez
    • Organizer
      33rd Annual Congress of the Japan Society for Organ Preservation and Medical Biology
    • Place of Presentation
      Tokyo, Japan
    • Year and Date
      2006-11-23
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Development of a newly implantable bio-artificial pancreas for treatment of diabetes2006

    • Author(s)
      Jorge, David, Rivas-Carrillo
    • Organizer
      33rd Annual Congress of the Japan Society for Organ Preservation and Medical Biology
    • Place of Presentation
      Tokyo, Japan
    • Year and Date
      2006-11-23
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Maintenance of human islet function using self-assembling peptide nanofibers2006

    • Author(s)
      Nalu, Navarro-Alvarez
    • Organizer
      33rd Annual Congress of the Japan Society for Organ Preservation and Medical Biology
    • Place of Presentation
      Tokyo, Japan
    • Year and Date
      2006-11-23
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Intelligent fabric-1 (IF-1) PFTE facilitates cell-fate pancreatic endocrine differentiation of endoderm-committed mouse ES cells.2006

    • Author(s)
      Jorge David Rivas-Carrillo
    • Organizer
      The 35th World Congress of the International College of Surgeons
    • Place of Presentation
      パタヤ(タイ)
    • Year and Date
      2006-10-27
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Type 1 autoimmune diabetes remission using a newly develop implantable bioartificial pancreas containing normal human pancreatic stem cells.2006

    • Author(s)
      Jorge David Rivas-Carrillo
    • Organizer
      The 35th World Congress of the International College of Surgeons
    • Place of Presentation
      パタヤ(タイ)
    • Year and Date
      2006-10-27
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Type 1 autoimmune diabetes remission using a newly develop implantable bioartificial pancreas containing normal human pancreatic stem cells2006

    • Author(s)
      Jorge, David, Rivas-Carrillo
    • Organizer
      The 35th World Congress of the International College of Surgeons
    • Place of Presentation
      Pattaya, Thailand
    • Year and Date
      2006-10-27
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Intelligent fabric-1 (IF-1) PFTE facilitates cell-fate pancreatic endocrine differentiation of endoderm- committed mouse ES cells2006

    • Author(s)
      Jorge, David, Rivas-Carrillo
    • Organizer
      The 35th World Congress of the International College of Surgeons
    • Place of Presentation
      Pattaya, Thailand
    • Year and Date
      2006-10-27
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Establishment of insulin-secreting human cell lines and their application to diabetes-targeted cell therapies.2006

    • Author(s)
      Naoya Kobayashi
    • Organizer
      The 3rd International Symposium of Chosun University Hospital
    • Place of Presentation
      光州(韓国)
    • Year and Date
      2006-09-30
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Establishment of insulin-secreting human cell lines and their application to diabetes-targeted cell therapies2006

    • Author(s)
      Naoya, Kobayashi
    • Organizer
      The 3rd International Symposium of Chosun University Hospital
    • Place of Presentation
      Gwangju, Korea
    • Year and Date
      2006-09-30
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Reversible immortalization of human pancreatic beta cells to develop diabetes-targeted cell therapy.2006

    • Author(s)
      Naoya Kobayashi
    • Organizer
      WTC Satellite Symposium "Advances in xenotransplantation: Is the gal knock-out pig essential to clinical success?"
    • Place of Presentation
      ボストン(アメリカ)
    • Year and Date
      2006-07-22
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Reversible immortalization of human pancreatic beta cells to develop diabetes-targeted cell therapy2006

    • Author(s)
      Naoya, Kobayashi
    • Organizer
      WTC Satellite Symposium "Advances in xenotransplantation : Is the gal knock-out pig essential to clinical success"
    • Place of Presentation
      Boston, Massachusetts, USA
    • Year and Date
      2006-07-22
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] ベイオ人工膵臓開発に向けた基礎的検討.2006

    • Author(s)
      小林 直哉
    • Organizer
      第31回日本外科系連合学会学術集会
    • Place of Presentation
      金沢市
    • Year and Date
      2006-06-23
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Basic study on the development of bioartificial pancreas2006

    • Author(s)
      Naoya, Kobayashi
    • Organizer
      31st Annual Congress of the Japanese College of Surgeons
    • Place of Presentation
      Kanazawa, Japan (in Japanese)
    • Year and Date
      2006-06-23
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] バイオ人工膵臓の開発とその糖尿病治療への応用.2006

    • Author(s)
      小林 直哉
    • Organizer
      第6回日本抗加齢医学会総会
    • Place of Presentation
      東京都
    • Year and Date
      2006-05-20
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Development of bioartificial pancreas and its application to diabetes treatment2006

    • Author(s)
      Naoya, Kobayashi
    • Organizer
      6th Scientific Meeting of the Japanese Society of Anti-Aging Medicine
    • Place of Presentation
      Tokyo, Japan (in Japanese)
    • Year and Date
      2006-05-20
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Analysis of pancreatic endocrine precursors in human ES cell culture using sodium butyrate and activin A.2006

    • Author(s)
      Jorge David Rivas-Carrillo
    • Organizer
      8th International Congress of the Cell Transplant Society
    • Place of Presentation
      ミラノ(イタリア)
    • Year and Date
      2006-05-19
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Maintenance of human islet function using self-assembling peptide nanofibers.2006

    • Author(s)
      Nalu Navarro-Alvarez
    • Organizer
      8th International Congress of the Cell Transplant Society
    • Place of Presentation
      ミラノ(イタリア)
    • Year and Date
      2006-05-19
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Achievement of a single-donor islet transplantation using anti-apoptotic pentapeptide V5.2006

    • Author(s)
      Jorge David Rivas-Carrillo
    • Organizer
      8th International Congress of the Cell Transplant Society
    • Place of Presentation
      ミラノ(イタリア)
    • Year and Date
      2006-05-19
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Analysis of pancreatic endocrine precursors in human ES cell culture using sodium butyrate and activin A2006

    • Author(s)
      Jorge, David, Rivas-Carrillo
    • Organizer
      8th International Congress of the Cell Transplant Society
    • Place of Presentation
      Milano, Italy
    • Year and Date
      2006-05-19
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Maintenance of human islet function using self-assembling peptide nanofibers2006

    • Author(s)
      Nalu, Navarro-Alvarez
    • Organizer
      8th International Congress of the Cell Transplant Society
    • Place of Presentation
      Milano, Italy
    • Year and Date
      2006-05-19
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Achievement of a single-donor islet transplantation using anti-apoptotic pentapeptide V52006

    • Author(s)
      Jorge, David, Rivas-Carrillo
    • Organizer
      8th International Congress of the Cell Transplant Society
    • Place of Presentation
      Milano, Italy
    • Year and Date
      2006-05-19
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary

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Published: 2006-04-01   Modified: 2016-04-21  

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