Study on the treatment of dural arteriovenous fistula by the inhibition of angiogenic growth factors
| Project/Area Number |
18390402
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Cerebral neurosurgery
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| Research Institution | Nara Medical University |
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Principal Investigator |
SAKAKI Toshisuke Nara Medical University, 医学部附属病院, その他 (20118029)
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| Co-Investigator(Kenkyū-buntansha) |
NAKASE Hiroyuki 奈良県立医科大学, 医学部, 教授 (10217739)
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| Project Period (FY) |
2006 – 2009
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| Project Status |
Completed (Fiscal Year 2009)
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| Budget Amount *help |
¥16,300,000 (Direct Cost: ¥14,800,000、Indirect Cost: ¥1,500,000)
Fiscal Year 2009: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2008: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2007: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2006: ¥9,800,000 (Direct Cost: ¥9,800,000)
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| Keywords | 脳硬膜動静脈瘻 / 脳虚血 / 静脈梗塞 / 血管新生因子 / 遺伝子治療 / 脳腫瘍 / 免疫治療 / 樹状細胞 / 養子免疫療法 / インターフェロン / 脳血管障害学 / 硬膜動静脈奇形 |
|---|
| Research Abstract |
The precise mechanisms responsible for the development and growth of dural arteriovenous fistula (DAVF) remain unclear, but it has been hypothesized that vascular angiogenic growth factors might be involved in the pathogenesis. Also, it remains unknown that Brain-Derived Neurotrophic Factor (BDNF) effect on regional Cerebral Blood Flow (rCBF) and has neuroprotective effect in cerebral venous ischemia. The present study was undertaken to investigate whether intraventricular BDNF infusion effects on infarct size and suppression of apoptosis in cerebral venous ischemic lesion in a rat 2-vein occlusion (2-VO) model and effect on rCBF. As the results, there were no statistical differences in rCBF between BDNF-treated and control groups. It was found that the mean infarct volumes after 2-VO were significantly smaller in BDNF-treated animals than controls at 2 days (1.49±1.44% v.s.3.66±1.51%, P<0.05) and 7 days (0.93±0.47% v.s. 1.69±0.58%, P<0.05). The number of TUNEL positive cells detected at 2 days after 2-VO was significantly fewer in BDNF-treated animals (17.0±15.1) than controls (39.0±19.6, P<0.05). These results suggest that continuous intraventricular administration of BDNF protects apoptotic change of brain cortex and reduced infarct size without effect on rCBF in rat venous infarction model.
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Report
(6 results)
Research Products
(34 results)
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[Journal Article] CoCl(2)inhibits neural differentiation of retinoic acid-treated embryo id bodies2008
Author(s)
Nonaka J., Yoshikawa M., Ouji Y., Matsuda R., Nishimura F., Yamada S., Nakase H., Moriya K., Nishiofuku M., Ishizaka S., Sakaki T.
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Journal Title
J Biosci Bioeng 106
Pages: 141-147
NAID
Related Report
Peer Reviewed
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[Journal Article] Basic study on the pathogenesis of dural arteriovenous2006
Author(s)
Nakase H., Shin Y., Tamura K., Tamaki R., Miyake H., Takeshima Y., Inui T., Nakamura M., Shimada K., Konishi N., Sakaki T.
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Journal Title
Neurotrauma Research 18
Pages: 4-7
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[Presentation]2009
Author(s)
堀内薫, 中瀬裕之, 田村健太郎, 竹島靖浩, 三宅仁, 榊寿右, LV Q., Heimann A., Li H., Kempski O.
Organizer
Stroke2009
Place of Presentation
松江
Year and Date
2009-03-22
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[Presentation]2007
Author(s)
堀内薫, 西岡利和, 木村僚太, 田村健太郎, 玉置亮, 乾登史孝, 竹島靖浩, 三宅仁, 中瀬裕之, 榊寿右
Organizer
第32回日本脳卒中学会総会
Place of Presentation
福岡
Year and Date
2007-03-23
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