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Molecular targeting for scirrhous gastric cancer

Research Project

Project/Area Number 18390369
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Digestive surgery
Research InstitutionOsaka City University

Principal Investigator

HIRAKAWA Kosei  Osaka City University, 大学院・医学研究科, 教授 (40188652)

Co-Investigator(Kenkyū-buntansha) YASHIRO Masakazu  大阪市立大学, 大学院・医学研究科, 准教授 (60305638)
Project Period (FY) 2006 – 2009
Project Status Completed (Fiscal Year 2009)
Budget Amount *help
¥7,430,000 (Direct Cost: ¥6,200,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2009: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2008: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2007: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2006: ¥2,100,000 (Direct Cost: ¥2,100,000)
Keywordsスキルス胃癌 / 分子標的治療 / FGFR阻害剤 / 抗癌剤 / トランスレーショナルリサーチ / スキルス骨癌 / 癌 / 胃癌腹膜転移 / COX-2阻害剤 / HGF / シグナル抑制
Research Abstract

Scirrhous gastric carcinoma is characterized by rapid cancer cell infiltration and proliferation accompanied by extensive stromal fibrosis. Scirrhous carcinomas carry a worse prognosis than other types of gastric carcinoma. Keratinocyte growth factor (KGF) ; a ligand of FGF-R2, produced by gastric fibroblasts is likely to contribute in a paracrine manner to the remarkable cell proliferation seen in scirrhous gastric cancer with FGF-R2 amplification. Also, COX2 signal from stromal fibroblasts stimulates the invasion ability of scirrhous gastric cancer cells. The FGF-R2 phosphorylation inhibitor or COX2 inhibitor appear therapeutically promising in scirrhous gastric carcinoma.

Report

(6 results)
  • 2009 Annual Research Report   Final Research Report ( PDF )
  • 2008 Annual Research Report   Self-evaluation Report ( PDF )
  • 2007 Annual Research Report
  • 2006 Annual Research Report
  • Research Products

    (59 results)

All 2010 2009 2008 2007 2006 Other

All Journal Article (35 results) (of which Peer Reviewed: 27 results) Presentation (18 results) Book (1 results) Remarks (1 results) Patent(Industrial Property Rights) (4 results)

  • [Journal Article] Effects of VEGFR-3 phosphorylation inhibitor on lymph node metastasis in an orthotopic diffuse-type gastric carcinoma model.2009

    • Author(s)
      Yashiro, M., Shinto, O., Nakamura, K., Tendo, M., Matsuoka, T., Matsuzaki, T., Kaizaki, R., Ohira, M., Miwa, A., Hirakawa, K
    • Journal Title

      Br J Cancer 101

      Pages: 1100-1106

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Diffuse-type gastric carcinoma: progression, angiogenesis, and transforming growth factor beta signaling.2009

    • Author(s)
      Komuro, A., Yashiro, M.., Iwata, C., Morishita, Y., Johansson, E., Matsumoto, Y., Watanabe, A., Aburatani, H., Miyoshi, H., Kiyono, K., Shirai, Y.T., Suzuki, H.I., Hirakawa, K.., Kano, M.R., Miyazono, K
    • Journal Title

      J Natl Cancer Inst 101

      Pages: 592-604

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Epigenetic regulation of the embryonic oncogene ERas in gastric cancer cells.2009

    • Author(s)
      Yashiro, M., Yasuda, K., Nishii, T., Kaizaki, R., Sawada, T., Ohira, M., Hirakawa, K.
    • Journal Title

      Int J Oncol 35

      Pages: 997-1003

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Synergistic antitumor effects of FGFR2 inhibitor with 5-fluorouracil on scirrhous gastric carcinoma.2009

    • Author(s)
      Yashiro, M.., Shinto, O., Nakamura, K., Tendo, M., Matsuoka, T., Matsuzaki, T., Kaizaki, R., Miwa, A., Hirakawa, K.
    • Journal Title

      Int J Cancer

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Allelic imbalance at p53 and microsatellite instability are predictive markers for resistance to chemotherapy in gastric carcinoma.2009

    • Author(s)
      Yashiro, M.., Inoue, T., Nishioka, N., Matsuoka, T., Bol, C.R., Hirakawa, K.
    • Journal Title

      Ann Surg Oncol 16

      Pages: 2926-2935

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Co-expression of keratinocyte growth factor and K-sam is an independent prognostic factor in gastric carcinoma.2009

