Mechanism of adult neurogenesis specific for primates

• Project/Area Number: 18390392
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Cerebral neurosurgery
• Research Institution: Kanazawa University
• Principal Investigator: YAMASHIMA Tetsumori (YAMASHIMA TETsumori) Kanazawa University, 医学系, 准教授 (60135077)
• Project Period (FY): 2006 – 2009
• Project Status: Completed (Fiscal Year 2009)
• Budget Amount: ¥18,520,000 (Direct Cost: ¥15,100,000、Indirect Cost: ¥3,420,000); Fiscal Year 2009: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000); Fiscal Year 2008: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000); Fiscal Year 2007: ¥6,500,000 (Direct Cost: ¥5,000,000、Indirect Cost: ¥1,500,000); Fiscal Year 2006: ¥3,700,000 (Direct Cost: ¥3,700,000)
• Keywords: 霊長類 / 成体脳 / 海馬 / ニューロン新生 / GPR40 / 多価不飽和脂肪酸 / 成体脳ニューロン新生 / ニホンザル / 神経幹細胞 / 脳虚血 / 記憶障害 / サル / ドコサヘキサエン酸 / アラキドン酸 / 歯状回 / 顆粒細胞下層 / 記憶 / ダウン症 / DSCAM

Research Abstract

多価不飽和脂肪酸のシグナルを受け膵臓でインスリン分泌に関わるGPR40が脳でも発現していることに注目し、成体脳ニューロン新生の研究を進めた。その結果、1)gpr40遺伝子を導入したPC12細胞はアラキドン酸に対して興奮する。2)虚血サル海馬において、ニューロン新生がピークとなる時期にGPR40は発現を増幅し、新生ニッチに局在する。さらに、3)GPR40を持つ骨髄幹細胞が、DHAでその発現を増幅しつつ神経細胞へと分化する。同様に、4)ラット神経幹細胞にgpr40遺伝子を導入すると、DHAによって神経細胞に分化すことがわかった。

Research Products

• [Journal Article] DHA promotes the neuronal differentiation of rat neural stem cells transfected with GPR40 gene (2010)
  • Author(s): Ma D, Zhang M, Larsen CP, Xu F, Hua W, Yamashima T, Mao Y, Zhou L.
  • Journal Title: Brain Res. 2010 Mar4([Epub ahead of print] 印刷中)
  • Peer Reviewed
• [Journal Article] Calpain-mediated Hsp70.1 cleavage in hippocampal CA1 neuronal death (2010)
  • Author(s): Sahara S, Yamashima T.
  • Journal Title: Biochem Biophys Res Commun 393 Pages: 806-811
  • Peer Reviewed
• [Journal Article] 3) Effects of discontinuing benzodiazepine-derivative hypnotics on postural sway and cognitive functions in the elderly (2010)
  • Author(s): Tsunoda K, Uchida H, Suzuki T, Watanabe K, Yamashima T, Kashima H.
  • Journal Title: Int J Geriatr Psychiatry 2010 Jan 6([Epub ahead of print] 印刷中)
  • Peer Reviewed
• [Journal Article] Caspase Inhibitor, ZVAD-fmk, facilitates engraftment of donor hematopoietic stem cells in intra-bone marrow transplantation (2010)
  • Author(s): Imai Y, Adachi Y, Shi M, Shima C, Yanai S, Okigaki M, Yamashima T, Kaneko, K., Ikehara S.
  • Journal Title: Stem Cells Dev. 2010 Mar 22([Epub ahead of print] 印刷中)
  • Peer Reviewed
• [Journal Article] Expression of fatty acid-binding proteins in adult hippocampal neurogenic niche of postischemic monkeys (2010)
  • Author(s): Boneva NB, Kaplamadzhiev DB, Sahara S, Kikuchi H, Pyko IV, Kikuchi M, Tonchev AB, Yamashima T.
  • Journal Title: Hippocampus 2010 Mar([Epub ahead of print] 印刷中)
  • Peer Reviewed
• [Journal Article] The role of lysosomal rupture in neuronal death (2009)
  • Author(s): Yamashima T, Oikawa S.
  • Journal Title: Prog Neurobiol. 89 Pages: 343-358
  • Peer Reviewed
• [Journal Article] Caspase Inhibitor, ZVAD-fmk, facilitates engraftment of donor hematopoietic stem cells in intra-bone marrow transplantation. (2009)
  • Author(s): Imai Y, Adachi Y, Shi M, Shima C, Yanai S, Okigaki M, Yamashima T, Kaneko K, Ikehara S.
  • Journal Title: Stem Cells Dev. 19 Pages: 461-468
  • Peer Reviewed
• [Journal Article] Cellular localization of epidermal-type and brain-type fatty acid-binding proteins in adult hippocampus and their response to cerebral ischemia. (2009)
  • Author(s): Ma D, Zhang M, Mori Y, Yao C, Larsen CP, Yamashima T, Zhou L.
  • Journal Title: Hippocampus. (Epub ahead of print) Pages: 19623607-19623607
• [Journal Article] Anomaly in aortic arch alters pathological outcome of transient global ischemia in rhesus macaques. (2009)
  • Author(s): Hara K, Yasuhara T, Maki M, Matsukawa N, Yu G, Xu L, Tambrallo L, Rodriguez NA, Stern DM, Yamashima T, Buccafusco JJ, Kawase T
  • Journal Title: Hess DC, Borlongan CV. Brain Res. 1286 Pages: 185-191
• [Journal Article] Morphological changes in the visual pathway induced by experimental glaucoma in Japanese monkeys. (2009)
  • Author(s): Ito Y, Shimazawa M, Chen YN, Tsuruma K, Yamashima T, Araie M, Hara H.
  • Journal Title: Exp Eye Res. 89(2) Pages: 246-255
  • Peer Reviewed
• [Journal Article] Proteomic identification of carbonylated proteins in the monkey hippocampus after ischemia-reperfusion. (2009)
  • Author(s): Oikawa S, Yamada T, Minohata T, Kobayashi H, Furukawa A, Tada-Oikawa S, Hiraku Y, Murata M, Kikuchi M, Yamashima T.
  • Journal Title: Free Radic Biol Med. 46(11) Pages: 1472-7
  • Peer Reviewed
• [Journal Article] The role of lysosomal rupture in neuronal death (2009)
  • Author(s): Yamashima T, Oikawa S.
  • Journal Title: Prog Neurobiol 89 Pages: 343-358
  • Peer Reviewed
• [Journal Article] Cellular localization of epidermal-type and brain-type fatty acid-binding proteins in adult hippocampus and their response to cerebral ischemia (2009)
  • Author(s): Ma D, Zhang M, Mori Y, Yao C, Larsen CP, Yamashima T, Zhou L.
  • Journal Title: Hippocampus PMID : 19623607([Epub ahead of print] 印刷中)
  • Peer Reviewed
• [Journal Article] Anomaly in aortic arch alters pathological outcome of transient global ischemia in rhesus macaques. (2009)
  • Author(s): Hara K, Yasuhara T, Maki M, Matsukawa N, Yu G, Xu L, Tambrallo L, Rodriguez NA, Stern DM, Yamashima T, Buccafusco JJ, Kawase T, Hess DC, Borlongan CV.
  • Journal Title: Brain Res. 1286 Pages: 185-191
  • Peer Reviewed
• [Journal Article] Morphological changes in the visual pathway induced by experimental glaucoma in Japanese monkeys (2009)
  • Author(s): Ito Y, Shimazawa M, Chen YN, Tsuruma K, Yamashima T, Araie M, Hara H.
  • Journal Title: Exp Eye Res. 89 Pages: 246-255
  • Peer Reviewed
• [Journal Article] Proteomic identification of carbonylated proteins in the monkey hippocampus after ischemia-reperfusion (2009)
  • Author(s): Oikawa S, Yamada T, Minohata T, Kobayashi H, Furukawa A, Tada-Oikawa S, Hiraku Y, Murata M, Kikuchi M, Yamashima T.
  • Journal Title: Free Radic Biol Med 46 Pages: 1472-1477
  • Peer Reviewed
• [Journal Article] Expression of fatty acid binding proteins in adult hippocampal neurogenic niche of postischemic monkeys. Boneva NB, Kaplamadzhiev DB (2008)
  • Author(s): Sahara S, Kikuchi H, Pyko IV, Kikuchi M, Tonchev AB, YamashimaT.
  • Journal Title: Hippocampus. (Epub ahead of print)
  • Peer Reviewed
• [Journal Article] Expression of neurotrophin receptors by proliferating glia in postischemic hippocampal CA1 sector of adult monkeys. (2008)
  • Author(s): Tonchev AB, Boneva NB, Kaplamadzhiev DB, Kikuchi M, Mori Y, Sahara S, Yamashima T., J.
  • Journal Title: Neuroimmunol 205(1-2) Pages: 20-24
  • Peer Reviewed
• [Journal Article] Expression of matrix metalloproteinases in the neurogenic niche of the adult monkey hippocampus after ischemia. (2008)
  • Author(s): Lu L, Tonchev AB, Kaplamadzhiev DB, Boneva NB, Mori Y, Sahara S, Ma D, Nakaya MA, Kikuchi M, Yamashima T.
  • Journal Title: Hippocampus. 18(10) Pages: 1074-1084
  • Peer Reviewed
• [Journal Article] A putative link of PUFA, GPR40 and adult-born hippocampal neurons for memory. (2008)
  • Author(s): Yamashima T.
  • Journal Title: Prog Neurobiol. 84(2) Pages: 105-115
  • NAID: 120000997253
  • Peer Reviewed
• [Journal Article] Expression of free fatty acid receptor GPR40 in the neurogenic niche of adult monkey hippocampus. (2008)
  • Author(s): Ma D, Lu L, Boneva NB, Warashina S, Kaplamadzhiev DB, Mori Y, Nakaya MA, Kikuchi M, Tonchev AB, Okano H, Yamashima T.
  • Journal Title: Hippocampus. 18(3) Pages: 326-333
  • Peer Reviewed
• [Journal Article] A putative link of PUFA, GPR40 and adult-born hippocampal neurons for memory (2008)
  • Author(s): Yamashima T.
  • Journal Title: Prog Neurobiol 84(2) Pages: 105-15
  • NAID: 120000997253
  • Peer Reviewed
• [Journal Article] Expression of free fatty acid receptor GPR40 in the neurogenic niche of adult monkey hippocampus (2008)
  • Author(s): Ma D, Lu L, Boneva NB, Warashina S, Kaplamadzhiev DB, Mori Y, Nakaya MA, Kikuchi M, Tonchev AB, Okano H, Yamashima T.
  • Journal Title: Hippocampus 18(3) Pages: 326-33
  • Peer Reviewed
• [Journal Article] A putative link of PUFA, GPR40 and adult-born hippocampal neurons for memory. (2008)
  • Author(s): Yamashima T.
  • Journal Title: Prog Neurobiol. 84 Pages: 105-115
  • NAID: 120000997253
  • Peer Reviewed
• [Journal Article] Expression of free fatty acid receptor GPR40 in the neurogenicniche of adult monkey hippocampus. (2008)
  • Author(s): Ma D, 他10名
  • Journal Title: Hippocampus 18 Pages: 326-333
  • Peer Reviewed
• [Journal Article] Expression of matrix metalloproteinases in the neurogenic niche of the adult monkey hippocampus after ischemia. (2008)
  • Author(s): Lu L, 他9名
  • Journal Title: Hippocampus 18 Pages: 1074-1084
  • Peer Reviewed
• [Journal Article] Expression of Free Fatty Acid Receptor GPR40 in the Neurogenic Niche of Adult Monkey Hippocampus (2008)
  • Author(s): D.Ma, L. Lu, N.B. Boneva, S. Warashina, D.B. Kaplamadzhiev, Y.Mori, M. Nakaya, M. Kikuchi, A.B. Tonchev, H. Okano, T. Yamashima
  • Journal Title: Hippocampus 18 Pages: 326-333
  • Peer Reviewed
• [Journal Article] A putative link of PUFA, GPR40 and adult-born hippocampal neurons for memory (2008)
  • Author(s): T.Yamashima
  • Journal Title: Prog Neurobiology 84 Pages: 105-115
  • NAID: 120000997253
  • Peer Reviewed
• [Journal Article] Hippocampal CA1 cell loss in a non-human primate model of transient global ischemia: a pilot study. (2007)
  • Author(s): Hara K, Yasuhara T, Matsukawa N, Maki M, Masuda T, Yu G, Xu L, Tambrallo L, Rodriguez NA, Stern DM, Kawase T, Yamashima T, Buccafusco JJ, Hess DC, Borlongan CV.
  • Journal Title: Brain Res Bull. 74(1-3) Pages: 164-171
  • Peer Reviewed
• [Journal Article] Expression of free fatty acid receptor GPR40 in the CNS of adult monkeys. (2007)
  • Author(s): Ma D, Tao B, Warashina S, Kotani S, Lu L, Kaplamadzhiev DB, Mori Y, Tonchev AB, Yamashima T.
  • Journal Title: Neurosci Res. 58(4) Pages: 394-401
  • Peer Reviewed
• [Journal Article] "Transcribing" postischemic neurogenesis: a tale revealing hopes of adult brain repair. (2007)
  • Author(s): Tonchev AB, Yamashima T.
  • Journal Title: J Mol Med. 85(6) Pages: 539-542
  • Peer Reviewed
• [Journal Article] Inhibition of axonal outgrowth in the tumor environment: involvement of class 3 semaphorins. (2007)
  • Author(s): Vachkov H, Huang X, Yamada Y, Tonchev A, Yamashima T, Kato S, Takakura N.
  • Journal Title: Cancer Sci. 98(8) Pages: 1192-1197
  • NAID: 10019539226
  • Peer Reviewed
• [Journal Article] Distribution and phenotype of proliferating cells in the forebrain of adult macaque monkeys after transient global cerebral ischemia. (2007)
  • Author(s): Tonchev AB, Yamashima T, Chaldakov GN.
  • Journal Title: Adv Anat Embryol Cell Biol.
  • Peer Reviewed
• [Journal Article] Adult hippocampal neurogenesis in rodents and primates: endogenous, enhanced, and engrafted. (2007)
  • Author(s): Yamashima T, Tonchev AB, Yukie M.
  • Journal Title: Rev Neurosci. 18(1) Pages: 67-82
  • Peer Reviewed
• [Journal Article] Differential response to ischemia in adjacent hippocampal sectors: neuronal death in CA1 versus neurogenesis in dentate gyrus. (2007)
  • Author(s): Yamashima T, Tonchev A, Borlongan CV.
  • Journal Title: Biotech J. 2(5) Pages: 596-607
  • Peer Reviewed
• [Journal Article] Expression of angiogenic and neurotrophic factors in the progenitor cell niche of adult monkey subventricular zone (2007)
  • Author(s): Tonchev AB, Yamashima T, Guo J, Chaldakov GN, Takakura N.
  • Journal Title: Neuroscience. 144(4) Pages: 1425-1435
  • Peer Reviewed
• [Journal Article] Expression of free fatty acid receptor GPR40 in the CNS of adult monkeys (2007)
  • Author(s): Ma D, Tao B, Warashina S, Kotani S, Lu L, Kaplamadzhiev DB, Mori Y, Tonchev AB, Yamashima T.
  • Journal Title: Neurosci Res 58(4) Pages: 394-401
  • Peer Reviewed
• [Journal Article] Hippocampal CAl cell loss in a non-human primate model of transient global ischemia: Apilot study (2007)
  • Author(s): Hara K, Yasuhara T, Matsukawa N, Maki M, Masuda T, Yu G, Xu L, TambralloL, Rodriguez NA, Stem DM, Kawase T, Yamashima T, Buccafusco JJ, Hess DC, Borlongan CV.
  • Journal Title: Brain Res Bull 74 Pages: 164-171
  • Peer Reviewed
• [Journal Article] Expression of free fatty acid receptor GPR40 in the central nervous system of adult monkeys (2007)
  • Author(s): Ma D, Tao B, Warashina S, Kotani S, LuL, Kaplamadzhiev DB, Mori Y, Tonchev AB, Yamashima T.
  • Journal Title: Neurosci Res 58 Pages: 394-401
  • NAID: 10024416365
  • Peer Reviewed
• [Journal Article] Transcribing postischemic neurogenesis: a tale revealing hopes of adult brain repair (2007)
  • Author(s): Tonchev AB, Yamashima T.
  • Journal Title: J Mol Med 85 Pages: 539-542
  • Peer Reviewed
• [Journal Article] Inhibition of axonal outgrowth in the tumor environment: Involvement of class 3 semaphorins (2007)
  • Author(s): Vachkov IH, Huang X, Yamada Y, Tonchev AB, Yamashima T, Kato S, Takakur N.
  • Journal Title: Cancer Sci 98 Pages: 1-106
  • NAID: 10019539226
  • Peer Reviewed
• [Journal Article] Distribution and phenotype of proliferating cells in the forebrain of adult macaque monkeys after transient global cerebral ischemia (2007)
  • Author(s): Tonchev AB, Yamashima T, Chaldakov GN.
  • Journal Title: Adv Anat Embryol Cell Biol 191 Pages: 1-106
  • Peer Reviewed
• [Journal Article] Differential response to ischemia in adjacent hippocampalsectors: neuronal death in CAl versus neurogenesis in dentate gyrus (2007)
  • Author(s): Yamashima T, Tonchev AB, Yukie M.
  • Journal Title: Rev Neurosci 18 Pages: 67-82
  • Peer Reviewed
• [Journal Article] Differential response to ischemia in adjacent hippocampalsectors:neuronal death in CAl versus neurogenesis in dentate gyrus (2007)
  • Author(s): Yamashima T, Tonchev AB, Borlongan CV.
  • Journal Title: Biotechnol J. 2 Pages: 596-607
  • Peer Reviewed
• [Journal Article] Expression of angiogenic and neurotrophic factors in the progenitor cell niche of adult monkey subventricular zone (2007)
  • Author(s): Tonchev AB, Yamashima T, Guo J, Chaldakov GN. Takakura N.
  • Journal Title: Neuroscience 144 Pages: 1425-1435
  • Peer Reviewed
• [Journal Article] Implication of "Down syndrome cell adhesion molecule" in the hippocampal neurogenesis of ischemic monkeys. (2006)
  • Author(s): Yamashima T, Popivanova BK, Guo J, Kotani S, Wakayama T, Iseki S, Sawamoto K, Okano H, Fujii C, Mukaida N, Tonchev AB.
  • Journal Title: Hippocampus. 16(11) Pages: 924-935
  • Peer Reviewed
• [Journal Article] Dietary supplementation of arachidonic and docosahexaenoic acids improves cognitive dysfunction. (2006)
  • Author(s): Kotani S, Sakaguchi E, Warashina S, Matsukawa N, Ishikura Y, Kiso Y, Sakakibara M, Yoshimoto T, Guo J, Yamashima T.
