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Development of novel drugs for the surgical field by intelligent bionanocapsule

Research Project

Project/Area Number 18390352
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field General surgery
Research InstitutionKeio University

Principal Investigator

UEDA Masakazu  Keio University, 医学部, 准教授 (50142419)

Co-Investigator(Kenkyū-buntansha) JINNO Hiromitsu  慶應義塾大学, 医学部, 講師 (20216261)
菅家 大介  慶應義塾大学, 医学部, 助教 (00365272)
Project Period (FY) 2006 – 2008
Project Status Completed (Fiscal Year 2008)
Budget Amount *help
¥17,860,000 (Direct Cost: ¥15,400,000、Indirect Cost: ¥2,460,000)
Fiscal Year 2008: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2007: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2006: ¥7,200,000 (Direct Cost: ¥7,200,000)
KeywordsHBs抗原 / ヒト肝細胞 / ナノカプセル / 分子標的 / L粒子 / DDS / 遺伝子治療 / HB_s抗原 / パクリタクセル / 分子標的能
Research Abstract

この3年間で、L粒子を用いたC型肝炎治療薬と肝細胞癌治療薬が、さらにはHBs抗原preS1を結合させたMPCポリマーによるヒト肝細胞癌への遺伝子送達と発現とヒト肝細胞癌に特異的な抗癌剤が開発された。また、ヒトの増殖因子やサイトカインを結合させたナノカプセルによる受容体標的細胞特異的治療薬の開発も行われた。インテリジェント型バイオナノカプセルにより外科領域における新治療薬が発展する可能性が証明された。こんごは、これらの成果を橋渡し研究やtranslational researchへと展開していきたいと考えている。

Report

(4 results)
  • 2008 Annual Research Report   Final Research Report ( PDF )
  • 2007 Annual Research Report
  • 2006 Annual Research Report
  • Research Products

    (48 results)

All 2009 2008 2007 2006 Other

All Journal Article (28 results) (of which Peer Reviewed: 23 results) Presentation (18 results) Patent(Industrial Property Rights) (2 results)

  • [Journal Article] Development of Targeted Therapy with Paclitaxel Incorporated into EGF-conjugated Nanoparticles.2009

    • Author(s)
      Shimada T., Ueda M., Jinno H., Chiba N., Wada M., Watanabe J., Ishihara K.and Kitagawa Y.,
    • Journal Title

      Anticancer Research 29

      Pages: 1009-1014

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] The clinical value of bilateral breast MR imaging : is it worth performing on patients showing suspicious microcalcifications on mammography2009

    • Author(s)
      Akita A, Tanimoto A, Jinno H, Kameyama K, Kuribayashi S.
    • Journal Title

      European Radiology 10

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Development of Targeted Therapy with Paclitaxel Incorporated into EGF-conjugated Nanoparticles.2009

    • Author(s)
      Shimada T., Ueda M., Jinno H., Chiba N., Wada M., Watanabe J., lshihara K., Kitagawa Y.
    • Journal Title

      Anticancer Research 29

      Pages: 1009-1014

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Establishment of combined immune-chemotherapy with systemically administered gemcitabine and intra-portal administration of interleukin-2 in murine Models of liver metastases of pancreatic cancer2008

    • Author(s)
      Ueda M., Ito Y, et.al.
    • Journal Title

      Int.J.Oncol. 33

      Pages: 49-58

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Selective targeting by hepatitis B surface antigen conjugated with phosphorylchline-based amphiphilic block copolymer micelles as a biocompatible2008

    • Author(s)
      Miyata R., Ueda M., et. al.
    • Journal Title

      drug delivery carrier for treatment of human hepatocellular carcinoma with paclitaxel., Int.J.Cancer 124

      Pages: 2460-2467

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Cross-sectional analysis of germline BRCA1 and BRCA2 mutations in Japanese patients suspected to have hereditary breast/ovarian cancer2008

    • Author(s)
      Sugano K, Nakamura S, Ando J, Takayama S, Kamata H, Sekiguchi I, Ubukata M, Kodama T, Arai M, Kasumi F, Hirai Y, Ikeda T, Jinno H, Kitajima M, Aoki D, Hirasawa A, Takeda Y, Yazaki K, Fukutomi T, Kinoshita T, Tsunematsu R, Yoshida T, Izumi M, Umezawa S, Yagata H, Komatsu H, Arimori N, Matoba N, Gondo N, Yokoyama S, Miki Y.
    • Journal Title

