• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Biological features and development/progression of malignant pleural mesothelioma

Research Project

Project/Area Number 18390384
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Thoracic surgery
Research InstitutionHyogo College of Medicine

Principal Investigator

HASEGAWA Seiki  Hyogo College of Medicine, FACULTY OF MEDICINE, PROFESSOR (10252438)

Co-Investigator(Kenkyū-buntansha) TANAKA Fumihiro  Hyogo College of Medicine, FACULTY OF MEDICINE, ASSOCIATE PROFESSOR (10283673)
OKUMURA Yoshitomo  Hyogo College of Medicine, FACULTY OF MEDICINE, INSTRUCTOR (30388813)
MATSUMOTO Seiji  Hyogo College of Medicine, FACULTY OF MEDICINE, INSTRUCTOR (60412011)
Project Period (FY) 2006 – 2007
Project Status Completed (Fiscal Year 2007)
Budget Amount *help
¥13,810,000 (Direct Cost: ¥12,100,000、Indirect Cost: ¥1,710,000)
Fiscal Year 2007: ¥7,410,000 (Direct Cost: ¥5,700,000、Indirect Cost: ¥1,710,000)
Fiscal Year 2006: ¥6,400,000 (Direct Cost: ¥6,400,000)
KeywordsThoracic surgery / Pleural mesothelioma / Biological features / Tumor progression / Surgery
Research Abstract

1) Malignant pleural mesothelioma (MPM) is a rare malignant tumor with a poor prognosis; only a few patients can be a candidate for surgical resection, and chemotherapy or radiotherapy is usually ineffective in MPM patients. Thus, to reveal biological features as well as the nature of development and progression of MPM for improvement of the prognosis, the present study has been conducted and the following results were obtained.
2) We routinely conducted mediastinoscopy, contra-lateral thoracoscopy and laparascopy for all potentially resectable MPM patients. As a result, although it had been mentioned that nodal metastases or distant metastases were less common in MPM patients, mediastinal nodal metastases and/or contra-lateral pleural invasion were documented in 36% of patients. In addition, preoperative clinical staging was under-estimated in all 8 patients who achieved complete resection with extrapleural pneumonectomy (EPP).
3) We analyzed biological features of MPM in resected or biopsied MPM tumor specimens, and revealed no novel change specific to MPM; for example, there have been no MPM case with EGFR mutations that is sometimes documented in lung adenocarcinoma and may predict an efficacy of EGFR-tyrosine kinase inhibitors (TKIs). These results suggest that EGER-TKIs are not effective for MPM patients, which is compatible with results in clinical studies.
4) We also examined in vitro sensitivity of MPM cell lines to a various chemotherapeutic agents, and revealed that a schedule-dependent synergistic effect was documented in combination therapy of gemcitabine (GEM) and pemetrexed (MTA), both are key drugs in the treatment of MPM. These results suggest that GEM following MTA can be an optimal chemotherapeutic regimen for MPM.

Report

(3 results)
  • 2007 Annual Research Report   Final Research Report Summary
  • 2006 Annual Research Report
  • Research Products

    (42 results)

All 2008 2007 2006 Other

All Journal Article (30 results) (of which Peer Reviewed: 11 results) Presentation (11 results) Book (1 results)

  • [Journal Article] 我が国における悪性胸膜中皮腫に対する集学的治療の現状2008

    • Author(s)
      長谷川 誠紀, 他
    • Journal Title

      肺癌 48

      Pages: 93-96

    • NAID

      110006668145

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] EPP and P/D:which to choose?2008

    • Author(s)
      Hasegawa S
    • Journal Title

      Eur J Cardiothorac Surg 7

      Pages: 102-106

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] 中皮腫に対する蛍光観察(AFI)および狭帯域観察(NBI)を用いた胸腔鏡検査の試み2008

    • Author(s)
      長谷川 誠紀, 他
    • Journal Title

      気管支学 30

      Pages: 5-12

    • NAID

      110006623733

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] 悪性胸膜中皮腫の手術・化学療法2008

    • Author(s)
      田中 文啓, 他
    • Journal Title

      モダンフィジシャン

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Schedule-dependent synergistic effect of pemetrexed combined with gemcitabine against malignant pleural mesothelioma and non-small cell lung cancer cell lines2008

    • Author(s)
      Tanaka F, et. al.
    • Journal Title

      Chemotherapy (in press)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Current status and multi-modality treatment for malignant pleural mesothelioma in Japan2008

    • Author(s)
      Hasegawa S, et. al.
    • Journal Title

      Jpn J Lung Cancer 48(2)

      Pages: 93-96

    • NAID

      110006668145

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] EPP and P/D : which to choose?2008

