Identification of risk factors related to poor angiogenic potency of bone marrow cells from different patients
| Project/Area Number |
18390378
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Thoracic surgery
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| Research Institution | Yamaguchi University |
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Principal Investigator |
HAMANO Kimikazu Yamaguchi University, Graduate School of Medicine, Professor (60263787)
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| Co-Investigator(Kenkyū-buntansha) |
MIKAMO Akihito Yamaguchi University, Graduate Schcol of Medicine, Associate Professor (30372709)
LI Tao-sheng Yamaguchi University, Graduate Schcol of Medicine, Assisting Professor (50379997)
伊東 博史 山口大学, 医学部附属病院, 助手 (90363100)
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| Project Period (FY) |
2006 – 2007
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| Project Status |
Completed (Fiscal Year 2007)
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| Budget Amount *help |
¥16,970,000 (Direct Cost: ¥14,900,000、Indirect Cost: ¥2,070,000)
Fiscal Year 2007: ¥8,970,000 (Direct Cost: ¥6,900,000、Indirect Cost: ¥2,070,000)
Fiscal Year 2006: ¥8,000,000 (Direct Cost: ¥8,000,000)
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| Keywords | Ischemia / Bone marrow cells / Therapeutic Angiogenesis / Risk factor |
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| Research Abstract |
Therapeutic angiogenesis induced by the implantation of autologous bone marrow-derived cells has been iced for the treatment of ischemic diseases. However, clinical trials have shown obvious individual differences in the improvement of regional perfusion after the implantation of autologous bone marrow cells. In this study, we aimed to identify the risk factors related to the functional impairment of bone marrow cells for inducing therapeutic angiogenesis.
We collected clinical and laboratory data from 25 patients scheduled to undergo sternotomy for various surgical procedures. Then, we aspirated bone marrow cells from the sternum during the operation, and investigated their angiogenic potency in vitro by cultivation, and in vivo using an ischemic limb model in SCID mice. We identified that aging, renal failure, anemia, and high serum levels of triglyceride, CRP, IL-6, and NTX (the markers of bone metabolism) were significantly correlated with poor angiogenic potency of bone marrow cells. We assigned scores to these risk factors according to their Pvalue, and found a strung correlation between the risk scores of patients and the angiogenic potency of their bone marrow cells (r=0.778, P<0.001). In elusion, we identified the risk factors related to poor angiogenic potency of bone marrow cells. Our results provide important information to help us select patients who will benefit most from this treatment in future clinical trials.
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Report
(3 results)
Research Products
(14 results)