      Cancer Sci. 99(10)

      Pages: 1967-76

    • NAID

      10024011931

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Predictors to assess non-sentinel lymph node status in breast cancer patients with sentinel lymph node metastasis2008

    • Author(s)
      Jinno H, Sakata M, Asaga S, Wada M, Shimada T, Kitagawa Y, Suzuki T, Nakahara T, Kitamura N, Kubo A, Mukai M, Ikeda T, Kitajima M.
    • Journal Title

      Breast J. 14(6)

      Pages: 551-5

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Establishment of combined immune-chemotherapy with systemically administered gemcitabine and intra-portal administration of interleukin-2 in murine Models of liver metastases of pancreatic cancer2008

    • Author(s)
      Ueda M., Ito Y, et al.
    • Journal Title

      Int. J. Oncol. 33

      Pages: 49-58

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Selective targeting by hepatitis B surface antigen conjugated with phosphorylchline-based amphiphilic block copolymer micelles as a biocompatible, drug delivery carrier for treatment of human hepatocellular carcinoma with paclitaxel.2008

    • Author(s)
      Miyata R., Ueda M., et al.
    • Journal Title

      Int. J. Cancer 124

      Pages: 2460-2467

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Knot-tying force during suturing and wound healing in the gastrointestinal tract2007

    • Author(s)
      Oguma J., Ozawa S., Morikawa Y., furukawa,T., Kitagawa Y., Ueda,M., Kitajima,M.
    • Journal Title

      J. Surg.Research 140

      Pages: 129-134

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Anticancer Research2007

    • Author(s)
      Wada M., Jinno H., Ueda M., Ikeda T., Kitajima M., Konno T., Watanabe J., Ishihara K.
    • Journal Title

      27

      Pages: 1431-1436

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] A novel Von Hippel-Lindau case with germline mutation at codon 167(CGG to TGG) having endocrine miceroadenomatosisi of the pancreas2007

    • Author(s)
      Akatsu T., Aiura K., Ito Y., Ueda M., Kameyama K., Kitajima M.
    • Journal Title

      Dig Dis Sci 52

      Pages: 3145-3148

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Co-expression of aFGF and FGFR-1 is predictive of a poor prognosis in patients with esophageal squamous cell carcinoma2007

    • Author(s)
      Sugiura K., Ozawa S., Kitagawa Y., Ueda M., Kitajima M.
    • Journal Title

      Oncology Rep. 17

      Pages: 557-564

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Gene therapy of liver tumors with human liver-specific nanoparticeles2007

    • Author(s)
      Iwasaki Y., Ueda M., Yamada T., Kondo A., Seno M., Tanizawa K., Kuroda S.
    • Journal Title

      Cancer gene therapy 14

      Pages: 74-81

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Characterization of bio-nanocapsule as a transfer vector targeting human hepatocyte carcinoma by disulfide linkage modificatgion2007

    • Author(s)
      Nagaoka T., Fukuda T., Yoshida S., Yu Dongewi., Kuroda S., Tanizawa K., Kondo A., Ueda M., Yamada H., Tada H., Seno M.
    • Journal Title

      Journal of controlled release 10

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] The novel immuinosuppressant agents targeting activated lymphocytes by biocompatible MPC polymer conjugated with interleukin22007

    • Author(s)
      Chiba T.,Ueda M.
    • Journal Title

      J Surgical Research 39

      Pages: 103-110

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Development of gene vectors for pinpoint targeting to human hepatocytes by cationically modified polymer complexes2007

    • Author(s)
      Chiba T., Ueda M.,Shimada T.,Jiino H.,Watanabe J.,Ishihara K.,Kitajima M.
    • Journal Title

      J Surgical Research 39

      Pages: 23-34

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Chemosensitivity-related genes of breast cancer detected by DNA microarray2007

    • Author(s)
      Ikeda T, Jinno H, Shirane M.
    • Journal Title

      Anticancer Res. 27(4C)