  • Journal Title: Neurosci Res. 56(2) Pages: 159-164
  • NAID: 10019272328
  • Peer Reviewed
• [Journal Article] Impairments in recognition memory for object and for location after transient brain ischemia in monkeys. (2006)
  • Author(s): Yukie M, Yamaguchi K, Yamashima T.
  • Journal Title: Rev Neurosci. 17(1) Pages: 201-214
  • Peer Reviewed
• [Journal Article] Transcription factor protein expression patterns by neural or neuronal progenitor cells of adult monkey subventricular zone. (2006)
  • Author(s): onchev AB, Yamashima T, Sawamoto K, Okano H.
  • Journal Title: Neuroscience. 139(4) Pages: 1355-1367
  • Peer Reviewed
• [Journal Article] Differential neurogenic potential of progenitor cells in dentate gyrus and CA1 sector of the postischemic adult monkey hippocampus. (2006)
  • Author(s): Tonchev AB, Yamashima T.
  • Journal Title: Exp Neurol. 198(1) Pages: 101-113
  • Peer Reviewed
• [Journal Article] Implication of "Down syndrome cell adhesion molecule" in the hippocampal neurogenesis of ischemic monkeys (2006)
  • Author(s): Yamashima T, Popivanova BK, Guo J, Kotani S, Wakayama T, Iseki S, Sawamoto K, Okano H, Fujii C, Mukaida N, Tonchev AB
  • Journal Title: Hippocampus 16(11) Pages: 924-35
  • Peer Reviewed
• [Journal Article] Dietary supplementation of arachidonic and docosahexaenoic acids improves cognitive dysfunction (2006)
  • Author(s): Kotani S, Sakaguchi E, Warashina S, Matsukawa N, Ishikura Y, Kiso Y, Sakakibara M, Yoshimoto T,Guo J, Yamashima T
  • Journal Title: Neurosci Res 56(2) Pages: 159-64
  • NAID: 10019272328
  • Peer Reviewed
• [Journal Article] Implication of "Down syndrome cell adhesion molecule" in the hippocampal neurogenesis of ischemic monkeys. (2006)
  • Author(s): Yamashima T, Popivanova BK, Guo J, Kotani S, Wakayama T, Iseki S, Sawamoto K, Okano H, Fujii C, Mukaida N, Tonchev AB.
  • Journal Title: Hippocampus 16・11 Pages: 924-935
• [Journal Article] Transcription factor protein expression patterns by neural or neuronal progenitor cells of adult monkey subventricular zone. (2006)
  • Author(s): Tonchev AB, Yamashima T, Sawamoto K, Okano H
  • Journal Title: Neuroscience 139・4 Pages: 1355-1367
• [Journal Article] Differential neurogenic potential of progenitor cells in dentate gyrus and CA1 sector of the postischemic adult monkey hippocampus. (2006)
  • Author(s): Tonchev AB, Yamashima T.
  • Journal Title: Expimental Neurology 198・1 Pages: 101-113
• [Journal Article] Impairment of recognition memory tasks after transient brain ischemia in monkeys. (2006)
  • Author(s): Yukie M, Yamaguchi K, Yamashima T.
  • Journal Title: Review in the Neuroscience 17・1-2 Pages: 201-214
• [Journal Article] Dietary supplementation of arachidonic and docosahexaenoic acids improves cognitive dysfunction. (2006)
  • Author(s): Kotani S, Sakaguchi E, Wara-shina S, Matsukawa N, Ishikura Y, Kiso Y, Sakakibara M, Yoshimoto T, Guto J, Yamashima T.
  • Journal Title: Neuroscience Research 56・2 Pages: 159-164
  • NAID: 10019272328
• [Journal Article] Expression of angiogenic and neurotrophic factors in the progenitor cell niche of adult monkey subventricular zone. (2006)
  • Author(s): Tonchev AB, Yamashima T
  • Journal Title: Neuroscience 144・4 Pages: 1425-1435
• [Presentation] 虚血性神経細胞死におけるリソソーム膜の破裂機構-新カルパイン-カテプシン仮説の提唱- (2009)
  • Author(s): 山嶋哲盛、及川伸二、小林果
  • Organizer: 第32回日本神経科学会
  • Place of Presentation: 名古屋国際会議場愛知県
  • Year and Date: 2009-09-16
• [Presentation] 虚血性神経細胞死におけるリソソーム膜の破裂機構 -新カルパイン-カテプシン仮説の提唱- (2009)
  • Author(s): 山嶋哲盛, 及川伸二, 小林果
  • Organizer: 第32回日本神経科学会
  • Place of Presentation: 名古屋国際会議場 (愛知県)
  • Year and Date: 2009-09-16
• [Presentation] 成体サル海馬におけるニューロン新生と (2009)
  • Author(s): 山嶋哲盛
  • Organizer: 第36回日本脳科学会GPR40
  • Place of Presentation: 金沢金沢大学医学部記念館石川県
  • Year and Date: 2009-06-12
• [Presentation] 成体サル海馬におけるニューロン新生とGPR40 (2009)
  • Author(s): 山嶋哲盛
  • Organizer: 第36回日本脳科学会
  • Place of Presentation: 金沢大学十全講堂 (石川県)
  • Year and Date: 2009-06-12
• [Presentation] 「霊長類に特異的な神経細胞の生と死」-20年間のサル研究から- (2008)
  • Author(s): 山嶋哲盛
  • Organizer: 第17回海馬と高次脳機能学会
  • Place of Presentation: 金沢創作の森交流研修棟石川県
  • Year and Date: 2008-11-23
• [Presentation] リーサスモンキーを用いた一過性全脳虚血モデルの作製 (2008)
  • Author(s): 原晃一、安原隆雄、松川則之、Nancy A. Rodrigue、山嶋哲盛、Jerry J. Buccafusco、河瀬文武、David C Hess
  • Organizer: 第31回日本神経科学大会
  • Place of Presentation: 東京フォーラム東京都
  • Year and Date: 2008-07-11
• [Presentation] プロテオミクス解析を用いた虚血再灌流後のサル海馬におけるカルボニル化蛋白質の同定 (2008)
  • Author(s): 小林果、山田智子、山嶋哲盛、及川伸二
  • Organizer: 第31回日本神経科学大会
  • Place of Presentation: 東京東京フォーラム東京都
  • Year and Date: 2008-07-11
• [Presentation] PUFAはGPR40を介して霊長類のニューロン新生に役立つシンポジウムSY3A-G「多価不飽和脂肪酸とニューロン機能」 (2008)
  • Author(s): 山嶋哲盛
  • Organizer: 第31回日本神経科学大会
  • Place of Presentation: 東京東京フォーラム東京都
  • Year and Date: 2008-07-11
• [Presentation] Role of PUFA and GPR40 for adult neurogenesis in primates (2008)
  • Author(s): Yamashima, T
  • Organizer: 31st Annual Meeting of the Japan Neuroscience Society
  • Place of Presentation: Tokyo
  • Year and Date: 2008-07-11
• [Presentation] Role of PUFA and GPR40 for adult neurogenesis in primates (2008)
  • Author(s): Yamashima T.
  • Organizer: The 31^<st>. annual meeting of the japanneuroscience society
  • Place of Presentation: 東京
  • Year and Date: 2008-07-11
• [Presentation] サル海馬の新生細胞は遊離脂肪酸レセプターのGPR40を発現する:何故? (2008)
  • Author(s): 山嶋哲盛
  • Organizer: 第7回成体脳のニューロン新生懇談会
  • Place of Presentation: 東京東京大学医学部東京都
  • Year and Date: 2008-03-22
• [Presentation] 「海馬における時間空間情報統合の比較心理学的研究」および「海馬の異なる情報統合機能に関する比較心理学的研究」 (2008)
  • Author(s): 山嶋哲盛
  • Organizer: 虚血サル海馬におけるニューロンの生と死科学研究費補助金基盤研究(A)研究集会
  • Place of Presentation: 東京慶應大学文学部東京都
  • Year and Date: 2008-02-01
• [Presentation] 虚血サル海馬のニューロン新生とDSCAM (2007)
  • Author(s): 山嶋哲盛、Popivanova B.、Guo J.向田直史
  • Organizer: 第16回海馬と高次脳機能学会
  • Place of Presentation: 奈良奈良県文化会館奈良県
  • Year and Date: 2007-11-24
• [Presentation] 虚血サル海馬のニューロン新生とDSCAM (2007)
  • Author(s): 山嶋 哲盛、Popivanova B.、 Guo J., 向田 直史
  • Organizer: 第16回 海馬と高次脳機能学会
  • Place of Presentation: 奈良
  • Year and Date: 2007-11-24
• [Presentation] 虚血サル海馬のニューロン新生とDSCAM (2007)
  • Author(s): 山嶋哲盛
  • Organizer: 第30回日本神経科学大会
  • Place of Presentation: 横浜パシフィコ横浜神奈川県
  • Year and Date: 2007-09-11
• [Presentation] 虚血サル海馬のニューロン新生とDSCAM (2007)
  • Author(s): 山嶋 哲盛
  • Organizer: 第30回 日本神経科学大会
  • Place of Presentation: 横浜
  • Year and Date: 2007-09-11
• [Presentation] 虚血サル海馬におけるニューロン新生とマトリックスメタロプロテアーゼ (2007)
  • Author(s): 陸莉、山嶋哲盛
  • Organizer: 第31回日本神経科学大会
  • Place of Presentation: 東京東京フォーラム東京都
  • Year and Date: 2007-07-09
• [Book] Acute Neuronal Injury (Edited by D. Fujikawa, Role ofμ-calpain and lysosomal cathepsins in hippocampal neuronal necrosis after transient global ischemia in primates.) (2009)
  • Author(s): Tonchev AB, Yamashima T.
  • Publisher: Springer Science Business Media, LLC
• [Book] Acute Neuronal Injury (2009)
  • Author(s): Tonchev AB, Yamashima T.
  • Total Pages: 250
  • Publisher: Springer Science Business Media, LLC
• [Book] Meningiomas (2008)
  • Author(s): Yamashima T.
  • Publisher: Human meninges : anatomy and its role in meningioma pathogenesis
• [Remarks]
  • URL: http://web.kanazawa-u.ac.jp/%7Emed66/
• [Remarks]
  • URL: http://web.kanazawa-u.ac.jp/~med66/
• [Remarks]
  • URL: http://web.kanazawa-u.ac.jp/%7Emed66/
• [Remarks]
  • URL: http://web.kanazawa-u.ac.jp/%7Emed66/
• [Remarks]
  • URL: http://web.kanazawa-u.ac.jp/%7Emed66/
• [Patent(Industrial Property Rights)] GPR40陽性骨髄幹細胞 (2010)
  • Inventor(s): 山嶋哲盛
  • Industrial Property Rights Holder: 金沢大学
  • Filing Date: 2010-01-05
• [Patent(Industrial Property Rights)] GPR40陽性骨髄幹細胞 (2010)
  • Inventor(s): 山嶋哲盛
  • Industrial Property Rights Holder: 金沢大学
  • Industrial Property Number: 2010-000736
  • Filing Date: 2010-01-05
• [Patent(Industrial Property Rights)] GPR40を利用した脳機能改善薬の評価方法 (2007)
  • Inventor(s): 山嶋哲盛
  • Industrial Property Rights Holder: 金沢大学
  • Filing Date: 2007-12-12