    • Author(s)
      Toyokawa, T., Yashiro, M., Hirakawa, K.
    • Journal Title

      Oncol Rep 21

      Pages: 875-880

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Direct cancer-stromal interaction increases fibroblast proliferation and enhances invasive properties of scirrhous-type gastric carcinoma cells.2009

    • Author(s)
      Semba, S., Kodama, Y., Ohnuma, K., Mizuuchi, E., Masuda, R., Yashiro, M.., Hirakawa, K., Yokozaki, H.
    • Journal Title

      Br J Cancer

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Synergistic antiproliferative effect of mTOR inhibitors in combination with 5-fluorouracil in scirrhous gastric cancer.2009

    • Author(s)
      Matsuzaki, T., Yashiro, M.., Kaizaki, R., Yasuda, K., Doi, Y., Sawada, T., Ohira, M., Hirakawa, K.
    • Journal Title

      Cancer Sci

    • NAID

      10027198595

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Expression of ERas oncogene in gastric carcinoma.2009

    • Author(s)
      Kaizaki, R., Yashiro, M.., Shinto, O., Yasuda, K., Hirakawa, K.
    • Journal Title

      Anticancer Res 29

      Pages: 2189-2193

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Effects of VEGFR-3 phosphorylation inhibitor on lymph node met astasis in an orthotopic diffuse-type gastric carcinoma model.2009

    • Author(s)
      Yashiro M, Shinto O, Hirakawa K.
    • Journal Title

      British journal of cancer 101

      Pages: 1100-1106

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Epigenetic regulation of the embryonic oncogene ERas in gastric cancer cells2009

    • Author(s)
      Yashiro M, Yasuda K, Hirakawa K
    • Journal Title

      International journal of oncology 35

      Pages: 997-1003

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Allelic Imbalance at p53 and Microsatellite Instability Are Predictive Markers for Resistance to Chemotherapy in Gastric Carcinoma2009

    • Author(s)
      Yashiro M, Inoue T, Hirakawa K
    • Journal Title

      Annals of surgical oncology 16

      Pages: 2926-2935

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Diffuse-type gastric carcinoma : progression, angiogenesis, and transforming growth factor beta signaling2009

    • Author(s)
      Komuro A, Yashiro M, Iwata C, Morishita Y, Johansson E, Matsumoto Y, Watanabe Aburatani H, Miyoshi H, Kiyono K, Shirai YT, Suzuki HI, Hirakawa K, Kano MR, Miyazono K.
    • Journal Title

      J Natl Cancer Inst 15 ; 101

      Pages: 592-604

    • Related Report
      2008 Self-evaluation Report
  • [Journal Article] FGFR2-amplified gastric cancer cell lines require FGFR2 and Erbb3 signaling for growth and survival.2008

    • Author(s)
      Kunii K, Davis L, Gorenstein J, Hatch H, Yashiro M, Di Bacco A, Elbi C, Lutterbach B.
    • Journal Title

      Cancer Res 68(7)

      Pages: 2340-2348

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] A novel transforming growth factor beta receptor kinase inhibitor, A-77, prevents the peritoneal dissemination of scirrhous gastric carcinoma.2008

    • Author(s)
      Kawajiri, H., Yashiro, M., Shinto, O., Nakamura, K., Tendo, M., Takemura, S, Node, M., Hamashima, Y., Kajimoto, T., Sawada, T., Ohira, M., Hirakawa, K.
    • Journal Title

      Clin Cancer Res 14

      Pages: 2850-2860

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Ulcerative colitis-associated colorectal cancer is frequently associated with the microsatellite instability pathway.2008

    • Author(s)
      Fujiwara, I., Yashiro, M.., Kubo, N., Maeda, K., Hirakawa, K.
    • Journal Title

      Dis Colon Rectum 51

      Pages: 1387-1394

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] A novel transforming growth factor beta receptor kinase inhibitor, A-77, prevents the peritoneal dissemination of scirrhous gastric carcinoma.2008

    • Author(s)
      Kawajiri H, Yashiro M, Shinto O, Nakamura K, Tendo M, Takemura S, Node M, Hamashima Y, Kajimoto T, Sawada T, Ohira M, Hirakawa K.
    • Journal Title

      Clinical Cancer Research 14

      Pages: 2850-60

    • Related Report
      2008 Self-evaluation Report
  • [Journal Article] A Novel Transforming Growth Factor beta Receptor Kinase Inhibitor, A-77, Prevents the Peritoneal Dissemination of Scirrhous Gastric Carcinoma.2008

    • Author(s)
      Kawajiri H, Yashiro M, Hirakawa K.
    • Journal Title

      Clin Cancer Res 14

      Pages: 2850-2860

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Selective cyclooxygenase-2 inhibitor downregulates the paracrine epithelial-mesenchymal interactions of growth in scirrhous gastric carcinoma.2007

    • Author(s)
      Yashiro, M.., Nakazawa, K., Tendo, M., Kosaka, K., Shinto, O., Hirakawa, K.
    • Journal Title

      Int J Cance 120

      Pages: 686-693

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Improvement of cancer-targeting therapy, using nanocarriers for intractable solid tumors by inhibition of TGF-beta signaling.2007

    • Author(s)
      Kano, M.R., Bae, Y., Iwata, C., Morishita, Y., Yashiro, M.., Oka, M., Fujii, T., Komuro, A., Kiyono, K., Kaminishi, M., Hirakawa, K.., Ouchi, Y., Nishiyama, N., Kataoka, K., Miyazono, K.
    • Journal Title

      Proc Natl Acad Sci U S A 104

      Pages: 3460-3465

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Inhibition of cyclooxygenase-2 suppresses lymph node metastasis via reduction of lymphangiogenesis.2007

    • Author(s)
      Iwata, C., Kano, M.R., Komuro, A., Oka, M., Kiyono, K., Johansson, E., Morishita, Y., Yashiro, M.., Hirakawa, K.., Kaminishi, M., Miyazono, K.
    • Journal Title

      Cancer Res 67

      Pages: 10181-10189

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Prognostic impact of PCR-based identification of isolated tumour cells in the peritoneal lavage fluid of gastric cancer patients who underwent a curative R0 resection.2007

    • Author(s)
      Katsuragi, K., Yashiro, M.., Sawada, T., Osaka, H., Ohira, M., Hirakawa, K.
    • Journal Title

      Br J Cancer 97

      Pages: 550-556

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Improvement of cancer-targeting therapy, using nanocarriers for intractable solid tumors by inhibition of TGF-beta signaling2007

    • Author(s)
      Kano MR, Bae Y, Iwata C, Morishita Y, Yashiro M, Oka M, Fujii T, Komuro A, Kiyono K, Kaminishi M, Hirakawa K, Ouchi Y, Nishiyama N, Kataoka K and Miyazono K.
    • Journal Title

      Proc. Natl. Acad. Sci. USA 104

      Pages: 3460-3465

    • Related Report
      2008 Self-evaluation Report
  • [Journal Article] Selective cyclooxygenase-2 inhibitor downregulates the paracrine epithelial-mesenchymal interactions of growth in scirrhous gastric carcinoma2007

    • Author(s)
      Yashiro M, Nakazawa K, Tendo M, Kosaka K, Shinto O, Hirakawa K
    • Journal Title

      Int J Cancer 120

      Pages: 686-693

    • Related Report
      2008 Self-evaluation Report
  • [Journal Article] Selective cyclooxygenase-2 inhibitor downregulates the paracrine epithehial-mesenchymal interactions of growth in scirrhous gastric carcinoma.2007

    • Author(s)
      Yashiro M, Hirakawa, K.
    • Journal Title

      International Journal of Cancer 120

      Pages: 686-693

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A novel angiogenesis inhibitor,Ki23057,is useful for preventing the progression of colon cancer and the spreading of cancer cells to the liver.2007

    • Author(s)
      Sakurai K, Yashiro M, Hirakawa K.
    • Journal Title

      European Journal of Cancer 43

      Pages: 2612-2620

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] FGF-R2/K-samllを分子標的としたスキルス胃癌の新規治療法2007

    • Author(s)
      八代 正和, 平川 弘聖
    • Journal Title

      消化器科 44

      Pages: 447-454

    • Related Report
      2007 Annual Research Report
  • [Journal Article] Decreased expression of the adhesion molecule desmoglein-2 is associated with diffuse-type gastric carcinoma.2006

    • Author(s)
      Yashiro, M.., Nishioka, N., Hirakawa, K.
    • Journal Title

      Eur J Cancer 42

      Pages: 2397-2403

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] A synergic inhibitory-effect of combination with selective cyclooxygenase-2 inhibitor and S-1 on the peritoneal metastasis for scirrhous gastric cancer cells.2006

    • Author(s)
      Tendo, M., Yashiro, M.., Nakazawa, K., Yamada, N., Sawada, T., Ohira, M., Hirakawa, K.
    • Journal Title

      Cancer Lett 244

      Pages: 247-251

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] A novel molecular targeting compound as K-samII/FGF-R2 phosphorylation inhibitor, Ki23057, for Scirrhous gastric cancer.2006

    • Author(s)
      Nakamura, K., Yashiro, M.., Matsuoka, T., Tendo, M., Shimizu, T., Miwa, A., Hirakawa, K.
    • Journal Title

      Gastroenterology 131

      Pages: 1530-1541

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Simultaneous bilateral laparoscopic adrenalectomy for adrenocorticotropic hormone-independent macronodular adrenal hyerplasia: report of a case.2006

    • Author(s)
      Kubo, N., Onoda, N., Ishikawa, T., Ogawa, Y., Takashima, T., Yamashita, Y., Tahara, H., Inaba, M., Hirakawa, K.
    • Journal Title

      Surg Today 36

      Pages: 642-646

    • NAID

      10017614290

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Antitumor effect of trastuzumab for pancreatic cancer with high HER-2 expression and enhancement of effect by combined therapy with gemcitabine.2006

    • Author(s)
      Kimura, K., Sawada, T., Komatsu, M., Inoue, M., Muguruma, K., Nishihara, T., Yamashita, Y., Yamada, N., Ohira, M., Hirakawa, K.
    • Journal Title

      Clin Cancer Res 12

      Pages: 4925-4932

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] A novel molecular targeting compound as K-samII/FGF-R2 phosphorylation inhibitor, Ki23057, for Scirrhous gastric cancer2006

    • Author(s)
      Nakamura K, Yashiro M, Matsuoka T, Tendo M, Shimizu T, Miwa A, Hirakawa K.
    • Journal Title

      Gastroenterology 131

      Pages: 1530-1541

    • Related Report
      2008 Self-evaluation Report
  • [Journal Article] A novel molecular targeting compound as K-samII/FGF-R2 phosphorylation inhibitor, Ki23057, for Scirrhous gastric cancer.2006

    • Author(s)
      Nakamura, K., Yashiro, M., Matsuoka, T., Tendo, M., Shimizu, T., Miwa, A., Hirakawa, K
    • Journal Title

      Gastroenterology 131

      Pages: 1530-1541

    • Related Report
      2006 Annual Research Report
  • [Journal Article] スキルス胃癌における縁組化は癌の進展にどのようにかかわるのか?2006

    • Author(s)
      八代正和, 井上透, 深田鉄二, 大平雅一, 平川弘聖
    • Journal Title

      分子消化器病 3巻3号

      Pages: 245-250

    • Related Report
      2006 Annual Research Report
  • [Presentation] A novel transforming growth factor β receptor kinase inhibitor, A-77, prevents the peritoneal dissemination of scirrhous gastric carcinoma2009

    • Author(s)
      Masakazu Yashiro, Hirakawa K
    • Organizer
      100^<th> AACR meeting
    • Place of Presentation
      Denver, CO, USA
    • Year and Date
      2009-04-20
    • Related Report
      2009 Annual Research Report
  • [Presentation] A novel transforming growth factor beta receptor kinase inhibitor, A-77, prevents the peritoneal dissemination of scirrhous gastric carcinoma2009

    • Author(s)
      Yashiro M, Kawajiri H, Shinto O, Nakamura K, Tendo M, Takemura S, Node M, Hamashima Y, Kajimoto T, Sawada T, Ohira M, Hirakawa K.
    • Organizer
      100th American Association for Cancer Research
    • Place of Presentation
      Denver
    • Year and Date
      2009-04-19
    • Related Report
      2008 Self-evaluation Report
  • [Presentation] A Novel Molecular Targeting Compound as K-samII/FGFR2 Phosphorylation Inhibitor, Ki23057, for Scirrhous Gastric Cancer2008

    • Author(s)
      Yashiro, M, Nakamura, K, Matsuoka, T, Tendo, M, Shimizu, T, Miwa, A, Hirakawa K.
    • Organizer
      99th American Association for Cancer Research
    • Place of Presentation
      San Diego
    • Year and Date
      2008-04-20
    • Related Report
      2008 Self-evaluation Report
  • [Presentation] A Novel Molecular Targeting Compound as K-samII/FGFR2 Phosphorylation Inhibitor, Ki23057, for Scirrhous Gastric Cancer2008

    • Author(s)
      Yashiro, M., Nakamura, K., Matsuoka, T., Tendo, M., Shimizu, T., Miwa, A., Hirakawa, K.
    • Organizer
      102th American Association for Cancer Research
    • Place of Presentation
      San Diego
    • Year and Date
      2008-04-14
    • Related Report
      2009 Final Research Report
  • [Presentation] A novel molecular targeting compound as FGF-R2 phosphorylation inhibitor, Ki23057, for scirrhous gastric cancer.2008