    • Author(s)
      Hasegawa S.
    • Journal Title

      Eur J Cardiothorac Surg 7(1)

      Pages: 106-106

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Thoracoscopy combined with autofluorescene imaging and narrow band imaging for the diagnosis of malignant pleural mesothelio2008

    • Author(s)
      Hasegawa S, et. al.
    • Journal Title

      J Jpn Soc Respir Endoscopy 30(1)

      Pages: 5-12

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] 中皮腫に対する蛍光観察(AFI)および狭帯域観察(NBI)を用いた胸腔鏡検査の試み2008

    • Author(s)
      長谷川 誠紀, 他
    • Journal Title

      気管支学 30巻1号

      Pages: 5-12

    • NAID

      110006623733

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Schedule-dependent synergistic effect of pemetrexed combined with gemcitabine against malignant pleural mesothelioma and non-small cell lungcancer cell lines2008

    • Author(s)
      Tanaka F, 他
    • Journal Title

      Chemotherapy (印刷中)(印刷中)

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] COPDを合併した肺癌症例に対する肺葉切除術チオトロピウム吸入の有用性2008

    • Author(s)
      長谷川 誠紀, 他
    • Journal Title

      Therapeutic Research 29巻1号

      Pages: 69-72

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] EPP and P/D:which to choose2008

    • Author(s)
      Hasegawa S
    • Journal Title

      Eur J Cardiothorac Surg 7巻1号

      Pages: 106-106

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 悪性胸膜中皮腫の術前評価と手術適応2007

    • Author(s)
      長谷川 誠紀, 他
    • Journal Title

      胸部外科 60

      Pages: 25-29

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] アスベスト検診要精検者に対する呼吸器内視鏡検査の有用性2007

    • Author(s)
      長谷川 誠紀, 他
    • Journal Title

      気管支学 29

      Pages: 177-185

    • NAID

      110006368559

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Preoperative evaluation and surgical indication for malignant pleural mesothelioma2007

    • Author(s)
      Hasegawa S, et. al.
    • Journal Title

      Kyobu geka 60(1)

      Pages: 25-29

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Efficacy of respiratory endoscopy on : subjects requiring further detailed examinations after initial asbestos-related disease screening2007

    • Author(s)
      Hasegawa S, et. al.
    • Journal Title

      J Jpn Soc Respir Endoscopy 29(3)

      Pages: 177-185

    • NAID

      110006368559

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] アスベスト検診要精検者に対する呼吸器内視鏡検査の有用性2007

    • Author(s)
      長谷川 誠紀, 他
    • Journal Title

      気管支学 29巻3号

      Pages: 177-185

    • NAID

      110006368559

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 悪性胸膜中皮腫の術前評価と手術適応2007

    • Author(s)
      長谷川 誠紀, 他
    • Journal Title

      胸部外科 60巻1号

      Pages: 25-29

    • Related Report
      2007 Annual Research Report
  • [Journal Article] 悪性胸膜中皮腫の術前評価と手術適応2007

    • Author(s)
      奥村 好邦
    • Journal Title

      胸部外科 60・1

      Pages: 25-29

    • Related Report
      2006 Annual Research Report
  • [Journal Article] アスベスト関連疾患における呼吸器外科の役割2006

    • Author(s)
      長谷川 誠紀, 他
    • Journal Title

      医学のあゆみ 219

      Pages: 843-846

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] 胸腔鏡の呼吸器疾患診断と治療への応用2006

    • Author(s)
      長谷川 誠紀, 他
    • Journal Title

      呼吸 25

      Pages: 666-681

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Role of thoracic surgeons in diagnosis and treatment for malignant mesothelioma2006

    • Author(s)
      Hasegawa S.
    • Journal Title

      Igaku no ayumi 219(11-12)

      Pages: 843-846

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] The use of thoracoscopy for the diagnosis and treatment of pulmonary diseases2006

    • Author(s)
      Hasegawa S, et. al.
    • Journal Title

      Kokyu 25(7)

      Pages: 666-681

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] アスベスト関連疾患における呼吸器外科の役割2006

    • Author(s)
      長谷川 誠紀
    • Journal Title

      医学のあゆみ 219・11-12

      Pages: 843-846

    • Related Report
      2006 Annual Research Report
  • [Journal Article] 胸腔鏡の呼吸器疾患診断と治療への応用2006

    • Author(s)
      長谷川 誠紀
    • Journal Title

      呼吸 25・7

      Pages: 666-681

    • Related Report
      2006 Annual Research Report
  • [Journal Article] 非小細胞肺がんの術後補助化学療法2006