      Pages: 2649-55

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Co-expression of aFGF and FGFR-1 is predictive of a poor prognosis in patients with esophageal squamous cell carcinoma.2007

    • Author(s)
      Sugiura.K., et. al.
    • Journal Title

      Oncology Rep. 17

      Pages: 557-564

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The novel immuinosuppressant agents targeting activated lymphocytes by biocompatible MPC polymer conjugated with interleukin2.2007

    • Author(s)
      Chiba.T., et. al.
    • Journal Title

      European Surgical Research 39

      Pages: 103-110

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Efficacy of an MPC-BMA co-polymer as a nanotransporter for paclitaxel.2007

    • Author(s)
      Wada M., et. al.
    • Journal Title

      Anticancer Res 27

      Pages: 1453-1436

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Gene therapy of liver tumors with human liver-specific nanonarticeles2007

    • Author(s)
      Iwasaki Y., et al.
    • Journal Title

      Cancer gene therapy 14

      Pages: 74-81

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Development of gene vectors for pinpoint targeting to human hepatocytes by cationically modified polymer complexes.2007

    • Author(s)
      Chiba T., et al.
    • Journal Title

      J Surgical Research 39

      Pages: 23-23

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Anti-tumor effect in vivo model by human-derived pancreatic RNase with basic FGF insertional fusion protein through anti-angiogenic properties.2006

    • Author(s)
      Yagi H., et al.
    • Journal Title

      Cancer Science. 97・12

      Pages: 1315-1320

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Engineered bio-nanocapsules, the selective vector for drug delivery system.2006

    • Author(s)
      Yu Dongwei, et al.
    • Journal Title

      IUBMB Life, 58・1

      Pages: 1-6

    • Related Report
      2006 Annual Research Report
  • [Journal Article] factors for surgical site infection in gastric and colon surgeries with special reference to their operative approach

    • Author(s)
      Imai E., Ueda M., Kanao K., Kubota T.,Hasegawa H., Omae K., Kitajima M.
    • Journal Title

      ICHE (in press)

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Efficacy of an MPC-BMA co-polymer as a nanotransporter for paclitaxel

    • Author(s)
      Wada M., Jinno H., Ueda M., Ikeda T., Kitajima M., Konno T., Watanabe J., Ishihara K.
    • Journal Title

      Anticancer Res (in press)

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Characterization of bio-nanocapsule as a transfer vector targeting human hepatocyte carcinoma by disulfide linkage modificathion

    • Author(s)
      Nagaoka T. et al.
    • Journal Title

      Journal of controlled release. In press

    • Related Report
      2006 Annual Research Report
  • [Presentation] Paclitaxelを封入したHBs抗原結合し生体適合性を有するMPC polymerを用いたヒト肝細胞癌に対する抗腫瘍効果の検討2008

    • Author(s)
      宮田量平(東京歯科大学附属市川総合病院外科), 上田政和, 北川雄光, 安藤暢敏
    • Organizer
      第108回日本外科学会定期学術集会
    • Place of Presentation
      長崎
    • Year and Date
      2008-05-16
    • Related Report
      2008 Final Research Report
  • [Presentation] 進行胆嚢癌の予後因子および手術適応の検討2008

    • Author(s)
      日比泰造(慶應義塾大学外科), 河地茂行, 上田政和, 相浦浩一, 田邊稔, 篠田昌宏, 八木洋, 長谷川康, 島津元秀, 北川雄光
    • Organizer
      第108回日本外科学会定期学術集会
    • Place of Presentation
      長崎
    • Year and Date
      2008-05-16
    • Related Report
      2008 Final Research Report
  • [Presentation] 肝硬変合併小肝細胞癌に対する小範囲切除ガイドニードル法により留置した染色フィブリン糊をナビゲーターとした系統的小範囲肝切除術2008

    • Author(s)
      田辺稔(慶應義塾大学外科), 上田政和, 河地茂行, 篠田昌宏, 日比泰造, 小島正之, 半田寛, 丸山正太郎, 山本立真, 高野公徳, 北川雄光
    • Organizer
      第108回日本外科学会定期学術集会
    • Place of Presentation
      長崎
    • Year and Date
      2008-05-15
    • Related Report
      2008 Final Research Report
  • [Presentation] リンパ管へのアプローチその新展開センチネルリンパ節理論を応用したリンパ行性癌微小転移診断と低侵襲個別化治療2008

    • Author(s)
      竹内裕也(慶應義塾大学医学部外科), 上田政和, 北川雄光
    • Organizer
      第113回日本解剖学会
    • Place of Presentation
      大分
    • Year and Date
      2008-03-27
    • Related Report
      2008 Final Research Report
  • [Presentation] Paclitaxelを封入したHBs抗原結合し生体適合性を有するMPC polymerを用いたヒト肝細胞癌に対する抗腫瘍効果の検討2008

    • Author(s)
      宮田量平(東京歯科大学附属市川総合病院外科), 上田政和, 北川雄光, 安藤暢敏
    • Organizer
      第108回日本外科学会
    • Place of Presentation
      長崎
    • Related Report
      2008 Annual Research Report
  • [Presentation] Paclitaxel封入抗EGFR抗体結合ナノ粒子による殺細胞効果と抗腫瘍効果の検討2007

    • Author(s)
      今井俊(慶應義塾大学外科), 長谷川博俊, 西堀英樹, 石井良幸, 遠藤高志, 迫田哲平,金野智浩, 石原一彦, 上田政和, 北島政樹
    • Organizer
      第107回日本外科学会定期学術集会
    • Place of Presentation
      大阪
    • Year and Date
      2007-10-05
    • Related Report
      2008 Final Research Report
  • [Presentation] パクリタキセルと抗EGFRモノクローナル抗体の共役ナノ粒子による抗腫瘍作用の評価(The evaluation of antitumor effect by the nanoparticles conjugated with paclitaxel and anti-EGFRmonoclonal antibody)2007

    • Author(s)
      今井俊(慶應義塾大学外科), 長谷川博俊, 石井良幸, 遠藤高志, 金野智浩, 石原一彦, 上田政和, 北川雄光
    • Organizer
      第66回日本癌学会学術総会
    • Place of Presentation
      横浜
    • Year and Date
      2007-10-03
    • Related Report
      2008 Final Research Report
  • [Presentation] 表皮成長因子受容体に対する温度反応性磁性ナノ粒子(Thermo-responsive magnetic nanoparticle directed against epidermal growth factor receptor)2007

    • Author(s)
      高橋洋子(慶應義塾大学医学部一般・消化器外科), 神野浩光, 麻賀創太, 坂田道生, 上田政和, 北川雄光
    • Organizer
      第66回日本癌学会学術総会
    • Place of Presentation
      横浜
    • Year and Date
      2007-10-03
    • Related Report
      2008 Final Research Report
  • [Presentation] 膜透過ペプチド提示バイオナノカプセルを用いる高効率薬剤導入法の開発2007

    • Author(s)
      米澤太作(神戸大学院・自科), 宍戸卓矢, 上田政和, 妹尾昌治, 多田宏子, 谷澤克行, 黒田俊一, 田中勉, 福田秀樹, 近藤昭彦
    • Organizer
      第59回日本生物工学会
    • Place of Presentation
      広島
    • Year and Date
      2007-09-25
    • Related Report
      2008 Final Research Report
  • [Presentation] 糖鎖提示型バイオナノカプセルの開発2007

    • Author(s)
      三瓶浩史(大阪大学産業科学研究所), 粕谷武史, 殿井裕之, 佐々木康雄, 角矢博保, 鄭周姫, 近藤昭彦, 妹尾昌治, 上田政和, 谷澤克行, 黒田俊一
    • Organizer
      日本DDS研究会
    • Place of Presentation
      熊本
    • Year and Date
      2007-06-14
    • Related Report
      2008 Final Research Report
  • [Presentation] バイオナノカプセルを用いたB型肝炎ウイルスのヒト肝臓特異的感染機構の解明2007

    • Author(s)
      粕谷武史(大阪大学産業科学研究所), 鄭周姫, 佐々木康雄, 近藤昭彦, 妹尾昌治, 上田政和, 谷澤克行, 黒田俊一
    • Organizer
      日本DDS研究会
    • Place of Presentation
      熊本
    • Year and Date
      2007-06-14
    • Related Report
      2008 Final Research Report
  • [Presentation] バイオナノカプセルのIn Vivoイメージングに向けた可視化2007

    • Author(s)
      佐々木康雄(大阪大学大学院生命機能研究科), 粕谷武史, 鄭周姫, 近藤昭彦, 妹尾昌治, 上田政和, 黒田俊一, 谷澤克行
    • Organizer
      日本DDS研究会
    • Place of Presentation
      熊本
    • Year and Date
      2007-06-14
    • Related Report
      2008 Final Research Report
  • [Presentation] ホーミングペプチド提示型バイオナノカプセルによる生体内ピンポイントDDSの開発2007

    • Author(s)
      殿井裕之(大阪大学産業科学研究所), 粕谷武史, 角矢博保, 鄭周姫, 佐々木康雄, 近藤昭彦, 妹尾昌治, 上田政和, 谷澤克行, 黒田俊一
    • Organizer
      日本DDS研究会
    • Place of Presentation
      熊本
    • Year and Date
      2007-06-14
    • Related Report
      2008 Final Research Report
  • [Presentation] ヒト肝臓特異的バイオナノカプセルのIn Vivoイメージングによる生体内動態解析2007

    • Author(s)
      鄭周姫(大阪大学産業科学研究所), 近藤昭彦, 妹尾昌治, 上田政和, 谷澤克行, 黒田俊一
    • Organizer
      日本DDS研究会
    • Place of Presentation
      熊本
    • Year and Date
      2007-06-14
    • Related Report
      2008 Final Research Report
  • [Presentation] FGF挿入型のヒト組み替えRNase-bFGFを介した腫瘍増殖抑制効果の検討2007

    • Author(s)
      八木洋(慶應義塾大学一般・消化器外科), 上田政和, 神野浩光, 相浦浩一, 妹尾昌治, 多田宏子, 山田秀徳, 北島政樹
    • Organizer
      第107回日本外科学会定期学術集会
    • Place of Presentation
      大阪
    • Year and Date
      2007-04-12
    • Related Report
      2008 Final Research Report
  • [Presentation] 抗体提示バイオナノカプセルを用いたピンポイントプロテインデリバリーシステムの開発2007

    • Author(s)
      倉田直弥(神戸大学院・自科), 宍戸卓矢, 上田政和, 妹尾昌治, 多田宏子, 谷澤克行, 黒田俊一, 田中勉, 福田秀樹, 近藤昭彦
    • Organizer
      化学工学会第73年会
    • Place of Presentation
      静岡
    • Year and Date
      2007-03-17
    • Related Report
      2008 Final Research Report
  • [Presentation] Optimization of sentinel lymph nodes with interstitial magnet resonance lym phography using thermo-resoponsive magnetic nanoparticles in rats2007

    • Author(s)
      Hiraiwa K., et. al.
    • Organizer
      米国癌学会
    • Place of Presentation
      米国
    • Related Report
      2007 Annual Research Report
  • [Presentation] 上皮増殖因子受容体過剰発現癌に対するEGF結合MPCポリマーによるターゲッティング療法の開発2006

    • Author(s)
      嶋田俊之(慶應義塾大学医学部外科学教室一般・消化器外科), 上田政和, 和田真弘, 高山伸, 神野浩光, 池田正, 渡邉順司, 金野智浩, 石原一彦, 北島政樹
    • Organizer
      COE研究報告会
    • Place of Presentation
      東京
    • Year and Date
      2006-05-11
    • Related Report
      2008 Final Research Report
  • [Patent(Industrial Property Rights)] 細胞特異的能動集積性を有する光線力学療法剤2008

    • Inventor(s)
      上田政和
    • Industrial Property Rights Holder
      慶應義塾大学
    • Industrial Property Number
      2008-321500
    • Filing Date
      2008-12-17
    • Related Report
      2008 Annual Research Report 2008 Final Research Report
  • [Patent(Industrial Property Rights)] センチネルリンパ節を検出するための熱応答性磁性体ナノ粒子を含む造影剤2008

    • Inventor(s)
      上田政和
    • Industrial Property Rights Holder
      慶應義塾大学
    • Industrial Property Number
      2007-065435
    • Filing Date
      2008-03-14
    • Related Report
      2008 Final Research Report

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Published: 2006-04-01   Modified: 2016-04-21  

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