    • Author(s)
      Yashiro M, Hirakawa, K.
    • Organizer
      AACR
    • Place of Presentation
      San Diego(USA)
    • Year and Date
      2008-04-14
    • Related Report
      2008 Annual Research Report
  • [Presentation] スキルス胃癌進展における病態と分子標的治療2007

    • Author(s)
      八代正和、中村和憲、豊川貴弘、井上透、山田靖哉、山下好人、前田清、小野田尚佳、澤田鉄二、仲田文造、加藤保之、大平雅一、石川哲郎、三輪篤史、平川弘聖
    • Organizer
      第18回日本消化器癌発生学会総会
    • Place of Presentation
      札幌
    • Year and Date
      2007-11-09
    • Related Report
      2009 Final Research Report
  • [Presentation] スキルス胃癌の分子標的治療2007

    • Author(s)
      八代正和、中村和憲、川尻成美、神藤理、豊川貴弘、宮園浩平、野出学、梶本哲也、三輪篤史、平川弘聖
    • Organizer
      第45回日本癌治療学会総会
    • Place of Presentation
      京都
    • Year and Date
      2007-10-26
    • Related Report
      2009 Final Research Report 2008 Self-evaluation Report
  • [Presentation] FGF-R2/K-samIIおよびTGF-βreceptorを分子標的としたスキルス胃癌転移の治療2007

    • Author(s)
      八代正和、川尻成美、神藤理、中村和憲、豊川貴弘、宮園浩平、野出学、梶本哲也、三輪篤史、平川弘聖
    • Organizer
      第62回日本消化器外科学会定期学術総会
    • Place of Presentation
      東京
    • Year and Date
      2007-07-18
    • Related Report
      2009 Final Research Report
  • [Presentation] Selective cyclooxygenase-2 inhibitor down-regulates the paracrine epithelial-mesenchymal interactions of growth in scirrhous gastric carcinoma2007

    • Author(s)
      Yashiro M, Nakazawa, K, Tendo, M, Kosaka, K, Shinto, O, Hirakawa, K.
    • Organizer
      98th American Association for Cancer Research
    • Place of Presentation
      Los Angels
    • Year and Date
      2007-04-19
    • Related Report
      2008 Self-evaluation Report
  • [Presentation] Selective cyclooxygenase-2 inhibitor down-regulates the paracrine epithelial-mesenchymal interactions of growth in scirrhous gastric carcinoma2007

    • Author(s)
      Yashiro M, Nakazawa, K., Tendo, M., Kosaka, K., Shinto, O., Hirakawa, K.
    • Organizer
      101th American Association for Cancer Research
    • Place of Presentation
      Los Angels
    • Year and Date
      2007-04-16
    • Related Report
      2009 Final Research Report
  • [Presentation] Selective cyclooxygenase-2 inhibitor downregulates the paracrine epithelial-mesenchymal interactions of growth in scirrhous gastric carcinoma.2007

    • Author(s)
      Yashiro M, Hirakawa, K.
    • Organizer
      AACR
    • Place of Presentation
      Los Angels(USA)
    • Year and Date
      2007-04-15
    • Related Report
      2007 Annual Research Report
  • [Presentation] Anti-tumor Effect of Fibroblast Growth Factor Receptor type2(FGF-R2)Inhibitor On Gastric Cancer Cells2007

    • Author(s)
      MYashiro, OShinto, TNishii, KNakamura, TInoue, A,Miwa, Khirakawa
    • Organizer
      New targets and delivery systems for cancer diagnosis and treatment
    • Place of Presentation
      San Diego
    • Year and Date
      2007-03-10
    • Related Report
      2008 Self-evaluation Report
  • [Presentation] Anti-tumor Effect of Fibroblast Growth Factor Receptor type2 (FGF-R2)Inhibitor On Gastric Cancer Cells2007

    • Author(s)
      M. Yashiro, O. Shinto, T. Nishii, K. Nakamura, T. Inoue, A, Miwa, K. Hirakawa
    • Organizer
      NEW TARGETS AND DELIVERY SYSTEMS FOR CANCER DIAGNOSIS AND TREATMENT
    • Place of Presentation
      San Diego
    • Year and Date
      2007-03-06
    • Related Report
      2009 Final Research Report
  • [Presentation] スキルス胃癌の分子標的治療2007

    • Author(s)
      八代正和、川尻成美、神藤理、井上透、西口幸雄、加藤保之、宮園浩平、野出学、榎本哲也、三輪篤史、平川弘聖
    • Organizer
      第79回日本胃癌学会総会
    • Place of Presentation
      名古屋
    • Year and Date
      2007-03-02
    • Related Report
      2009 Final Research Report
  • [Presentation] Fibroblast growth factor receptor2/K-samIIを分子標的としたスキルス胃癌の治療2006

    • Author(s)
      八代正和、中村和憲、平川弘聖
    • Organizer
      第48回日本消化器病学会大会
    • Place of Presentation
      札幌
    • Year and Date
      2006-10-11
    • Related Report
      2009 Final Research Report
  • [Presentation] TGFβレセプター阻害剤と抗腫瘍剤(S-1)の併用によるスキルス胃癌の新規治療法2006

    • Author(s)
      八代正和、川尻成美、平川弘聖
    • Organizer
      第48回日本消化器病学会大会
    • Place of Presentation
      札幌
    • Year and Date
      2006-10-11
    • Related Report
      2009 Final Research Report
  • [Presentation] DYSPLASIA-COLITIC CANCER SEQUENCE IN ULCERATIVE COLITIS IS FREQUENTLY ASSOCIATED WITH MICROSATELLITE INSTABILITY PATHWAY.2006

    • Author(s)
      M. Yashiro, I. Fujiwara, N Kubo, K. Maeda, K. Hirakawa
    • Organizer
      12th International Conference on Ulcer Research (ICUR)
    • Place of Presentation
      Osaka
    • Year and Date
      2006-07-08
    • Related Report
      2009 Final Research Report
  • [Presentation] スキルス胃癌の病態と分子標的治2006

    • Author(s)
      八代正和、中村和憲、井上透、山田靖哉、西口幸雄、澤田鉄二、大平雅一、前田清、加藤保之、石川哲郎、平川弘聖
    • Organizer
      第78回日本胃癌学会総会
    • Place of Presentation
      大阪
    • Year and Date
      2006-03-11
    • Related Report
      2009 Final Research Report
  • [Book] スキルス胃癌ー基礎と臨床ー(曽和融生、井藤久雄編)2010

    • Author(s)
      平川弘聖、八代正和
    • Publisher
      医薬ジャーナル社
    • Related Report
      2009 Final Research Report
  • [Remarks]

    • URL

      http://www.med.osaka-cu.ac.jp/surgical-oncology/

    • Related Report
      2009 Final Research Report
  • [Patent(Industrial Property Rights)] プライマー、腫瘍マーカー、及び癌の検出方法2007

    • Inventor(s)
      八代正和, 平川弘聖, 澤田鉄二
    • Industrial Property Rights Holder
      財団法人大阪産業振興機構、八代正和,平川弘聖,澤田鉄二
    • Filing Date
      2007-05-15
    • Related Report
      2009 Final Research Report
  • [Patent(Industrial Property Rights)] TGF-βシグナル阻害剤と抗腫瘍剤の組み合せ使用2007

    • Inventor(s)
      片岡一則, 宮園浩平, 狩野光伸, 平川弘聖, 八代正和, 野出學, Bae Younsoo, 西山伸宏
    • Industrial Property Rights Holder
      科学技術振興機構
    • Industrial Property Number
      2006-024843
    • Filing Date
      2007
    • Related Report
      2008 Self-evaluation Report
  • [Patent(Industrial Property Rights)] tgf-βシグナル阻害剤と抗腫瘍剤の組み合せ使用2006

    • Inventor(s)
      片岡一則(東京大学), 宮園浩平(東京大学), 狩野光伸(東京大学), 平川弘聖(大阪市立大学), 八代正和(大阪市立大学), 野出學(京都薬科大学), Bae Younsoo(東京大学), 西山伸宏(東京大学)
    • Industrial Property Rights Holder
      科学技術振興機構
    • Industrial Property Number
      2006-024843
    • Filing Date
      2006-08-30
    • Related Report
      2009 Final Research Report
  • [Patent(Industrial Property Rights)] プライマー、腫瘍マーカー、及び癌の検出方法2006

    • Inventor(s)
      八代正和, 平川弘聖, 澤田鉄二
    • Industrial Property Rights Holder
      財団法人大阪産業振興機構
    • Filing Date
      2006
    • Related Report
      2008 Self-evaluation Report

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Published: 2006-04-01   Modified: 2016-04-21  

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