    • Author(s)
      田中 文啓
    • Journal Title

      呼吸器科 9・2

      Pages: 117-123

    • Related Report
      2006 Annual Research Report
  • [Journal Article] A novel classification of MUC1 expression is correlated with tumor differentiation and postoperative prognosis in non-small cell lung cancer2006

    • Author(s)
      Nagai S
    • Journal Title

      J Thorac Oncol 1・1

      Pages: 46-51

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Maspin expression and its clinical significance in non-small cell lung cancer2006

    • Author(s)
      Nakagawa M
    • Journal Title

      Ann Surg Oncol 13・11

      Pages: 1517-1523

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Therapy for malignant pleural mesothelioma

    • Author(s)
      Tanaka F.
    • Journal Title

      Modern Physician (in press)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Schedule-dependent synergistic effect of pemetrexed combined with gemcitabine against malignant pleural mesothelioma and non-small cell lung cancer cell lines

    • Author(s)
      Tanaka F, et. al.
    • Journal Title

      Chemotherapy (in press)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Circulating tumor cell(CTC) and circulating endothelial cell(CEC) in malignant pleural mesothelioma(MPM) and primary lung cancer(LC)2008

    • Author(s)
      Tanaka F, et. al.
    • Organizer
      The 2008 annual meeting of the American Society of Clinical Oncology(ASCO)
    • Place of Presentation
      Chicago(USA)
    • Year and Date
      2008-06-06
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Circulating tumor cell (CTC) and endothelial cell (CEC) in malignant pleural mesothelioma(MPM) and primary lung cancer(LC)2008

    • Author(s)
      Tanaka F, et. al.
    • Organizer
      2008年米国臨床腫瘍学会(ASCO)
    • Place of Presentation
      シカゴ市
    • Year and Date
      2008-06-03
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 悪性胸膜中皮腫に対する胸腔鏡下生検の適応と注意点2008

    • Author(s)
      奥村 好邦, 他
    • Organizer
      第25回日本呼吸器外科学会総会
    • Place of Presentation
      宇都宮市
    • Year and Date
      2008-05-29
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] EGFR-activating mutations in malignant pleural mesothelioma cancer(NSCLC)2008

    • Author(s)
      Hasegawa S, et. al.
    • Organizer
      The 99th annual meeting of the American Association for Cancer Research(AACR)
    • Place of Presentation
      San Diego(USA)
    • Year and Date
      2008-04-14
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 悪性胸膜中皮腫に対する胸膜肺全摘術に関するアンケート調査2007

    • Author(s)
      長谷川 誠紀, 他
    • Organizer
      第48回日本肺癌学会総会
    • Place of Presentation
      名古屋市
    • Year and Date
      2007-11-09
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 悪性胸膜中皮腫の術前評価と手術適応の検討2007

    • Author(s)
      長谷川 誠紀, 他
    • Organizer
      第48回日本肺癌学会総会
    • Place of Presentation
      名古屋市
    • Year and Date
      2007-11-09
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 切除可能悪性胸膜中皮腫に対するペメトレキセドを含む集学的治療に関する妥当性試験2007

    • Author(s)
      田中 文啓, 他
    • Organizer
      第48回日本肺癌学会総会
    • Place of Presentation
      名古屋市
    • Year and Date
      2007-11-09
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 胸膜中皮腫に対する集学的治療に向けて2007

    • Author(s)
      田中 文啓, 他
    • Organizer
      第48回日本肺癌学会総会
    • Place of Presentation
      名古屋市
    • Year and Date
      2007-11-09
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 悪性胸膜中皮腫におけるEGFR遺伝子変異2007

    • Author(s)
      長谷川 誠紀, 他
    • Organizer
      第48回日本肺癌学会総会
    • Place of Presentation
      名古屋市
    • Year and Date
      2007-11-08
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 悪性胸膜中皮腫に対する肺全摘術を含めた集学的治療2007

    • Author(s)
      長谷川 誠紀, 他
    • Organizer
      第45回日本癌治療学会総会
    • Place of Presentation
      京都市
    • Year and Date
      2007-10-25
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] EGFR-activating mutations in malignant pleural mesothelioma2007

    • Author(s)
      Hasegawa S, et. al.
    • Organizer
      第99回米国癌学会(AACR)
    • Place of Presentation
      サンヂエゴ市
    • Year and Date
      2007-04-14
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Book] Annual Review 呼吸器20072007

    • Author(s)
      田中 文啓
    • Total Pages
      246
    • Publisher
      中外医学社
    • Related Report
      2006 Annual Research Report

URL: 

Published: 2006-04-01   Modified: 2016-04-21  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi